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Keywords = self-evolving neural networks

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24 pages, 2003 KB  
Article
SEN-Batch Pseudo-Labeling with NeuroStack for Robust Semi-Supervised Liver Classification
by Pranabes Gangopadhyay, Perumal Ganeshkumar, Tirtharaj Sen, Bidesh Chakraborty, Arindam Biswas and Prabu Pachiyannan
Appl. Sci. 2026, 16(7), 3446; https://doi.org/10.3390/app16073446 - 2 Apr 2026
Viewed by 646
Abstract
The liver is vital for metabolism, detoxification, and homeostasis. Untreated liver disease leads to severe consequences, stressing the need for early diagnosis. However, patient classification using statistical learning is limited by the scarcity of large, labeled datasets due to high acquisition and expertise [...] Read more.
The liver is vital for metabolism, detoxification, and homeostasis. Untreated liver disease leads to severe consequences, stressing the need for early diagnosis. However, patient classification using statistical learning is limited by the scarcity of large, labeled datasets due to high acquisition and expertise cost. Surmounting this impediment, a novel Self-Evolving Neighborhood (SEN)-batched pseudo-labeling (PL) technique is proposed within the context of a semi-supervised learning framework. At its core, the NeuroStack model has been developed for labeling the datasets. The study examines the performance of the proposed PL algorithm across datasets like ILPD, BUPA Liver Disorder, and LFT. It is further compared to the state-of-the-art (SOTA) FixMatch. This study achieved the best accuracy of 98%, which is ≈11% higher than the FixMatch algorithm, and a confidence score of 97%, which is ≈12% higher than the FixMatch algorithm. The average accuracy, confidence score, F1-score and AUC across all the datasets are 94.6%, 94%, 0.96 and 0.98, respectively. The confidence interval was ±1.2 which is significantly lower than other algorithms. The experiments also achieved the best patient classification accuracy of 98% using the novel NeuroStack model which is adaptable for labeling any non-image datasets. Full article
(This article belongs to the Special Issue Advances and Applications of Machine Learning for Bioinformatics)
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23 pages, 1208 KB  
Article
NeSySwarm-IDS: End-to-End Differentiable Neuro-Symbolic Logic for Privacy-Preserving Intrusion Detection in UAV Swarms
by Gang Yang, Lin Ni, Tao Xia, Qinfang Shi and Jiajian Li
Appl. Sci. 2026, 16(7), 3204; https://doi.org/10.3390/app16073204 - 26 Mar 2026
Viewed by 472
Abstract
Unmanned Aerial Vehicle (UAV) swarms operating in contested environments face a critical “semantic gap” between raw, high-velocity network traffic and high-level mission security constraints, compounded by the risk of privacy leakage during collaborative learning. Existing deep learning (DL)-based Network Intrusion Detection Systems (NIDSs) [...] Read more.
