Search Results (19,026)

Lung cancer remains the leading cause of cancer mortality, hindered by drug resistance, limited targeting, and low immunotherapy response. This review presents biomimetic superparamagnetic iron-oxide nanoparticles (SPIONs) as a next-generation theranostic platform. By cloaking SPIONs with cell membranes—macrophage, neutrophil, or cancer cell—we endow them with biological targeting, immune evasion, and deep lung penetration. Coupled with magnetic field-guided retention and real-time imaging, these systems enable precision hyperthermia, on-demand drug release, and immune microenvironment reprogramming. We critically compare membrane types, outline translational challenges, and propose a regulatory-aligned safety framework. This biomimetic strategy offers a dual diagnostic–therapeutic solution for lung cancer and potentially other solid tumors. Full article

In this paper, the impact of SiN passivation on dynamic-R_ON degradation of AlGaN/GaN HEMTs devices is put in evidence. To this end, samples showing different SiN passivation stoichiometry are considered, labeled as Sample A and Sample B. For dynamic-R_ON tests, two different experimental setups are employed to investigate the R_ON-drift showing up during conventional switch mode operation by driving the DUTs under both (i) resistive load and (ii) soft-switching trajectory. This allows to discern the impact of hot carriers and off-state drain voltage stress on the R_ON parameter drift. Measurements performed with both switching loci shows similar dynamic-R_ON response, indicating that hot carriers are not involved in the degradation of tested devices. Nevertheless, a significant difference was observed between Sample A and Sample B, with the former showing an additional R_ON-degradation mechanism, not present on the latter. This additional drift is totally ascribed to the SiN passivation layer and is confirmed by the different leakage current measured across the two SiN types. The mechanism is explained by the injection of negative charges from the Source Field-Plate towards the AlGaN surface that are captured by surface/dielectric states and partially depletes the 2DEG underneath. Full article

Riemerella anatipestifer (R. anatipestifer, RA) is a globally distributed pathogen responsible for duck serositis, an acute multisystemic disease whose infection leads to substantial economic impacts in duck production. There is currently no specific therapeutic drug available for effective treatment. Importantly, the severity of the disease is closely associated with multiple environmental factors, including feeding conditions, management practices, weather fluctuations, and air quality parameters. Furthermore, the prevalence of various serotypes is a matter of concern, and the emergence of multi-drug-resistant mutants through continuous use of various antibiotics is a major challenge. Recently, it has been reported that RA infects domestic ducks, turkeys, geese, wild birds and chicken, which leads to its remarkable influence on the healthy development of waterfowl breeding industry and even poultry breeding industry. Given these challenges, vaccination is essential for disease control. Various vaccine types are currently available, including but not limited to live vaccines, inactivated vaccines, subunit vaccines and vector vaccines. This paper provides a comprehensive review of the development of vaccines for RA. Full article

Obesity contributes to the development of metabolic disorders such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) through sustained low-grade inflammation and mitochondrial dysfunction. In obesity, hypertrophied adipose tissue release high levels of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, and elevates circulating free fatty acids. These changes promote systemic insulin resistance and ectopic lipid deposition. Mitochondrial dysfunction, including reduced oxidative phosphorylation, excess reactive oxygen species (ROS) production, and mitochondrial DNA damage, further stimulate inflammatory pathways such as the NLRP3 inflammasome, creating a feedback loop that worsens metabolic stress. Ultimately, this interaction disrupts energy balance, weakens insulin signaling, and accelerates β-cell dysfunction and hepatic steatosis. In both T2DM and MASLD, oxidative stress, defective mitochondrial quality control, and dysregulated immunometabolic responses are consistently observed pathophysiological features. Interventions aimed at reducing inflammation and restoring mitochondrial function—including lifestyle modification, mitochondria-targeted therapies, inflammasome regulation, and enhancement of mitochondrial biogenesis or mitophagy—may retard disease progression. Full article

