Search Results (3,154)

The potential damage to aviation products caused by vibration and shock during road transportation has long been overlooked, despite structural failure under dynamic loading emerging as a critical technical challenge affecting product reliability. For aviation components, both stress and vibration analysis are essential prerequisites prior to formal assembly. This study investigates a symmetric vertical tail, a common aviation structure, employing an innovative model group analysis method to characterize its dynamic stress and strain distributions under real transportation conditions. Experimental measurements of vibration acceleration and impact loads during transport served as input data for constructing a numerical model based on stress and vibration theory. The model elucidates the mechanical responses of the tail in both modal and vibrational states, enabling effectively evaluation of dynamic vibrations on the tail and its critical subcomponents during road transport. The findings provide actionable insights for optimizing aviation component packaging design, mitigating vibration-induced damage, and enhancing transportation safety. Full article

Acyl-CoA dehydrogenase 9 deficiency is considered as a rare neuromuscular syndrome with an autosomal recessive transmission. The ACAD9 protein presents two essential functions, i.e., the limiting step enzyme of the fatty acid β-oxidation pathway and one of the complex’s compounds involved in the respiratory chain complex I assembly. Thus, loss-of-function mutations are known to convey mitochondrial cytopathologies. A patient with a mild and late-onset phenotype, suffering from exercise intolerance and hypertrophic cardiomyopathy, was diagnosed as a compound heterozygote of the ACAD9 gene. The first c.1240C> T p.Arg414Cys variant has been previously reported and is known to be responsible for ACAD9 deficiency. However, the second c.1636G> A p.Val546Met variant has never been described. The goal was to investigate the eventual pathogenicity of this new genetic variant. For this purpose, molecular cloning was generated to express the ACAD9 gene with the V546M variant in a cell line (ACAD9mut) and compared to cells expressing the wild-type ACAD9. Then, the mitochondrial respiration, ATP production, the mitochondrial network, and the oxidative phosphorylation’s composition were investigated to reveal the effects of the V546M variant. While avoiding to affect the amount of the respiratory chain’s complexes, the new ACAD9 variant was entirely responsible for reducing over 50% of the mitochondrial complex I activity. Full article

This study investigates the effectiveness of the Xsens motion capture system in performing ergonomic analysis compared to traditional manual assessments by experts in the specific environment of assembly lines. A comprehensive literature review emphasizes the need to investigate the reliability of new, promising high-tech systems. The main objective was therefore to compare the Ergonomic Assessment Worksheet (EAWS) assessment approach performed with Xsens motion capture technology and Process Simulate V16 software with the manual method using EAWS digital prepared by experts in the controlled workflow. The greatest value of the research conducted lies in the novel integration of the state-of-the-art Xsens motion capture technology with the Process Simulate V16 software environment and the use of the licensed EAWS ergonomic method and Methods-Time Measurement Universal Analyzing System (MTM-UAS). The results are presented in the form of a case study. The results show a large similarity between the whole-body results and a large difference in the upper limb results, confirming the initial benefits of the Xsens equipment but also pointing to the need to verify its reliability on larger samples. The study highlights the potential of integrating Xsens motion capture data into ergonomic assessments and tuning of the assembly line to increase productivity and worker safety. Full article

