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Article

3 Citations

2,747 Views

23 Pages

The Multivalent Polyampholyte Domain of Nst1, a P-Body-Associated Saccharomyces cerevisiae Protein, Provides a Platform for Interacting with P-Body Components

Yoon-Jeong Choi,
Yujin Lee,
Yuxi Lin,
Yunseok Heo,
Young-Ho Lee and
Kiwon Song

Int. J. Mol. Sci.2022, 23(13), 7380;https://doi.org/10.3390/ijms23137380

2 July 2022

The condensation of nuclear promyelocytic leukemia bodies, cytoplasmic P-granules, P-bodies (PBs), and stress granules is reversible and dynamic via liquid–liquid phase separation. Although each condensate comprises hundreds of proteins with pr...

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Article

19 Citations

4,145 Views

18 Pages

The Role of Non-Specific Interactions in Canonical and ALT-Associated PML-Bodies Formation and Dynamics

Alexander V. Fonin,
Sergey A. Silonov,
Olesya G. Shpironok,
Iuliia A. Antifeeva,
Alexey V. Petukhov,
Anna E. Romanovich,
Irina M. Kuznetsova,
Vladimir N. Uversky and
Konstantin K. Turoverov

Int. J. Mol. Sci.2021, 22(11), 5821;https://doi.org/10.3390/ijms22115821

29 May 2021

In this work, we put forward a hypothesis about the decisive role of multivalent nonspecific interactions in the early stages of PML body formation. Our analysis of the PML isoform sequences showed that some of the PML isoforms, primarily PML-II, are...

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Article

8 Citations

4,171 Views

13 Pages

Systematic Modification of the Glass Transition Temperature of Ion-Pair Comonomer Based Polyelectrolytes and Ionomers by Copolymerization with a Chemically Similar Cationic Monomer

Guodong Deng,
Timothy D. Schoch and
Kevin A. Cavicchi

Gels2021, 7(2), 45;https://doi.org/10.3390/gels7020045

13 April 2021

Ion-pair comonomers (IPCs) where both the anion and cation contain polymerizable functional groups offer a route to prepare polyampholyte, ion-containing polymers. Polymerizing vinyl functional groups by free-radical polymerization produces bridging...

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Article

29 Citations

4,647 Views

19 Pages

Bioinformatic Analysis of Lytic Polysaccharide Monooxygenases Reveals the Pan-Families Occurrence of Intrinsically Disordered C-Terminal Extensions

Ketty C. Tamburrini,
Nicolas Terrapon,
Vincent Lombard,
Bastien Bissaro,
Sonia Longhi and
Jean-Guy Berrin

Biomolecules2021, 11(11), 1632;https://doi.org/10.3390/biom11111632

4 November 2021

Lytic polysaccharide monooxygenases (LPMOs) are monocopper enzymes secreted by many organisms and viruses. LPMOs catalyze the oxidative cleavage of different types of polysaccharides and are today divided into eight families (AA9–11, AA13–17) within...

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Article

5 Citations

2,843 Views

17 Pages

Different Forms of Disorder in NMDA-Sensitive Glutamate Receptor Cytoplasmic Domains Are Associated with Differences in Condensate Formation

Sujit Basak,
Nabanita Saikia,
David Kwun,
Ucheor B. Choi,
Feng Ding and
Mark E. Bowen

Biomolecules2023, 13(1), 4;https://doi.org/10.3390/biom13010004

20 December 2022

The N-methyl-D-aspartate (NMDA)-sensitive glutamate receptor (NMDAR) helps assemble downstream signaling pathways through protein interactions within the postsynaptic density (PSD), which are mediated by its intracellular C-terminal domain (CTD). The...

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