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Search Results (24,165)

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24 pages, 2584 KiB  
Article
Precise and Continuous Biomass Measurement for Plant Growth Using a Low-Cost Sensor Setup
by Lukas Munser, Kiran Kumar Sathyanarayanan, Jonathan Raecke, Mohamed Mokhtar Mansour, Morgan Emily Uland and Stefan Streif
Sensors 2025, 25(15), 4770; https://doi.org/10.3390/s25154770 (registering DOI) - 2 Aug 2025
Abstract
Continuous and accurate biomass measurement is a critical enabler for control, decision making, and optimization in modern plant production systems. It supports the development of plant growth models for advanced control strategies like model predictive control, and enables responsive, data-driven, and plant state-dependent [...] Read more.
Continuous and accurate biomass measurement is a critical enabler for control, decision making, and optimization in modern plant production systems. It supports the development of plant growth models for advanced control strategies like model predictive control, and enables responsive, data-driven, and plant state-dependent cultivation. Traditional biomass measurement methods, such as destructive sampling, are time-consuming and unsuitable for high-frequency monitoring. In contrast, image-based estimation using computer vision and deep learning requires frequent retraining and is sensitive to changes in lighting or plant morphology. This work introduces a low-cost, load-cell-based biomass monitoring system tailored for vertical farming applications. The system operates at the level of individual growing trays, offering a valuable middle ground between impractical plant-level sensing and overly coarse rack-level measurements. Tray-level data allow localized control actions, such as adjusting light spectrum and intensity per tray, thereby enhancing the utility of controllable LED systems. This granularity supports layer-specific optimization and anomaly detection, which are not feasible with rack-level feedback. The biomass sensor is easily scalable and can be retrofitted, addressing common challenges such as mechanical noise and thermal drift. It offers a practical and robust solution for biomass monitoring in dynamic, growing environments, enabling finer control and smarter decision making in both commercial and research-oriented vertical farming systems. The developed sensor was tested and validated against manual harvest data, demonstrating high agreement with actual plant biomass and confirming its suitability for integration into vertical farming systems. Full article
(This article belongs to the Special Issue Feature Papers in Smart Agriculture 2025)
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21 pages, 875 KiB  
Article
Comprehensive Analysis of Neural Network Inference on Embedded Systems: Response Time, Calibration, and Model Optimisation
by Patrick Huber, Ulrich Göhner, Mario Trapp, Jonathan Zender and Rabea Lichtenberg
Sensors 2025, 25(15), 4769; https://doi.org/10.3390/s25154769 (registering DOI) - 2 Aug 2025
Abstract
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of [...] Read more.
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of model response times based on the underlying platform, highlighting the importance of benchmarking generic ANN applications on edge devices. We analyze the impact of network parameters, activation functions, and single- versus multi-threading on response times. Additionally, potential hardware-related influences, such as clock rate variances, are discussed. The results underline the complexity of task partitioning and scheduling strategies, stressing the need for precise parameter coordination to optimise performance across platforms. This study shows that cutting-edge frameworks do not necessarily perform the required operations automatically for all configurations, which may negatively impact performance. This paper further investigates the influence of network structure on model calibration, quantified using the Expected Calibration Error (ECE), and the limits of potential optimisation opportunities. It also examines the effects of model conversion to Tensorflow Lite (TFLite), highlighting the necessity of considering both performance and calibration when deploying models on embedded systems. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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31 pages, 2458 KiB  
Article
Control Range and Power Efficiency of Multiphase Cage Induction Generators Operating Alone at a Varying Speed on a Direct Current Load
by Piotr Drozdowski
Energies 2025, 18(15), 4108; https://doi.org/10.3390/en18154108 (registering DOI) - 2 Aug 2025
Abstract
The aim of the article is to determine the control range of a multiphase squirrel cage induction generator with more than three stator phases, operating in a wide range of driving speeds. The generator produces an output DC voltage using a multiphase converter [...] Read more.
