Search Results (11,797)

Clarifying the residential space differentiation in urban fringe areas and its influencing factors are crucial for land use planning and sustainable urban development. This study investigates residential space differentiation and its influencing factors in the urban fringe area of Beijing from the perspective of housing rent. Utilizing multi-source data, including housing rent statistics from the China Real Estate Price Platform, remote sensing imagery, and POI big data, we employ the residential dissimilarity index for tenants, geographical detector, and MGWR model to analyze spatial patterns and driving mechanisms. The results show the following: (1) The residential space differentiation in the urban fringe area of Beijing is obvious, showing an “X”-shaped fragmentation pattern, with the northeast and southwest regions forming high differentiation values, while the northwest and southeast regions form low differentiation values. (2) The residential space differentiation in the marginal area shows a strong scale effect, which originates from the historic “collage” development mode of Beijing. (3) The differentiation of residential space in Beijing’s urban fringe area is sensitive to the spatial accessibility of residential areas to other facilities, and is less affected by the spatial proximity, such as the number of facilities. (4) The central potential and traffic potential factors are still the core driving forces shaping the differentiation pattern of residential space in the marginal area; the role of leisure supporting factors has become increasingly prominent, and it has gradually become the key factor strengthening residential space differentiation; and the influence of medical and commercial supporting factors is relatively weak. Full article

This research aims to evaluate how socio-economic and environmental factors influence the development of electromobility. To this end, the research was applied to regions of the Czech Republic, divided into metropolitan, urban and rural types. Based on a panel multiple linear regression with fixed effects of regions and years, the influence of socio-economic and infrastructure variables, in particular average gross wages, the development of charging points by region type and other factors, is analysed. The results show that average wages are a consistently statistically significant factor in the growth of new electric vehicle registrations across the regions. In contrast, the current level of charging infrastructure has no direct effect; its influence is only felt after a delay. Interaction models further confirm that the influence of income is relevant in both urban and rural areas. The study provides new insights into the temporal dynamics of electromobility adoption and formulates recommendations for targeted regional transport policy with an emphasis on proactive infrastructure planning. Full article

The establishment of Green Agricultural Development Pilot Programs (GAPPs) is a strategic initiative aimed at advancing agricultural green transformation in China. It plays a crucial role in transitioning the production methods of family farms to more sustainable practices and facilitating their high-quality development. China Academy Agri-Research Database (CCAD) has been used to assess the production efficiency of family farms in this study. Furthermore, the study examines the impact mechanisms and effects of establishing GAPPs on the production efficiency of family farms. The results show the following: (i) The average production efficiency of family farms in China is 0.424, indicating that further improvements are required. (ii) The GAPPs significantly enhance the production efficiency of family farms through three synergistic mechanisms: technological integration, institutional innovation, and demonstration-driven effects. This finding is statistically confirmed by endogeneity tests and robustness checks. (iii) The heterogeneity analysis indicates that the establishment of GAPPs makes a more pronounced effect on enhancing the production efficiency of family farms in the western region, where internet penetration remains relatively low. Overall, the findings demonstrate that implementing GAPPs contributes significantly to improving the productivity of family farms. So, it is necessary to continue improving the pilot policies to promote the sustainable development of agriculture in China. Full article

