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Article

1 Citations

2,513 Views

14 Pages

A Study of a Protein-Folding Machine: Transient Rotation of the Polypeptide Backbone Facilitates Rapid Folding of Protein Domains in All-Atom Molecular Dynamics Simulations

Harutyun Sahakyan,
Karen Nazaryan,
Arcady Mushegian and
Irina Sorokina

Int. J. Mol. Sci.2023, 24(12), 10049;https://doi.org/10.3390/ijms241210049

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13 June 2023

Molecular dynamics simulations of protein folding typically consider the polypeptide chain at equilibrium and in isolation from the cellular components. We argue that in order to understand protein folding as it occurs in vivo, it should be modeled a...

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Review

41 Citations

8,269 Views

17 Pages

Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Yang Li,
Wang Li and
Zhengshuang Xu

Mar. Drugs2021, 19(6), 311;https://doi.org/10.3390/md19060311

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27 May 2021

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challen...

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Article

7 Citations

6,889 Views

14 Pages

Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

Brooke A. Anderson,
Saswata Karmakar and
Patrick J. Hrdlicka

Molecules2015, 20(8), 13780-13793;https://doi.org/10.3390/molecules200813780

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29 July 2015

Development of probes that allow for sequence-unrestricted recognition of double-stranded DNA (dsDNA) continues to attract much attention due to the prospect for molecular tools that enable detection, regulation, and manipulation of genes. We have re...

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