Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise

Meza-Torres, Catherine; Reyes-Torres, Iván; Bui Thanh, Tung; Campos-Silva, Carmen; Rodriguez-Bies, Elisabet; Navas, Plácido; López-Lluch, Guillermo

doi:10.3390/antiox14070800

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Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise

by

Catherine Meza-Torres

^1,2,

Iván Reyes-Torres

^1,3,

Tung Bui Thanh

^1,4,

Carmen Campos-Silva

¹

,

Elisabet Rodriguez-Bies

^1,5,

Plácido Navas

¹

and

Guillermo López-Lluch

^1,*

¹

Department of Physiology, Anatomy and Cell Biology, Andalusian Centre for Developmental Biology, CABD-CSIC, CIBERER, Institute of Health Carlos III, Pablo de Olavide University, Carretera de Utrera km. 1, 41013 Sevilla, Spain

²

Grupo de Investigación en Inmunología y Biología Molecular, Universidad del Norte, Barranquilla 760046, Colombia

³

OverT Bio, Inc., New York, NY 10016, USA

⁴

Department of Pharmacology, University of Medicine and Pharmacy, Vietnam National University, Hanoi 10000, Vietnam

⁵

Sports and Informatics Department, Pablo de Olavide University, 41013 Sevilla, Spain

^*

Author to whom correspondence should be addressed.

Antioxidants 2025, 14(7), 800; https://doi.org/10.3390/antiox14070800 (registering DOI)

Submission received: 24 April 2025 / Revised: 24 June 2025 / Accepted: 26 June 2025 / Published: 27 June 2025

(This article belongs to the Special Issue CoQ10 and Aging and Age-Related Diseases—2nd Edition)

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Abstract

The balanced control of the synthesis of CoQ along the life of the organism is essential to maintain the respiratory capacity at the mitochondria and the antioxidant protection of cell membranes and plasma lipoproteins. For this reason, we determined the levels of the transcripts of the CoQ-synthome along the life of mice in comparison with the levels of antioxidant enzymes and the levels of CoQ in these animals. Surprisingly, we found that some organs such as liver, kidney and heart show great differences in mRNA levels of some COQ-genes along life whereas others such as the brain or gastrocnemius muscle do not show differences. Interestingly, these differences were not related to the total amount of CoQ in these tissues, indicating a discrepancy between the transcript activity of the CoQ-synthome and the level of the product, CoQ. This likely responds to different regulatory levels including mRNA lifespan and CoQ turnover. Further, resveratrol and physical activity in old animals can modulate some transcripts but many of them are in an organ-dependent effect, indicating a different response to the regulators.

Keywords: ubiquinone; coenzyme Q; aging; mice; mitochondria; antioxidant

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MDPI and ACS Style

Meza-Torres, C.; Reyes-Torres, I.; Bui Thanh, T.; Campos-Silva, C.; Rodriguez-Bies, E.; Navas, P.; López-Lluch, G. Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise. Antioxidants 2025, 14, 800. https://doi.org/10.3390/antiox14070800

AMA Style

Meza-Torres C, Reyes-Torres I, Bui Thanh T, Campos-Silva C, Rodriguez-Bies E, Navas P, López-Lluch G. Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise. Antioxidants. 2025; 14(7):800. https://doi.org/10.3390/antiox14070800

Chicago/Turabian Style

Meza-Torres, Catherine, Iván Reyes-Torres, Tung Bui Thanh, Carmen Campos-Silva, Elisabet Rodriguez-Bies, Plácido Navas, and Guillermo López-Lluch. 2025. "Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise" Antioxidants 14, no. 7: 800. https://doi.org/10.3390/antiox14070800

APA Style

Meza-Torres, C., Reyes-Torres, I., Bui Thanh, T., Campos-Silva, C., Rodriguez-Bies, E., Navas, P., & López-Lluch, G. (2025). Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise. Antioxidants, 14(7), 800. https://doi.org/10.3390/antiox14070800

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Evolution of COQ-Synthome Transcripts and CoQ Levels in Mice Tissues Along Aging: Effect of Resveratrol and Exercise

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