Real-time precipitation monitoring through satellite remote sensing represents a critical technological frontier for operational hydrology in data-scarce mountainous regions. Following a comprehensive evaluation of reanalysis precipitation products in the downstream Yarlung Zangpo watershed, this investigation advances understanding by systematically assessing eight satellite-based precipitation retrieval algorithms against ground truth observations from 18 meteorological stations (2014–2022). Multi-temporal performance analysis employed statistical metrics including correlation analysis, root mean square error, mean absolute error, and bias assessment to characterize algorithm reliability across annual, monthly, and seasonal scales. Representative monthly spatial analysis (January, April, July) and comprehensive 12 month × 18 station heatmap visualization revealed pronounced seasonal performance variations and elevation-dependent error patterns. Satellite retrieval algorithms demonstrated systematic underestimation tendencies, with observational precipitation averaging 2358 mm/yr, substantially exceeding remote sensing estimates across six of eight products. IMERG_EarlyRun and IMERG_LateRun achieved optimal performance with annual correlation coefficients of 0.41/0.37 and minimal bias (relative bias: −3.0%/1.4%), substantially outperforming other products. Unexpectedly, IMERG_FinalRun exhibited severe deterioration (correlation: 0.37, relative bias: −73.8%) compared to Early/Late Run products despite comprehensive gauge adjustment, indicating critical limitations of statistical correction procedures in data-sparse mountainous environments. Temporal analysis revealed substantial year-to-year performance variability across all products, with algorithm accuracy strongly modulated by annual precipitation characteristics and underlying meteorological conditions. Station-level assessment demonstrated that 100% of stations showed underestimation for IMERG_FinalRun versus balanced patterns for IMERG_EarlyRun/LateRun (53% underestimation, 47% overestimation), confirming systematic gauge-adjustment failures. Supplementary terrain–precipitation analysis indicated GSMaP_MVK_G shows superior spatial pattern representation, while IMERG_LateRun excels in capturing temporal variations, suggesting multi-product integration strategies for comprehensive monitoring. Comparative assessment with previous reanalysis evaluation establishes that satellite products offer superior real-time availability but exhibit greater temporal variability compared to model-based approaches’ consistent performance. IMERG_EarlyRun and IMERG_LateRun are recommended for operational real-time applications, GSMaP_MVK_G for terrain-sensitive spatial analysis, and reanalysis products for seasonal assessment, while IMERG_FinalRun and FY2 require substantial improvement before deployment in high-altitude watershed management systems. Full article

Background: Ankle sprains are one of the most frequent ligament injuries in elite sports. Despite their high incidence, current rehabilitation approaches are often based on time-based criteria and neglect the physiological status of the injured tissues. Infrared thermography (IRT) is a non-invasive tool useful for detecting temperature asymmetries related to inflammation and tissue dysfunction. This study aimed to analyze the temporal evolution of ankle temperature asymmetry during return-to-play (RTP). Methods: A retrospective observational study of 26 ankle injuries analyzed with thermography that met the inclusion criteria. Thermograms were processed with a software to calculate temperature asymmetry in the ankle region of interest (ankleROI). Statistical analyses included paired and one-sample t-tests, as well as linear regression models, to assess temporal changes throughout the RTP process. Results: A significant hyperthermic response was observed immediately after injury (Δ = +0.594 °C; p < 0.001, Cohen’s d = 0.918). The first significant asymmetry reduction occurred between 21.5 and 28.5 days post-injury (Δ = −0.488 °C; p = 0.004), with a consistent weekly decrease of −0.109 °C (95% CI [−0.143, −0.078]). These findings indicate a progressive decrease in decrement on thermal asymmetry over approximately four weeks of RTP. Conclusions: IRT demonstrates potential as a physiological monitoring tool during the RTP process after ankle sprains. The observed pattern of temperature recovery provides objective reference thresholds that could complement existing functional and clinical criteria. Full article

