Search Results (86)

This study examines the extended dissipativity analysis for newly designed mixed traffic systems (MTSs) utilizing the coupling memory sampled-data control (CMSDC) approach. The traffic flow creates a platoon, and the behavior of human-driven vehicles (HDVs) is presumed to adhere to the optimal velocity model, with the acceleration of a single-linked automated vehicle regulated directly by a suggested CMSDC. The ultimate objective of this work is to present a CMSDC approach for optimizing traffic flow amidst disruptions. The primary emphasis is on the proper design of the CMSDC to ensure that the closed-loop MTS is extended dissipative and quadratically stable. A more generalized CMSDC methodology incorporating a time delay effect is created using a Bernoulli-distributed sequence. The existing Lyapunov–Krasovskii functional (LKF) and enhanced integral inequality methods offer sufficient conditions for the suggested system to achieve an extended dissipative performance index. The suggested criteria provide a comprehensive dissipative study, evaluating $L_2-L_{\infty }$, $H_{\infty }$, passivity, and dissipativity performance. A simulation example illustrates the accuracy and superiority of the proposed controller architecture for the MTS. Full article

We present a miniaturized, inexpensive, and user-friendly microfluidic platform to support biological applications. The system integrates a mini-incubator providing controlled environmental conditions and housing a microfluidic device for long-term cell culture experiments. The incubator is designed to be compatible with standard inverted optical microscopes and Raman spectrometers, allowing for the non-invasive imaging and spectroscopic analysis of cell cultures in vitro. The microfluidic device, which reproduces a dynamic environment, was optimized to sustain a passive, gravity-driven flow of medium, eliminating the need for an external pumping system and reducing mechanical stress on the cells. The platform was tested using Raman analysis and adherent tumoral cells to assess proliferation prior and subsequent to hydrogen peroxide treatment for oxidative stress induction. The results demonstrated a successful adhesion of cells onto the substrate and their proliferation. Furthermore, the platform is suitable for carrying out optical monitoring of cultures and Raman analysis. In fact, it was possible to discriminate spectra deriving from control and hydrogen peroxide-treated cells in terms of DNA backbone and cellular membrane modification effects provoked by reactive oxygen species (ROS) activity. The 800–1100 cm⁻¹ band highlights the destructive effects of ROS on the DNA backbone’s structure, as its rupture modifies its vibration; moreover, unpaired nucleotides are increased in treated sample, as shown in the 1154–1185 cm⁻¹ band. Protein synthesis deterioration, led by DNA structure damage, is highlighted in the 1257–1341 cm⁻¹, 1440–1450 cm⁻¹, and 1640–1670 cm⁻¹ bands. Furthermore, membrane damage is emphasized in changes in the 1270, 1301, and 1738 cm⁻¹ frequencies, as phospholipid synthesis is accelerated in an attempt to compensate for the membrane damage brought about by the ROS attack. This study highlights the potential use of this platform as an alternative to conventional culturing and analysis procedures, considering that cell culturing, optical imaging, and Raman spectroscopy can be performed simultaneously on living cells with minimal cellular stress and without the need for labeling or fixation. Full article

In recent years, UAV formations have garnered significant attention in fields such as reconnaissance, communications, and transportation. This paper aims to design an efficient passive localization method for UAV formations that satisfies system electromagnetic compatibility (EMC) requirements. A self-adjustment model characterized by internally active communication and externally silent operation for UAV formations is proposed, which optimizes the positions of the UAVs under test based on their current locations and standard reference positions while adhering to formation geometry constraints. By comprehensively considering constraints including the number of UAVs, formation geometry, and system EMC, this study evaluates electromagnetic radiation interference within the UAV formation system and derives an iterative adjustment scheme for formation positions. Finally, simulation experiments through specific case studies calculate polar radius deviations and polar angle deviations during the adjustment process. The results validate that the proposed method meets the requirements for both formation adjustment and EMC, thereby providing a more scientific basis for passive localization and position adjustment in UAV formations. Full article

