Search Results (9,482)

Introduction: Oxidative stress is a key factor in the pathogenesis of many chronic diseases, especially in postmenopausal women. Xylitol, a sugar alcohol with potential antioxidant properties, may affect oxidative balance when used as a sugar substitute. Aim: This pilot study aimed to assess the effect of replacing sucrose with xylitol on serum antioxidant capacity in postmenopausal women. Methods: This study included 34 women aged 50 to 65 years who successively consumed 5 g/d, 10 g/d, and 15 g/d of xylitol. The dietary intervention lasted a total of 6 weeks, with each phase covering a 2-week period. Diet was assessed twice based on a 7-day dietary interview (Diet 6.0, NIZP–PZH, Warsaw). The material for this study was venous blood. Antioxidant capacity was determined using the DPPH radical scavenging method and the ABTS cation radical scavenging method. Results: In both methods, a significant increase in serum antioxidant potential was observed after replacing sugar with xylitol (p < 0.0001). An increase in the ability to neutralize free radicals was observed in almost all women studied. Additional analysis of the effect of selected nutrients on the obtained effects of the nutritional intervention showed that the most significant effect could potentially be exerted by manganese, maltose, sucrose, and mercury, and the strongest positive correlation was exerted by vitamin A, retinol, and vitamin E. Although the values obtained in the constructed models were not statistically significant, the large effect indicates potentially significant relationships that could have a significant impact on serum antioxidant potential in the studied group of women. Conclusions: The results suggest a potential role of xylitol in enhancing antioxidant defense mechanisms in menopausal women. Although the sample size was relatively small, this study was powered at approximately 80% to detect large effects, supporting the reliability of the observed results. Nevertheless, given the pilot nature of this study, further research with larger cohorts is warranted to confirm these preliminary observations and to clarify the clinical significance of xylitol supplementation in populations exposed to oxidative stress. Full article

Flexible energy sources such as electric vehicles and the battery energy storage systems of intelligent distribution systems can provide system-wide auxiliary services such as frequency regulation for power systems. This paper proposes an optimal method for operating the local energy community that is based on two-stage scheduling. Firstly, the basic concepts of the local energy community and flexible service are introduced in detail. Taking LEC as the reserve unit of artificial frequency recovery, an energy information interaction model among LEC, balance service providers, and the power grid is established. Then, a two-stage scheduling framework is proposed to ensure the rationality and economy of community energy scheduling. In the first stage, day-ahead scheduling uses the energy community management center to predict the up/down flexibility capacity that LEC can provide by adjusting the BESS control parameters. In the second stage, real-time scheduling aims at maximizing community profits and scheduling LEC based on the allocation and activation of standby flexibility determined in real time. Finally, the correctness of the two-stage scheduling framework is verified through a case study. The results show that the control parameters used in the day-ahead stage can significantly affect the real-time profitability of LEC, and that LEC benefits more in the case of low BESS utilization than in the case of high BESS utilization and non-participation in frequency recovery reserve. Full article

Faba bean (Vicia faba L.), a nutrient-rich legume beneficial to human health, is valued for its high L-3,4-dihydroxyphenylalanine (L-DOPA) and phenolic content. This study investigated phytochemical diversity and bioactivity across 29 Chinese faba bean varieties. Phenolics were profiled using ultrahigh-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) and quantified via high-performance liquid chromatography (HPLC). Antioxidant capacity was evaluated, including DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging activity, and ferric reducing antioxidant power (FRAP), along with α-amylase/α-glucosidase inhibitory effects. Twenty-five phenolics were identified, including L-DOPA (11.96–17.93 mg/g, >70% of total content), seven phenolic acids, and seventeen flavonoids. L-DOPA showed potent enzyme inhibition (IC₅₀ values of 22.45 μM for α-amylase and 16.66 μM for α-glucosidase) but demonstrated limited antioxidant effects. Lincan 13 (Gansu) exhibited the strongest antioxidant activity (DPPH, 16.32 μmol trolox/g; ABTS, 5.85 μmol trolox/g; FRAP, 21.38 mmol Fe²⁺/g), which correlated with it having the highest flavonoid content (40.51 mg rutin/g), while Yican 4 (Yunnan) showed the strongest α-amylase inhibition (43.33%). Correlation analysis confirmed flavonoids as the primary antioxidants, and principal component analysis (PCA) revealed geographical trends (e.g., Jiangsu varieties were particularly phenolic-rich). These findings highlight faba beans’ potential as functional foods and guide genotype selection in targeted breeding programs aimed at enhancing health benefits. Full article