Background: Colorectal cancer (CRC) is significantly associated with multiple metabolic diseases, with plasma metabolites potentially mediating this relationship. This large-scale metabolomics study aims to (1) quantify the genetic correlations and causal effects between 10 metabolic disease-related phenotypes and CRC risk; (2) identify the plasma metabolites mediating these effects; and (3) explore downstream regulatory genes and druggable targets. Methods: Using linkage disequilibrium score regression and two-sample Mendelian randomization, we assessed the causal relationships between each metabolic trait and CRC. A total of 1091 plasma metabolites and 309 metabolite ratios were identified and analyzed for mediating effects by a two-step MR approach. Colocalization analyses evaluated shared genetic loci. The findings were validated in the UK Biobank for metabolite-trait associations. The expression of candidate genes was explored using data from TCGA, GTEx, and GEO. A FADS1-centered protein–protein interaction (PPI) network was constructed via STRING. Results: BMI, waist circumference, basal metabolic rate, insulin resistance and metabolic syndrome exhibited both genetic correlation and causal effects on CRC. Five plasma metabolites—mannonate, the glucose/mannose ratio, plasma free asparagine, 1-linolenoyl-2-linolenoyl-GPC (18:2/18:3), and the mannose/trans-4-hydroxyproline ratio—were identified as shared central mediators. A colocalization analysis showed rs174546 linked CRC and 1-linolenoyl-2-linoleoyl-GPC. Validation in the UK Biobank confirmed the associations between phosphatidylcholine (the lipid class of this metabolite), adiposity measures, and CRC risk. An integrative analysis of TCGA, GTEx, and GEO revealed consistent upregulation of FADS1/2/3 and FEN1 in CRC, with high FADS1 expression predicting a poorer prognosis and showing the distinct cell-type expression in adipose and colon tissue. The PPI network mapping uncovered nine FADS1 interacting proteins targeted by supplements such as α-linolenic acid and eicosapentaenoic acid. Conclusions: This study systematically reveals, for the first time, the shared intermediary plasma metabolites and their regulatory genes in the causal pathway from metabolic diseases to CRC. These findings provide candidate targets for subsequent functional validation and biomarker development. Full article

Stroke is a leading cause of long-term disability worldwide, with survivors often facing significant challenges in regaining upper-limb functionality. In response, robotic rehabilitation systems have emerged as promising tools to enhance post-stroke recovery by delivering precise, adaptable, and patient-specific therapy. This paper presents a review of robotic interfaces developed specifically for upper-limb rehabilitation. It analyses existing exoskeleton- and end-effector-based systems, with respect to three core design pillars: assistance types, control philosophies, and actuation methods. The review highlights that most solutions favor electrically actuated exoskeletons, which use impedance- or electromyography-driven control, with active assistance being the predominant rehabilitation mode. Resistance-providing systems remain underutilized. Furthermore, no hybrid approaches featuring the combination of robotic manipulators with actuated interfaces were found. This paper also identifies a recent trend towards lightweight, modular, and portable solutions and discusses the challenges in bridging research prototypes with clinical adoption. By focusing exclusively on upper-limb applications, this work provides a targeted reference for researchers and engineers developing next-generation rehabilitation technologies. Full article

Inconel 625 is a nickel-based superalloy widely applied in aerospace and energy sectors due to its high strength and corrosion resistance. However, its poor machinability remains a significant challenge in precision manufacturing. This study investigates the influence of tool geometry and cutting parameters on surface roughness of Inconel 625 during turning operations under the minimum quantity lubrication (MQL) conditions. Experiments were carried out using three types of cutting inserts with distinct chip breaker geometries while systematically varying the cutting speed, feed rate, and depth of cut. The results were statistically analyzed using analysis of variance (ANOVA) to determine the significance of individual factors. The findings reveal that both the type of cutting insert and the process parameters have a considerable effect on surface roughness, which is the key output examined in this study. Cutting forces and chip type were examined to provide complementary insights and improve understanding of the observed relationships. Based on the results, an optimal set of cutting data was proposed to achieve a required surface roughness during the turning of Inconel 625 with MQL. Furthermore, a practical algorithm was developed to support the selection of cutting parameters in industrial applications. Analysis of the results showed that a cutting insert with a 0.4 mm corner radius achieved the required surface finish (Rz ≤ 0.4 µm). Furthermore, the analysis revealed a significant effect of the thermal properties of Inconel 625 on machining results and chip geometry. Full article