Unmanned Aerial Vehicle (UAV) swarms operating in contested environments face a critical “semantic gap” between raw, high-velocity network traffic and high-level mission security constraints, compounded by the risk of privacy leakage during collaborative learning. Existing deep learning (DL)-based Network Intrusion Detection Systems (NIDSs) suffer from opacity, prohibitive resource consumption, and vulnerability to gradient leakage attacks in federated settings, while traditional rule-based systems fail to handle encrypted payloads and evolving attack patterns. To bridge this gap, we present NeSySwarm-IDS (Neuro-Symbolic Swarm Intrusion Detection System), an end-to-end differentiable neuro-symbolic framework that simultaneously achieves high accuracy, strong privacy guarantees, and built-in interpretability under resource constraints. NeSySwarm-IDS integrates an extremely lightweight 1D convolutional neural network with a differentiable Łukasiewicz fuzzy logic reasoner incorporating attack-specific rules. By aggregating only low-dimensional logic rule weights with calibrated differential privacy noise, we drastically reduce communication overhead while providing (ϵ,δ)-DP guarantees with negligible utility loss. Extensive experiments on the UAV-NIDD dataset and our self-collected dataset demonstrate that NeSySwarm-IDS achieves near-perfect detection accuracy, significantly outperforming traditional machine learning baselines despite using limited training data. A detailed case study on GPS spoofing confirms the interpretability of our approach, providing axiomatic explanations suitable for autonomous mission verification. These results establish that end-to-end neuro-symbolic learning can effectively bridge the semantic gap in UAV swarm security while ensuring privacy and interpretability, offering a practical pathway for deploying trustworthy AI in contested environments. Full article
(This article belongs to the Special Issue Cyberspace Security Technology in Computer Science)
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21 pages, 19468 KB  
Article
Comparative Study of Four Hybrid Spatiotemporal Models for Daily PM2.5 Prediction in the Chengdu–Chongqing Region
by Bin Hu, Ling Zeng and Haiming Fan
Sustainability 2026, 18(6), 3126; https://doi.org/10.3390/su18063126 - 23 Mar 2026
Viewed by 333
Abstract
The Chengdu–Chongqing Twin-City Economic Circle (CC-TCEC), located in the Sichuan Basin, frequently experiences persistent winter PM2.5 pollution due to basin-constrained ventilation and strong meteorology–emission coupling. Using daily PM2.5 observations from 113 monitoring stations with a strict two-year training and one-year testing [...] Read more.
The Chengdu–Chongqing Twin-City Economic Circle (CC-TCEC), located in the Sichuan Basin, frequently experiences persistent winter PM2.5 pollution due to basin-constrained ventilation and strong meteorology–emission coupling. Using daily PM2.5 observations from 113 monitoring stations with a strict two-year training and one-year testing split, we develop hybrid spatiotemporal forecasting models that couple a graph neural network (GCN/GAT) for inter-station spatial dependence learning with a temporal backbone (LSTM/Transformer) for evolving concentration dynamics. We adopt a rolling one-day-ahead forecasting scheme using a 7-day look-back window. Across 12-month, 6-month, and 3-month evaluation windows, the meteorology-augmented Multi-GAT-Transformer shows a slight but consistent advantage over the other tested variants, suggesting potential benefits of attention-based spatial weighting and long-range temporal self-attention under nonstationary basin pollution regimes. Spatiotemporal mappings derived from the best-performing configuration suggest that elevated winter PM2.5 is mainly associated with low-lying areas such as the Chengdu Plain, industry clusters, and dense urban cores, with peaks that also coincide with the New Year and the pre-Lunar New Year period, suggesting a possible contribution from elevated traffic and production activity. These impacts are amplified by winter stagnation (low winds, high humidity, limited precipitation). From a policy perspective, the results support sustainability-oriented winter haze management by enabling early episode warning and hotspot prioritization. Full article
(This article belongs to the Section Air, Climate Change and Sustainability)
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25 pages, 1678 KB  
Review
Artificial Intelligence for Pulmonary Abnormality Detection in Chest X-Ray Imaging: A Detailed Review of Methods, Datasets and Future Directions
by G. Parra-Cabrera, J. J. Jiménez-Delgado and F. D. Pérez-Cano
Technologies 2026, 14(3), 147; https://doi.org/10.3390/technologies14030147 - 28 Feb 2026
Viewed by 964
Abstract
Chest X-ray (CXR) imaging remains the most widely used radiological modality for assessing pulmonary and cardiothoracic disease, yet its interpretation is inherently constrained by tissue superposition, subtle radiographic findings and marked inter-observer variability. Recent advances in artificial intelligence (AI) have driven significant progress [...] Read more.