The aim of the article is to determine the control range of a multiphase squirrel cage induction generator with more than three stator phases, operating in a wide range of driving speeds. The generator produces an output DC voltage using a multiphase converter operating as a PWM rectifier. The entire speed range is divided into intervals in which the sequence of stator phase voltages and, in effect, the number of pole pairs, is changed. In each interval, the output voltage is regulated by the frequency and amplitude of the stator voltages causing the highest possible power efficiency of the generator. The system can be scalar controlled or regulated using field orientation. Generator characteristics are calculated based on the set of steady-state equations derived from differential equations describing the multiphase induction machine. The calculation results are compared with simulations and with the steady-state measurement of the vector-controlled nine-phase generator. Recognizing the reliability of the obtained results, calculations are performed for a twelve-phase generator, obtaining satisfactory efficiency from 70% to 85% in the generator speed range from 0.2 to 1.0 of the assumed reference speed of 314 rad/s. The generator producing DC voltage can charge an electrical energy storage system or can be used directly to provide electrical power. This solution is not patented. Full article
(This article belongs to the Special Issue Advanced Technologies for Electrified Transportation and Robotics)
21 pages, 7537 KiB  
Article
Variable Step-Size FxLMS Algorithm Based on Cooperative Coupling of Double Nonlinear Functions
by Jialong Wang, Jian Liao, Lin He, Xiaopeng Tan and Zongbin Chen
Symmetry 2025, 17(8), 1222; https://doi.org/10.3390/sym17081222 (registering DOI) - 2 Aug 2025
Abstract
Based on the principle of symmetry, we propose a variable step-size FxLMS algorithm with double nonlinear functions cooperative coupling (DNVSS-FxLMS), aiming to optimize the contradiction between convergence rate and steady-state error in the active pressure pulsation control system of hydraulic systems. The algorithm [...] Read more.
Based on the principle of symmetry, we propose a variable step-size FxLMS algorithm with double nonlinear functions cooperative coupling (DNVSS-FxLMS), aiming to optimize the contradiction between convergence rate and steady-state error in the active pressure pulsation control system of hydraulic systems. The algorithm innovatively couples two types of nonlinear mechanisms (rational-fractional and exponential-function-based), constructing a refined error-step mapping relationship to achieve a balance between rapid convergence and low steady-state error. Simulation experiments were conducted considering the complex time-varying operating environment of a simulation-based hydraulic system. The results demonstrate that, when the system undergoes unstable random changes, the DNVSS-FxLMS algorithm converges at least twice as fast as traditional and existing variable step size algorithms, while reducing steady-state error by 2–5 dB. The proposed DNVSS-FxLMS algorithm exhibits significant advantages in convergence rate, steady-state error reduction, and tracking capability, providing a highly efficient and robust solution for real-time active control of hydraulic system pressure pulsation under complex operating conditions. Full article
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20 pages, 1907 KiB  
Article
Multi-Innovation-Based Parameter Identification for Vertical Dynamic Modeling of AUV Under High Maneuverability and Large Attitude Variations
by Jianping Yuan, Zhixun Luo, Lei Wan, Cenan Wang, Chi Zhang and Qingdong Chen
J. Mar. Sci. Eng. 2025, 13(8), 1489; https://doi.org/10.3390/jmse13081489 (registering DOI) - 1 Aug 2025
Abstract
The parameter identification of Autonomous Underwater Vehicles (AUVs) serves as a fundamental basis for achieving high-precision motion control, state monitoring, and system development. Currently, AUV parameter identification typically relies on the complete motion information obtained from onboard sensors. However, in practical applications, it [...] Read more.