In this work, a series of novel high-entropy alloys CoCrFeNiSiV_x (x = 0.25; 0.5; 0.75; 1.0) with an intermetallic compound structure was proposed. The effect of vanadium addition on the structure, as well as selected mechanical and corrosion properties, was investigated. In the case of the CoCrFeNiSiV_0.25 alloy, the structural analysis revealed the formation of a dual-phase structure consisting of Fe_1.812V_0.907Si_0.906-type and Fe₅Ni₃Si₂-type intermetallic phases. The increase in vanadium concentration results in the crystallization of one Fe_1.812V_0.907Si_0.906 intermetallic phase detected by the X-ray diffraction method. The increase in vanadium content had a beneficial influence on the corrosion resistance of CoCrFeNiSiV_x alloys in 3.5% NaCl. The CoCrFeNiSiV alloy exhibited the lowest corrosion current density of 0.17 μA/cm² and the highest corrosion potential of −0.228 V. The hardness of the alloys investigated increased with vanadium content, reaching 1006 HV for the equimolar alloy. In turn, the lowest friction coefficient of 0.63 ± 0.06 was obtained for the CoCrFeNiSiV_0.75 alloy. The abrasive, fatigue, and oxidative wear were identified as the main wear mechanisms. Full article

In plants, resistance genes (R) are key players in combatting diseases caused by various phytopathogens. Typically, resistance relies on detecting a single pathogen-derived molecular pattern. However, R-gene-mediated resistance is often race specific, follows the gene-for-gene hypothesis, and can be overcome in field conditions as pathogens evolve. On the contrary, altering plant susceptibility genes (S-genes) facilitates compatibility and results in broad and durable resistance. S-genes are negative regulators present in plants and exploited by pathogens to facilitate their growth and cause infection. Several studies across crop species have reported manipulation of S-genes using genome editing to confer broad spectrum resistance. This review focuses on the plant defense mechanism against biotic stress, R-genes vs. S-genes, different types/classes of S-genes, different tools for S-gene discovery, and the use of gene editing technologies to target S-genes in addition to their applications, challenges, and future perspectives. Full article

The use of molybdenum-based alloys as materials for components operating under high temperatures and significant mechanical loads is widely recognized due to their excellent mechanical properties. However, their low high-temperature resistance remains a critical limitation, which can be effectively mitigated by applying protective coatings. In this study, we investigate the influence of a two-step coating process on the properties and performance of the TZM molybdenum alloy. In the first step, pack cementation was performed. Simultaneous surface saturation with aluminum and silicon, a process known as aluminosiliconizing, was conducted at 1000 °C for 6 h. The saturating mixture comprised powders of aluminum, silicon, aluminum oxide, and ammonium chloride. The second step involved the application of a pre-ceramic coating based on polyhydrosiloxane modified with silicon and boron. This treatment effectively eliminated pores and cracks within the coating. Thermodynamic calculations were carried out to evaluate the likelihood of aluminizing and siliconizing reactions under the applied conditions. Aluminosiliconizing of the TZM alloy resulted in the formation of a protective layer 20–30 µm thick. The multiphase structure of this layer included intermetallics (Al₆₃Mo₃₇, MoAl₃), nitrides (Mo₂N, AlN, Si₃N₄), oxide (Al₂O₃), and a solid solution α-Mo(Al). Subsequent treatment with silicon- and boron-modified polyhydrosiloxane led to the development of a thicker surface layer, 130–160 µm in thickness, composed of crystalline Si, amorphous SiO₂, and likely amorphous boron. A transitional oxide layer ((Al,Si)₂O₃) 5–7 µm thick was also observed. The resulting coating demonstrated excellent structural integrity and chemical inertness in an argon atmosphere at temperatures up to 1100 °C. High-temperature stability at 800 °C was observed for both coating types: aluminosiliconizing, and aluminosiliconizing followed by the pre-ceramic coating. Moreover, additional oxide layers of SiO₂ and B₂O₃ formed on the two-step coated TZM alloy during heating at 800 °C for 24 h. These layers acted as an effective barrier, preventing the evaporation of the substrate material. Full article

