Search Results (669)

Background: Brain health is a growing public health priority due to the high global burden of neurological and mental disorders. Promoting brain health across the lifespan supports individual and societal well-being, creativity, and productivity. Objective: To address the need for specialized education in this field, the University of Bern developed a Certificate of Advanced Studies (CAS) in Brain Health. This article outlines the program’s rationale, structure, and goals. Program Description: The one-year, 15 ECTS-credit program is primarily online and consists of four modules: (1) Introduction to Brain Health, (2) Brain Disorders, (3) Risk Factors, Protective Factors and Interventions, and (4) Brain Health Implementation. It offers a multidisciplinary, interprofessional, life-course approach, integrating theory with practice through case studies and interactive sessions. Designed for healthcare and allied professionals, the CAS equips participants with skills to promote brain health in clinical, research, and public health contexts. Given the shortage of trained professionals in Europe and globally, the program seeks to build a new generation of brain health advocates. It aims to inspire action and initiatives that support the prevention, early detection, and management of brain disorders. Conclusions: The CAS in Brain Health is an innovative educational response to a pressing global need. By fostering interdisciplinary expertise and practical skills, it enhances professional development and supports improved brain health outcomes at individual and population levels. Full article

Upon reaching stabilized production in waterflooded reservoirs, waterflood performance curves are conventionally used to predict technically recoverable reserves (TRRs). However, as reservoirs enter high water-cut stages, the relationship between the relative permeability ratio and saturation becomes nonlinear, causing deflection in waterflood performance curves. This leads to systematic overestimation of both predicted TRR and ultimate recovery factors. To overcome these limitations in conventional TRR prediction methods, this study establishes a novel relative permeability ratio-saturation relationship based on characteristic relative permeability curve behaviors. The proposed model is validated for three distinct fluid-rock interaction types. We further develop a permeability-driven forecasting model for oil production rates and water cuts. Comparative analyses with a conventional waterflood curve methodology demonstrate significant accuracy improvements. The results show that while traditional methods predict TRR ranging from 78.40 to 92.29 million tons, our model yields 70.73 million tons—effectively resolving overestimation issues caused by curve deflection during high water-cut phases. This approach establishes a robust framework for determining critical development parameters, including economic field lifespan, strategy adjustments, and ultimate recovery factor. Full article

This study experimentally validates a solar-thermal desalination system equipped with predictive feedwater control guided by real-time solar forecasting. Unlike conventional systems that react to temperature changes, the proposed approach proactively adjusts feedwater flow in anticipation of solar variability. To assess environmental and financial sustainability, the study integrates this control logic with a full Life Cycle Assessment (LCA) and Techno-Economic Analysis (TEA). Field testing in a high-temperature, arid region demonstrated strong performance, achieving a Global Warming Potential (GWP) of 1.80 kg CO₂-eq/m³ and a Levelized Cost of Water (LCOW) of $0.88/m³. Environmental impacts were quantified using OpenLCA and ecoinvent datasets, covering climate change, acidification, and eutrophication categories. The TEA confirmed economic feasibility, reporting a positive Net Present Value (NPV) and an Internal Rate of Return (IRR) exceeding 11.5% over a 20-year lifespan. Sensitivity analysis showed that forecast precision and TES design strongly influence both environmental and economic outcomes. The integration of intelligent control with simplified thermal storage offers a scalable, cost-effective solution for off-grid freshwater production in solar-rich regions. Full article