The parameter identification of Autonomous Underwater Vehicles (AUVs) serves as a fundamental basis for achieving high-precision motion control, state monitoring, and system development. Currently, AUV parameter identification typically relies on the complete motion information obtained from onboard sensors. However, in practical applications, it is often challenging to accurately measure key state variables such as velocity and angular velocity, resulting in incomplete measurement data that compromises identification accuracy and model reliability. This issue is particularly pronounced in vertical motion tasks involving low-speed, large pitch angles, and highly maneuverable conditions, where the strong coupling and nonlinear characteristics of underwater vehicles become more significant. Traditional hydrodynamic models based on full-state measurements often suffer from limited descriptive capability and difficulties in parameter estimation under such conditions. To address these challenges, this study investigates a parameter identification method for AUVs operating under vertical, large-amplitude maneuvers with constrained measurement information. A control autoregressive (CAR) model-based identification approach is derived, which requires only pitch angle, vertical velocity, and vertical position data, thereby reducing the dependence on complete state observations. To overcome the limitations of the conventional Recursive Least Squares (RLS) algorithm—namely, its slow convergence and low accuracy under rapidly changing conditions—a Multi-Innovation Least Squares (MILS) algorithm is proposed to enable the efficient estimation of nonlinear hydrodynamic characteristics in complex dynamic environments. The simulation and experimental results validate the effectiveness of the proposed method, demonstrating high identification accuracy and robustness in scenarios involving large pitch angles and rapid maneuvering. The results confirm that the combined use of the CAR model and MILS algorithm significantly enhances model adaptability and accuracy, providing a solid data foundation and theoretical support for the design of AUV control systems in complex operational environments. Full article
(This article belongs to the Section Ocean Engineering)
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25 pages, 8312 KiB  
Article
Quantitative Assessment of Woven Fabric Surface Changes During Martindale Abrasion Using Contactless Optical Profilometry
by Małgorzata Matusiak and Gabriela Kosiuk
Materials 2025, 18(15), 3636; https://doi.org/10.3390/ma18153636 (registering DOI) - 1 Aug 2025
Abstract
The abrasion resistance of fabrics is one of the basic properties determining the utility performance and durability. The abrasion resistance of textile materials is measured using the Martindale device according to appropriate standards. The sample breakage method is the most commonly used of [...] Read more.
The abrasion resistance of fabrics is one of the basic properties determining the utility performance and durability. The abrasion resistance of textile materials is measured using the Martindale device according to appropriate standards. The sample breakage method is the most commonly used of the three methods. The method is based on organoleptic assessment of fabric breakage. The method is time-consuming, and results may be subject to error resulting from the subjective nature of the assessment. The aim of the presented work was to check the possibility of the application of contactless 3D surface geometry measurement using an optical profilometer in an assessment of changes in fabrics’ surface due to the abrasion process. The obtained results confirmed that some parameters of the geometric structure of fabric surfaces, such as the highest height of the roughness profile Rz, the height of the highest pick of the roughness profile Rp, the depth of the lowest valley of the roughness profile Rv, the depth of the total height of the roughness profile Rt, and the kurtosis Rku, can be used to assess the abrasion resistance of fabrics. It is also stated that using the non-contact optical measurement of fabric surface geometry allows for an assessment of the directionality of surface texture. For this purpose, the autocorrelation function and angle distribution function can be applied. Full article
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16 pages, 1131 KiB  
Article
Clinical and Cognitive Improvement Following Treatment with a Hemp-Derived, Full-Spectrum, High-Cannabidiol Product in Patients with Anxiety: An Open-Label Pilot Study
by Rosemary T. Smith, Mary Kathryn Dahlgren, Kelly A. Sagar, Deniz Kosereisoglu and Staci A. Gruber
Biomedicines 2025, 13(8), 1874; https://doi.org/10.3390/biomedicines13081874 (registering DOI) - 1 Aug 2025
Abstract
Background/Objectives: Cannabidiol (CBD) is a non-intoxicating cannabinoid touted for a variety of medical benefits, including alleviation of anxiety. While legalization of hemp-derived products in the United States (containing ≤0.3% delta-9-tetrahydrocannabinol [d9-THC] by weight) has led to a rapid increase in the commercialization [...] Read more.