Background: Elevated Lp-PLA2 activity, a marker of inflammation and oxidative stress, is linked to increased cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM). Given that high Lp-PLA2 activity is a hallmark of metabolic-dysfunction-associated steatotic liver disease (MASLD), we aimed to investigate whether it contributes additional CVD risks when MASLD coexists with T2DM. Methods: This study included 1095 patients with T2DM, consecutively enrolled at the First Affiliated Hospital, Sun Yat-sen University, between June 2020 and November 2022. Liver steatosis and stiffness were assessed via abdominal ultrasound/CT and fibrosis-4 (FIB-4) scores, respectively. Carotid atherosclerosis (CAS) was defined as the presence of intima-media thickening or carotid plaque and was evaluated using high-resolution B-mode ultrasonography. Results: Among 674 MASLD patients, higher levels of Lp-PLA2 activity were observed compared to those in 421 non-MASLD individuals (573 ± 164 U/L vs. 540 ± 170 U/L, p = 0.002), while no association was found between steatosis degree and Lp-PLA2. Lp-PLA2 levels exceeding a threshold of 570 U/L were identified as a risk factor for CAS, with each one standard deviation increase in Lp-PLA2 corresponding to an odds ratio of 2.67 (95% confidence interval: 1.31–5.42, p = 0.007), while a similar association was not observed in patients with normal FIB-4 levels. Conclusions: Elevated Lp-PLA2 activity is associated with MASLD and insulin resistance in T2DM, while Lp-PLA2 was not related to the degree of liver steatosis. A threshold of 570 U/L is associated with CAS risk, specifically in those with concurrent advanced liver fibrosis, highlighting the potential role of Lp-PLA2 in cardiovascular risk stratification in this subset but within the limitations of a cross-sectional study. Full article

Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular risk characterized by low-grade inflammation. The aim of this systematic review and meta-analysis was to assess the effects of resistance exercise training (RET) predominantly on cytokines, along with changes in glucose profile and body composition in T2DM patients. The present systematic review and meta-analysis was conducted utilizing PubMed, Web of Science, Embase, and the Cochrane Library databases from their inception up to July 2024 (PROSPERO; registration number CRD420251149352). We screened only for randomized controlled trials investigating the effects of systematic, supervised RET on C-reactive protein (CRP) and adipokines: adiponectin, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), along with changes in anthropometric indices and glycemic control in adult T2DM patients. Pooled post-exercise weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated for all outcomes of interest between exercise-treated patients and controls. Sixteen studies involving a total of 668 T2DM patients were retrieved from the databases for meta-analysis. We used the GRADE framework for assessing the certainty of evidence. Cochran Q-score (I²) was used to estimate heterogeneity among studies (level of significance p < 0.10) and risk of bias analysis was also performed. The cumulative results showed that post-RET inflammatory markers were lower in exercise-treated patients compared to controls regarding CRP (mg/L) (WMD: −0.63; 95%CIs: −1.05, −0.20; p < 0.001); adiponectin (μg/mL) (WMD: −0.94; 95%CIs: −1.49, −0.38; p < 0.001). The results from adiponectin are quite conflicting since they derived from only three studies, where one of them had the greater impact. In parallel, we noticed significant amelioration of fasting glucose and HbA1c (p < 0.001), while body weight remained unaltered. Our meta-analysis demonstrated non-significantly lower levels of IL-6 and TNF-α in RET vs. control group. RET can merely reduce the inflammatory burden in T2DM patients by ameliorating the circulating levels of CRP and adiponectin, while in the rest of the biomarkers, non-significant results were obtained. Hence, the overall clinical impact of those anti-inflammatory effects of RET needs to be determined. Full article

