Search Results (1,246)

Existing research predominantly focuses on the preservation or renewal models of the physical forms of historic cultural districts, with limited exploration of their roles in stimulating tourists’ cognitive, affective resonance, and behavioral interactions. This study addresses historic cultural districts by evaluating the space quality and its impact on tourist experiences through the “cognition-affect-behavior” framework, integrating GIS, street view semantic segmentation, VR eye-tracking, and web crawling technologies. The findings reveal significant multidimensional differences in how space quality influences tourist experiences: the impact intensities of functional diversity, sky visibility, road network accessibility, green visibility, interface openness, and public facility convenience decrease sequentially, with path coefficients of 0.261, 0.206, 0.205, 0.204, 0.201, and 0.155, respectively. Additionally, space quality exerts an indirect effect on tourist experiences through the mediating roles of cognitive, affective, and behavioral dimensions, with a path coefficient of 0.143. This research provides theoretical support and practical insights for empowering cultural heritage space governance with digital technologies in the context of cultural and tourism integration. Full article

E-commerce growth has reshaped consumer behavior and retail services, driving parcel demand and challenging last-mile logistics. Existing research predominantly relies on survey data and global regression models that overlook intra-urban spatial heterogeneity in shopping behaviors. This study bridges this gap by analyzing e-commerce demand’s spatial distribution from a retail service perspective, identifying key drivers, and evaluating implications for omnichannel strategies and logistics. Utilizing waybill big data, spatial analysis, and multiscale geographically weighted regression, we reveal: (1) High-density e-commerce demand areas are predominantly located in central districts, whereas peripheral regions exhibit statistically lower volumes. The spatial distribution pattern of e-commerce demand aligns with the urban development spatial structure. (2) Factors such as population density and education levels significantly influence e-commerce demand. (3) Convenience stores play a dual role as retail service providers and parcel collection points, reinforcing their importance in shaping consumer accessibility and service efficiency, particularly in underserved urban areas. (4) Supermarkets exert a substitution effect on online shopping by offering immediate product availability, highlighting their role in shaping consumer purchasing preferences and retail service strategies. These findings contribute to retail and consumer services research by demonstrating how spatial e-commerce demand patterns reflect consumer shopping preferences, the role of omnichannel retail strategies, and the competitive dynamics between e-commerce and physical retail formats. Full article

Adipose stem cells (ASCs) are a subset of mesenchymal stem cells with validated immunomodulatory and regenerative capabilities that make them attractive tools for treating neurodegenerative disorders, such as multiple sclerosis (MS). Several studies conducted on experimental autoimmune encephalomyelitis (EAE), the animal model of MS, have clearly shown a therapeutic effect of ASCs. However, controversial data on their efficacy were obtained from I- and II-phase clinical trials in MS patients, highlighting standardization issues and limited data on long-term safety. In this context, ASC-derived extracellular vesicles from (ASC-EVs) represent a safer, more reproducible alternative for EAE and MS treatment. Moreover, their physical characteristics lend themselves to a non-invasive, efficient, and easy handling of intranasal delivery. Using an in vitro setting, we first verified ASC-EVs’ ability to cross the human nasal epithelium under an inflammatory milieu. Magnetic resonance corroborated these data in vivo in intranasally treated MOG35-55-induced EAE mice, showing a preferential accumulation of ASC-EVs in brain-inflamed lesions compared to a stochastic distribution in healthy control mice. Moreover, intranasal treatment of ASC-EVs at the EAE onset led to a long-term therapeutic effect using two different experimental protocols. A marked reduction in T cell infiltration, demyelination, axonal damage, and cytokine production were correlated to EAE amelioration in ASC-EV-treated mice compared to control mice, highlighting the immunomodulatory and neuroprotective roles exerted by ASC-EVs during EAE progression. Overall, our study paves the way for promising clinical applications of self-administered ASC-EV intranasal treatment in CNS disorders, including MS. Full article