Chest X-ray (CXR) imaging remains the most widely used radiological modality for assessing pulmonary and cardiothoracic disease, yet its interpretation is inherently constrained by tissue superposition, subtle radiographic findings and marked inter-observer variability. Recent advances in artificial intelligence (AI) have driven significant progress in automated CXR analysis, supported by large public datasets, evolving annotation strategies and increasingly expressive deep learning architectures. This review presents a comprehensive synthesis of approaches for pulmonary abnormality detection, encompassing convolutional neural networks, transformers, multimodal and vision–language models and self-supervised representation learning. We critically discuss their strengths, limitations and vulnerability to label noise, domain shift and shortcut learning. In parallel, we examine dataset properties, annotation practices, robustness challenges, explainability methods and the heterogeneity of evaluation protocols that hinder fair comparison and clinical translation. Building on these observations, the review identifies key future directions, including foundation models, multimodal integration, federated and domain-generalized training, longitudinal modeling, synthetic data generation and standardized clinical evaluation frameworks. By integrating methodological and clinical perspectives, this work offers an up-to-date reference for researchers and clinicians and outlines a roadmap toward reliable, interpretable and clinically deployable AI systems for chest radiography. Full article
(This article belongs to the Section Information and Communication Technologies)
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16 pages, 38449 KB  
Article
Explainable Dynamic Graph Learning and Multi-Scale Feature Fusion for Hydraulic System Health Monitoring
by Ziheng Gu, Xiansong He, Yibo Song, Gongning Li, Shufeng Zhang, Xiaowei Yang, Xiaoli Zhao, Jianyong Yao and Chuanjie Lu
Sensors 2026, 26(5), 1478; https://doi.org/10.3390/s26051478 - 26 Feb 2026
Viewed by 431
Abstract
Hydraulic systems are pivotal components in safety-critical aerospace and industrial applications, making reliable health monitoring essential. However, traditional data-driven diagnosis methods typically rely on static graph structures that fail to capture evolving sensor correlations during different fault modes. Furthermore, existing grid-based models often [...] Read more.
Hydraulic systems are pivotal components in safety-critical aerospace and industrial applications, making reliable health monitoring essential. However, traditional data-driven diagnosis methods typically rely on static graph structures that fail to capture evolving sensor correlations during different fault modes. Furthermore, existing grid-based models often struggle to extract multi-resolution features and maintain performance under data-limited conditions. To address these challenges, this paper proposes a novel Dynamic Multi-Scale Graph Neural Network (DMS-GNN) for hydraulic system fault diagnosis. The framework integrates a hierarchical multi-scale feature extraction module to capture diverse fault signatures across different frequency bands. Crucially, a self-attention-based dynamic graph learner is introduced to adaptively infer latent sensor topologies end-to-end, eliminating the reliance on predefined physical connections. Experimental validation on a dedicated electro-hydraulic test bench demonstrates that the proposed DMS-GNN achieves a superior diagnostic accuracy of 98.47%, outperforming state-of-the-art baselines such as GraphSAGE, Static GCN, and GAT. The result confirms the efficacy of combining multi-scale temporal learning with dynamic spatial reasoning for robust multi-sensor fusion diagnosis. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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20 pages, 1459 KB  
Article
Entropy and Chaos in Self-Organizing Systems
by Nikitas Gerolimos, Vasileios Alevizos and Georgios Priniotakis
Mathematics 2026, 14(4), 685; https://doi.org/10.3390/math14040685 - 15 Feb 2026
Viewed by 678
Abstract
Self-organizing systems arise in complex biomechanical structures, human locomotion, and neural control hierarchies, yet quantitative methods for describing order formation and loss of stability remain limited. This study develops a mathematical framework for analyzing self-organization using entropy-based measures, indicators of chaotic dynamics, and [...] Read more.