Against the backdrop of global energy transition and strict environmental regulations, supercritical carbon dioxide (scCO₂) fracturing and oil displacement technologies have emerged as pivotal green approaches in shale gas exploitation, offering the dual advantages of zero water consumption and carbon sequestration. However, the inherent low viscosity of scCO₂ severely restricts its sand-carrying capacity, fracture propagation efficiency, and oil recovery rate, necessitating the urgent development of high-performance thickeners. The current research on scCO₂ thickeners faces a critical trade-off: traditional fluorinated polymers exhibit excellent philicity CO₂, but suffer from high costs and environmental hazards, while non-fluorinated systems often struggle to balance solubility and thickening performance. The development of new thickeners primarily involves two directions. On one hand, efforts focus on modifying non-fluorinated polymers, driven by environmental protection needs—traditional fluorinated thickeners may cause environmental pollution, and improving non-fluorinated polymers can maintain good thickening performance while reducing environmental impacts. On the other hand, there is a commitment to developing non-noble metal-catalyzed siloxane modification and synthesis processes, aiming to enhance the technical and economic feasibility of scCO₂ thickeners. Compared with noble metal catalysts like platinum, non-noble metal catalysts can reduce production costs, making the synthesis process more economically viable for large-scale industrial applications. These studies are crucial for promoting the practical application of scCO₂ technology in unconventional oil and gas development, including improving fracturing efficiency and oil displacement efficiency, and providing new technical support for the sustainable development of the energy industry. This study innovatively designed an amphiphilic modified amino silicone oil polymer (MA-co-MPEGA-AS) by combining maleic anhydride (MA), methoxy polyethylene glycol acrylate (MPEGA), and amino silicone oil (AS) through a molecular bridge strategy. The synthesis process involved three key steps: radical polymerization of MA and MPEGA, amidation with AS, and in situ network formation. Fourier transform infrared spectroscopy (FT-IR) confirmed the successful introduction of ether-based CO₂-philic groups. Rheological tests conducted under scCO₂ conditions demonstrated a 114-fold increase in viscosity for MA-co-MPEGA-AS. Mechanistic studies revealed that the ether oxygen atoms (Lewis base) in MPEGA formed dipole–quadrupole interactions with CO₂ (Lewis acid), enhancing solubility by 47%. Simultaneously, the self-assembly of siloxane chains into a three-dimensional network suppressed interlayer sliding in scCO₂ and maintained over 90% viscosity retention at 80 °C. This fluorine-free design eliminates the need for platinum-based catalysts and reduces production costs compared to fluorinated polymers. The hierarchical interactions (coordination bonds and hydrogen bonds) within the system provide a novel synthetic paradigm for scCO₂ thickeners. This research lays the foundation for green CO₂-based energy extraction technologies. Full article

Xenorhabdus species are entomopathogenic bacteria that live in symbiosis with Steinernema nematodes and produce a wide range of bioactive secondary metabolites. This study aimed to characterize the complete genomes and biosynthetic potential of two novel Xenorhabdus isolates, ALN7.1 and ALN11.5, recovered from Steinernema lamjungense collected in Northern Thailand. High-quality genome assemblies were generated, and phylogenomic comparisons confirmed that both isolates belonged to the recently described species Xenorhabdus thailandensis. The assembled genomes were approximately 4.02 Mb in size, each comprising a single circular chromosome with a GC content of 44.6% and encoding ~3800 protein-coding sequences, consistent with the features observed in other members of the genus. Biosynthetic gene cluster (BGCs) prediction using antiSMASH identified 19 BGCs in ALN7.1 and 18 in ALN11.5, including known clusters for holomycin, pyrrolizixenamide, hydrogen cyanide, and gamexpeptide C, along with several uncharacterized clusters, suggesting unexplored metabolic potential. Comparative analyses highlighted conserved yet strain-specific BGC profiles, indicating possible diversification within the species. These results provide genomic insights into X. thailandensis ALN7.1 and ALN11.5 and support their potential as valuable sources for the discovery of novel natural products and for future biotechnological applications. Full article