Benign prostatic hyperplasia (BPH) is a multifactorial condition that is highly prevalent and affects aging males. It frequently results in lower urinary tract symptoms (LUTS) and a reduced quality of life. While hormonal dysregulation and chronic inflammation have long been implicated in BPH pathogenesis, recent evidence highlights the role of physical activity in modulating prostate health. In this narrative review, evidence from quantitative studies examining the effect of exercise on BPH risk and symptom severity was first synthesized. Collectively, these studies suggest that regular physical activity is associated with a lower incidence and reduced progression of BPH. The potential mechanisms through which exercise may exert protective effects on the prostate were then explored. These include modulation of sympathetic nervous system activity, alterations in hormonal profiles (e.g., testosterone and insulin), suppression of chronic inflammation and oxidative stress, and the promotion of autophagy within prostatic tissue. Central to these mechanisms is the role of myokines—signaling molecules secreted by skeletal muscle during exercise. Key myokines, such as irisin, interleukin-6 (IL-6), brain-derived neurotrophic factor (BDNF), and myostatin, are reviewed in the context of prostate health. These molecules regulate inflammatory pathways, metabolic processes, and tissue remodeling. For instance, exercise-induced reductions in myostatin are linked to improved insulin sensitivity and decreased fat accumulation, while elevated irisin and BDNF levels may exert anti-inflammatory and metabolic benefits relevant to BPH pathophysiology. Although direct causal evidence linking myokines to BPH is still emerging, their biological plausibility and observed systemic effects suggest a promising avenue for non-pharmacological intervention. Future research should focus on identifying the specific myokines involved, elucidating their molecular mechanisms within the prostate, and evaluating their therapeutic potential in clinical trials. Full article

Global resource consumption continues to grow each year, exerting increasing pressure on their availability. This trend could lead to a shortage of raw materials in the coming years. Aware of the risks associated with this situation, the European Union has implemented policies and strategies aimed at diversifying its supply sources, including waste recycling. In this context, the present study was conducted with the objective of developing innovative processes to concentrate valuable metals present in the non-recovered fractions of waste electrical and electronic equipment (WEEE). Three types of samples were studied: washing table residues (WTRs), printed circuit boards (PCBs), and powders from cathode-ray tube screens (CRT powders). Several separation techniques, based on the physical properties of the elements, were implemented, including electrostatic separation, magnetic separation, and density and gravity-based separations. The results obtained are promising. For WTRs and PCBs, the recovery rates of targeted metals (Cu, Al, Pb, Zn, Sn) reached approximately 91% and 80%, respectively. In addition to these metals, other valuable metals, present in significant quantities, deserve further exploration. Regarding CRT powders, the performances are also encouraging, with recovery rates of 54.7% for zinc, 57.1% for yttrium, and approximately 71% for europium. Although these results are satisfactory, optimizations are possible to maximize the recovery of these critical elements. The techniques implemented have demonstrated their effectiveness in concentrating target metals in the treated fractions. These results confirm that recycling constitutes a viable alternative to address resource shortages and secure part of the supplies needed for the European Union’s industry. Full article

Football performance results from the dynamic interaction between physical, tactical, technical, and psychological dimensions—each of which also influences player well-being, recovery, and readiness. However, integrated monitoring approaches remain scarce, particularly in youth and sub-elite contexts. This systematic review screened 341 records from PubMed, Scopus, and Web of Science, with 46 studies meeting the inclusion criteria (n = 1763 players; age range: 13.2–28.7 years). Physical external load was reported in 44 studies using GPS-derived metrics such as total distance and high-speed running, while internal load was examined in 36 studies through session-RPE (rate of perceived exertion × duration), heart rate zones, training impulse (TRIMP), and Player Load (PL). A total of 22 studies included well-being indicators capturing fatigue, sleep quality, stress levels, and muscle soreness, through tools such as the Hooper Index (HI), the Total Quality Recovery (TQR) scale, and various Likert-type or composite wellness scores. Tactical behaviours (n = 15) were derived from positional tracking systems, while technical performance (n = 7) was assessed using metrics like pass accuracy and expected goals, typically obtained from Wyscout^® or TRACAB^® (a multi-camera optical tracking system). Only five studies employed multivariate models to examine interactions between performance domains or to predict well-being outcomes. Most remained observational, relying on descriptive analyses and examining each domain in isolation. These findings reveal a fragmented approach to player monitoring and a lack of conceptual integration between physical, psychological, tactical, and technical indicators. Future research should prioritise multidimensional, standardised monitoring frameworks that combine contextual, psychophysiological, and performance data to improve applied decision-making and support player health, particularly in sub-elite and youth populations. Full article