This study focuses on the optimization of valve assemblies in downhole rod pumping units (DRPUs), which remain the predominant artificial lift technology in oil production worldwide. The research addresses the critical issue of premature failures in DRPUs caused by leakage in valve pairs, i.e., a problem that accounts for approximately 15% of all failures, as identified in a statistical analysis of the 2022 operational data from the Uzen oilfield in Kazakhstan. The leakage is primarily attributed to the accumulation of mechanical impurities and paraffin deposits between the valve ball and seat, leading to concentrated surface wear and compromised sealing. To mitigate this issue, a novel valve assembly design was developed featuring a flow turbulizer positioned beneath the valve seat. The turbulizer generates controlled vortex motion in the fluid flow, which increases the rotational frequency of the valve ball during operation. This motion promotes more uniform wear across the contact surfaces and reduces the risk of localized degradation. The turbulizers were manufactured using additive FDM technology, and several design variants were tested in a full-scale laboratory setup simulating downhole conditions. Experimental results revealed that the most effective configuration was a spiral plate turbulizer with a 7.5 mm width, installed without axis deviation from the vertical, which achieved the highest ball rotation frequency and enhanced lapping effect between the ball and the seat. Subsequent field trials using valves with duralumin-based turbulizers demonstrated increased operational lifespans compared to standard valves, confirming the viability of the proposed solution. However, cases of abrasive wear were observed under conditions of high mechanical impurity concentration, indicating the need for more durable materials. To address this, the study recommends transitioning to 316 L stainless steel for turbulizer fabrication due to its superior tensile strength, corrosion resistance, and wear resistance. Implementing this design improvement can significantly reduce maintenance intervals, improve pump reliability, and lower operating costs in mature oilfields with high water cut and solid content. The findings of this research contribute to the broader efforts in petroleum engineering to enhance the longevity and performance of artificial lift systems through targeted mechanical design improvements and material innovation. Full article

Marine biofouling significantly impacts the performance and longevity of polymer-based marine structures, particularly those designed for hydrodynamic applications such as Vortex-Induced Vibration suppression systems. Traditional antifouling solutions rely on copper-based multilayer coatings, which present challenges including mechanical vulnerability (e.g., chipping and scratching), high material and labor demands, and environmental concerns such as volatile organic compound emissions and copper leaching. Recent developments in material science have introduced an alternative system involving the direct incorporation of copper oxide (Cu₂O) into high-density polyethylene (HDPE) during the molding process. This study conducts a comparative life cycle assessment (LCA) of two antifouling integration methods—System 1 (traditional coating-based) and System 2 (Cu₂O-impregnated HDPE)—evaluating their environmental impact across production, application, use, and end-of-life stages. The functional unit used for this study was 1 square meter for a time period of five years. Using ISO 14040-compliant methodology and data from Ecoinvent and OpenLCA, three impact categories were assessed: global warming potential (GWP), cumulative energy demand (CED), and marine aquatic ecotoxicity Potential (MAETP). The results indicate that System 2 outperforms System 1 in GWP (4.42 vs. 5.65 kg CO₂-eq), CED (75.3 vs. 91.0 MJ-eq), and MAETP (327,002 vs. 469,929 kg 1,4-DCB-eq) per functional unit over a five-year lifespan, indicating a 21.8%, 17.3%, and 30.4% reduction in the key impact factors, respectively. These results suggest that direct Cu₂O incorporation offers a more environmentally sustainable and mechanically resilient antifouling strategy, supporting the potential of embedded antifouling systems to shift industry practices toward more sustainable marine infrastructure. Full article

This study investigates the effects of salinity, temperature, and diet on the biological characteristics of the rotifer Brachionus plicatilis, an essential live feed in aquaculture. The results indicate that environmental factors have a significant influence on reproductive traits and survival. At a salinity of 5 ppt, B. plicatilis achieved the highest fecundity (25.50 ± 0.58 inds.), while the longest lifespan (273.00 ± 72.52 h) was observed at 35 ppt. The temperature had a strong influence on developmental rates, with the shortest juvenile period recorded at 35 °C (8.00 ± 0.00 h) and the longest lifespan at 20 °C (270.62 ± 30.38 h). The diet also played a critical role, with Chlorella vulgaris supporting maximum fecundity, whereas mixed diets prolonged lifespan to 290.50 ± 62.83 (h). These findings provide valuable insights into optimizing rotifer culture systems to improve aquaculture productivity and sustainability. Full article