Remote monitoring technologies have transformed healthcare delivery by enabling the in-home management of chronic conditions, improving patient autonomy, and supporting clinical oversight. Passive sensing, a subset of remote monitoring, facilitates unobtrusive, real-time data collection without active user engagement. Leveraging devices such as smartphones, wearables, and smart home sensors, these technologies offer advantages over traditional self-reports and intermittent evaluations by capturing behavioural, physiological, and environmental metrics. This systematic review evaluates the clinical utility of passive sensing technologies used in remote monitoring, with a specific emphasis on their impact on clinical outcomes and feasibility in real-world healthcare settings. A PRISMA-guided search identified 26 studies addressing conditions such as Parkinson’s disease, dementia, cancer, cardiopulmonary disorders, and musculoskeletal issues. Findings demonstrated significant correlations between sensor-derived metrics and clinical assessments, validating their potential as digital biomarkers. These technologies demonstrated feasibility and ecological validity in capturing continuous, real-world health data and offer a unified framework for enhancing patient care through three main applications: monitoring chronic disease progression, detecting acute health deterioration, and supporting therapeutic interventions. For example, these technologies successfully identified gait speed changes in Parkinson’s disease, tracked symptom fluctuations in cancer patients, and provided real-time alerts for acute events such as heart failure decompensation. Challenges included long-term adherence, scalability, data integration, security, and ownership. Future research should prioritise validation across diverse settings, long-term impact assessment, and integration into clinical workflows to maximise their utility. Full article

Zirconia crowns are employed in pediatric dentistry for the complete restoration of anterior and posterior deciduous teeth. They are considered the best option due to their esthetic appeal, high strength, biocompatibility, and resistance to wear and corrosion. This study aims to evaluate the physico-chemical, cytological, and microbial properties of zirconia crowns to determine their biocompatibility, safety for surrounding tissues, and effectiveness in preventing microbial influence on tooth tissue based on their biofilm deposition potential. XRD measurements were conducted to confirm the crown composition. For the microbiological examination, a quantitative assessment of the adhesion capacity of the analyzed strains and the formation of a mixed biofilm was performed using a Zeiss Cell Observer SD confocal microscope. This study used a mixed biofilm containing Streptococcus mutans (ATCC 25175), Lactobacillus rhamnosus (ATCC 9595), Candida albicans (ATCC 90028), and Candida albicans (ATCC 10231) to simulate the oral environment and the possible dynamics created between different types of microorganisms. A direct contact method was used to assess cytotoxic properties. The zirconia crown biomaterial shows a low ability to adhere to specific microorganisms, with L. rhamnosus predominating, indicating low clinical potential for causing inflammation of the tissues surrounding the crown. The cytotoxic properties of the biomaterial were found to be at level 2, indicating moderate cytotoxicity. Their biggest flaws are price and the need for passive fitting, which involves aggressive grinding; this is a potential limitation when it occurs in children, as their cooperation with the treatment can be difficult to guarantee. Full article