Skeletal muscle regeneration depends on muscle stem cells, which give rise to myoblasts that drive muscle growth, repair, and maintenance. In bats—the only mammals capable of powered flight—these processes must also sustain contractile performance under extreme mechanical and metabolic stress. However, the cellular and molecular mechanisms underlying bat muscle physiology remain largely unknown. To enable mechanistic investigation of these traits, we established the first myoblast cell lines from the pectoralis muscle of Pteronotus mesoamericanus, a highly maneuverable aerial insectivore. Using both spontaneous immortalization and exogenous hTERT/CDK4 gene overexpression, we generated two stable cell lines that retain proliferative capacity and differentiate into contractile myotubes. These cells exhibit frequent spontaneous contractions, suggesting robust functional integrity at the neuromuscular junction. In parallel, we performed transcriptomic and metabolic profiling of native pectoralis tissue in the closely related Pteronotus parnellii to define molecular programs supporting muscle specialization. Gene expression analyses revealed enriched pathways for muscle metabolism, development, and regeneration, highlighting supporting roles in tissue maintenance and repair. Consistent with this profile, the flight muscle is triglyceride-rich, which serves as an important fuel source for energetically demanding processes, including muscle contraction and cellular recovery. Integration of transcriptomic and metabolic data identified three key metabolic modules—glucose utilization, lipid handling, and nutrient signaling—that likely coordinate ATP production and support metabolic flexibility. Together, these complementary tools and datasets provide the first in vitro platform for investigating bat muscle research, enabling direct exploration of muscle regeneration, metabolic resilience, and evolutionary physiology. Full article

This paper analyzes the availability of lithium resources required to support a global decarbonized energy system featuring electrical energy storage based on lithium iron phosphate (LFP) batteries. A net-zero carbon grid consisting of existing nuclear and hydro capacity, with the balance being a 50/50 mix of wind and solar power generation, is assumed to satisfy projected world electrical demand in 2050, incorporating the electrification of transportation. The battery electrical storage capacity needed to support this grid is estimated and translated into the required number of nominal 10 MWh LFP storage plants similar to the ones currently in operation. The total lithium required for the global storage system is determined from the number of nominal plants and the inventory of lithium in each plant. The energy required to refine this amount of lithium is accounted for in the estimation of the total lithium requirement. Comparison of the estimated lithium requirements with known global lithium resources indicates that a global storage system consisting only of LFP plants would require only around 12.3% of currently known lithium reserves in a high-economic-growth scenario. The overall cost for a global LFP-based grid-scale energy storage system is estimated to be approximately USD 17 trillion. Full article