To address the limitations of traditional hardened concrete road surfaces in coal mine tunnels, which are prone to damage and entail high maintenance costs, this study proposes using modular concrete blocks composed of fly ash and coal gangue as an alternative to conventional materials. These blocks offer advantages including ease of construction and rapid, straightforward maintenance, while also facilitating the reuse of substantial quantities of solid waste, thereby mitigating resource wastage and environmental pollution. Initially, the mineral composition of the raw materials was analyzed, confirming that although the physical and chemical properties of Liangshui Well coal gangue are slightly inferior to those of natural crushed stone, they still meet the criteria for use as concrete aggregate. For concrete blocks incorporating 20% fly ash, the steam curing process was optimized with a recommended static curing period of 16–24 h, a temperature ramp-up rate of 20 °C/h, and a constant temperature of 50 °C maintained for 24 h to ensure optimal performance. Orthogonal experimental analysis revealed that fly ash content exerted the greatest influence on the compressive strength of concrete, followed by the additional water content, whereas the aggregate particle size had a comparatively minor effect. The optimal mix proportion was identified as 20% fly ash content, a maximum aggregate size of 20 mm, and an additional water content of 70%. Performance testing indicated that the fabricated blocks exhibited a compressive strength of 32.1 MPa and a tensile strength of 2.93 MPa, with strong resistance to hydrolysis and sulfate attack, rendering them suitable for deployment in weakly alkaline underground environments. Considering the site-specific conditions of the Liangshuijing coal mine, ANSYS 2020 was employed to simulate and analyze the mechanical behavior of the blocks under varying loads, thicknesses, and dynamic conditions. The findings suggest that hexagonal coal gangue blocks with a side length of 20 cm and a thickness of 16 cm meet the structural requirements of most underground mine tunnels, offering a reference model for cost-effective paving and efficient roadway maintenance in coal mines. Full article

The chiral nonlinear Schrödinger equation (CNLSE) serves as a simplified model for characterizing edge states in the fractional quantum Hall effect. In this paper, we leverage the generalization and parameter inversion capabilities of physics-informed neural networks (PINNs) to investigate both forward and inverse problems of 1D and 2D CNLSEs. Specifically, a hybrid optimization strategy incorporating exponential learning rate decay is proposed to reconstruct data-driven solutions, including bright soliton for the 1D case and bright, dark soliton as well as periodic solutions for the 2D case. Moreover, we conduct a comprehensive discussion on varying parameter configurations derived from the equations and their corresponding solutions to evaluate the adaptability of the PINNs framework. The effects of residual points, network architectures, and weight settings are additionally examined. For the inverse problems, the coefficients of 1D and 2D CNLSEs are successfully identified using soliton solution data, and several factors that can impact the robustness of the proposed model, such as noise interference, time range, and observation moment are explored as well. Numerical experiments highlight the remarkable efficacy of PINNs in solution reconstruction and coefficient identification while revealing that observational noise exerts a more pronounced influence on accuracy compared to boundary perturbations. Our research offers new insights into simulating dynamics and discovering parameters of nonlinear chiral systems with deep learning. Full article

The sustainability of coastal ecosystems, associated fisheries, and environmental quality is increasingly threatened by anthropogenic activities and rapidly expanding urbanization. This study investigated the ecological impacts of increased coastal urbanization on intertidal sediment quality and the biological parameters of the wedge clam Donax trunculus along the central Moroccan Atlantic coast. Between 2018 and 2022, a period characterized by intensified urban activity, total organic matter (TOM) in sediment significantly increased, whereas temperature and pH remained stable. Concurrently, D. trunculus populations experienced notable declines in abundance and biomass, along with marked disruptions in reproductive dynamics. The proportion of sexually mature individuals decreased, while spent individuals and male-biased sex ratios became more prominent. These findings suggest that urbanization-related pressures such as sediment enrichment, pollution, and physical disturbance are exerting measurable stress on this key bioindicator species. The results highlight the need for improved coastal management to mitigate the ecological consequences of rapid urban expansion on coastal sustainability. Full article