The cationic chloro-P-{[4-(diphenylphosphanyl)phenyl]-N,N-dimethylmethanammonio(norbornadiene)rhodium(I) complex was encapsulated inside a self-assembled hexameric capsule. This capsule was obtained through a reaction involving 2,8,14,20-tetra-undecyl-resorcin[4]arene and water in chloroform. The formation of an inclusion complex was deduced from a combination of spectral measurements (UV-visible spectroscopy, ¹H, ³¹P{¹H} NMR and DOSY). The rhodium complex was evaluated in the [2+2+2] cycloaddition between N,N-dipropargyl-p-toluenesulfonamide and arylacetylene derivatives. In the presence of two equivalents of arylacetylenes in water-saturated chloroform at 60 °C for 24 h, the 4-methyl-N-(prop-2-yn-1-yl)-N-((2-tosylisoindolin-5-yl)methyl)benzenesulfonamide, the homocycloaddition product of 1,6-diyne is predominantly formed. In the presence of the supramolecular capsule, a selectivity inversion in favor of 5-aryl-2-tosylisoindoline is observed, with heterocycloaddition products formed in proportions between 53 and 69%. Full article

Tissue engineering enables autologous reconstruction of human tissues, addressing limitations in tissue availability and immune compatibility. Several tissue engineering techniques, such as self-assembly, rely on or benefit from extracellular matrix (ECM) secretion by fibroblasts to produce biomimetic scaffolds. Models have been developed for use in humans, such as skin and corneas. Ascorbic acid (vitamin C, AA) is essential for collagen biosynthesis. However, AA is chemically unstable in culture, with a half-life of 24 h, requiring freshly prepared AA with each change of medium. This study aims to demonstrate the functional equivalence of 2-phospho-L-ascorbate (2PAA), a stable form of AA, for tissue reconstruction. Dermal, vaginal, and bladder stroma were reconstructed by self-assembly using tissue-specific protocols. The tissues were cultured in a medium supplemented with either freshly prepared or frozen AA, or with 2PAA. Biochemical analyses were performed on the tissues to evaluate cell density and tissue composition, including collagen secretion and deposition. Histology and quantitative polarized light microscopy were used to evaluate tissue architecture, and mechanical evaluation was performed both by tensiometry and atomic force microscopy (AFM) to evaluate its macroscopic and cell-scale mechanical properties. The tissues produced by the three ascorbate conditions had similar collagen deposition, architecture, and mechanical properties in each organ-specific stroma. Mechanical characterization revealed tissue-specific differences, with tensile modulus values ranging from 1–5 MPa and AFM-derived apparent stiffness in the 1–2 kPa range, reflecting the nonlinear and scale-dependent behavior of the engineered stroma. The results demonstrate the possibility of substituting AA with 2PAA for tissue engineering. This protocol could significantly reduce the costs associated with tissue production by reducing preparation time and use of materials. This is a crucial factor for any scale-up activity. Full article

Packaging equipment plays a crucial role in the semiconductor industry by enhancing product quality and reducing labor costs through automation. Research was conducted on IGBT module packaging equipment (an automatic pin insertion machine) during the pin assembly process of insulated gate bipolar transistor (IGBT) modules to improve productivity and product quality. First, the manual pin assembly process was divided into four stages: feeding, stabilizing, clamping, and inserting. Each stage was completed by separate cams, and corresponding step timing diagrams are drawn. The profiles of the four cams were designed and verified through theoretical calculations and kinematic simulations using a seventh-degree polynomial curve fitting method. Then, image algorithms were developed to detect pin tilt defects, pin tip defects, and to provide visual guidance for pin insertion. Finally, a pin insertion machine and its human–machine interaction interface were constructed. On-machine results show that the pin cutting pass rate reached 97%, the average insertion time for one pin was 2.84 s, the pass rate for pin insertion reached 99.75%, and the pin image guidance accuracy was 0.02 mm. Therefore, the designed pin assembly machine can reliably and consistently perform the pin insertion task, providing theoretical and experimental insights for the automated production of IGBT modules. Full article