Rare genetic diseases (RGDs) affect individuals, families, and healthcare systems worldwide. Population-scale genomic data remain largely restricted to Western cohorts with an estimated 10,000 RGDs. South Asian populations remain underrepresented in molecular, clinical, and genomic databases. This study presents the first preliminary molecular genetic characterization of RGDs in the Punjabi population of Pakistan. Data were collected from the provincial RGD registry at the Punjab Thalassemia and Other Genetic Disorders Prevention and Research Institute (PTGDPRI), Lahore. Families diagnosed using next-generation sequencing (NGS) between 2021 and 2023 were enrolled. Structured questionnaires captured clinical, demographic, and socioeconomic information, and statistical and genetic analyses were performed to assess allele frequencies, and disease distribution. The registry included 167 families with 72 distinct RGDs, with a mean burden of 0.81 ± 0.24 affected children per family. Niemann–Pick disease (NP), progressive familial intrahepatic cholestasis (PFIC), and mucopolysaccharidosis (MPS) were the most common diseases. Consanguinity was observed in 89% of families, 77% of which involved first-cousin marriages, and was significantly associated with RGD incidence. Most families belonged to low-income groups despite high literacy rates, underscoring inequity in healthcare. The primary and secondary variants included 131 variants, including copy number variants (CNVs) and single nucleotide variants (SNVs), annotated as pathogenic, likely pathogenic, or variants of unknown significance (VUS) across 109 genes, including 24 South Asian-enriched variants. This study provides the first genomic and epidemiological overview of RGDs in the Punjabi population. The findings reveal how genetic, socioeconomic, and cultural factors converge to amplify the RGD burden and highlight the need for affordable molecular diagnostics, inclusive genomic databases, and regional genomic surveillance initiatives in South Asia. Full article

Background: The intestinal microflora is a population of microorganisms that resides in the human gastrointestinal tract and is important in maintaining metabolic and immune homeostasis in the body. Bacteria residing in the intestine produce short-chain fatty acids (SCFAs), which communicate with, among other things, the brain–gut axis—disorders of which are one of the causes of MS-like pathologies. A particular property of SCFAs is the induction of regulatory T cells, which are finding their way into pioneering therapies for MS patients. The aim of the study is to evaluate SCFA secretion in patients with multiple sclerosis from the West Pomeranian region depending on the genotypes of rs778986 and rs3894326 polymorphisms of the FUT3 gene. Methods: The study group included 47 patients clinically diagnosed with MS. Genotyping was performed by real-time PCR using TaqMan probes. Analysis of short-chain fatty acids in faeces was performed on a quadrupole mass spectrometer coupled to a time-of-flight (QTOF) analyser coupled to an AB Sciex high-performance liquid chromatograph (UHPLC). Results: Statistical analysis did not reveal any statistically significant differences in the prevalence of the studied polymorphisms in MS patients compared to the healthy control group. It was observed that the intestinal microflora and SCFA production in MS patients may be disturbed, while the studied FUT3 gene polymorphisms probably do not have a significant effect on their concentrations. A statistical tendency towards higher caproic acid content in heterozygotes of the rs778986 polymorphism and higher valeric acid secretion in homozygotes of rs3894326 was demonstrated. Conclusions: In summary, the studied FUT3 gene polymorphisms are not overrepresented in patients with MS. The rs778986 FUT3 polymorphism may affect the caproic acid content in the faeces of patients with MS, and the rs3894326 polymorphism may affect valeric acid secretion. Due to the small sample size and sparse genotype groups, the study has limited power and negative findings may reflect Type II error; replication in larger cohorts is warranted. Full article

The pursuit of low-carbon economic development represents an inherent requirement for implementing the Sustainable Development Goals (SDGs) and serves as a vital support for advancing SDG 7, SDG 9, and SDG 13. Drawing on provincial data from China (2006–2023), this research investigates how digital-real convergence influences low-carbon economic development. The results demonstrate a positive contribution of this convergence to growth in the low-carbon economy, and it proves to be superior to models reliant solely on either digital-digital or real-real convergence. A notable finding is the considerable regional variation in the effect. It is strong in both eastern and western parts of the country, which stands in sharp contrast to central China, where the effect is statistically insignificant or negative. Identified as underlying mechanisms are the agglomeration of innovative talent and the accumulation of innovative capital. Additionally, a single-threshold effect of urbanization level is identified, indicating that the positive impact strengthens only after urbanization surpasses a critical value. Furthermore, digital-real convergence not only enhances local low-carbon development but also generates positive spillover effects on neighboring regions. Thus, to fully advance the SDGs, policy formulation and implementation must account for regional heterogeneity, prioritize the elevation of urbanization levels, enhance cross-regional collaboration, and amplify the enabling role of digital-real integration. Full article

