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Search Results (843)

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Keywords = product manufacturing reliability

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16 pages, 1621 KiB  
Article
Integration of Data Analytics and Data Mining for Machine Failure Mitigation and Decision Support in Metal–Mechanical Industry
by Sidnei Alves de Araujo, Silas Luiz Bomfim, Dimitria T. Boukouvalas, Sergio Ricardo Lourenço, Ugo Ibusuki and Geraldo Cardoso de Oliveira Neto
Logistics 2025, 9(3), 109; https://doi.org/10.3390/logistics9030109 (registering DOI) - 7 Aug 2025
Abstract
Background: The growing complexity of production processes in the metal–mechanical industry demands ever more effective strategies for managing machine and equipment maintenance, as unexpected failures can incur high operational costs and compromise productivity by interrupting workflows and delaying deliveries. However, few studies [...] Read more.
Background: The growing complexity of production processes in the metal–mechanical industry demands ever more effective strategies for managing machine and equipment maintenance, as unexpected failures can incur high operational costs and compromise productivity by interrupting workflows and delaying deliveries. However, few studies have combined end-to-end data analytics and data mining methods to proactively predict and mitigate such failures. This study aims to develop and validate a comprehensive framework combining data analytics and data mining to prevent machine failures and support decision-making in a metal–mechanical manufacturing environment. Methods: First, exploratory data analytics were performed on the sensor and logistics data to identify significant relationships and trends between variables. Next, a preprocessing pipeline including data cleaning, data transformation, feature selection, and resampling was applied. Finally, a decision tree model was trained to identify conditions prone to failures, enabling not only predictions but also the explicit representation of knowledge in the form of decision rules. Results: The outstanding performance of the decision tree (82.1% accuracy and a Kappa index of 78.5%), which was modeled from preprocessed data and the insights produced by data analytics, demonstrates its ability to generate reliable rules for predicting failures to support decision-making. The implementation of the proposed framework enables the optimization of predictive maintenance strategies, effectively reducing unplanned downtimes and enhancing the reliability of production processes in the metal–mechanical industry. Full article
18 pages, 5831 KiB  
Article
Cure Kinetics-Driven Compression Molding of CFRP for Fast and Low-Cost Manufacturing
by Xintong Wu, Ming Zhang, Zhongling Liu, Xin Fu, Haonan Liu, Yuchen Zhang and Xiaobo Yang
Polymers 2025, 17(15), 2154; https://doi.org/10.3390/polym17152154 - 6 Aug 2025
Abstract
Carbon fiber-reinforced polymer (CFRP) composites are widely used in aerospace due to their excellent strength-to-weight ratio and tailorable properties. However, these properties critically depend on the CFRP curing cycle. The commonly adopted manufacturer-recommended curing cycle (MRCC), designed to accommodate the most conservative conditions, [...] Read more.
Carbon fiber-reinforced polymer (CFRP) composites are widely used in aerospace due to their excellent strength-to-weight ratio and tailorable properties. However, these properties critically depend on the CFRP curing cycle. The commonly adopted manufacturer-recommended curing cycle (MRCC), designed to accommodate the most conservative conditions, involves prolonged curing times and high energy consumption. To overcome these limitations, this study proposes an efficient and adaptable method to determine the optimal curing cycle. The effects of varying heating rates on resin dynamic and isothermal–exothermic behavior were characterized via reaction kinetics analysis using differential scanning calorimetry (DSC) and rheological measurements. The activation energy of the reaction system was substituted into the modified Sun–Gang model, and the parameters were estimated using a particle swarm optimization algorithm. Based on the curing kinetic behavior of the resin, CFRP compression molding process orthogonal experiments were conducted. A weighted scoring system incorporating strength, energy consumption, and cycle time enabled multidimensional evaluation of optimized solutions. Applying this curing cycle optimization method to a commercial epoxy resin increased efficiency by 247.22% and reduced energy consumption by 35.7% while meeting general product performance requirements. These results confirm the method’s reliability and its significance for improving production efficiency. Full article
(This article belongs to the Special Issue Advances in High-Performance Polymer Materials, 2nd Edition)
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36 pages, 1832 KiB  
Review
Enabling Intelligent Industrial Automation: A Review of Machine Learning Applications with Digital Twin and Edge AI Integration
by Mohammad Abidur Rahman, Md Farhan Shahrior, Kamran Iqbal and Ali A. Abushaiba
Automation 2025, 6(3), 37; https://doi.org/10.3390/automation6030037 - 5 Aug 2025
Abstract
The integration of machine learning (ML) into industrial automation is fundamentally reshaping how manufacturing systems are monitored, inspected, and optimized. By applying machine learning to real-time sensor data and operational histories, advanced models enable proactive fault prediction, intelligent inspection, and dynamic process control—directly [...] Read more.