Self-organizing systems arise in complex biomechanical structures, human locomotion, and neural control hierarchies, yet quantitative methods for describing order formation and loss of stability remain limited. This study develops a mathematical framework for analyzing self-organization using entropy-based measures, indicators of chaotic dynamics, and network-theoretic structure. The approach (the LET framework) combines Lyapunov exponents with entropy families and graph metrics (algebraic connectivity, Load-Path Heterogeneity Index) to: (i) examine transitions between ordered and disordered states, (ii) assess sensitivity to perturbations, and (iii) characterize structural coherence in evolving cervical spine kinematics. Analytical models and computational validations are presented for cervical stability and post-operative Adjacent Segment Disease (ASD) using the Branney–Breen dataset. The findings indicate that entropy and chaos measures identify regime shifts and the emergence of a “stability corridor” more clearly than task-oriented indices, and provide finer resolution of dynamical variability within self-organizing processes. Network metrics complement these results by linking local segmental interactions to global structural fragility transfer. The study shows that entropy, chaos indicators, and network structure together form a consistent basis for describing self-organization in biomechanical systems, enabling quantitative comparison of dynamical regimes and improved interpretation of emergent pathological behavior. The approach utilizes a hybrid kinematic surrogate model to resolve passive and active components, bypassing direct force measurements by employing viscoelastic mechanotransduction principles. Full article
(This article belongs to the Special Issue Mathematical Modeling and Control for Engineering Applications)
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28 pages, 3453 KB  
Article
Denoising Adaptive Multi-Branch Architecture for Detecting Cyber Attacks in Industrial Internet of Services
by Ghazia Qaiser and Siva Chandrasekaran
J. Cybersecur. Priv. 2026, 6(1), 26; https://doi.org/10.3390/jcp6010026 - 5 Feb 2026
Viewed by 702
Abstract
The emerging scope of the Industrial Internet of Services (IIoS) requires a robust intrusion detection system to detect malicious attacks. The increasing frequency of sophisticated and high-impact cyber attacks has resulted in financial losses and catastrophes in IIoS-based manufacturing industries. However, existing solutions [...] Read more.
The emerging scope of the Industrial Internet of Services (IIoS) requires a robust intrusion detection system to detect malicious attacks. The increasing frequency of sophisticated and high-impact cyber attacks has resulted in financial losses and catastrophes in IIoS-based manufacturing industries. However, existing solutions often struggle to adapt and generalize to new cyber attacks. This study proposes a unique approach designed for known and zero-day network attack detection in IIoS environments, called Denoising Adaptive Multi-Branch Architecture (DA-MBA). The proposed approach is a smart, conformal, and self-adjusting cyber attack detection framework featuring denoising representation learning, hybrid neural inference, and open-set uncertainty calibration. The model merges a denoising autoencoder (DAE) to generate noise-tolerant latent representations, which are processed using a hybrid multi-branch classifier combining dense and bidirectional recurrent layers to capture both static and temporal attack signatures. Moreover, it addresses challenges such as adaptability and generalizability by hybridizing a Multilayer Perceptron (MLP) and bidirectional LSTM (BiLSTM). The proposed hybrid model was designed to fuse feed-forward transformations with sequence-aware modeling, which can capture direct feature interactions and any underlying temporal and order-dependent patterns. Multiple approaches have been applied to strengthen the dual-branch architecture, such as class weighting and comprehensive hyperparameter optimization via Optuna, which collectively address imbalanced data, overfitting, and dynamically shifting threat vectors. The proposed DA-MBA is evaluated on two widely recognized IIoT-based datasets, Edge-IIoT set and WUSTL-IIoT-2021 and achieves over 99% accuracy and a near 0.02 loss, underscoring its effectiveness in detecting the most sophisticated attacks and outperforming recent deep learning IDS baselines. The solution offers a scalable and flexible architecture for enhancing cybersecurity within evolving IIoS environments by coupling feature denoising, multi-branch classification, and automated hyperparameter tuning. The results confirm that coupling robust feature denoising with sequence-aware classification can provide a scalable and flexible framework for improving cybersecurity within the IIoS. The proposed architecture offers a scalable, interpretable, and risk sensitive defense mechanism for IIoS, advancing secure, adaptive, and trustworthy industrial cyber-resilience. Full article
(This article belongs to the Special Issue Cyber Security and Digital Forensics—2nd Edition)
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19 pages, 1638 KB  
Article
An Intrusion Detection Method for the Internet of Things Based on Spatiotemporal Fusion
by Junzhong He and Xiaorui An
Mathematics 2026, 14(3), 504; https://doi.org/10.3390/math14030504 - 30 Jan 2026
Viewed by 580
Abstract
In the information age, Internet of Things (IoT) devices are more susceptible to intrusion due to today’s complex network attack methods. Therefore, accurately detecting evolving network attacks from complex and ever-changing IoT environments has become a key research goal in the current intrusion [...] Read more.