Constructing a heterojunction is considered one of the most effective strategies for enhancing photocatalytic activity. Herein, we employ Ta₃N₅ and tubular graphitic carbon nitride (TCN) to construct a Ta₃N₅/TCN van der Waals heterojunction via electrostatic self-assembly for enhanced photocatalytic H₂ production. SEM and TEM results show that Ta₃N₅ particles (~300 nm in size) are successfully anchored onto the surface of TCN. The light absorption capability of the Ta₃N₅/TCN heterojunction is between those of Ta₃N₅ and TCN. The strong interaction between Ta₃N₅ and TCN with different energy structures (Fermi levels) by van der Waals force renders the formation of an interfacial electric field to drive the separation and transfer of photogenerated charge carriers in the Ta₃N₅/TCN heterojunction, as evidenced by the photoluminescence (PL) and photoelectrochemical (PEC) characterization results. Consequently, the optimal Ta₃N₅/TCN heterojunction exhibits a remarkable H₂ production rate of 12.73 mmol g⁻¹ h⁻¹ under visible light irradiation, which is 3.3 and 16.8 times those of TCN and Ta₃N₅, respectively. Meanwhile, the cyclic experiment demonstrates excellent stability of the Ta₃N₅/TCN heterojunction upon photocatalytic reaction. Notably, the photocatalytic performance of 15-TaN/TCN outperforms the most previously reported CN-based and Ta₃N₅-based heterojunctions for H₂ production. This work provides a new avenue for the rational design of CN-based van der Waals heterojunction photocatalysts with enhanced photocatalytic activity. Full article

For complex assembly workshops, optimizing AGV scheduling is critical to enhancing production efficiency and resource utilization. Traditional scheduling methods often rely on fixed priority rules and basic path planning algorithms, which are insufficient to accommodate the dynamic changes in resource availability and task demands. To overcome these limitations, this study proposes a DES-based optimization approach that dynamically adjusts AGV task allocation and path planning to improve scheduling performance in complex manufacturing environments. By integrating lean production principles with intelligent simulation technologies, a comprehensive simulation model was developed using the Plant Simulation platform. This model simulates the coordination between AGVs and workstations while optimizing workstation layout and material flow. Simulation results demonstrate that the proposed approach significantly improves AGV scheduling efficiency and overall production performance. Notably, workstation utilization increased from below 6% to over 28%, while the work-in-progress rate dropped from 94% to under 74%. This study offers a practical and effective AGV scheduling strategy for complex product assembly workshops, with strong potential for real-world implementation. Full article

This paper focuses on the complex dynamics that concern assembly line balance in the context of mass customization within manufacturing. In fact, the increase in demand for customized products has heightened the complexities associated with achieving optimal efficiency, productivity, product quality, and customer satisfaction. The research proposes a multi-criteria analysis of statistical methods to determine the fluctuation of parameters affecting the state of balance of an assembly line. A 3D matrix model is suggested to analyze the parameters managing the assembly line. This representation is executed using the MATLAB R2024b tool, and a methodology for finding the variability of parameters affecting balance through statistical approaches is proposed. We observed that changes in parameters such as task times, worker efficiency, or material flow led to significant changes in the line’s overall balance. As a result, static balancing becomes inadequate to deal with the complexities introduced by these highly variable parameters. The novelty of this paper consists of the innovative integration of multi-criteria statistical analysis and 3D matrix modeling to detect parameter variability and optimize assembly line balancing. Conventional static approaches are often unable to capture the process-dynamic aspect of modern manufacturing. This work presents a systematic methodology capable of identifying, quantifying, and moderating the variability of key operating parameters. This methodology, carried out using MATLAB-based simulations, is based on principal component analysis (PCA) and correlation analysis to detect critical factors influencing balancing efficiency. By structuring assembly line parameters in a 3D matrix representation, this research gives a holistic, data-based method for improving decision-making in balancing procedures. The research goes beyond theoretical modeling by applying the approach to a real automotive assembly line, validating its effectiveness and demonstrating its practical applicability in industrial conditions. Full article