The integration of machine learning (ML) into industrial automation is fundamentally reshaping how manufacturing systems are monitored, inspected, and optimized. By applying machine learning to real-time sensor data and operational histories, advanced models enable proactive fault prediction, intelligent inspection, and dynamic process control—directly enhancing system reliability, product quality, and efficiency. This review explores the transformative role of ML across three key domains: Predictive Maintenance (PdM), Quality Control (QC), and Process Optimization (PO). It also analyzes how Digital Twin (DT) and Edge AI technologies are expanding the practical impact of ML in these areas. Our analysis reveals a marked rise in deep learning, especially convolutional and recurrent architectures, with a growing shift toward real-time, edge-based deployment. The paper also catalogs the datasets used, the tools and sensors employed for data collection, and the industrial software platforms supporting ML deployment in practice. This review not only maps the current research terrain but also highlights emerging opportunities in self-learning systems, federated architectures, explainable AI, and themes such as self-adaptive control, collaborative intelligence, and autonomous defect diagnosis—indicating that ML is poised to become deeply embedded across the full spectrum of industrial operations in the coming years. Full article
(This article belongs to the Section Industrial Automation and Process Control)
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17 pages, 2522 KiB  
Article
Organization of the Optimal Shift Start in an Automotive Environment
by Gábor Lakatos, Bence Zoltán Vámos, István Aupek and Mátyás Andó
Computation 2025, 13(8), 181; https://doi.org/10.3390/computation13080181 - 1 Aug 2025
Viewed by 173
Abstract
Shift organizations in automotive manufacturing often rely on manual task allocation, resulting in inefficiencies, human error, and increased workload for supervisors. This research introduces an automated solution using the Kuhn-Munkres algorithm, integrated with the Moodle learning management system, to optimize task assignments based [...] Read more.
Shift organizations in automotive manufacturing often rely on manual task allocation, resulting in inefficiencies, human error, and increased workload for supervisors. This research introduces an automated solution using the Kuhn-Munkres algorithm, integrated with the Moodle learning management system, to optimize task assignments based on operator qualifications and task complexity. Simulations conducted with real industrial data demonstrate that the proposed method meets operational requirements, both logically and mathematically. The system improves the start of shifts by assigning simpler tasks initially, enhancing operator confidence and reducing the need for assistance. It also ensures that task assignments align with required training levels, improving quality and process reliability. For industrial practitioners, the approach provides a practical tool to reduce planning time, human error, and supervisory burden, while increasing shift productivity. From an academic perspective, the study contributes to applied operations research and workforce optimization, offering a replicable model grounded in real-world applications. The integration of algorithmic task allocation with training systems enables a more accurate matching of workforce capabilities to production demands. This study aims to support data-driven decision-making in shift management, with the potential to enhance operational efficiency and encourage timely start of work, thereby possibly contributing to smoother production flow and improved organizational performance. Full article
(This article belongs to the Special Issue Computational Approaches for Manufacturing)
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33 pages, 3561 KiB  
Article
A Robust Analytical Network Process for Biocomposites Supply Chain Design: Integrating Sustainability Dimensions into Feedstock Pre-Processing Decisions
by Niloofar Akbarian-Saravi, Taraneh Sowlati and Abbas S. Milani
Sustainability 2025, 17(15), 7004; https://doi.org/10.3390/su17157004 - 1 Aug 2025
Viewed by 250
Abstract
Natural fiber-based biocomposites are rapidly gaining traction in sustainable manufacturing. However, their supply chain (SC) designs at the feedstock pre-processing stage often lack robust multicriteria decision-making evaluations, which can impact downstream processes and final product quality. This case study proposes a sustainability-driven multicriteria [...] Read more.