In the information age, Internet of Things (IoT) devices are more susceptible to intrusion due to today’s complex network attack methods. Therefore, accurately detecting evolving network attacks from complex and ever-changing IoT environments has become a key research goal in the current intrusion detection field. Due to the spatial and temporal characteristics of IoT data, this paper proposes a Spatiotemporal Feature Weighted Fusion Approach Combining Gating Attention Transformation (STWGA). STWGA consists of three parts, namely spatial feature learning, the gated attention transformer, and the temporal feature learning module. It integrates improved convolutional neural networks (CNN), batch normalization, and Bidirectional Long Short-Term Memory Network (Bi-LSTM) to fully learn the deep spatial and temporal features of the data, achieving the goal of global deep spatiotemporal feature extraction. The gated attention transformer introduces an attention mechanism. In addition, an additional control mechanism is introduced in the self-attention module to more effectively improve detection accuracy. Finally, the experimental results show that STWGA has better spatiotemporal feature extraction ability and can effectively improve the intrusion detection effect of anomalies. Full article
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68 pages, 2705 KB  
Systematic Review
A Systematic Review of Computational and Data-Driven Approaches for Energy-Efficient Battery Management in Electrified Vehicles
by Milos Poliak, Damian Frej, Piotr Łagowski and Justyna Jaśkiewicz
Appl. Sci. 2026, 16(2), 618; https://doi.org/10.3390/app16020618 - 7 Jan 2026
Viewed by 970
Abstract
The dynamic growth of the electrified vehicle (xEV) market, including both electric and hybrid vehicles, has increased the demand for advanced Battery Management Systems (BMS). From an energy-systems perspective, xEV batteries act as distributed energy storage units that strongly interact with power grids, [...] Read more.
The dynamic growth of the electrified vehicle (xEV) market, including both electric and hybrid vehicles, has increased the demand for advanced Battery Management Systems (BMS). From an energy-systems perspective, xEV batteries act as distributed energy storage units that strongly interact with power grids, renewable generation, and charging infrastructure, making their efficient control a key element of low-carbon energy systems. Traditional BMS methods face challenges in accurately estimating key battery states and parameters, especially under dynamic operating conditions. This review systematically analyzes the progress in applying artificial intelligence, machine learning, and other advanced computational and data-driven algorithms to improve the performance of xEV battery management with a particular focus on energy efficiency, safe utilization of stored electrochemical energy, and the interaction between vehicles and the power system. The literature analysis covers key research trends from 2020 to 2025. This review covers a wide range of applications, including State of Charge (SOC) estimation, State of Health (SOH) prediction, and thermal management. We examine the use of various methods, such as deep learning, neural networks, genetic algorithms, regression, and also filtering algorithms, to solve these complex problems. This review also classifies the research by geographical distribution and document types, providing insight into the global landscape of this rapidly evolving field. By explicitly linking BMS functions with energy-system indicators such as charging load profiles, peak-load reduction, self-consumption of photovoltaic generation, and lifetime-aware energy use, this synthesis of contemporary research serves as a valuable resource for scientists and engineers who wish to understand the latest achievements and future directions in data-driven battery management and its role in modern energy systems. Full article
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33 pages, 3147 KB  
Review
Perception–Production of Second-Language Mandarin Tones Based on Interpretable Computational Methods: A Review
by Yujiao Huang, Zhaohong Xu, Xianming Bei and Huakun Huang
Mathematics 2026, 14(1), 145; https://doi.org/10.3390/math14010145 - 30 Dec 2025
Cited by 1 | Viewed by 1267
Abstract
We survey recent advances in second-language (L2) Mandarin lexical tones research and show how an interpretable computational approach can deliver parameter-aligned feedback across perception–production (P ↔ P). We synthesize four strands: (A) conventional evaluations and tasks (identification, same–different, imitation/read-aloud) that reveal robust tone-pair [...] Read more.
