Search Results (35)

Parents have a major influence on a child’s wellbeing, including the development of internalizing problems in their children. Furthermore, the influences between parents and their children could be reciprocal. This study examined the longitudinal, reciprocal association between maternal aggravation and child internalizing problems from childhood to adolescence and the potential mediating role of maternal verbal aggression. Using a sample of approximately 5000 mothers across four waves from the Future of Families & Child Wellbeing Study (FFCWS), results from a cross-lagged autoregressive model suggested that maternal aggravation was related to child internalizing problems from childhood to adolescence, whereas child internalizing problems were related to maternal aggravation only during early childhood. No mediation effect through maternal verbal aggression was found. Taken together, these findings highlight the long-term and direct impact of maternal aggravation on child internalizing problems, which has important implications for family researchers and practitioners. Full article

Parental psychological control has emerged as a significant risk factor for mental health challenges in young adults. This study aimed to investigate the relationship between parental psychological control and depression, with a specific focus on the chain mediating role of self-compassion and emotion regulation difficulties among Chinese university students. A cross-sectional survey was administered to 363 university students (aged 17–24, 43.3% males, 56.7% females), who completed measures of parental psychological control, emotion regulation difficulties, self-compassion and depression. Findings revealed a significant positive relationship between parental psychological control and depression. Both self-compassion and emotion regulation difficulties independently mediated this association. Furthermore, the chain mediation of self-compassion and emotion regulation difficulties was significant, indicating that parental psychological control was linked with increased depression through decreased self-compassion and increased emotion regulation difficulties. This study sheds light on the significance of minimizing parental psychological control and cultivating a positive family atmosphere to alleviate depression. Parental psychological control has been identified as a potential risk factor for depression, hindering the development of self-compassion, increasing emotional regulation difficulties, with the diminished self-compassion also aggravating emotion regulation difficulties. Despite the cross-sectional design limiting causal inferences, our findings still highlight potential targets for interventions aimed at reducing depression. Full article

This study uses the National Survey of Children’s Health to examine the nationwide prevalence and severity of US adolescent mental health issues in the 12–17 age group between the years 2022 and 2023 in relation to parental mental health and exposure to adverse childhood experiences (ACEs). We used the NSCH data collected for 12–17-year-old adolescents. Descriptive statistics were generated for the selected sample and binary logistics regressions were conducted to examine influential factors for the presence and severity of adolescent depression and anxiety for the selected year. Adolescents aged 12–17 who experienced neighborhood violence had higher odds of being diagnosed with anxiety (OR = 1.369, p = 0.009) and depression (OR = 1.508, p = 0.004). Those living with someone who was mentally ill, suicidal, or severely depressed showed increased odds of anxiety (OR = 1.642, p < 0.001) and depression (OR = 1.587, p < 0.001). Adolescents judged unfairly due to a health condition or disability had markedly higher odds of anxiety (OR = 3.056, p < 0.001) and depression (OR = 1.835, p < 0.001), including severe forms (severe anxiety OR = 2.569; severe depression OR = 2.238; both p < 0.001). Poorer parental emotional health was consistently associated with higher adolescent anxiety and depression, with “fair” parental emotional health showing the strongest association for depression (OR = 7.320, p < 0.001). These findings demonstrate the need for better tailored mental health efforts towards both adolescents and their caregivers highlighting the harm of long-term environmental and familial stressors, and the gaps in community approaches in this population. Full article

Objectives: This study planned to determine the biological effects associated with ZnFe₂O₄-NPs exposure using Drosophila melanogaster as an in vivo model. Methods: ZnFe₂O₄-NPs were hydrothermally synthesized, and the development of offspring flies were evaluated via dietary exposure to different doses of ZnFe₂O₄-NPs (0, 200, 400, 600 μg/mL). Rhythmic behaviors of parent male flies were monitored. Results: Internalization of ZnFe₂O₄-NPs through the intestinal barrier occurred. Oral intake of ZnFe₂O₄-NPs decreased the eclosed adult numbers and perturbed the insect developmental process. In male flies, significant upregulation of HSPs and Turandot family genes was detected, accompanied by ROS reduction and suppressed antioxidant defense responses, and exposure of ZnFe₂O₄-NPs disrupted sleep patterns of males, including a reduction in sleep duration and aggravation of sleep fragmentation. Suppressed activity levels were also found after ZnFe₂O₄-NPs exposure. Significant increased expressions of circadian genes (Clk and Cyc) were detected, alongside elevation of neurotransmitter levels and related gene expressions. Conclusions: Overall, ZnFe₂O₄-NPs can perturb development process via inducing heat shock and detoxification response, and disrupted rhythmic behaviors may be attributed to elevation of neurotransmitter levels and upregulated gene expressions of circadian genes. Our findings may offer valuable insights for evaluating ecological risks of metal-based nanoparticles and suggest potential applications in developing novel pest management strategies by utilizing insect behavioral and physiological responses to nanomaterials. Full article