Background: Dorsal pedicle skin flap application is a cover procedure frequently used by plastic surgeons to cover acute and chronic wounds, but preventing postoperative flap loss and disruption of the wound healing process has not yet been achieved. Injecting boron nitride during the transfer of the dorsal pedicle skin flap may increase flap survival. Objective: This study investigated the efficacy of hexagonal boron nitride (hBN) injection in enhancing the survival of pedicled skin flaps harvested from the dorsal region of rats. Method: This study employed an experimental design. A total of 24 Wistar albino rats were divided into three groups of eight each: Control (Group 1), Sham (Group 2), and Experimental (Group 3). A 27 cm² (3 cm × 9 cm) dorsal skin flap with a proximal pedicle was harvested at the level of the iliac crests, with the flap extending cranially, and then reattached. During flap transfer, no intervention was performed in Group 1, physiological saline was injected into Group 2, and hBN was injected into Group 3. After a certain period of time, sections were taken from the proximal pedicle skin flap on the dorsal side of the rats, and histochemical examination and biochemical analyses were performed on these sections. Results: In this study, it was observed that the epithelial integrity of the epidermal layer was disrupted and the epithelium was thinned in places in Group 2. Compared to Group 1, collagen fiber density was lower, collagen fiber arrangement was irregular, and mast cell density was higher. In Group 3, similar to Group 1, the epidermis and dermis layers were composed of multilayered flat keratinized epithelium, collagen fiber density was high and had a regular arrangement, and elastic fiber structure was of normal density. The TGF-β1 and MMP-1 measurement results for the three groups were compared, and no statistically significant difference was found between the groups (p > 0.05). Conclusions: The results of this study support the benefit of hBN injection in improving flap survival after proximal pedicle skin flap application on the dorsal side of rats. Although the improved healing of skin layers after flap transfer with hBN suggests that it supports cell proliferation, the mechanism of action and pathophysiology remain unclear. Full article

Rapid urbanization in developing megacities has exacerbated hydrological imbalances, positioning urban flooding as a major environmental and socio-economic challenge of the twenty-first century. This study investigates the spatial relationship between building density, topography, and flood susceptibility in Jakarta, Indonesia—one of the most flood-prone urban regions globally. Employing geospatial analysis and spatial autocorrelation techniques, the research assesses how variations in land-use concentration and elevation influence the spatial clustering of flood vulnerability. The analytical framework integrates multiple spatial datasets, including Digital Elevation Models (DEMs), building footprint densities, and flood hazard maps, within a Geographic Information System (GIS) environment. Spatial statistical measures, specifically Moran’s I and Local Indicators of Spatial Association (LISA), are utilized to quantify and visualize patterns of flood susceptibility. The findings reveal that zones characterized by high building density and low elevation form statistically significant clusters of heightened flood risk, particularly within the southern and eastern subdistricts of Jakarta. The study concludes that incorporating spatially explicit and statistically rigorous methodologies enhances the accuracy of flood-risk assessments and supports evidence-based strategies for sustainable urban development and resilience planning. Full article