Natural fiber-based biocomposites are rapidly gaining traction in sustainable manufacturing. However, their supply chain (SC) designs at the feedstock pre-processing stage often lack robust multicriteria decision-making evaluations, which can impact downstream processes and final product quality. This case study proposes a sustainability-driven multicriteria decision-making framework for selecting pre-processing equipment configurations within a hemp-based biocomposite SC. Using a cradle-to-gate system boundary, four alternative configurations combining balers (square vs. round) and hammer mills (full-screen vs. half-screen) are evaluated. The analytical network process (ANP) model is used to evaluate alternative SC configurations while capturing the interdependencies among environmental, economic, social, and technical sustainability criteria. These criteria are further refined with the inclusion of sub-criteria, resulting in a list of 11 key performance indicators (KPIs). To evaluate ranking robustness, a non-linear programming (NLP)-based sensitivity model is developed, which minimizes the weight perturbations required to trigger rank reversals, using an IPOPT solver. The results indicated that the Half-Round setup provides the most balanced sustainability performance, while Full-Square performs best in economic and environmental terms but ranks lower socially and technically. Also, the ranking was most sensitive to the weight of the system reliability and product quality criteria, with up to a 100% shift being required to change the top choice under the ANP model, indicating strong robustness. Overall, the proposed framework enables decision-makers to incorporate uncertainty, interdependencies, and sustainability-related KPIs into the early-stage SC design of bio-based composite materials. Full article
(This article belongs to the Special Issue Sustainable Enterprise Operation and Supply Chain Management)
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15 pages, 2158 KiB  
Article
A Data-Driven Approach for Internal Crack Prediction in Continuous Casting of HSLA Steels Using CTGAN and CatBoost
by Mengying Geng, Haonan Ma, Shuangli Liu, Zhuosuo Zhou, Lei Xing, Yibo Ai and Weidong Zhang
Materials 2025, 18(15), 3599; https://doi.org/10.3390/ma18153599 - 31 Jul 2025
Viewed by 198
Abstract
Internal crack defects in high-strength low-alloy (HSLA) steels during continuous casting pose significant challenges to downstream processing and product reliability. However, due to the inherent class imbalance in industrial defect datasets, conventional machine learning models often suffer from poor sensitivity to minority class [...] Read more.
Internal crack defects in high-strength low-alloy (HSLA) steels during continuous casting pose significant challenges to downstream processing and product reliability. However, due to the inherent class imbalance in industrial defect datasets, conventional machine learning models often suffer from poor sensitivity to minority class instances. This study proposes a predictive framework that integrates conditional tabular generative adversarial network (CTGAN) for synthetic minority sample generation and CatBoost for classification. A dataset of 733 process records was collected from a continuous caster, and 25 informative features were selected using mutual information. CTGAN was employed to augment the minority class (crack) samples, achieving a balanced training set. Feature distribution analysis and principal component visualization indicated that the synthetic data effectively preserved the statistical structure of the original minority class. Compared with the other machine learning methods, including KNN, SVM, and MLP, CatBoost achieved the highest metrics, with an accuracy of 0.9239, precision of 0.9041, recall of 0.9018, and F1-score of 0.9022. Results show that CTGAN-based augmentation improves classification performance across all models. These findings highlight the effectiveness of GAN-based augmentation for imbalanced industrial data and validate the CTGAN–CatBoost model as a robust solution for online defect prediction in steel manufacturing. Full article
(This article belongs to the Special Issue Latest Developments in Advanced Machining Technologies for Materials)
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16 pages, 1870 KiB  
Review
Recent Advances in the Development and Industrial Applications of Wax Inhibitors: A Comprehensive Review of Nano, Green, and Classic Materials Approaches
by Parham Joolaei Ahranjani, Hamed Sadatfaraji, Kamine Dehghan, Vaibhav A. Edlabadkar, Prasant Khadka, Ifeanyi Nwobodo, VN Ramachander Turaga, Justin Disney and Hamid Rashidi Nodeh
J. Compos. Sci. 2025, 9(8), 395; https://doi.org/10.3390/jcs9080395 - 26 Jul 2025
Viewed by 364
Abstract
Wax deposition, driven by the crystallization of long-chain n-alkanes, poses severe challenges across industries such as petroleum, oil and natural gas, food processing, and chemical manufacturing. This phenomenon compromises flow efficiency, increases energy demands, and necessitates costly maintenance interventions. Wax inhibitors, designed to [...] Read more.