The global aging trend increases chronic diseases and lowers quality of life. Exercise is vital for physiological, cognitive, and mental health, countering age-related decline. Outdoor multidomain interventions enhance adherence, motivation, and resilience, supporting independence and well-being. Objectives: This paper aimed to apply an outdoor exercise protocol for middle-aged and older people and to study its preliminary effects on cognitive state, body composition, cardiovascular health, physical fitness, physiological function, physical activity, frailty, incidence of sarcopenia, and satisfaction with life. Methods: This protocol describes an eighteen-week, two-pronged, parallel, single-blind randomized controlled trial. This paper complies with the Consort and SPIRIT guidelines. A cohort comprising a minimum of fifty-two older adults from the University for Seniors program will be equally allocated to a multidomain training group (TG) and a passive control group (CG). Intervention: The TG will follow a multidomain outdoor intervention twice a week for a complete duration of 18 weeks, with recommendations for additional autonomous cardiorespiratory training. The supervised sessions will be divided into a 10-min warm-up session focusing on activation and joint mobility, followed by 40 min of resistance training, cardiorespiratory training, and balance and coordination; and it concludes with a 10-min cool-down featuring flexibility, relaxation, and playful emotional intelligence tasks. Cognitive training will be integrated across different parts of the session. Conclusions: This preliminary study aims to explore the feasibility and potential effectiveness of outdoor multidomain training in improving the health of older adults. Importantly, by including late middle-aged adults from the age of 55, this study also aims to explore the potential of preventive strategies initiated before reaching old age. This reflects a broader conceptualization of healthy aging as a lifelong process, where early interventions may help mitigate decline and extend independence into later life. The partnership between health professionals and physical activity fosters independence for older adults, addressing the increasing burden on health services. Full article

Wave-based control (WBC) offers a relatively novel approach to the challenge of controlling flexible mechanisms by treating the interaction between actuator and system as the launch and absorption of mechanical waves. WBC is a robust approach but has been unexplored in active suspension systems to date. This study adapts WBC to a quarter-car suspension model. Having embedded an actuator as the active element of a car suspension, a novel but simple ‘force impedance’ adaptation of WBC is introduced and implemented for effective vibration control. Testing with various input signals (pulse, sinusoidal, and random profile) highlights the active system’s significant ride comfort and rapid vibration suppression with zero steady-state error. Compared to two other models—one employing an ideal skyhook strategy and the other a passive suspension—the active system utilizing WBC outperforms across many criteria. The active controller achieves over 38% superior ride comfort compared to the skyhook model for a pulse road input. This is accomplished while adhering to WBC principles: relying solely on actuator-interface measurements, simplicity, cost-effectiveness, with no need for detailed system models, extensive sensors, or deep system knowledge. Full article

This case report explores the experience of a newly diagnosed type 2 diabetes (T2DM) patient transitioning from passive non-adherence to active adherence over a two-month period following hospital discharge. During this two-month period, he participated in four exploratory, non-interventional research interviews investigating his medication adherence, beliefs, and self-management strategies. His feedback on these research interviews highlighted the role of key communication strategies—such as patient partnership, non-judgmental communication, and interprofessional active listening—in fostering self-reflection and behavioural change. While these techniques are well-documented, there remains an urgent need to translate them into routine practice by integrating behavioural science and interprofessional collaboration into healthcare pregraduate and postgraduate education in order to increase awareness and skills in clinical environments. Full article

Passive buildings are increasing in popularity in Canada. This paper examines two passive buildings initially constructed in the past decade: the Peterborough passive multi-unit residential building (MURB) and the Wolfe Island single-family dwelling. A post-occupancy evaluation was performed on the buildings. The buildings were modelled in HOT2000 and the Passive House Planning Package (PHPP) to ensure the validity of the results. The energy bills were collected from the building owners to acquire the real-time consumption of the buildings. The models have shown a good agreement with the collected data. Furthermore, data loggers were installed in both buildings for indoor temperature monitoring to ensure that they adhere to the passive house explicit criteria. Internal gains, shading, and orientation were analyzed to assess their effect on heating and cooling loads. Peterborough MURB has shown more energy-saving potential compared to the Wolfe Island passive house. Heating load reduction has been compared, more than five times, to the cooling load reduction potential. The reduction in GHG emissions can be up to 39% when passive house parameters are applied to the Wolfe Island house. This paper has shown the potential of the passive house in relation to sustainable buildings in Northern climates. Full article