Background/Objectives: Cannabidiol (CBD) is a non-intoxicating cannabinoid touted for a variety of medical benefits, including alleviation of anxiety. While legalization of hemp-derived products in the United States (containing ≤0.3% delta-9-tetrahydrocannabinol [d9-THC] by weight) has led to a rapid increase in the commercialization of hemp-derived CBD products, most therapeutic claims have not been substantiated using clinical trials. This trial aimed to assess the impact of 6 weeks of treatment with a proprietary hemp-derived, full-spectrum, high-CBD sublingual solution similar to those available in the marketplace in patients with anxiety. Methods: An open-label pilot clinical trial (NCT04286594) was conducted in 12 patients with at least moderate levels of anxiety. Patients self-administered a hemp-derived, high-CBD sublingual solution twice daily during the 6-week trial (target daily dose: 30 mg/day CBD). Clinical change over time relative to baseline was assessed for anxiety, mood, sleep, and quality of life, as well as changes in cognitive performance on measures of executive function and memory. Safety and tolerability of the study product were also evaluated. Results: Patients reported significant reductions in anxiety symptoms over time. Concurrent improvements in mood, sleep, and relevant quality of life domains were also observed, along with stable or improved performance on all neurocognitive measures. Few side effects were reported, and no serious adverse events occurred. Conclusions: These pilot findings provide initial support for the efficacy and tolerability of the hemp-derived, high-CBD product in patients with moderate-to-severe levels of anxiety. Double-blind, placebo-controlled studies are indicated to obtain robust data regarding efficacy and tolerability of these types of products for anxiety. Full article
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14 pages, 1714 KiB  
Article
A Kalman Filter-Based Localization Calibration Method Optimized by Reinforcement Learning and Information Matrix Fusion
by Zijia Huang, Qiushi Xu, Menghao Sun and Xuzhen Zhu
Entropy 2025, 27(8), 821; https://doi.org/10.3390/e27080821 (registering DOI) - 1 Aug 2025
Abstract
To address the degradation in localization accuracy caused by insufficient robustness of filter parameters and inefficient multi-trajectory data fusion in dynamic environments, this paper proposes a Kalman filter-based localization calibration method optimized by reinforcement learning and information matrix fusion (RL-IMKF). An actor–critic reinforcement [...] Read more.
To address the degradation in localization accuracy caused by insufficient robustness of filter parameters and inefficient multi-trajectory data fusion in dynamic environments, this paper proposes a Kalman filter-based localization calibration method optimized by reinforcement learning and information matrix fusion (RL-IMKF). An actor–critic reinforcement learning network is designed to adaptively adjust the state covariance matrix, enhancing the Kalman filter’s adaptability to environmental changes. Meanwhile, a multi-trajectory information matrix fusion strategy is introduced, which aggregates multiple trajectories in the information domain via weighted inverse covariance matrices to suppress error propagation and improve system consistency. Experiments using both simulated and real-world sensor data demonstrate that the proposed method outperforms traditional extended Kalman filter approaches in terms of localization accuracy and stability, providing a novel solution for cooperative localization calibration of unmanned aerial vehicle (UAV) swarms in dynamic environments. Full article
(This article belongs to the Special Issue Complexity, Entropy and the Physics of Information II)
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43 pages, 2466 KiB  
Article
Adaptive Ensemble Learning for Financial Time-Series Forecasting: A Hypernetwork-Enhanced Reservoir Computing Framework with Multi-Scale Temporal Modeling
by Yinuo Sun, Zhaoen Qu, Tingwei Zhang and Xiangyu Li
Axioms 2025, 14(8), 597; https://doi.org/10.3390/axioms14080597 (registering DOI) - 1 Aug 2025
Abstract
Financial market forecasting remains challenging due to complex nonlinear dynamics and regime-dependent behaviors that traditional models struggle to capture effectively. This research introduces the Adaptive Financial Reservoir Network with Hypernetwork Flow (AFRN–HyperFlow) framework, a novel ensemble architecture integrating Echo State Networks, temporal convolutional [...] Read more.