Background/Objectives: The assessment of platelet kinetics (APK) is recommended for patients with chronic idiopathic thrombocytopenic purpura (chITP). The aim of this study was to examine the importance of APK as a prognostic instrument in the selection of therapy in children with chITP. Methods: Retrospective, observational research, which included chITP children who were treated and subjected to APK in Serbia for 25 years (total number was 152). Results: In the acute phase of the disease, 15% of patients had life-threatening bleeding, 15% were asymptomatic, and there were no cases of fatal bleeding. Mean platelet life was 0.89 ± 0.47 days. A total of 45% of patients had normal platelet production, and 35% had very low production. Among the patients, 55% exhibited splenic platelet sequestration, 35% had mixed sequestration, and 10% showed hepatic platelet sequestration. Platelet lifespan and production indices were less reliable parameters, due to numerous contradictory results, especially when compared with the location of platelet sequestration. Distribution of bleeding and therapy-resistant patients was dominant with mixed sequestration. Good therapy responders had dominant splenic sequestration. In the chronic phase of the disease, initial therapy was sufficient for 40–45% of patients, while another 25% required second-line therapy, regardless of platelet sequestration location. A total of 25% percent of patients had undergone splenectomy, and all of them were in stable remission. The remaining 10%, which represented the most severe cases, required all available therapies, had equally mixed and liver sequestration, and splenectomy showed no effect. Conclusions: APK may be a determining factor for the selection of splenectomy as a therapeutic option in case of predominantly splenic sequestration. Although the platelet production index has been explored in several studies, its clinical relevance remains controversial. In our findings, it did not contribute to therapeutic decision-making and may even lead to misinterpretation. The factors distinguishing the minority of bleeding and therapy-resistant patients with similar laboratory profiles remain unclear. Full article

Electric passenger vehicles are set to dominate the European car market, driven by EU climate policies and the 2035 ban on internal combustion engine production. This study assesses the sustainability of this transition, focusing on global warming potential and Critical Raw Material (CRM) extraction throughout its life cycle. The intensive use of CRMs raises environmental, economic, social, and geopolitical concerns. These materials are scarce and are concentrated in a few politically sensitive regions, leaving the EU highly dependent on external suppliers. The extraction, transport, and refining of CRMs and battery production are high-emission processes that contribute to climate change and pose risks to ecosystems and human health. A Life Cycle Assessment (LCA) was conducted, using OpenLCA software and the Ecoinvent 3.10 database, comparing a Peugeot 308 in its diesel and electric versions. This study adopts a cradle-to-grave approach, analyzing three phases: production, utilization, and end-of-life treatment. Key indicators included Global Warming Potential (GWP100) and Abiotic Resource Depletion Potential (ADP) to assess CO₂ emissions and mineral resource consumption. Technological advancements could mitigate mineral depletion concerns. Li-ion battery recycling is still underdeveloped, but has high recovery potential, with the sector expected to expand significantly. Moreover, repurposing used Li-ion batteries for stationary energy storage in renewable energy systems can extend their lifespan by over a decade, decreasing the demand for new batteries. Such innovations underscore the potential for a more sustainable electric vehicle industry. Full article

The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), is a highly destructive pest that poses serious threats and causes significant losses to the production of maize in China. This study evaluated the feeding and oviposition preferences of S. frugiperda when reared on four maize cultivars—sweet, waxy, common, and silage—across three consecutive generations. It also compared population adaptability among these cultivars and analyzed population parameters between the F1 and F3 generations. The findings revealed that all four F1 generation populations showed a preference for feeding and oviposition on sweet maize. However, over time, S. frugiperda exhibited a stronger preference, in terms of feeding and oviposition behaviors, for the natal host plant across three consecutive generations of rearing. The fall armyworm completed its life cycle and oviposited on all four maize varieties over three generations. The sweet cultivar population had the highest intrinsic rate of increase, finite rate of increase, net reproductive rate, larval survival rate, pupation rate, eclosion rate, fecundity, and pupal weight, while the silage cultivar population had the shortest larval stage, pre-adult stage, and adult lifespan and the pupal weight and the fecundity were the lowest. Overall, the population fitness was the highest on the sweet cultivar, and the lowest on the silage cultivar. Compared with F1, the F3 generation of the FAW had a significantly shorter developmental duration in four maize cultivars. Except for the waxy maize cultivars, the fecundity of the other three cultivars did not differ significantly between F1 and F3. This study provides fundamental information on the trend of fall armyworm population changes in maize fields and serves as a reference for rational maize cultivar planting decisions. Full article