Stainless steels are used in the aeronautical industry for their corrosion resistance and good mechanical performance. The chemical treatment used to improve corrosion resistance is passivation, forming a compact, continuous, adherent chromium oxide film. This research aimed to investigate the effect of citric acid at different concentrations (citric acid; citric acid + oxalic acid, citric acid + hydrogen peroxide, and citric acid + hydrogen peroxide + ethanol) on AM 350 stainless steel passivated for 90 and 120 min at 25 and 50 °C and immersed in 5% by weight sodium chloride (NaCl) solutions. The electrochemical technique used was electrochemical impedance spectroscopy (EIS) based on ASTM-G106. The EIS (equivalent circuit) results indicate that there are one and two constant phase elements (CPE), which indicate the presence of various factors on the stainless steel surface, such as roughness and the formation of porous and passive layers, respectively. A double-layer system was employed for some samples. However, when the ethanol was added to the passivation bath, the behavior changed to a one-time constant system. The AM 350 passivated in citric and oxalic acid presented the higher corrosion resistance with values of 6 × 10⁵ Ω·cm². Full article

This study developed and evaluated a novel upper-limb rehabilitation device that integrates piano playing into task-oriented occupational therapy, addressing the limitations of traditional continuous passive motion (CPM) training in patient engagement and functional recovery. The system features a bi-axial sliding platform for precise 61-key positioning and a ten-link, four-loop robotic hand for key striking. A hierarchical control framework incorporates MIDI-based task mapping, finger optimization using an improved Hungarian algorithm, and impedance–admittance hybrid control for adaptive force–position modulation. An 8-week randomized controlled trial demonstrated that the experimental group significantly outperformed the control group, with a 74.7% increase in Fugl–Meyer scores (50.5 ± 2.5), a 14.6-point improvement in the box and block test (BBT), a 20.2-s reduction in nine-hole peg test (NHPT) time, and a 72.6% increase in rehabilitation motivation scale (RMS) scores (55.4 ± 3.8). The results indicate that combining piano playing with robotic rehabilitation enhances neuroplasticity and engagement, significantly improving motor function, daily activity performance, and rehabilitation adherence. This mechanical-control synergy introduces a new paradigm for music-interactive rehabilitation, with potential applications in home-based remote therapy and multimodal treatment integration. Full article

Intensive Care Unit-Acquired Weakness (ICUAW) is a very common condition in patients admitted to intensive care units (ICUs), even after relatively short stays. This weakness can develop with a pre-existing background of sarcopenia or cachexia, although these conditions are not always the direct cause. Over the years, much of the literature has focused on the nutritional aspect of the issue, leading to the development of widely accepted guidelines recommending the initiation of early nutrition, with the goal of achieving caloric and protein targets within the first five days of ICU admission. Despite adherence to these guidelines, several studies have shown a significant loss of muscle mass in critically ill patients, which directly impacts their ability to generate strength. However, it has become increasingly evident that nutrition alone is not sufficient to counteract this muscle loss, which is often closely linked to the prolonged immobility experienced by ICU patients due to a variety of clinical and logistical factors. In particular, there is growing evidence suggesting that even the introduction of early and minimal rehabilitation—including passive mobilization—when combined with appropriate nutritional support, can be a valuable strategy to help reduce the incidence of ICUAW. In this narrative review, we aim to summarize the current scientific knowledge on this topic, emphasizing the importance of an integrated approach that combines nutrition and early mobilization. Such a combined strategy not only holds the potential to reduce the acute incidence of ICUAW but also contributes to better recovery outcomes and, eventually, improved quality of life for these patients. Full article