We survey recent advances in second-language (L2) Mandarin lexical tones research and show how an interpretable computational approach can deliver parameter-aligned feedback across perception–production (P ↔ P). We synthesize four strands: (A) conventional evaluations and tasks (identification, same–different, imitation/read-aloud) that reveal robust tone-pair asymmetries and early P ↔ P decoupling; (B) physiological and behavioral instrumentation (e.g., EEG, eye-tracking) that clarifies cue weighting and time course; (C) audio-only speech analysis, from classic F0 tracking and MFCC–prosody fusion to CNN/RNN/CTC and self-supervised pipelines; and (D) interpretable learning, including attention and relational models (e.g., graph neural networks, GNNs) opened with explainable AI (XAI). Across strands, evidence converges on tones as time-evolving F0 trajectories, so movement, turning-point timing, and local F0 range are more diagnostic than height alone, and the contrast between Tone 2 (rising) and Tone 3 (dipping/low) remains the persistent difficulty; learners with tonal vs. non-tonal language backgrounds weight these cues differently. Guided by this synthesis, we outline a tool-oriented framework that pairs perception and production on the same items, jointly predicts tone labels and parameter targets, and uses XAI to generate local attributions and counterfactual edits, making feedback classroom-ready. Full article
(This article belongs to the Section E1: Mathematics and Computer Science)
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31 pages, 2296 KB  
Review
AI-Driven Digital Twins for Manufacturing: A Review Across Hierarchical Manufacturing System Levels
by Phat Nguyen, Minjung Kim, Elaina Nichols and Hwan-Sik Yoon
Sensors 2026, 26(1), 124; https://doi.org/10.3390/s26010124 - 24 Dec 2025
Cited by 5 | Viewed by 4131
Abstract
Digital Twins (DTs) integrated with Artificial Intelligence (AI) are emerging as transformative tools in smart manufacturing. By bridging the physical and virtual domains, DTs enable real-time monitoring, predictive analytics, and autonomous decision-making. Originally conceived as advanced simulation models, DTs have evolved significantly with [...] Read more.
Digital Twins (DTs) integrated with Artificial Intelligence (AI) are emerging as transformative tools in smart manufacturing. By bridging the physical and virtual domains, DTs enable real-time monitoring, predictive analytics, and autonomous decision-making. Originally conceived as advanced simulation models, DTs have evolved significantly with the incorporation of AI, which enhances their ability to acquire process knowledge, optimize scheduling, and autonomously control system variables. This evolution transforms DTs from passive representations into prescriptive, self-optimizing systems. AI-driven DTs support a wide range of applications, including predictive maintenance, process optimization, quality control, and dynamic scheduling, using techniques such as deep reinforcement learning and convolutional neural networks. These capabilities have been successfully deployed across industrial domains such as CNC machining, robotics, and industrial printing, yielding substantial improvements in efficiency, reliability, and responsiveness. Despite these advancements, the full realization of intelligent DTs relies heavily on the availability of high-fidelity, real-time data and a seamless alignment between physical systems and their digital counterparts. This literature survey provides a state-of-the-art review of AI-driven DTs in manufacturing, highlighting their key applications, challenges, and emerging research directions that will shape the future of intelligent and adaptive manufacturing systems. To present a structured perspective on the evolution and scalability of AI-driven DTs, the application case studies are organized according to four integration levels—machine, cell, shop floor, and enterprise—highlighting how these technologies scale from individual assets to fully interconnected manufacturing ecosystems. Full article
(This article belongs to the Section Industrial Sensors)
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12 pages, 453 KB  
Review
Placebo in Functional Neurological Disorders: Promise and Controversy
by Natalia Szejko, Ali Abusrair, Tomasz Pasierski, Simon Schmitt, Catharina Cramer, Tomasz Pietrzykowski, Anna Dunalska, Kamila Saramak, Katarzyna Śmiłowska, Tereza Serranova and Kirsten R. Müller-Vahl
Healthcare 2025, 13(22), 2863; https://doi.org/10.3390/healthcare13222863 - 11 Nov 2025
Viewed by 2052
Abstract
Placebo, nocebo, and lessebo effects are very frequent in patients with both neurological and psychiatric disorders. Interestingly, the neural mechanisms underlying placebo effects have been found to be the same as or similar to mechanisms targeted by active pharmaceutical interventions for many of [...] Read more.