Dry reforming of methane and ethanol is a promising catalytic process for the conversion of carbon dioxide and hydrocarbon feedstocks into synthesis gas (H₂/CO), which serves as a key platform for the production of fuels and chemicals. Over the past decade, substantial progress has been achieved in the design of catalysts with enhanced activity and stability under the demanding conditions of these strongly endothermic reactions. This review summarizes the latest developments in catalyst systems for DRM and EDR, including Ni-based catalysts, perovskite-type oxides, MOF-derived materials, and high-entropy alloys. Particular attention is given to strategies for suppressing carbon deposition and preventing metal sintering, such as oxygen vacancy engineering in oxide supports, rare earth and transition metal doping, strong metal–support interactions, and morphological control via core–shell and mesoporous architectures. These approaches have been shown to improve coke resistance, maintain metal dispersion, and extend catalyst lifetimes. The review also highlights emerging concepts such as multifunctional hybrid systems and innovative synthesis methods. By consolidating recent findings, this work provides a comprehensive overview of current progress and future perspectives in catalyst development for DRM and EDR, offering valuable guidelines for the rational design of advanced catalytic materials. Full article

Extracellular vesicles (EVs) secreted by glioblastoma multiforme and other types of cancer cells are key factors contributing to the aggressiveness of the disease and its resistance to therapy. Chloroquine (CHQ), a lysosomal inhibitor, has shown potential as an enhancer of temozolomide (TMZ) cytotoxicity against glioblastoma cells. Since both CHQ and TMZ are known to modulate EV secretion, we sought to investigate their potential interplay in this process. Simultaneous treatment of TMZ-sensitive (U87-MG) and TMZ-resistant (U138-MG) glioblastoma cells with TMZ and CHQ led to a synergistic upregulation of EV secretion. Although CHQ did not enhance the TMZ cytotoxicity in U87-MG cells, it synergized with the latter to upregulate the release of extracellular nucleic acids implicating activation of unconventional secretory pathways. Synergistic upregulation of the autophagy markers LC3B-II and p62 by CHQ and TMZ in both cells and EVs indicates that secretory autophagy is likely involved in the observed unconventional secretion. Moreover, a significant enrichment of caveolin-1 in small EVs highlights their potential role in modulating tumor aggressiveness. The synergy in EV upregulation was not confined to the specific biological activity of TMZ and CHQ; similar effects were observed upon co-treatments with CHQ and etoposide (a topoisomerase inhibitor) and TMZ and Bafilomycin A1 (another lysosomal inhibitor). Heightened EV release was also observed in THP-1 monocytes and macrophages treated with Bafilomycin and TMZ, highlighting a broader, cell-type-independent mechanism. These findings indicate that combined DNA damage and lysosomal inhibition synergistically stimulate secretory autophagy and EV release, potentially impacting the tumor microenvironment and driving disease progression. Full article

Screw piles are widely used in infrastructure, such as railways, highways, and ports, etc., owing to their large pile resistance compared to unthreaded piles. While most screw pile research focuses on single pile behavior under rotational installation using torque-capacity correlations. Limited studies investigate group effects under alternative installation methods. In this study, the load-transfer mechanism of screw piles and soil displacement under vertical installation was explored using laboratory model tests combined with digital image correlation techniques. In addition, numerical simulations using the discrete element method were performed. Based on both lab tests and numerical simulation results, it is discovered that the ultimate bearing capacity of a single screw pile was approximately 50% higher than that of a cylindrical pile with the same outer diameter and length. For pile groups, the group effect coefficient of a triple-pile group composed of screw piles was 0.64, while that of cylindrical piles was 0.55. This phenomenon was caused by the unique thread-soil interaction of screw piles. The threads generated greater side resistance and reduced stress concentration at the pile tip compared with cylindrical piles. Moreover, the effects of pile type, pile number, embedment length, pile spacing, and thread pitch on pile resistance and soil displacement were also investigated. The findings in this study revealed the micro–macro correspondence of screw pile performance and can serve as references for pile construction in practice. Full article