Polysaccharides isolated from Radix Cyathula officinalis Kuan (RCP) are key bioactive components with immunomodulatory, antioxidant, and anti-inflammatory effects. Their efficacy varies according to their geographic origin and processing methods. However, the systemic anti-aging mechanisms and antioxidant efficacy of RCP have not yet been comprehensively characterized. This study investigated the antioxidant and anti-aging effects of RCP in vitro and in vivo using a Caenorhabditis elegans heat stress model, comparing rRCP (RCP from raw samples) and wRCP (RCP from wine-processed samples) from key production areas. Among these, the RCP collected from the Zhonggang region exhibited the strongest antioxidant activity. Both rRCP and wRCP enhanced worms’ oxidative stress resistance, reduced their ROS levels, increased their antioxidant enzyme activities, prolonged their lifespan, and improved their reproductive capacity under thermal stress. Notably, the wRCP exhibited more pronounced benefits. Additionally, 16S rRNA sequencing revealed that RCP altered the gut microbiota’s composition by increasing its microbial diversity, enriching beneficial bacteria like Bacillus, and decreasing potential pathogens such as Escherichia and Citricoccus. The treatment also led to an increased abundance of Firmicutes and a slight reduction in Bacteroidetes. Collectively, these findings suggest that RCP, particularly wRCP, holds promise as a therapeutic agent for combating oxidative stress and promoting longevity, in part by modulating the gut microbiome. Full article

The climate in extremely cold regions is becoming increasingly unstable, resulting in more frequent freeze-thaw cycles. These cycles significantly degrade the mechanical properties of soft soil foundations, reducing their bearing capacity and ultimately compromising the safety and lifespan of construction and infrastructure. To mitigate these effects, soil stabilization technology is commonly employed to reinforce soft soil in cold regions. However, evaluating the durability of stabilized soft soil, particularly its resistance to freezing in extremely cold environments, remains a critical challenge. This study investigates the use of industrial waste raw materials, such as slag and fly ash (FA), in combination with a solid alkali activator (NaOH), to develop one-part alkali-activated cementitious materials (ACMs) for soft soil stabilization. The effects of different raw material ratios, freeze-thaw temperatures, and the number of freeze-thaw cycles on the freezing resistance of one-part alkali-activated slag/FA (OP-ASF) stabilized soft soil were examined. Mass loss, unconfined compressive strength (UCS), and pH value were conducted to assess soil deterioration and structural integrity under freeze-thaw conditions. Additionally, microstructure analysis was conducted using scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDS) and X-ray diffraction (XRD) to analyze hydration product formation and internal structure characteristics. Image-pro plus (IPP) was also employed for structure looseness evolution, providing deeper insights into the freezing resistance mechanisms of OP-ASF stabilized soft soil. The results indicated that as the freezing temperature decreases and the number of freeze-thaw cycles increases, both mass loss and UCS loss become more pronounced. When the ratio of slag to fly ash was optimized at 80:20, OP-ASF stabilized soft soil exhibited the highest freezing resistance, characterized by the lowest mass loss and UCS loss, along with the highest UCS and pH value. Furthermore, structure looseness remained at its lowest across all freeze-thaw temperatures and cycles, highlighting the beneficial role of slag and FA in OP-ASF. These findings contribute to the advancement of sustainable and durable construction materials by demonstrating the potential of one-part alkali-activated slag/fly ash for stabilizing soft soils in seasonally frozen regions. Full article

This perspective explores the use of biochar, a carbon-rich material derived from biomass, as a sustainable solution for mitigating volatile organic compounds (VOCs) emitted during asphalt production and use. VOCs from asphalt contribute to ozone formation and harmful secondary organic aerosols (SOAs), which negatively impact air quality and public health. Biochar, with its high surface area and capacity to adsorb VOCs, provides an effective means of addressing these challenges. By tailoring biochar’s surface chemistry, it can efficiently capture VOCs, while also offering long-term carbon sequestration benefits. Additionally, biochar enhances the durability of asphalt, extending road lifespan and reducing maintenance needs, making it a promising material for sustainable infrastructure. Despite these promising benefits, several challenges remain. Variations in biochar properties, driven by differences in feedstock and production methods, can affect its performance in asphalt. Moreover, the integration of biochar into existing plant operations requires the further development of methods to streamline the process and ensure consistency in biochar’s quality and cost-effectiveness. Standardizing production methods and addressing logistical hurdles will be crucial for biochar’s widespread adoption. Research into improving its long-term stability in asphalt is also needed to ensure sustained efficacy over time. Overcoming these challenges will be essential for fully realizing biochar’s potential in sustainable infrastructure development Full article

