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4 Results Found

  • Article
  • Open Access
2 Citations
2,007 Views
12 Pages

Pseudolaric Acid B Targets CD147 to Selectively Kill Acute Myeloid Leukemia Cells

  • Sheng Zou,
  • Ekaterina Parfenova,
  • Nikolina Vrdoljak,
  • Mark D. Minden and
  • Paul A. Spagnuolo

Acute myeloid leukemia (AML) is an aggressive blood cancer. With low survival rates, new drug targets are needed to improve treatment regimens and patient outcomes. Pseudolaric acid B (PAB) is a plant-derived bioactive compound predicted to interact...

  • Article
  • Open Access
1,033 Views
22 Pages

Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth

  • Xia Peng,
  • Siqi Yu,
  • Lin Xu,
  • Qinghua Wang,
  • Lin Yang,
  • Yi Su,
  • Zhirou Xiong,
  • Mengjie Shao,
  • Meiyu Geng and
  • Chunyong Ding
  • + 3 authors

Tumor-associated macrophages (TAMs) are pivotal for tumor development and progression. Reprogramming the M2-like pro-tumoral behavior of TAMs towards the M1-like anti-tumor phenotype to unleash their potential against tumors has become one of the mos...

  • Article
  • Open Access
10 Citations
3,484 Views
12 Pages

Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5

  • Su-Jung Choi,
  • Chi-Hyun Ahn,
  • In-Hyoung Yang,
  • Bohwan Jin,
  • Won Woo Lee,
  • Ji-Hoon Kim,
  • Min-Hye Ahn,
  • Neeti Swarup,
  • Kyoung-Ok Hong and
  • Sung-Dae Cho
  • + 4 authors

16 October 2019

Pseudolaric Acid B (PAB), diterpenoid isolated from the root bark of Pseudolarix kaempferi Gordon tree (Pinaceae), exhibits an anti-proliferative and apoptotic activity in various cancer cell lines but to date, the effects of PAB on head and neck can...

  • Article
  • Open Access
3 Citations
1,971 Views
18 Pages

6 June 2025

As one of the medicinal and edible resources, Gastrodia elata (GE) is considered to hold potential in alleviating alcoholic liver injury, yet its mechanism needs further elucidation. To explore the molecular mechanisms of GE against alcoholic liver i...