This qualitative study explores the experiences of 24 parents who have experienced the death of a child, focusing on identifying practices that either facilitated or hindered their grieving process. In-depth interviews revealed key supportive practices, including emotional empathy, clear communication, and the presence of healthcare professionals during critical moments. Parents highlighted the significance of support groups, such as “Renacer”, in providing emotional connection, hope, and the opportunity for personal transformation. However, negative experiences emerged related to impersonal communication, lack of empathy, and delays in bureaucratic processes, which aggravated the pain and hindered emotional adjustment over time. The findings underscore the importance of personalized, empathetic care and the need for more efficient systems in supporting grieving parents. These insights can guide professionals in improving grief care, emphasizing respect for the emotional needs of parents and the creation of safe, supportive environments. Full article

Radioresistance remains a major obstacle in cervical cancer treatment, frequently engendering tumor relapse and metastasis. However, the details of its mechanism of action remain largely enigmatic. This study delineates the prospective impacts of short-form human T-cell lymphoma invasion and metastasis 2 (TIAM2S) involving the radiation resistance of cervical cancer. In this study, we established three pairs of radioresistant (RR) cervical cancer cells (HeLa, C33A and CaSki) and their parental wild-type (WT) cells. We revealed a consistent augmentation of TIAM2S, but not long-form human T-cell lymphoma invasion and metastasis 2 (TIAM2L) were displayed in RR cells that underwent a 6 Gy radiation administration. Remarkably, RR cells exhibited decreased radiosensitivity and abridged apoptosis, as estimated through a clonogenic survival curve assay and Annexin V/Propidium Iodide apoptosis assay, respectively. TIAM2S suppression increased radiosensitivity and enhanced cell apoptosis in RR cells, whereas its forced introduction modestly abolished radiosensitivity and diminished WT cell apoptosis. Furthermore, TIAM2S overexpression notably aggravated RR cell migration, whereas its blockage reduced WT cell mobilities, as confirmed by an in vitro time-lapse recording assay. Notably, augmented lung localization was revealed after a tail-vein injection of CaSki-RR cells using the in vivo short-term lung locomotion BALB/c nude mouse model. TIAM2S impediment notably reduced radioresistance-increased lung locomotion. This study provides evidence that TIAM2S may operate as an innovative signature in cervical cancer that is resistant to radiotherapy. It displays multi-faceted roles including radioprotection, restricting apoptosis, promoting cell proliferation, and escalating cell migration/metastasis. Targeting TIAM2S, together with conventional radiotherapy, may be an innovative strategy for intensifying radiosensitivity and protecting against subsequent uncontrolled tumor growth and metastasis in cervical cancer treatment. Full article

Background: The work main purposes were to identify the sources of problems and demands causing parental burnout and to specify the resources/support factors during the COVID-19 pandemic. The study was based on the Balance Theory of Risk and Support/Resource Factors (BR² Model) by Mikolajczak and Roskam. Methods: The study explored the predictive value of socio-economic variables, religiosity, the meaning of life, positivity, perceived social support, family functionality, and balance between risks and resources in parental burnout using the structural equation modelling method on a sample of 337 parents. Results: The presence of children’s learning difficulties and behavioural problems are the most important risk factors and aggravate parental burnout, and the presence of a meaning of life, support coming from the family, family affection, and relationship lengths are the main protective resources, allowing parental burnout to decrease during the pandemic crisis. Conclusions: The findings are instructive for both theory and practice. The study successfully operationalised the BR² model—the model obtained from the path analysis fits well, confirms the structure of parental burnout theory, and demonstrates the appropriateness of the application of BR² theory in crisis conditions. The most effective way to help parents in a crisis situation is (in addition to psychological support) the effective provision of specialist help for children, resulting in a reduced risk of an unfavourable balance between demands and family resources. The family- or parent-oriented interventions that address professional help in problems with children can be the most effective at reducing the negative consequences of a pandemic on children and their parents. The COVID-19 pandemic has shown the importance of investing in healthcare infrastructures. Full article