Wax deposition, driven by the crystallization of long-chain n-alkanes, poses severe challenges across industries such as petroleum, oil and natural gas, food processing, and chemical manufacturing. This phenomenon compromises flow efficiency, increases energy demands, and necessitates costly maintenance interventions. Wax inhibitors, designed to mitigate these issues, operate by altering wax crystallization, aggregation, and adhesion over the pipelines. Classic wax inhibitors, comprising synthetic polymers and natural compounds, have been widely utilized due to their established efficiency and scalability. However, synthetic inhibitors face environmental concerns, while natural inhibitors exhibit reduced performance under extreme conditions. The advent of nano-based wax inhibitors has revolutionized wax management strategies. These advanced materials, including nanoparticles, nanoemulsions, and nanocomposites, leverage their high surface area and tunable interfacial properties to enhance efficiency, particularly in harsh environments. While offering superior performance, nano-based inhibitors are constrained by high production costs, scalability challenges, and potential environmental risks. In parallel, the development of “green” wax inhibitors derived from renewable resources such as vegetable oils addresses sustainability demands. These eco-friendly formulations introduce functionalities that reinforce inhibitory interactions with wax crystals, enabling effective deposition control while reducing reliance on synthetic components. This review provides a comprehensive analysis of the mechanisms, applications, and comparative performance of classic and nano-based wax inhibitors. It highlights the growing integration of sustainable and hybrid approaches that combine the reliability of classic inhibitors with the advanced capabilities of nano-based systems. Future directions emphasize the need for cost-effective, eco-friendly solutions through innovations in material science, computational modeling, and biotechnology. Full article
(This article belongs to the Section Composites Manufacturing and Processing)
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22 pages, 6823 KiB  
Article
Design Optimization of Valve Assemblies in Downhole Rod Pumps to Enhance Operational Reliability in Oil Production
by Seitzhan Zaurbekov, Kadyrzhan Zaurbekov, Doszhan Balgayev, Galina Boiko, Ertis Aksholakov, Roman V. Klyuev and Nikita V. Martyushev
Energies 2025, 18(15), 3976; https://doi.org/10.3390/en18153976 - 25 Jul 2025
Viewed by 290
Abstract
This study focuses on the optimization of valve assemblies in downhole rod pumping units (DRPUs), which remain the predominant artificial lift technology in oil production worldwide. The research addresses the critical issue of premature failures in DRPUs caused by leakage in valve pairs, [...] Read more.
This study focuses on the optimization of valve assemblies in downhole rod pumping units (DRPUs), which remain the predominant artificial lift technology in oil production worldwide. The research addresses the critical issue of premature failures in DRPUs caused by leakage in valve pairs, i.e., a problem that accounts for approximately 15% of all failures, as identified in a statistical analysis of the 2022 operational data from the Uzen oilfield in Kazakhstan. The leakage is primarily attributed to the accumulation of mechanical impurities and paraffin deposits between the valve ball and seat, leading to concentrated surface wear and compromised sealing. To mitigate this issue, a novel valve assembly design was developed featuring a flow turbulizer positioned beneath the valve seat. The turbulizer generates controlled vortex motion in the fluid flow, which increases the rotational frequency of the valve ball during operation. This motion promotes more uniform wear across the contact surfaces and reduces the risk of localized degradation. The turbulizers were manufactured using additive FDM technology, and several design variants were tested in a full-scale laboratory setup simulating downhole conditions. Experimental results revealed that the most effective configuration was a spiral plate turbulizer with a 7.5 mm width, installed without axis deviation from the vertical, which achieved the highest ball rotation frequency and enhanced lapping effect between the ball and the seat. Subsequent field trials using valves with duralumin-based turbulizers demonstrated increased operational lifespans compared to standard valves, confirming the viability of the proposed solution. However, cases of abrasive wear were observed under conditions of high mechanical impurity concentration, indicating the need for more durable materials. To address this, the study recommends transitioning to 316 L stainless steel for turbulizer fabrication due to its superior tensile strength, corrosion resistance, and wear resistance. Implementing this design improvement can significantly reduce maintenance intervals, improve pump reliability, and lower operating costs in mature oilfields with high water cut and solid content. The findings of this research contribute to the broader efforts in petroleum engineering to enhance the longevity and performance of artificial lift systems through targeted mechanical design improvements and material innovation. Full article
(This article belongs to the Special Issue Petroleum and Natural Gas Engineering)
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19 pages, 2311 KiB  
Article
Stochastic Optimization of Quality Assurance Systems in Manufacturing: Integrating Robust and Probabilistic Models for Enhanced Process Performance and Product Reliability
by Kehinde Afolabi, Busola Akintayo, Olubayo Babatunde, Uthman Abiola Kareem, John Ogbemhe, Desmond Ighravwe and Olanrewaju Oludolapo
J. Manuf. Mater. Process. 2025, 9(8), 250; https://doi.org/10.3390/jmmp9080250 - 23 Jul 2025
Viewed by 396
Abstract
This research integrates stochastic optimization techniques with robust modeling and probabilistic modeling approaches to enhance photovoltaic cell manufacturing processes and product reliability. The study employed an adapted genetic algorithm to tackle uncertainties in the manufacturing process, resulting in improved operational efficiency. It consistently [...] Read more.