The surface adhesion and stiffness of underlying substrates mediate the geometry, mechanics, and self-organization of expanding bacterial colonies. Recent studies have qualitatively indicted that stiffness may impact bacterial attachment and accumulation, yet the variation in the cell-to-surface adhesion with substrate stiffness remains to be quantified. Here, by developing a cell-level force–distance spectroscopy (FDS) technique based on atomic force microscopy (AFM), we simultaneously quantify the cell–surface adhesion and stiffness of the underlying substrates to reveal the stiffness-dependent adhesion of the phototrophic bacterium Chromatium okenii. As the stiffness of the soft substrate, modeled using a low-melting-point (LMP) agarose pad, was varied between 20 kPa and 120 kPa by changing the agarose concentrations, we observed a progressive increase in the mean adhesion force by over an order of magnitude, from $0.21\pm 0.10$ nN to $2.42\pm 1.16$ nN. In contrast, passive polystyrene (PS) microparticles of comparable dimensions showed no perceptible change in their surface adhesion, confirming that the stiffness-dependent adhesive interaction of C. okenii is of a biological origin. Furthermore, for Escherichia coli, the cell–surface adhesion varied between $0.29\pm 0.17$ nN and $0.39\pm 0.20$ nN, showing a weak dependence on the substrate stiffness, thus suggesting that stiffness-modulated adhesion is a species-specific trait. Finally, by quantifying the adhesion of the C. okenii population across different timescales, we reported the emergent co-existence of weak and strongly adherent sub-populations, demonstrating diversification of the adherent phenotypes over the growth stages. Taken together, these findings suggest that bacteria, depending on the species and their physiological stage, may actively modulate cell-to-surface adhesion in response to the stiffness of soft surfaces. While the surface properties, for instance, hydrophobicity (or hydrophilicity), play a key role in mediating bacterial attachment, this work introduces substrate stiffness as a biophysical parameter that could reinforce or suppress effective surface interactions. Our results suggest how bacteria could leverage stiffness-dependent adhesion and the diversity therein as functional traits to modulate their initial attachment to, colonization of, and proliferation on soft substrates during the early stages of biofilm development. Full article

Background: The prevalence of gingival recessions (GRs) in the global population is 78%. A long-term study showed a 47% increase in the prevalence of GRs five years post-orthodontic treatment, particularly in the lower anterior region. It can be caused and/or exacerbated after orthodontic treatment, where the retainer placed can induce tooth movement or when it fails to maintain a passive position upon bonding. Thus, the goal of this case report was to present treatments for gingival recessions, with the approaches of the laterally closed tunnel technique and parallel incision methods, after orthodontic treatment in patients using non-passive lingual retainers. Methods: This case report adhered to the CARE guidelines. Three healthy patients were referred due to GR defects in the lower anterior region (RT1 and RT2). All patients had GR associated with deficient lingual-fixed orthodontics retainers. The same experienced periodontist (ATD) developed the surgeries and aimed to achieve root coverage using the connective tissue graft associated with a coronally advanced flap (CAF) and modify the recipient area’s gingival phenotype. Results: In all cases, a new orthodontic treatment was not possible due to anatomical or patient-related factors. Outcomes after six months, three years, and five years are presented, encompassing clinical and esthetic evaluations. Conclusions: GRs must always be addressed by orthodontic therapy or lingual-fixed orthodontic retainers. In cases where dental elements are positioned outside the bone envelope, orthodontic treatment may be considered before root coverage surgery. Therefore, surgical intervention should be undertaken for the keratinized tissue and volume gain, independently of the tooth position. Modifying the phenotype in these situations is vital for the long-term maintenance of periodontal health. Full article

Online learning during the COVID-19 pandemic has positioned students as objects. They are not given a position as subjects in the teaching–learning process. The policies of the online education system have forced students to lose their rights to negotiate and interact with teachers and friends. They are required to comply with all applicable regulations in their schooling during the COVID-19 pandemic. This paper maps the objectification aspects experienced by students during online education, including the types of burdens experienced during the learning process, as well as learning evaluations that are not optimal. The qualitative method used in this paper relies on data from interviews with 30 elementary school students. The results of this paper show that the online education system during the pandemic has positioned children as passive objects who only accept the decisions of adults, depriving them of opportunities to ask questions or engage in discussions with their teachers and peers. Children were expected to adhere to all predetermined policies without being given a platform to express their perspectives. This paper concludes that learning in the time of COVID-19 has taken away the ideal meaning of education for students, which should have been realized and safeguarded according to the expected goals. Full article