African swine fever (ASF) is a transboundary viral disease that has heavily impacted Southeast Asia since its introduction in 2019. Smallholder pig production systems in Cambodia and the Lao People’s Democratic Republic (the Lao PDR), characterized by low biosecurity, free-ranging practices, and limited veterinary oversight, remain particularly vulnerable. To assess farmers’ awareness and practices regarding ASF, a knowledge, attitudes, and practices (KAP) survey was implemented between March and September 2023 by Agronomes et Vétérinaires Sans Frontières within the framework of the Biosecurity in Pig Farming (BIG) project. A total of 471 pig farmers, including 56% women, were interviewed across eight provinces using a standardized questionnaire (188 in Cambodia and 283 in the Lao PDR). Results showed that ASF awareness was generally high (92% in Cambodia, 66% in the Lao PDR), yet 15% of Cambodian and 30% of Lao respondents expressed doubts about the presence of ASF in their country. While recognition of ASF symptoms was moderate and positively correlated with farmers’ perceived capacity to identify the disease, knowledge of transmission pathways was low and often misaligned with perceptions. Airborne transmission was frequently cited as a risk, and the risks related to visitors and fomites were underestimated by more than 50% of the farmers. Implementation of biosecurity measures (BSM) was limited, with mean scores of 43% in Cambodia and 27% in the Lao PDR. Risky practices such as swill feeding, free-ranging, sharing of boars, traders, and inadequate carcass disposal remained widespread. Statistical analysis identified education level, herd size, knowledge, perceived risks, and perceived benefits of BSM as the main determinants of biosecurity implementation. Farmers with larger herds or stronger commercial orientation demonstrated higher biosecurity adoption, while misconceptions and knowledge gaps remained frequent among smallholder farmers. Strengthening awareness, promoting low-cost and feasible biosecurity practices, and integrating farmer-centred approaches are essential for reducing ASF transmission risks and improving the resilience of smallholder pig production systems in the region. Full article

Background/Objectives: Mucormycosis is a rapidly progressive invasive fungal infection that commonly involves the sinonasal region and skull base in patients with systemic comorbidities, yet robust ENT data from middle-income settings are scarce. Methods: We performed a single-center retrospective review of all patients with histopathologically confirmed mucormycosis treated in the Otorhinolaryngology Department of Dicle University between 2010 and 2023, covering a 14-year period. Eligible patients had paranasal sinus computed tomography at presentation and received surgical and/or systemic antifungal therapy. Demographic data, comorbidities, disease subtype, radiological extent, treatment modality and survival were extracted from records. Survival was estimated using Kaplan–Meier analysis, and group differences were tested with chi-square statistics (p ≤ 0.05). Results: Fifty-two patients met the inclusion criteria (mean age 56.5 ± 15.2 years; 57.7% male); 73.1% had at least one systemic comorbidity, most frequently diabetes mellitus (65.4%) and hematological malignancy (19.2%). Disease was sinonasal in 42.3%, rhino-orbital in 28.8% and rhino-orbito-cerebral in 28.8%. Baseline CT showed intracranial extension in 26.9%. Overall survival was 59.6% and differed markedly by subtype, highest in isolated sinonasal disease (81.8%) and lowest in rhino-orbito-cerebral disease (26.7%). Intracranial extension was associated with higher mortality (71.4% vs. 28.9%). Combined surgical debridement plus systemic antifungal therapy, used in 84.6% of patients, yielded lower mortality than antifungal therapy alone (31.8% vs. 87.5%). Conclusions: In this ENT cohort, prognosis was mainly determined by anatomical extent and treatment strategy. Our findings suggest that timely combined surgical and antifungal management, when feasible and in appropriately selected patients, is associated with improved survival outcomes. Full article