Remote sensing images are often degraded by atmospheric haze, which not only reduces image quality but also complicates information extraction, particularly in high-level visual analysis tasks such as object detection and scene classification. State-space models (SSMs) have recently emerged as a powerful paradigm for vision tasks, showing great promise due to their computational efficiency and robust capacity to model global dependencies. However, most existing learning-based dehazing methods lack physical interpretability, leading to weak generalization. Furthermore, they typically rely on spatial features while neglecting crucial frequency domain information, resulting in incomplete feature representation. To address these challenges, we propose ScaleViM-PDD, a novel network that enhances an SSM backbone with two key innovations: a Multi-scale EfficientViM with Physical Decoupling (ScaleViM-P) module and a Dual-Domain Fusion (DD Fusion) module. The ScaleViM-P module synergistically integrates a Physical Decoupling block within a Multi-scale EfficientViM architecture. This design enables the network to mitigate haze interference in a physically grounded manner at each representational scale while simultaneously capturing global contextual information to adaptively handle complex haze distributions. To further address detail loss, the DD Fusion module replaces conventional skip connections by incorporating a novel Frequency Domain Module (FDM) alongside channel and position attention. This allows for a more effective fusion of spatial and frequency features, significantly improving the recovery of fine-grained details, including color and texture information. Extensive experiments on nine publicly available remote sensing datasets demonstrate that ScaleViM-PDD consistently surpasses state-of-the-art baselines in both qualitative and quantitative evaluations, highlighting its strong generalization ability. Full article

Railway systems occupy a predominant role in urban transport, providing efficient, high-capacity mobility. Progress in rail transport allows fast traveling, whilst environmental concerns and CO₂ emissions are on the rise. The integration of railway systems with renewable energy source (RES)-based stations presents a promising avenue to improve the sustainability, reliability, and efficiency of urban transport networks. A storage system is needed to both ensure a continuous power supply and meet train demand at the station. Batteries (BTs) offer high energy density, while supercapacitors (SCs) offer both a large number of charge and discharge cycles, and high-power density. This paper proposes a hybrid RES (photovoltaic and wind), combined with batteries and supercapacitors constituting the hybrid energy storage system (HESS). One major drawback of trains is the long charging time required in stations, so they have been fitted with SCs to allow them to charge up quickly. A new fuzzy energy management strategy (F-EMS) is proposed. This supervision strategy optimizes the power flow between renewable energy sources, HESS, and trains. DC bus voltage regulation is involved, maintaining BT and SC charging levels within acceptable ranges. The simulation results, carried out using MATLAB/Simulink, demonstrate the effectiveness of the suggested fuzzy energy management strategy for various production conditions and train demand. Full article

Histotripsy is a novel, noninvasive, non-thermal technology invented in 2004 for the precise destruction of biologic tissue. It offers a powerful alternative to more conventional thermal or surgical interventions. Using short-pulse, low-duty cycle ultrasonic waves, histotripsy creates cavitation bubble clouds that selectively and precisely destroy targeted tissue in a predefined volume while sparing critical structures like bile ducts, ureters, and blood vessels. Such precision is of value when treating tumors near vital structures. The FDA has cleared histotripsy for the treatment of all liver tumors. Major medical centers are currently spearheading clinical trials, and some institutions have already integrated the technology into patient care. Histotripsy is now being studied for a host of other cancers, including primary kidney and pancreatic tumors. Preclinical murine and porcine models have already revealed promising outcomes. One of histotripsy’s primary advantages is its non-thermal mechanical actuation. This feature allows it to circumvent the limitations of heat-based techniques, including the heat sink effect and unpredictable treatment margins near sensitive tissues. In addition to its non-invasive ablative capacities, it is being preliminarily explored for its potential to induce immunomodulation and promote abscopal inhibition of distant, untreated tumors through CD8+ T cell responses. Thus, it may provide a multilayered therapeutic effect in the treatment of cancer. Histotripsy has the potential to improve precision and outcomes across a multitude of specialties, from oncology to cardiovascular medicine. Continued trials are crucial to further expand its applications and validate its long-term efficacy. Due to the speed of recent developments, the goal of this review is to provide a comprehensive and updated overview of histotripsy. It will explore its physics-based mechanisms, differentiating it from similar technologies, discuss its clinical applications, and examine its advantages, limitations, and future. Full article