This research integrates stochastic optimization techniques with robust modeling and probabilistic modeling approaches to enhance photovoltaic cell manufacturing processes and product reliability. The study employed an adapted genetic algorithm to tackle uncertainties in the manufacturing process, resulting in improved operational efficiency. It consistently achieved optimal fitness, with values remaining at 1.0 over 100 generations. The model displayed a dynamic convergence rate, demonstrating its ability to adjust performance in response to process fluctuations. The system preserved resource efficiency by utilizing approximately 2600 units per generation, while minimizing machine downtime to 0.03%. Product reliability reached an average level of 0.98, with a maximum value of 1.02, indicating enhanced consistency. The manufacturing process achieved better optimization through a significant reduction in defect rates, which fell to 0.04. The objective function value fluctuated between 0.86 and 0.96, illustrating how the model effectively managed conflicting variables. Sensitivity analysis revealed that changes in sigma material and lambda failure had a minimal effect on average reliability, which stayed above 0.99, while average defect rates remained below 0.05. This research exemplifies how stochastic, robust, and probabilistic optimization methods can collaborate to enhance manufacturing system quality assurance and product reliability under uncertain conditions. Full article
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11 pages, 1293 KiB  
Article
DOE-Based Investigation of Microstructural Factors Influencing Residual Stress in Aluminum Alloys
by Nawon Kwak and Eunkyung Lee
Metals 2025, 15(7), 816; https://doi.org/10.3390/met15070816 - 21 Jul 2025
Viewed by 257
Abstract
Residual stresses generated during the casting process significantly affect the reliability of the final product, making accurate prediction and analysis of these stresses crucial. In particular, to minimize the difference between simulation results and actual measurements, it is essential to develop predictive simulations [...] Read more.
Residual stresses generated during the casting process significantly affect the reliability of the final product, making accurate prediction and analysis of these stresses crucial. In particular, to minimize the difference between simulation results and actual measurements, it is essential to develop predictive simulations that incorporate microstructural characteristics. Therefore, in this study, residual stress prediction simulations were conducted for aluminum components manufactured by high-pressure die casting (HPDC), and measurement locations were selected based on the simulation results. Subsequently, the microstructural characteristics at each location (Si and intermetallic compounds) were quantitatively analyzed, and significant factors affecting residual stress were identified through design of experiments (DOE). As a result, Si sphericity (p-value ≤ 0.05) was observed to be the most significant factor among Si area fraction, IMC area fraction, and Si sphericity, and the residual stress and Si sphericity showed a positive interaction due to the rapid cooling rate and inhomogeneous microstructure distribution. Furthermore, the study demonstrated the effectiveness of DOE in clearly distinguishing the significance of variables with strong interdependencies. Full article
(This article belongs to the Special Issue Mechanical Structure Damage of Metallic Materials)
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17 pages, 2829 KiB  
Article
Apparatus and Experiments Towards Fully Automated Medical Isotope Production Using an Ion Beam Accelerator
by Abdulaziz Yahya M. Hussain, Aliaksandr Baidak, Ananya Choudhury, Andy Smith, Carl Andrews, Eliza Wojcik, Liam Brown, Matthew Nancekievill, Samir De Moraes Shubeita, Tim A. D. Smith, Volkan Yasakci and Frederick Currell
Instruments 2025, 9(3), 18; https://doi.org/10.3390/instruments9030018 - 18 Jul 2025
Viewed by 261
Abstract
Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated [...] Read more.
Zirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated system for the agile and reliable production of radiopharmaceuticals. The system performs transmutations, dissolution, and separation for a range of radioisotopes. Steps in the production of 89Zr-oxalate are used as an exemplar to illustrate its use. Three-dimensional (3D) printing was exploited to design and manufacture a target holder able to include solid targets, in this case an 89Y foil. Spot welding was used to attach 89Y to a refractory tantalum (Ta) substrate. A commercially available CPU chiller was repurposed to efficiently cool the metal target. Furthermore, a commercial resin (ZR Resin) and compact peristaltic pumps were employed in a compact (10 × 10 × 10 cm3) chemical separation unit that operates automatically via computer-controlled software. Additionally, a standalone 3D-printed unit was designed with three automated functionalities: photolabelling, vortex mixing, and controlled heating. All components of the assembly, except for the target holder, are housed inside a commercially available hot cell, ensuring safe and efficient operation in a controlled environment. This paper details the design, construction, and modelling of the entire assembly, emphasising its innovative integration and operational efficiency for widespread radiopharmaceutical automation. Full article
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38 pages, 5137 KiB  
Systematic Review
Current State of the Art and Potential for Construction and Demolition Waste Processing: A Scoping Review of Sensor-Based Quality Monitoring and Control for In- and Online Implementation in Production Processes
by Lieve Göbbels, Alexander Feil, Karoline Raulf and Kathrin Greiff
Sensors 2025, 25(14), 4401; https://doi.org/10.3390/s25144401 - 14 Jul 2025
Viewed by 622
Abstract
Automated quality assurance is gaining popularity across application areas; however, automatization for monitoring and control of product quality in waste processing is still in its infancy. At the same time, research on this topic is scattered, limiting efficient implementation of already developed strategies [...] Read more.
Automated quality assurance is gaining popularity across application areas; however, automatization for monitoring and control of product quality in waste processing is still in its infancy. At the same time, research on this topic is scattered, limiting efficient implementation of already developed strategies and technologies across research and application areas. To this end, the current work describes a scoping review conducted to systematically map available sensor-based quality assurance technologies and research based on the PRISMA-ScR framework. Additionally, the current state of research and potential automatization strategies are described in the context of construction and demolition waste processing. The results show 31 different sensor types extracted from a collection of 364 works, which have varied popularity depending on the application. However, visual imaging and spectroscopy sensors in particular seem to be popular overall. Only five works describing quality control system implementation were found, of which three describe varying manufacturing applications. Most works found describe proof-of-concept quality prediction systems on a laboratory scale. Compared to other application areas, works regarding construction and demolition waste processing indicate that the area seems to be especially behind in terms of implementing visual imaging at higher technology readiness levels. Moreover, given the importance of reliable and detailed data on material quality to transform the construction sector into a sustainable one, future research on quality monitoring and control systems could therefore focus on the implementation on higher technology readiness levels and the inclusion of detailed descriptions on how these systems have been verified. Full article
(This article belongs to the Section Intelligent Sensors)
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20 pages, 5319 KiB  
Article
Multiscale 2PP and LCD 3D Printing for High-Resolution Membrane-Integrated Microfluidic Chips
by Julia K. Hoskins, Patrick M. Pysz, Julie A. Stenken and Min Zou
Nanomanufacturing 2025, 5(3), 11; https://doi.org/10.3390/nanomanufacturing5030011 - 12 Jul 2025
Viewed by 320
Abstract
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of [...] Read more.