Autism spectrum disorder is a neurodevelopmental disorder that presents with repetitive behavior and weakness in social interaction. The nutritional problems experienced by children with autism aggravate the symptoms of autism, but also cause aggravation of the gastrointestinal system, an increase in hyperactivity disorders and sleep problems. This study was conducted to measure the effects of the nutritional status of children with autism on GIS symptoms, hyperactivity disorders and sleep problems. This study was conducted to measure the effects of the nutritional status of children with autism on GIS symptoms, hyperactivity disorders and sleep problems. The study was carried out with the families of children with autism at Kartal Umut Işığı Special Education and Rehabilitation Center. Within the scope of the study, a questionnaire consisting of four parts was given to the parents of 62 children with autism. The questionnaire included a voluntary consent form, personal information form, Conners Parent Rating Scale (CADS-48) and food frequency questionnaire. The parents completed these questionnaires in a face-to-face environment. The data obtained from the questionnaires were analyzed and presented with the SPSS 22 program. As a result of the study, it was found that different food groups can affect GI problems, hyperactivity disorders and sleep problems. It was found that the children who consumed dry broad beans did not have GIS complaints, and the children who consumed fast food experienced the problem of hyperactivity more regularly (p < 0.05). It was concluded that children who did not have GIS problems did not have sleep problems (p < 0.05). It was confirmed that simple carbohydrate consumption causes hyperactivity in children, but no significant results were found regarding GI problems and sleep disorders in the literature, and there are studies that overlap or contradict our study. More work is needed on this subject. Full article

Congenital cataract (CC), the most prevalent cause of childhood blindness and amblyopia, necessitates prompt and precise genetic diagnosis. The objective of this study is to identify the underlying genetic cause in a Swiss patient with isolated CC. Whole exome sequencing (WES) and copy number variation (CNV) analysis were conducted for variant identification in a patient born with a total binocular CC without a family history of CC. Sanger Sequencing was used to confirm the variant and segregation analysis was used to screen the non-affected parents. The first de novo missense mutation at c.391T>C was identified in exon 3 of CRYGC on chromosome 2 causing the substitution of a highly conserved Tryptophan to an Arginine located at p.Trp131Arg. Previous studies exhibit significant changes in the tertiary structure of the crystallin family in the following variant locus, making CRYGC prone to aggregation aggravated by photodamage resulting in cataract. The variant can be classified as pathogenic according to the American College of Medical Genetics and Genomics (ACMG) criteria (PP3 + PM1 + PM2 + PS2; scoring 10 points). The identification of this novel variant expands the existing knowledge on the range of variants found in the CRYGC gene and contributes to a better comprehension of cataract heterogeneity. Full article

Social risk factors are long-term or repeated environmental exposures in childhood and youth that change the brain and may, via epigenetic effects, change gene expression. They thus have the power to initiate or aggravate mental disorders. Because these effects can be mediated via hormonal or immune/inflammatory pathways that differ between men and women, their influence is often sex-specific. The goal of this narrative review is to explore the literature on social risk factors as they affect women with schizophrenia. We searched the PubMed and Scopus databases from 2000 to May 2023 using terms referring to the various social determinants of health in conjunction with “women” and with “schizophrenia”. A total of 57 studies fulfilled the inclusion criteria. In the domains of childhood and adult abuse or trauma, victimization, stigma, housing, and socioeconomics, women with schizophrenia showed greater probability than their male peers of suffering negative consequences. Interventions targeting appropriate housing, income support, social and parenting support, protection from abuse, violence, and mothering-directed stigma have, to different degrees, yielded success in reducing stress levels and alleviating the many burdens of schizophrenia in women. Full article

The effect of maternal folate status on the fetal central nervous system (CNS) is well recognized, while evidence is emerging that such an association also exists between fathers and offspring. The biological functions of telomeres and telomerase are also related to neural cell proliferation and apoptosis. The study aimed to investigate the effect of parental folate deficiency on the proliferation and apoptosis of neural stem cells (NSCs) in neonatal offspring and the role of telomeres in this effect. In this study, rats were divided into four groups: maternal folate-deficient and paternal folate-deficient diet (D-D) group; maternal folate-deficient and paternal folate-normal diet (D-N) group; maternal folate-normal and paternal folate-deficient diet (N-D) group; and the maternal folate-normal and paternal folate-normal diet (N-N) group. The offspring were sacrificed at postnatal day 0 (PND0), and NSCs were cultured from the hippocampus and striatum tissues of offspring for future assay. The results revealed that parental folate deficiency decreased folate levels, increased homocysteine (Hcy) levels of the offspring’s brain tissue, inhibited proliferation, increased apoptosis, shortened telomere length, and aggravated telomere attrition of offspring NSCs in vivo and in vitro. In vitro experiments further showed that offspring NSCs telomerase activity was inhibited due to parental folate deficiency. In conclusion, parental folate deficiency inhibited the proliferation and increased apoptosis of offspring NSCs, maternal folate deficiency had more adverse effects than paternal, and the mechanisms may involve the telomere attrition of NSCs. Full article