Rivers in tropical semi-arid regions face increasing anthropogenic pressures yet remain critically understudied despite their global importance. This study evaluated the aquatic macroinvertebrate community structure in the Ranchería River, Colombia, across three land use conditions: conserved zones (CZs), urban/agricultural zones (UAZs), and mining influence zones (MZs). Ten sampling stations were established, and macroinvertebrate communities were assessed alongside physical, chemical, and hydromorphological variables during the dry season (January–March 2021). A total of 9288 individuals from 84 genera across 16 orders were collected. Generalized Linear Models revealed significant differences among zones for 67 genera (79.8%), indicating strong community responses to land use gradients. Conserved zones exhibited the highest diversity according to the Hill numbers and were dominated by sensitive taxa, including Simulium, Smicridea, and Leptohyphes. Urban/agricultural zones showed the lowest richness (35 genera) and were characterized by disturbance-tolerant species, particularly Melanoides. Mining zones displayed intermediate diversity but exhibited severe habitat alterations. A redundancy analysis with variance partitioning revealed that land use types constituted the primary driver of community structure (a 24.1% pure effect), exceeding the physical and chemical variables (19.5%) and land cover characteristics (19.2%). The integrated model explained 63.5% of the total compositional variation, demonstrating that landscape-scale anthropogenic disturbances exert a greater influence on aquatic communities than local environmental conditions alone. Different anthropogenic activities create distinct environmental filters affecting macroinvertebrate assemblages, emphasizing the importance of land use planning for maintaining aquatic ecosystem integrity in semi-arid watersheds. Full article

This paper presents some of the most significant findings in the design of a hydraulic servomechanism for flight controls, which were primarily achieved by the first author during his activity in an aviation institute. These results are grouped into four main topics. The first one outlines a classical theory, from the 1950s–1970s, of the analysis of nonlinear automatic systems and namely the issue of absolute stability. The uninformed public may be misled by the adjective “absolute”. This is not a “maximalist” solution of stability but rather highlights in the system of equations a nonlinear function that describes, for the case of hydraulic servomechanisms, the flow-control dependence in the distributor spool. This function is odd, and it is therefore located in quadrants 1 and 3. The decision regarding stability is made within the so-called Lurie problem and is materialized by a matrix inequality, called the Lefschetz condition, which must be satisfied by the parameters of the electrohydraulic servomechanism and also by the components of the control feedback vector. Another approach starts from a classical theorem of V. M. Popov, extended in a stochastic framework by T. Morozan and I. Ursu, which ends with the description of the local and global spool valve flow-control characteristics that ensure stability in the large with respect to bounded perturbations for the mechano-hydraulic servomechanism. We add that a conjecture regarding the more pronounced flexibility of mathematical models in relation to mathematical instruments (theories) was used. Furthermore, the second topic concerns, the importance of the impedance characteristic of the mechano-hydraulic servomechanism in preventing flutter of the flight controls is emphasized. Impedance, also called dynamic stiffness, is defined as the ratio, in a dynamic regime, between the output exerted force (at the actuator rod of the servomechanism) and the displacement induced by this force under the assumption of a blocked input. It is demonstrated in the paper that there are two forms of the impedance function: one that favors the appearance of flutter and another that allows for flutter damping. It is interesting to note that these theoretical considerations were established in the institute’s reports some time before their introduction in the Aviation Regulation AvP.970. However, it was precisely the absence of the impedance criterion in the regulation at the appropriate time that ultimately led, by chance or not, to a disaster: the crash of a prototype due to tailplane flutter. A third topic shows how an important problem in the theory of automatic systems of the 1970s–1980s, namely the robust synthesis of the servomechanism, is formulated, applied and solved in the case of an electrohydraulic servomechanism. In general, the solution of a robust servomechanism problem consists of two distinct components: a servo-compensator, in fact an internal model of the exogenous dynamics, and a stabilizing compensator. These components are adapted in the case of an electrohydraulic servomechanism. In addition to the classical case mentioned above, a synthesis problem of an anti-windup (anti-saturation) compensator is formulated and solved. The fourth topic, and the last one presented in detail, is the synthesis of a fuzzy supervised neurocontrol (FSNC) for the position tracking of an electrohydraulic servomechanism, with experimental validation, in the laboratory, of this control law. The neurocontrol module is designed using a single-layered perceptron architecture. Neurocontrol is in principle optimal, but it is not free from saturation. To this end, in order to counteract saturation, a Mamdani-type fuzzy logic was developed, which takes control when neurocontrol has saturated. It returns to neurocontrol when it returns to normal, respectively, when saturation is eliminated. What distinguishes this FSNC law is its simplicity and efficiency and especially the fact that against quite a few opponents in the field, it still works very well on quite complicated physical systems. Finally, a brief section reviews some recent works by the authors, in which current approaches to hydraulic servomechanisms are presented: the backstepping control synthesis technique, input delay treated with Lyapunov–Krasovskii functionals, and critical stability treated with Lyapunov–Malkin theory. Full article