This study presents a microfluidic chip platform designed using a multiscale 3D printing strategy for fabricating microfluidic chips with integrated, high-resolution, and customizable membrane structures. By combining two-photon polymerization (2PP) for submicron membrane fabrication with liquid crystal display printing for rapid production of larger components, this approach addresses key challenges in membrane integration, including sealing reliability and the use of transparent materials. Compared to fully 2PP-based fabrication, the multiscale method achieved a 56-fold reduction in production time, reducing total fabrication time to approximately 7.2 h per chip and offering a highly efficient solution for integrating complex structures into fluidic chips. The fabricated chips demonstrated excellent mechanical integrity. Burst pressure testing showed that all samples withstood internal pressures averaging 1.27 ± 0.099 MPa, with some reaching up to 1.4 MPa. Flow testing from ~35 μL/min to ~345 μL/min confirmed stable operation in 75 μm square channels, with no leakage and minimal flow resistance up to ~175 μL/min without deviation from the predicted behavior in the 75 μm. Membrane-integrated chips exhibited outlet flow asymmetries greater than 10%, indicating active fluid transfer across the membrane and highlighting flow-dependent permeability. Overall, this multiscale 3D printing approach offers a scalable and versatile solution for microfluidic device manufacturing. The method’s ability to integrate precise membrane structures enable advanced functionalities such as diffusion-driven particle sorting and molecular filtration, supporting a wide range of biomedical, environmental, and industrial lab-on-a-chip applications. Full article
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13 pages, 3158 KiB  
Article
Process Safety Assessment of the Entire Nitration Process of Benzotriazole Ketone
by Yingxia Sheng, Qianjin Xiao, Hui Hu, Tianya Zhang and Guofeng Guan
Processes 2025, 13(7), 2201; https://doi.org/10.3390/pr13072201 - 9 Jul 2025
Viewed by 419
Abstract
To ensure the inherent safety of fine chemical nitration processes, the nitration reaction of benzotriazole ketone was selected as the research object. The thermal decomposition and reaction characteristics of the nitration system were studied using a combination of differential scanning calorimetry (DSC), reaction [...] Read more.
To ensure the inherent safety of fine chemical nitration processes, the nitration reaction of benzotriazole ketone was selected as the research object. The thermal decomposition and reaction characteristics of the nitration system were studied using a combination of differential scanning calorimetry (DSC), reaction calorimetry (RC1), and accelerating rate calorimetry (ARC). The results showed that the nitration product released 455.77 kJ/kg of heat upon decomposition, significantly higher than the 306.86 kJ/kg of the original material, indicating increased thermal risk. Through process hazard analysis based on GB/T 42300-2022, key parameters such as the temperature at which the time to maximum rate is 24 h under adiabatic conditions (TD24), maximum temperature of the synthesis reaction (MTSR), and maximum temperature for technical reason (MTT) were determined, and the reaction was classified as hazard level 5, suggesting a high risk of runaway and secondary explosion. Process intensification strategies were then proposed and verified by dynamic calorimetry: the adiabatic temperature increase (ΔTad) was reduced from 86.70 °C in the semi-batch reactor to 19.95 °C in the optimized continuous process, effectively improving thermal safety. These findings provide a reliable reference for the quantitative risk evaluation and safe design of nitration processes in fine chemical manufacturing. Full article
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26 pages, 3079 KiB  
Article
Implementing CAD API Automated Processes in Engineering Design: A Case Study Approach
by Konstantinos Sofias, Zoe Kanetaki, Constantinos Stergiou, Antreas Kantaros, Sébastien Jacques and Theodore Ganetsos
Appl. Sci. 2025, 15(14), 7692; https://doi.org/10.3390/app15147692 - 9 Jul 2025
Viewed by 662
Abstract
Increasing mechanical design complexity and volume, particularly in component-based manufacturing, require scalable, traceable, and efficient design processes. In this research, a modular in-house automation platform using Autodesk Inventor’s Application Programming Interface (API) and Visual Basic for Applications (VBA) is developed to automate recurrent [...] Read more.
Increasing mechanical design complexity and volume, particularly in component-based manufacturing, require scalable, traceable, and efficient design processes. In this research, a modular in-house automation platform using Autodesk Inventor’s Application Programming Interface (API) and Visual Basic for Applications (VBA) is developed to automate recurrent tasks such as CAD file generation, drawing production, structured archiving, and cost estimation. The proposed framework was implemented and tested on three real-world case studies in a turbocharger reconditioning unit with varying degrees of automation. Findings indicate remarkable time savings of up to 90% in certain documentation tasks with improved consistency, traceability, and reduced manual intervention. Moreover, the system also facilitated automatic generation of metadata-rich Excel and Word documents, allowing centralized documentation and access to data. In comparison with commercial automation software, the solution is flexible, cost-effective, and responsive to project changes and thus suitable for small and medium enterprises. Though automation reduced workload and rendered the system more reliable, some limitations remain, especially in fully removing engineering judgment, especially in complex design scenarios. Overall, this study investigates how API-based automation can significantly increase productivity and data integrity in CAD-intensive environments and explores future integration opportunities using AI and other CAD software. Full article
(This article belongs to the Section Mechanical Engineering)
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