Pine wilt disease (PWD), a destructive pine forest disease caused by pine wood nematode (PWN), Bursaphelenchus xylophilus, has led to huge economic losses and ecological environment damage. Thaumatin-like proteins (TLPs) are the products of a complex gene family involved in host defense and a wide range of developmental processes in fungi, plants, and animals. In this study, a tlp gene of B. xylophilus (Bxtlp) (GenBank: OQ863020.1) was amplified via PCR and cloned into the expression vector pET-15b to construct the recombinant vector PET-15b-Bxtlp, which was then transformed into Escherichia coli BL-21(DE3). The recombinant protein was successfully purified using Ni-NTA affinity chromatography. The effect of the Bxtlp gene on the vitality and pathogenicity of PWNs was elucidated through RNA interference (RNAi) and overexpression. Bxtlp dsRNA significantly reduced the feeding, motility, spawning, and reproduction abilities of PWN; shortened its lifespan; and increased the female–male ratio. In contrast, the recombinant BxTLP markedly enhanced the reproductive ability of PWN. In addition, Bxtlp dsRNA increased reactive oxygen species (ROS) content in nematodes, while the recombinant BxTLP was confirmed to have antioxidant capacity in vitro. Furthermore, the bioassays on Pinus thunbergii saplings demonstrated that Bxtlp could significantly influence PWN pathogenicity. Overall, we speculate that Bxtlp affects the pathogenicity of PWNs mainly via regulating ROS levels, the motility, and hatching of PWN. Full article

This systematic literature review examines the development of a conceptual certification framework for solar panel reuse, positioned within the broader context of the circular economy. It emphasizes sustainable production and consumption in response to the climate crisis and resource depletion. This review was conducted using Scopus and Google Scholar, following a structured search strategy. A final set of 63 sources, including peer-reviewed journal articles, conference papers, and gray literature recommended by domain experts, were selected to analyze existing certification frameworks across various sectors, focusing on their relevance to solar panel reuse. Key aspects of product reuse such as safety, quality, and technical standards are explored, highlighting the unique challenges associated with the long lifespans and environmental exposure of solar panels. Through this analysis, this study reveals the core elements vital for an effective certification framework. While structured certification frameworks are essential for sustainability, empirical evidence on their effectiveness in the solar panel reuse remains scarce, and regulatory inconsistencies add complexity. Using established practices in electronics, batteries, and other high-liability sectors as an anchor, the proposed framework, emerging from this systematic review, aims to extend solar panels’ lifecycle, contributing to environmental sustainability and socio-economic equity. The findings provide valuable insights for policymakers, industry stakeholders, and researchers by addressing key certification gaps and identifying future research directions in solar panel reuse standardization. Full article

The balanced control of the synthesis of CoQ along the life of the organism is essential to maintain the respiratory capacity at the mitochondria and the antioxidant protection of cell membranes and plasma lipoproteins. For this reason, we determined the levels of the transcripts of the CoQ-synthome along the life of mice in comparison with the levels of antioxidant enzymes and the levels of CoQ in these animals. Surprisingly, we found that some organs such as liver, kidney and heart show great differences in mRNA levels of some COQ-genes along life whereas others such as the brain or gastrocnemius muscle do not show differences. Interestingly, these differences were not related to the total amount of CoQ in these tissues, indicating a discrepancy between the transcript activity of the CoQ-synthome and the level of the product, CoQ. This likely responds to different regulatory levels including mRNA lifespan and CoQ turnover. Further, resveratrol and physical activity in old animals can modulate some transcripts but many of them are in an organ-dependent effect, indicating a different response to the regulators. Full article