In the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics and post-TBI outcomes (functional recovery, post-concussion depression, anxiety) and their impact on disease-specific health-related quality of life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using a structural equation model (SEM). The final SEM evaluates the associations between these four latent variables. We retrospectively investigated 152 children (8–12 years) and 148 adolescents (13–17 years) after TBI at the recruiting clinics or online. The final SEM displayed a fair goodness-of-fit (SRMR = 0.09, RMSEA = 0.08 with 90% CI [0.068, 0.085], GFI = 0.87, CFI = 0.83), explaining 39% of the variance across the four latent variables and 45% of the variance in HRQoL in particular. The relationships between pre-injury and post-injury outcomes and between post-injury outcomes and TBI-specific HRQoL were moderately strong. Especially, pre-injury characteristics (children’s age, sensory, cognitive, or physical impairments, neurological and chronic diseases, and parental education) may aggravate post-injury outcomes, which in turn may influence TBI-specific HRQoL negatively. Thus, the SEM comprises potential risk factors for developing negative post-injury outcomes, impacting TBI-specific HRQoL. Our findings may assist healthcare providers and parents in the management, therapy, rehabilitation, and care of pediatric individuals after TBI. Full article

The placebo response has a substantial impact on treatment outcome. However, data regarding mediators of the placebo response in children with autism spectrum disorder (ASD) are sparse. This retrospective study investigated possible mediators of the placebo response among participants of a placebo-controlled trial of cannabinoid treatment for behavioral problems in children with ASD (CBA trial, age 5–21 years). We used a specifically designed questionnaire to explore possible mediators of the placebo response in 88 participants of the CBA trial who received a placebo and had valid outcome scores. The parents of 67 participants completed the questionnaire. The placebo response was positively associated with the child’s comprehension of the treatment purpose (p = 0.037). There was also a trend for participants who had a relative aggravation of symptoms before treatment onset to improve following placebo treatment (p = 0.053). No other domains, including parental expectations, previous positive experience with similar treatments (behavioral conditioning), parental locus of control, quality of the patient–physician relationships, and adherence to study medications were associated with placebo-response. This finding suggests that efforts to explain the treatment purpose to children with disabilities may enhance treatment efficacy in clinical practice and decrease differences in the placebo response between study arms. Contrary to our hypothesis, parental expectations regarding cannabinoid treatment were not associated with the placebo response. Full article

This Aboriginal-led study explores Aboriginal and Torres Strait Islander parents’ experiences of COVID-19. 110 Aboriginal and Torres Strait Islander parents were interviewed between October 2020 and March 2022. Participants were recruited through community networks and partner health services in South Australia, Victoria, and Northern Territory, Australia. Participants were predominantly female (89%) and based in Victoria (47%) or South Australia (45%). Inductive thematic analysis identified three themes: (1) Changes to daily living; (2) Impact on social and emotional wellbeing; and (3) Disconnection from family, community, and culture. COVID-19 impacted Aboriginal and Torres Strait Islander families. Disruption to cultural practice, and disconnection from country, family, and community was detrimental to wellbeing. These impacts aggravated pre-existing inequalities and may continue to have greater impact on Aboriginal and Torres Strait Islander parents and communities due to intergenerational trauma, stemming from colonisation, violence and dispossession and ongoing systemic racism. We advocate for the development of a framework that ensures an equitable approach to future public health responses for Aboriginal and Torres Strait Islander people. Full article

(1) Introduction: The aim of our research was to explore emotional/behavioral changes in adolescents with neuropsychiatric conditions during the COVID-19 pandemic, and parental stress levels through a standardized assessment, comparing the data collected before and during the first months of lockdown. Moreover, an additional goal was to detect a possible relationship between emotional/behavioural symptoms of adolescents and the stress levels of their parents. (2) Methods: We enrolled 178 Italian adolescents aged between 12–18 that were referred to the Child Neuropsychiatry Unit of the University Hospital of Salerno with different neuropsychiatric diagnoses. Two standardized questionnaires were provided to all parents for the assessment of parental stress (PSI-Parenting Stress Index-Short Form) and the emotional/behavioral problems of their children (Child Behaviour Check List). The data collected from questionnaires administered during the six months preceding the pandemic, as is our usual clinical practice, were compared to those recorded during the pandemic. (3) Results: The statistical comparison of PSI and CBCL scores before/during the pandemic showed a statistically significant increase in all subscales in the total sample. The correlation analysis highlighted a significant positive relationship between Parental Stress and Internalizing/Externalizing symptoms of adolescent patients. Age and gender did not significantly affect CBCL and PSI scores, while the type of diagnosis could affect behavioral symptoms and parental stress. (4) Conclusions: our study suggests that the lockdown and the containment measures adopted during the COVID-19 pandemic could have aggravated the emotional/behavioral symptoms of adolescents with neuropsychiatric disorders and the stress of their parents. Further studies should be conducted in order to monitor the evolution of these aspects over time. Full article