Zirconium-89 (⁸⁹Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of ⁸⁹Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation solutions available. To address this, we developed an automated system for the agile and reliable production of radiopharmaceuticals. The system performs transmutations, dissolution, and separation for a range of radioisotopes. Steps in the production of ⁸⁹Zr-oxalate are used as an exemplar to illustrate its use. Three-dimensional (3D) printing was exploited to design and manufacture a target holder able to include solid targets, in this case an ⁸⁹Y foil. Spot welding was used to attach ⁸⁹Y to a refractory tantalum (Ta) substrate. A commercially available CPU chiller was repurposed to efficiently cool the metal target. Furthermore, a commercial resin (ZR Resin) and compact peristaltic pumps were employed in a compact (10 × 10 × 10 cm³) chemical separation unit that operates automatically via computer-controlled software. Additionally, a standalone 3D-printed unit was designed with three automated functionalities: photolabelling, vortex mixing, and controlled heating. All components of the assembly, except for the target holder, are housed inside a commercially available hot cell, ensuring safe and efficient operation in a controlled environment. This paper details the design, construction, and modelling of the entire assembly, emphasising its innovative integration and operational efficiency for widespread radiopharmaceutical automation. Full article

This paper presents a method to model and optimize the supply chain processes for floating offshore wind turbines using a network model based on Generalized Multi-Commodity Network Flows (GMCNF). The proposed method represents production bases, base ports, installation sites, component transfer areas, and transportation routes as nodes and arcs within the network. The installation process is modeled using three transport concepts: assembling components at the base port, direct assembly and installation at the installation site, and transferring components to the installation vessel at a nearby port. These processes are expressed as a linear network model, with the objective function set to minimize total transportation and assembly costs. The optimal transportation network is derived by solving the network problem while incorporating constraints such as supply, demand, and transportation capacity. Case studies demonstrate the method’s effectiveness in optimizing the supply chain and evaluating potential new production site locations for floating foundations, considering overall supply chain optimization. Full article

Collaborative robots are vital in Industry 5.0 operations. They are utilized to perform tasks in collaboration with humans or other robots to increase overall production efficiency and execute complex tasks. Aiming at a comprehensive approach to assembly processes and highlighting new applications of collaborative robots, this paper presents the development of a digital twin (DT) for the design, monitoring, optimization and simulation of robots’ deployment in assembly cells. The DT integrates information from both the physical and virtual worlds to design the trajectory of collaborative robots. The physical information about the industrial environment is replicated within the DT in a computationally efficient way that aligns with the requirements of the path planning algorithm and the DT’s objectives. An enhanced artificial fish swarm algorithm (AFSA) is utilized for the 4D path planning optimization, taking into account dynamic and static obstacles. Finally, the proposed framework is utilized for the examination of a case in which four industrial robotic arms are collaborating for the assembly of an industrial component. Full article

Natural products possess potent pharmacological activities and health benefits. However, drawbacks such as water insolubility, poor stability, and low bioavailability limit their practical applications. This research is dedicated to the development of suitable natural self-assembled nano-delivery systems to encapsulate natural molecule drugs, improving their dispersion and stability in aqueous solution. As a model drug, curcumin (Cur) was encapsulated in zinc–adenine nanoparticles (Zn–Adenine), based on the self-assembly of a coordination matrix material. Hyaluronic acid (HA) was further functionalized on the surface of Cur@(Zn–Adenine) to realize a tumor-targeted delivery system. The morphology was characterized through TEM and zeta potential analyses, while the encapsulation mechanism of the nanoparticles was researched via XRD and FTIR. The formed Cur@(Zn–Adenine)@HA nanoparticles exhibited good drug loading efficiency and drug loading rate. Moreover, compared to free Cur, Cur-loaded (Zn–Adenine)@HA showed enhanced pH stability and thermal stability. In particular, Cur@(Zn–Adenine)@HA demonstrated excellent biocompatibility and strong specificity for targeting CD44 protein on cancer cells. The above results indicate that (Zn–Adenine)@HA NPs can serve as an effective nano-delivery system for hydrophobic substances. Full article