Background and Objectives: The aim of this study was to evaluate the radiographic progression of non-surgically managed jaw lesions that remained untreated due to patient deferral or refusal of surgery. Radiographic changes were assessed using two panoramic radiographs obtained at different time points, with a focus on dimensional progression, morphological characteristics, and anatomical involvement. Materials and Methods: A total of 85 non-surgically managed intraosseous cystic and cyst-like jaw lesions were evaluated on two panoramic radiographs obtained at least one year apart. Histopathological confirmation was available for 26 of the lesions (30.6%), while the remaining cases were evaluated radiographically due to the absence of surgical intervention or accessible pathology records. Assessments included localization, size, shape, internal structure, borders, association with non-erupted teeth, root resorption, tooth displacement, involvement of anatomical structures, and cortical changes such as thinning, expansion, or destruction. Nonparametric statistical comparisons were used to assess time-dependent changes and differences between follow-up groups. Results: A total of 57 lesions occurred in the mandible and 28 in the maxilla, predominantly in the posterior regions. The mean vertical/horizontal measurements of the intraosseous lesions was found to be 10.9 ± 4.6 mm/12.2 ± 6.5 mm (Mean ± SD) on the initial panoramic radiographs (Med: 10.0–IQR: 6.50/Med: 12.0–IQR: 8.75) and 14.8 ± 5.3 mm/17.5 ± 8.3 mm (Mean ± SD) on the second panoramic radiographs (Med: 14.5–IQR: 6.75/Med: 16.0–IQR: 10.75), respectively. Both vertical and horizontal dimensions showed a statistically significant increase between the two time points (p < 0.05). Initially, 41 lesions exhibited corticated margins; at follow-up, an additional 33 non-corticated lesions developed cortication. Lesions without corticated margins on the initial images exhibited significantly greater vertical and horizontal growth than those with corticated borders (p < 0.05). Lesions followed for 3–5 years showed significantly greater dimensional changes compared with those observed for shorter or longer intervals (p < 0.05). Lesion shape, internal structure, and multilocularity remained largely stable. Conclusions: Within the limitations of this retrospective study, non-surgically managed jaw lesions showed a tendency to increase in size over time. While the development of corticated borders may be associated with reduced growth activity, panoramic radiography alone is insufficient for definitive assessment, and regular radiographic follow-up should be considered within a broader clinical context. Full article

Background: Prehospital emergency professionals are exposed to high psychosocial demands that may impact their mental health, but pre-COVID-19 baseline data from Spanish services are scarce. This study aimed to assess the general health and psychosocial risk factors in a regional prehospital emergency service before the COVID-19 pandemic. Methods: We conducted a cross-sectional descriptive study (September–December 2019) including 51 physicians, nurses, and emergency medical technicians working at the 061 Health Emergency Center in Granada (Andalusia, Spain). General health and chronic problems were assessed with the Goldberg General Health Questionnaire (GHQ-28/CGHQ-28), and work-related psychosocial risks were evaluated using the COPSOQ-ISTAS21 questionnaire. Descriptive statistics, group comparisons, and exploratory Spearman correlations between health indicators and psychosocial dimensions were performed. Results: Most participants reported good self-perceived general health, but the chronic coding of the GHQ (CGHQ-28) indicated long-term difficulties mainly related to social dysfunction, somatic symptoms, and anxiety/insomnia. Exposure to unfavorable psychosocial risk was frequent, particularly in psychological demands, double presence (work–family conflict), and low esteem, with intermediate–unfavorable patterns in active job/development, insecurity, and social support/leadership. Exploratory correlations suggested that double presence was the psychosocial factor most consistently associated with chronic distress. Conclusions: In this pre-COVID-19 cohort of prehospital emergency professionals, good perceived general health coexisted with chronic psychological strain and high exposure to adverse psychosocial work factors. These findings support the need for organizational measures to reduce psychological demands and work–family conflict and to strengthen social support and leadership in prehospital emergency teams. Full article

This study offers a comprehensive in situ measurement and assessment of electromagnetic field (EMF) exposure in the central urban districts of Samsun, Türkiye, focusing on low-frequency magnetic flux density (B_LF) and radiofrequency electric field strength (E_RF). Drive-test measurements were performed across Atakum, İlkadım, and Canik districts to capture spatial variability and identify primary exposure sources. Band-selective analysis revealed that downlink (DL) transmissions are the main contributors to total E_RF exposure, indicating that base station emissions dominate the exposed E_RF levels in the environment. Six-minute averaged B_LF and E_RF values account for temporal fluctuations and confirm that exposure remains well below recommended limits. A one-way ANOVA test indicated that the differences in exposure levels among the three districts were not statistically significant. These findings provide a detailed spatial evaluation of EMF exposure in a large metropolitan region, demonstrating the value of integrated B_LF and E_RF measurements for environmental monitoring. Full article