An increasing number of soils, including those in EU countries, are affected by organic matter deficiency and the deterioration of nutrients, and using mineral fertilizers is often associated with negative environmental impacts. One of the basic recommendations for sustainable agriculture is to increase the proportion of organic fertilizers in crop production and preserve soil biodiversity. An increasingly common organic fertilizer is biogas plant digestate, the physical and chemical properties of which depend primarily on the waste material used in biogas production. However, the fertilizer value of this additive and its effects on the soil environment, including beneficial organisms, remain insufficiently studied. Soil macrofauna, particularly earthworms, play a crucial role in soil ecosystems, because they significantly impact the presence of plant nutrients, actively participate in forming soil structures, and strongly influence organic matter dynamics. The present study was undertaken to determine the effects of fertilizing a silt loam soil with the solid fraction of digestate in monoculture crop production on earthworm community characteristics and the resulting changes in selected soil physicochemical properties. The research was conducted at a single site, so the original soil characteristics across the experimental plots were identical. Plots were treated annually (for 3 years; 2021–2023) with different levels of digestate: DG100 (100% of the recommended rate; 30 t ha⁻¹), DG75 (75% of the recommended rate; 22.5 t ha⁻¹), DG50 (15 t ha⁻¹), DG25 (7.5 t ha⁻¹), and CL (a control plot without fertilizer). An electrical method was used to extract earthworms. Those found at the study site belonged to seven species representing three ecological groups: Dendrodrilus rubidus (Sav.), Lumbricus rubellus (Hoff.), and Dendrobaena octaedra (Sav.) (epigeics); Aporrectodea caliginosa (Sav.), Aporrectodea rosea (Sav.), and Octolasion lacteum (Örley) (endogeics); and Lumbricus terrestris (L.) (anecics). Significant differences in the abundance and biomass of earthworms were found between the higher level treatments (DG100, DG75, and DG50), and the lowest level of fertilization and the control plot (DG25 and CL). The DG25 and CL plots showed an average of 24.7% lower earthworm abundance and 22.8% lower biomass than the other plots. There were no significant differences in the earthworm metrics between the plots within each of the two groups (DG100, DG75, and DG50; and DG25 and CL). The most significant influence on the average abundance and average biomass of Lumbricidae was probably exerted by soil moisture and the annual dosage of digestate. A significant increase in the abundance and biomass of Lumbricidae was shown at plots DG100, DG75, and DG50 in the three successive years of the experiment. The different fertilizer treatments were found to have different effects on selected soil parameters. No significant differences were found among the values of the analyzed soil traits within each plot in the successive years of the study. Full article

Background/Objectives: Childhood obesity is a global epidemic. Addressing the modifiable risk factors with effective policies is crucial for both prevention and intervention. This scoping review aims to provide a situational analysis of childhood obesity in Greece by mapping the available evidence on the prevalence of obesity among Greek children and adolescents and exploring the existing policies implemented to address this issue. Methods: A systematic literature search was conducted on 15 September 2023, using the PubMed, Scopus, and IATROTEK-online databases to identify studies related to childhood obesity and policies in Greece. Keyword groups were developed for “childhood obesity,” “Greece,” and either “prevalence” or “policies”. Additional sources, including Google and Google Scholar, were screened to ensure comprehensiveness. Results: A total of 66 studies were included: 61 on obesity prevalence (≤18 years of age) and 5 on existing policies tackling childhood obesity, all in Greece. The collective prevalence was observed to lie within the subsequent range of values: 2.8–21.2%. Regarding both genders, the observed prevalence ranged from 2.8% to 26.7% in males, and between 1.3% and 33.7% in females. The policies adopted in Greece cover various domains (healthy nutrition, public preferences, physical activity, school policies, and programs related to childhood obesity). Conclusions: Childhood obesity in Greece is a major challenge. Greece currently uses some policies and strategies to combat childhood obesity. There is still work to be done: policies play a pivotal role as a key tool to influence lifestyle habits on a broad scale and exert a considerable impact on the reduction in this prevalent health concern. Full article