To study the effect of cold plasma (CP) on the refrigerator shelf life of coconut water, microorganism growth and diversity and physicochemical properties were investigated. Results indicated that CP treatment did not cause significant color changes in coconut water, with turbidity remaining lower than the control even after 6 days of storage. Enzymatic activity analysis revealed reduced polyphenol oxidase (PPO) and peroxidase (POD) levels in treated samples. Specifically, the 12 s CP treatment resulted in the lowest antioxidant capacity values: 15.77 Fe²⁺/g for ferric reducing antioxidant power (FRAP), 37.15% for DPPH radical scavenging, and 39.51% for ABTS⁺ radical scavenging. Microbial enumeration showed that extended CP treatment effectively inhibited the growth of total viable counts, psychrophilic bacteria, lactic acid bacteria, and yeast. High-throughput sequencing identified Leuconostoc, Carnobacterium, and Lactobacillus as the dominant bacterial genera. During storage, Carnobacterium was the primary genus in the early stage, while Leuconostoc emerged as the dominant genus by the end of the storage period. In summary, CP as an effective non-thermal technology was able to maintain quality and antioxidant capacity, inhibit microbial growth, and delay the spoilage in coconut water to help extend the refrigerated shelf life of the product. Full article

The structural design of rail vehicle bodies significantly influences rail vehicle performance, passenger comfort, and operational efficiency. This study presents a comparative analysis of three key concepts of a rail vehicle body, namely a differential, an integral, and a hybrid structure, with a focus on their structural principles, material utilization, and implications for manufacturability and maintenance. Three rail vehicle body variants were developed, each incorporating a low-floor configuration to enhance accessibility and interior layout flexibility. The research explores the suitable placement of technical components such as a power unit and an air-conditioning system, and it evaluates interior layouts aimed at maximizing both passenger capacity and their travelling comfort. Key features, including door and window technologies, thermal comfort solutions, and seating arrangements, are also analyzed. The study emphasizes the importance of compromises between structural stiffness, reparability, production complexity, and passenger-oriented design considerations. A part of the research includes a proposal of three variants of a rail vehicle body frame, together with their strength analysis by means of the finite element method. These analyses identified that the maximal permissible stresses for the individual versions of the frame were not exceeded. Findings contribute to the development of more efficient, accessible, and sustainable regional passenger rail vehicles. Full article

This article examines how digital innovation ecosystems have emerged as strategic institutions of power in contemporary world politics. It argues that, unlike Cold War technological rivalries driven by centralized, state-led control, today’s digital competition depends on states’ capacity to orchestrate scalable, multistakeholder ecosystems. Using a cultural–institutional framework, we explain how differences in strategic culture and institutional governance impact the ecosystem’s vitality and performance. A qualitative comparative analysis of the United States, China, and Russia reveals that constructive orchestration, aligning state institutions with generative, commercial-to-national innovation flows, enhances digital leadership, whereas rigid, obstructive governance limits it. This highlights ecosystem governance as a critical dimension of statecraft in the digital age. The findings underscore that the positions of great powers in the global technological hierarchy depend not only on resources or capabilities but also on the effectiveness of ecosystem governance as an evolving instrument of geopolitical power. Full article

This paper addresses the economic–environmental dispatch (EED) problem in DC power grids integrating thermoelectric and photovoltaic generation. A multi-objective optimization model is developed to minimize both fuel costs and CO₂ emissions while considering power balance, voltage constraints, generation limits, and thermal line capacities. To overcome the non-convexity introduced by quadratic voltage products in the power flow equations, a convex reformulation is proposed using second-order cone programming (SOCP) with auxiliary variables. This reformulation ensures global optimality and enhances computational efficiency. Two test systems are used for validation: a 6-node DC grid and an 11-node grid incorporating hourly photovoltaic generation. Comparative analyses show that the convex model achieves objective values with errors below 0.01% compared to the original non-convex formulation. For the 11-node system, the integration of photovoltaic generation led to a 24.34% reduction in operating costs (from USD 10.45 million to USD 7.91 million) and a 27.27% decrease in CO₂ emissions (from 9.14 million kg to 6.64 million kg) over a 24 h period. These results confirm the effectiveness of the proposed SOCP-based methodology and demonstrate the environmental and economic benefits of renewable integration in DC networks. Full article