Financial market forecasting remains challenging due to complex nonlinear dynamics and regime-dependent behaviors that traditional models struggle to capture effectively. This research introduces the Adaptive Financial Reservoir Network with Hypernetwork Flow (AFRN–HyperFlow) framework, a novel ensemble architecture integrating Echo State Networks, temporal convolutional networks, mixture density networks, adaptive Hypernetworks, and deep state-space models for enhanced financial time-series prediction. Through comprehensive feature engineering incorporating technical indicators, spectral decomposition, reservoir-based representations, and flow dynamics characteristics, the framework achieves superior forecasting performance across diverse market conditions. Experimental validation on 26,817 balanced samples demonstrates exceptional results with an F1-score of 0.8947, representing a 12.3% improvement over State-of-the-Art baseline methods, while maintaining robust performance across asset classes from equities to cryptocurrencies. The adaptive Hypernetwork mechanism enables real-time regime-change detection with 2.3 days average lag and 95% accuracy, while systematic SHAP analysis provides comprehensive interpretability essential for regulatory compliance. Ablation studies reveal Echo State Networks contribute 9.47% performance improvement, validating the architectural design. The AFRN–HyperFlow framework addresses critical limitations in uncertainty quantification, regime adaptability, and interpretability, offering promising directions for next-generation financial forecasting systems incorporating quantum computing and federated learning approaches. Full article
(This article belongs to the Special Issue Financial Mathematics and Econophysics)
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23 pages, 5773 KiB  
Article
Climate Activism in Our Part of The World and Methodological Insights on How to Study It
by Rezvaneh Erfani
Youth 2025, 5(3), 80; https://doi.org/10.3390/youth5030080 (registering DOI) - 1 Aug 2025
Abstract
This paper presents an ethnographically informed analysis of research in Cairo and Sharm El-Sheikh (Egypt) surrounding the 2022 United Nations Framework Convention on Climate Change (UNFCCC) Conference of Parties (COP27) summit. I discuss the geopolitics and geopolitical disruptions of researching activism and activist [...] Read more.
This paper presents an ethnographically informed analysis of research in Cairo and Sharm El-Sheikh (Egypt) surrounding the 2022 United Nations Framework Convention on Climate Change (UNFCCC) Conference of Parties (COP27) summit. I discuss the geopolitics and geopolitical disruptions of researching activism and activist lives in politically sensitive environments. As shown here, developing new methodological interventions plays a crucial role in understanding contextual methodological limitations, dealing with logistical challenges, and building authentic relationships with research participants. Here, I introduce counter-interviews as a methodological strategy to build trust and invest in researcher–participant relationships. This article draws on participant observation, conversations with environmental and climate activists and non-activists in Cairo prior to and after COP27 and in Sharm El-Sheikh during the second week of the summit, reflective field notes, and 20 semi-structured interviews conducted online between February and August 2023. Here, I use the term “environmental non-activism” to draw attention to the sensitivity, complexity, and fragility of political or apolitical environmental and climate action in an authoritarian context where any form of collective action is highly monitored, regulated, and sometimes criminalized by the state. The main argument of this paper is that examining interlocking power dynamics that shape and reshape the activist space in relation to the state is a requirement for understanding and researching the complexities and specificities of climate activism and non-activism in authoritarian contexts. Along with this argument, this paper invites climate education researchers to reevaluate what non-movements and non-activists in the Global South offer to their analyses of possible alternatives, socio-political change, and politics of hope (and to the broader field of activism in educational research, where commitment to disruption, refusal, and subversion play a key role. Full article
(This article belongs to the Special Issue Politics of Disruption: Youth Climate Activisms and Education)
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19 pages, 523 KiB  
Review
Whey Proteins and Metabolic Dysfunction-Associated Steatotic Liver Disease Features: Evolving the Current Knowledge and Future Trends
by Maja Milanović, Nataša Milošević, Maja Ružić, Ludovico Abenavoli and Nataša Milić
Metabolites 2025, 15(8), 516; https://doi.org/10.3390/metabo15080516 (registering DOI) - 1 Aug 2025
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent, multisystem disease affecting approximately 30% of adults worldwide. Obesity, along with dyslipidemia, type 2 diabetes mellitus, and hypertension, are closely intertwined with MASLD. In people with [...] Read more.