Placebo, nocebo, and lessebo effects are very frequent in patients with both neurological and psychiatric disorders. Interestingly, the neural mechanisms underlying placebo effects have been found to be the same as or similar to mechanisms targeted by active pharmaceutical interventions for many of these disorders. In the case of functional neurological disorders (FNDs), there are shared neural substrates between the central nervous system “placebo network” and the dysfunctional networks implicated in the pathophysiology. These networks are primarily involved in emotion regulation, stress responses, and the sense of self-agency. Therefore, placebo effects have also been discussed as therapeutic interventions in FNDs. Such an approach, however, has a variety of ethical implications evolving around informed consent, autonomy, nonmaleficence, beneficence, and justice. In this paper, we discuss the use of placebo, nocebo, and lessebo in FNDs as well as related ethical issues. Overall, the use of placebo in FNDs is currently still considered controversial both for diagnostic as well as therapeutic purposes. Although it is a safe and almost unique intervention, its use violates the core principles of medical ethics and doctor–patient interactions involving autonomy or openness in the therapeutic relationship. Full article
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26 pages, 10083 KB  
Article
Triple-Stream Contrastive Deep Embedding Clustering via Semantic Structure
by Aiyu Zheng, Jianghui Cai, Haifeng Yang, Yalin Xun and Xujun Zhao
Mathematics 2025, 13(22), 3578; https://doi.org/10.3390/math13223578 - 7 Nov 2025
Cited by 1 | Viewed by 985
Abstract
Deep neural network-based deep clustering has achieved remarkable success by unifying representation learning and clustering. However, conventional representation modules are typically not tailored for clustering, resulting in conflicting objectives that hinder the model’s ability to capture semantic structures with high intra-cluster cohesion and [...] Read more.
Deep neural network-based deep clustering has achieved remarkable success by unifying representation learning and clustering. However, conventional representation modules are typically not tailored for clustering, resulting in conflicting objectives that hinder the model’s ability to capture semantic structures with high intra-cluster cohesion and low inter-cluster separation. To overcome this limitation, we propose a novel framework called Triple-stream Contrastive Deep Embedding Clustering via Semantic Structure (TCSS). TCSS is composed of representation and clustering modules, with its innovation rooted in several key designs that ensure their synergistic interaction for modeling semantic structures. First, TCSS introduces a triple-stream input framework that processes the raw instance along with its limited and aggressive augmented views. This design enables a new triple-stream self-training clustering loss, which uncovers implicit cluster structures by contrasting the three input streams. Second, within this loss, a dynamic clustering structure factor is developed to represent the evolving semantic structure in the representation space, thereby constraining the clustering-prediction distribution. Third, TCSS integrates semantic structure-aware techniques, including a clustering-oriented negative sampling strategy and a triple-stream alignment scheme based on k-nearest neighbors and centroids, to refine semantic structures both locally and globally. Extensive experiments on five benchmark datasets demonstrate that TCSS outperforms state-of-the-art methods. Full article
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18 pages, 382 KB  
Article
Self-Organized Criticality and Quantum Coherence in Tubulin Networks Under the Orch-OR Theory
by José Luis Díaz Palencia
AppliedMath 2025, 5(4), 132; https://doi.org/10.3390/appliedmath5040132 - 2 Oct 2025
Cited by 1 | Viewed by 5898
Abstract
We present a theoretical model to explain how tubulin dimers in neuronal microtubules might achieve collective quantum coherence, resulting in wavefunction collapses that manifest as avalanches within a self-organized criticality (SOC) framework. Using the Orchestrated Objective Reduction (Orch-OR) theory as inspiration, we propose [...] Read more.