Background and Objectives: Schizophrenia is a disabling psychiatric condition, affecting around 1% of people worldwide. It has been ranked among the ten most disabling conditions globally. Alongside the psychological and social burdens imposed on individuals suffering from this disease, there are also serious complications regarding the physical health of these patients. Pneumonia is a significant cause of death in patients with schizophrenia. This group of patients also has a higher risk of developing pneumonia and all-cause mortality compared to those without schizophrenia, along with an increased overall mortality rate. A retrospective study revealed that advanced age, underweight, smoking, and the use of high-dose atypical antipsychotics increase the risk of pneumonia-related mortality in hospitalized patients. Our study aims to examine differences in factors associated with pneumonia in hospitalized patients with schizophrenia, before and after the COVID-19 pandemic, as well as to identify potential changes in clinical characteristics and outcomes. Materials and Methods: This is an observational, retrospective analysis, based on the review of medical records of psychiatric inpatients diagnosed with schizophrenia according to the DSM-5 criteria. Patients were selected according to the following criteria: both schizophrenia and pneumonia diagnoses, hospitalized in Spitalul Clinic de Psihiatrie si Neurologie Brasov during 1 March 2018–1 March 2020, and 1 March 2022–1 March 2024, respectively. Results: A total of 27 patients met the inclusion criteria; 13 patients (48%) were in the pre-pandemic group and 14 patients (52%) in the post-pandemic group. Contrary to other reports, our results showed relatively low pneumonia rates in hospitalized schizophrenia patients (1.02% pre-pandemic and 1.63% post-pandemic), and rates were higher in female patients (61.54% pre-pandemic and 71.43% post-pandemic). Post-pandemic, most cases (42.86%) were registered during summer, in a schizophrenia population with mostly urban residence and with lower smoking rates than the pre-pandemic group. Physical restraints were, however, more frequently utilized in the post-pandemic group. Conclusions: Pneumonia risk factors might register a change in the post-pandemic years. Polypharmacy and physical restraints are probably underestimated risk factors for pneumonia in schizophrenia patients, while a multidisciplinary approach and preventive measures might exert a protective role. Full article

Background: This study aimed to evaluate the changes in fat utilization associated with transitioning from a traditional to a vegan Mediterranean diet in healthy, physically active men during a ramp exercise test. Methods: In a controlled crossover design, fourteen healthy, physically active men followed a traditional Mediterranean diet for three weeks (baseline). Then, participants transitioned to a four-week isocaloric vegan version of the Mediterranean diet, matched for macronutrient distribution but excluding all animal foods. Immediately after each dietary intervention, participants completed an incremental exercise test (from 30% to 70% of VO_2peak) on a cycle ergometer in a fasted state to determine peak fat oxidation (PFO) and its associated exercise intensity (Fatmax). Exercise heart rate and the rating of perceived exertion were also recorded at each exercise intensity. Results: The traditional and vegan Mediterranean diets provided comparable amounts of energy (2599.6 ± 180.8 and 2634.9 ± 148.3 kcal/day, p = 0.140) and total fat (97.0 ± 17.8 and 99.0 ± 13.2 g/day; p = 0.620). However, the vegan Mediterranean diet contained a lower proportion of saturated fat (25.2 ± 6.8 vs. 13.6 ± 4.4% of total fat, p < 0.010). Still, the dietary transition was not associated with modifications in PFO (0.323 ± 0.153 and 0.347 ± 0.147 g/min; p = 0.678) or Fatmax (40.51 ± 7.30 and 40.51 ± 10.71%VO_2peak; p = 1.000) during exercise. Moreover, the dietary transition did not significantly change the response curves across exercise intensities for fat oxidation (p = 0.553), heart rate (p = 0.280), or the rating of perceived exertion (p = 0.433). Conclusions: Switching from a traditional to a vegan Mediterranean diet did not affect fat oxidation, exercise intensity at peak fat oxidation, or perceptual responses during exercise in healthy, active men. These findings suggest that physically active individuals can adopt a vegan version of the Mediterranean diet without compromising fat utilization during submaximal aerobic exercise. Clinical Trial Registry: NCT06008886. Date of registration: 28 July 2023. Full article