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent, multisystem disease affecting approximately 30% of adults worldwide. Obesity, along with dyslipidemia, type 2 diabetes mellitus, and hypertension, are closely intertwined with MASLD. In people with obesity, MASLD prevalence is estimated to be about 75%. Despite various approaches to MASLD treatment, dietary changes remain the most accessible and safe interventions in MASLD, especially in obese and overweight patients. Whey proteins are rich in bioactive compounds, essential amino acids with antioxidant properties, offering potential benefits for MASLD prevention and management. This state-of-the-art review summarizes whey protein impacts on a spectrum of MASLD-related manifestations, such as obesity, impaired glucose and lipid metabolism, hypertension, liver injury, oxidative stress, and inflammation. The results obtained in clinical environments, with a focus on meta-analysis, propose whey protein supplementation as a promising strategy aimed at managing multifaced MASLD disorders. Well-designed cohort studies are needed for validation of the efficacy and long-term safety of whey proteins in MASLD patients. Full article
(This article belongs to the Special Issue Effects of Diet on Metabolic Health of Obese People)
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22 pages, 7156 KiB  
Communication
Water Management, Environmental Challenges, and Rehabilitation Strategies in the Khyargas Lake–Zavkhan River Basin, Western Mongolia: A Case Study of Ereen Lake
by Tseren Ochir Soyol-Erdene, Ganbat Munguntsetseg, Zambuu Burmaa, Ulziibat Bilguun, Shagijav Oyungerel, Soninkhishig Nergui, Nyam-Osor Nandintsetseg, Michael Walther and Ulrich Kamp
Geographies 2025, 5(3), 38; https://doi.org/10.3390/geographies5030038 (registering DOI) - 1 Aug 2025
Abstract
The depletion of water resources caused by climate change and human activities is a pressing global issue. Lake Ereen is one of the ten natural landmarks of the Gobi-Altai of western Mongolia is included in the list of “important areas for birds” recognized [...] Read more.
The depletion of water resources caused by climate change and human activities is a pressing global issue. Lake Ereen is one of the ten natural landmarks of the Gobi-Altai of western Mongolia is included in the list of “important areas for birds” recognized by the international organization Birdlife. However, the construction of the Taishir Hydroelectric Power Station, aimed at supplying electricity to the western provinces of Mongolia, had a detrimental effect on the flow of the Zavkhan River, resulting in a drying-up and pollution of Lake Ereen, which relies on the river as its water source. This study assesses the pollution levels in Ereen Lake and determines the feasibility of its rehabilitation by redirecting the flow of the Zavkhan River. Field studies included the analysis of water quality, sediment contamination, and the composition of flora. The results show that the concentrations of ammonium, chlorine, fluorine, and sulfate in the lake water exceed the permissible levels set by the Mongolian standard. Analyses of elements from sediments revealed elevated levels of arsenic, chromium, and copper, exceeding international sediment quality guidelines and posing risks to biological organisms. Furthermore, several species of diatoms indicative of polluted water were discovered. Lake Ereen is currently in a eutrophic state and, based on a water quality index (WQI) of 49.4, also in a “polluted” state. Mass balance calculations and box model analysis determined the period of pollutant replacement for two restoration options: drying-up and complete removal of contaminated sediments and plants vs. dilution-flushing without direct interventions in the lake. We recommend the latter being the most efficient, eco-friendly, and cost-effective approach to rehabilitate Lake Ereen. Full article
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14 pages, 1813 KiB  
Article
Elevated Antigen-Presenting-Cell Signature Genes Predict Stemness and Metabolic Reprogramming States in Glioblastoma
by Ji-Yong Sung and Kihwan Hwang
Int. J. Mol. Sci. 2025, 26(15), 7411; https://doi.org/10.3390/ijms26157411 (registering DOI) - 1 Aug 2025
Abstract
Glioblastoma (GBM) is a highly aggressive and heterogeneous brain tumor. Glioma stem-like cells (GSCs) play a central role in tumor progression, therapeutic resistance, and recurrence. Although immune cells are known to shape the GBM microenvironment, the impact of antigen-presenting-cell (APC) signature genes on [...] Read more.