We present a theoretical model to explain how tubulin dimers in neuronal microtubules might achieve collective quantum coherence, resulting in wavefunction collapses that manifest as avalanches within a self-organized criticality (SOC) framework. Using the Orchestrated Objective Reduction (Orch-OR) theory as inspiration, we propose that microtubule subunits (tubulins) become transiently entangled via dipole–dipole couplings, forming coherent domains susceptible to sudden self-collapse. We model a network of tubulin-like nodes with scale-free (Barabási–Albert) connectivity, each evolving via local coupling and stochastic noise. Near criticality, the system exhibits power-law avalanches—abrupt collective state changes that we identify with instantaneous quantum wavefunction collapse events. Using the Diósi–Penrose gravitational self-energy formula, we estimate objective reduction times TOR=/Eg for these events in the 10–200 ms range, consistent with the Orch-OR conscious moment timescale. Our results demonstrate that quantum coherence at the tubulin level can be amplified by scale-free critical dynamics, providing a possible bridge between sub-neuronal quantum processes and large-scale neural activity. Full article
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18 pages, 15272 KB  
Article
IDP-Head: An Interactive Dual-Perception Architecture for Organoid Detection in Mouse Microscopic Images
by Yuhang Yang, Changyuan Fan, Xi Zhou and Peiyang Wei
Biomimetics 2025, 10(9), 614; https://doi.org/10.3390/biomimetics10090614 - 11 Sep 2025
Viewed by 881
Abstract
The widespread application of organoids in disease modeling and drug development is significantly constrained by challenges in automated quantitative analysis. In bright-field microscopy images, organoids exhibit complex characteristics, including irregular morphology, blurred boundaries, and substantial scale variations, largely stemming from their dynamic self-organization [...] Read more.
The widespread application of organoids in disease modeling and drug development is significantly constrained by challenges in automated quantitative analysis. In bright-field microscopy images, organoids exhibit complex characteristics, including irregular morphology, blurred boundaries, and substantial scale variations, largely stemming from their dynamic self-organization that mimics in vivo tissue development. Existing convolutional neural network-based methods are limited by fixed receptive fields and insufficient modeling of inter-channel relationships, making them inadequate for detecting such evolving biological structures. To address these challenges, we propose a novel detection head, termed Interactive Dual-Perception Head (IDP-Head), inspired by hierarchical perception mechanisms in the biological visual cortex. Integrated into the RTMDet framework, IDP-Head comprises two bio-inspired components: a Large-Kernel Global Perception Module (LGPM) to capture global morphological dependencies, analogous to the wide receptive fields of cortical neurons, and a Progressive Channel Synergy Module (PCSM) that models inter-channel semantic collaboration, echoing the integrative processing of multi-channel stimuli in neural systems. Additionally, we construct a new organoid detection dataset to mitigate the scarcity of annotated data. Extensive experiments on both our dataset and public benchmarks demonstrate that IDP-Head achieves a 5-percentage-point improvement in mean Average Precision (mAP) over the baseline model, offering a biologically inspired and effective solution for high-fidelity organoid detection. Full article
(This article belongs to the Special Issue Nature-Inspired Metaheuristic Optimization Algorithms 2025)
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