Τhe Greek Seas are one of the most favorable locations for offshore wind energy development in the Mediterranean basin. In 2023, the Hellenic Hydrocarbons & Energy Resources Management Company SA published the draft National Offshore Wind Farm Development Programme (NDP-OWF), including the main pillars for the design, development, siting, installation, and exploitation of offshore wind farms, along with the Strategic Environmental Impact Assessment. The NDP-OWF is under assessment by the relevant authorities and is expected to be finally approved through a Joint Ministerial Decision. In this work, the preliminary offshore wind energy assessment of the Greek Seas is performed using the CERRA wind reanalysis data and in situ measurements from six offshore locations of the Greek Seas. The in situ measurements are used in order to assess the performance of the reanalysis datasets. The results reveal that CERRA is a reliable source for preliminary offshore wind energy assessment studies. Taking into consideration the potential offshore wind farm organized development areas (OWFODA) according to the NDP-OWF, the study of the local wind characteristics is performed. The local wind speed and wind power density are assessed, and the wind energy produced from each OWFODA is estimated based on three different capacity density settings. According to the balanced setting (capacity density of 5.0 MW/km²), the annual energy production will be 17.5 TWh, which is equivalent to 1509.1 ktoe. An analysis of the wind energy correlation, synergy, and complementarity between the OWFODA is also performed, and a high degree of wind energy synergy is identified, with a very low degree of complementarity. Full article

Combining Organic Rankine Cycles (ORC) with cooling cycles offers a promising approach to achieving greater outputs within a single system. In this study, a novel directly combined ORC-VCC system has been designed to not only meet the cooling demand using a geothermal heat source but also generate power. The proposed novel ORC-VCC system has been analyzed for its energetic performance using four selected fluids: R290, R600a, R601, and R1234ze(E). Parametric analysis has been conducted to investigate the effects of parameters of heat source temperature, heat source mass flow rate, cooling capacities, condenser temperature, ORC evaporator temperature, pinch point temperature difference and isentropic efficiencies on net power production. Among the working fluids, R290 has provided the highest net power production under all conditions in which it was available to operate. Additionally, the results have been analyzed concerning a reference cycle for comparative evaluation. The proposed novel cycle has outperformed the reference cycle in all investigated cases in terms of net power production such as demonstrating an improvement of approximately from 8.7% to 57.8% in geothermal heat source temperature investigations. Similar improvements have been observed over the reference cycle at lower heat source mass flow rates, where net power increases by up to 50.8%. Full article

Cement-based batteries (CBBs) are an emerging category of multifunctional materials that combine structural load-bearing capacity with integrated electrochemical energy storage, enabling the development of self-powered infrastructure. Although previous reviews have explored selected aspects of CBB technology, a comprehensive synthesis encompassing system architectures, material strategies, and performance metrics remains insufficient. In this review, CBB systems are categorized into two representative configurations: probe-type galvanic cells and layered monolithic structures. Their structural characteristics and electrochemical behaviors are critically compared. Strategies to enhance performance include improving ionic conductivity through alkaline pore solutions, facilitating electron transport using carbon-based conductive networks, and incorporating redox-active materials such as zinc–manganese dioxide and nickel–iron couples. Early CBB prototypes demonstrated limited energy densities due to high internal resistance and inefficient utilization of active components. Recent advancements in electrode architecture, including nickel-coated carbon fiber meshes and three-dimensional nickel foam scaffolds, have achieved stable rechargeability across multiple cycles with energy densities surpassing 11 Wh/m². These findings demonstrate the practical potential of CBBs for both energy storage and additional functionalities, such as strain sensing enabled by conductive cement matrices. This review establishes a critical basis for future development of CBBs as multifunctional structural components in infrastructure applications. Full article