Glioblastoma (GBM) is a highly aggressive and heterogeneous brain tumor. Glioma stem-like cells (GSCs) play a central role in tumor progression, therapeutic resistance, and recurrence. Although immune cells are known to shape the GBM microenvironment, the impact of antigen-presenting-cell (APC) signature genes on tumor-intrinsic phenotypes remains underexplored. We analyzed both bulk- and single-cell RNA sequencing datasets of GBM to investigate the association between APC gene expression and tumor-cell states, including stemness and metabolic reprogramming. Signature scores were computed using curated gene sets related to APC activity, KEGG metabolic pathways, and cancer hallmark pathways. Protein–protein interaction (PPI) networks were constructed to examine the links between immune regulators and metabolic programs. The high expression of APC-related genes, such as HLA-DRA, CD74, CD80, CD86, and CIITA, was associated with lower stemness signatures and enhanced inflammatory signaling. These APC-high states (mean difference = –0.43, adjusted p < 0.001) also showed a shift in metabolic activity, with decreased oxidative phosphorylation and increased lipid and steroid metabolism. This pattern suggests coordinated changes in immune activity and metabolic status. Furthermore, TNF-α and other inflammatory markers were more highly expressed in the less stem-like tumor cells, indicating a possible role of inflammation in promoting differentiation. Our findings revealed that elevated APC gene signatures are associated with more differentiated and metabolically specialized GBM cell states. These transcriptional features may also reflect greater immunogenicity and inflammation sensitivity. The APC metabolic signature may serve as a useful biomarker to identify GBM subpopulations with reduced stemness and increased immune engagement, offering potential therapeutic implications. Full article
(This article belongs to the Special Issue Advanced Research on Cancer Stem Cells)
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0 pages, 1583 KiB  
Article
Heat Transfer Characteristics of Thermosyphons Used in Vacuum Water Heaters
by Zied Lataoui, Adel M. Benselama and Abdelmajid Jemni
Fluids 2025, 10(8), 199; https://doi.org/10.3390/fluids10080199 - 31 Jul 2025
Abstract
A two-phase closed thermosyphon (TPCT), a gravity-assisted heat pipe, is a highly efficient heat transmitter involving liquid–vapor phase change. It is used in many applications, including heat spreading, thermal management and control, and energy saving. The main objective of this study is to [...] Read more.
A two-phase closed thermosyphon (TPCT), a gravity-assisted heat pipe, is a highly efficient heat transmitter involving liquid–vapor phase change. It is used in many applications, including heat spreading, thermal management and control, and energy saving. The main objective of this study is to investigate the effects of the operating conditions for a thermosyphon used in solar water heaters. The study particularly focuses on the influence of the inclination angle. Thus, a comprehensive simulation model is developed using the volume of fluid (VOF) approach. Complex and related phenomena, including two-phase flow, phase change, and heat exchange, are taken into account. To implement the model, an open-source CFD toolbox based on finite volume formulation, OpenFOAM, is used. The model is then validated by comparing numerical results to the experimental data from the literature. The obtained results show that the simulation model is reliable for investigating the effects of various operating conditions on the transient and steady-state behavior of the thermosyphon. In fact, bubble creation, growth, and advection can be tracked correctly in the liquid pool at the evaporator. The effects of the designed operating conditions on the heat transfer parameters are also discussed. In particular, the optimal tilt angle is shown to be 60° for the intermediate saturation temperature (<50 °C) and 90° for the larger saturation temperature (>60 °C). Full article
(This article belongs to the Special Issue Convective Flows and Heat Transfer)
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0 pages, 525 KiB  
Article
An Analytical Review of Cyber Risk Management by Insurance Companies: A Mathematical Perspective
by Maria Carannante and Alessandro Mazzoccoli
Risks 2025, 13(8), 144; https://doi.org/10.3390/risks13080144 - 31 Jul 2025
Abstract
This article provides an overview of the current state-of-the-art in cyber risk and cyber risk management, focusing on the mathematical models that have been created to help with risk quantification and insurance pricing. We discuss the main ways that cyber risk is measured, [...] Read more.
This article provides an overview of the current state-of-the-art in cyber risk and cyber risk management, focusing on the mathematical models that have been created to help with risk quantification and insurance pricing. We discuss the main ways that cyber risk is measured, starting with vulnerability functions that show how systems react to threats and going all the way up to more complex stochastic and dynamic models that show how cyber attacks change over time. Next, we examine cyber insurance, including the structure and main features of the cyber insurance market, as well as the growing role of cyber reinsurance in strategies for transferring risk. Finally, we review the mathematical models that have been proposed in the literature for setting the prices of cyber insurance premiums and structuring reinsurance contracts, analysing their advantages, limitations, and potential applications for more effective risk management. The aim of this article is to provide researchers and professionals with a clear picture of the main quantitative tools available and to point out areas that need further research by summarising these contributions. Full article
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