You are currently viewing a new version of our website. To view the old version click .

5 Results Found

  • Article
  • Open Access
1,209 Views
24 Pages

Novel Gene-Informed Regional Brain Targets for Clinical Screening for Major Depression

  • G. Lorenzo Odierna,
  • Christopher F. Sharpley,
  • Vicki Bitsika,
  • Ian D. Evans and
  • Kirstan A. Vessey

Background/Objectives: Major Depression (MD) is a common disorder that has significant social and economic impacts. Approximately 30% of all MD patients are refractory to common treatments, representing a major obstacle to managing the impacts of dep...

  • Article
  • Open Access
15 Citations
6,122 Views
19 Pages

Effective Connectivity in the Human Brain for Sour Taste, Retronasal Smell, and Combined Flavour

  • Justin Long Kiu Suen,
  • Andy Wai Kan Yeung,
  • Ed X. Wu,
  • Wai Keung Leung,
  • Hiroki C. Tanabe and
  • Tazuko K. Goto

29 August 2021

The anterior insula and rolandic operculum are key regions for flavour perception in the human brain; however, it is unclear how taste and congruent retronasal smell are perceived as flavours. The multisensory integration required for sour flavour pe...

  • Article
  • Open Access
7 Citations
4,197 Views
22 Pages

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

  • Anja Schulze-Krebs,
  • Fabio Canneva,
  • Judith Stemick,
  • Anne-Christine Plank,
  • Julia Harrer,
  • Gillian P. Bates,
  • Daniel Aeschlimann,
  • Joan S. Steffan and
  • Stephan von Hörsten

18 August 2021

Mammalian transglutaminases (TGs) catalyze calcium-dependent irreversible posttranslational modifications of proteins and their enzymatic activities contribute to the pathogenesis of several human neurodegenerative diseases. Although different transg...

  • Article
  • Open Access
929 Views
20 Pages

Ultrastructural Characterization of Developmental Stages and Head Sensilla in Portici okadai, Vector of Thelazia callipaeda

  • Da Sun,
  • Yang Luo,
  • Yikang Wang,
  • Hongle Cui,
  • Yanting Gou,
  • Juan Zhou,
  • Bo Luo,
  • Hui Liu,
  • Rong Yan and
  • Lingjun Wang

20 May 2025

Phortica okadai, a vector of Thelazia callipaeda, is associated with an increasing incidence of thelaziasis. The complex habitat and chemosensory system of P. okadai are critical for its proliferation and expansion. However, ultrastructural data acro...

  • Review
  • Open Access
12 Citations
5,441 Views
13 Pages

Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons’ Degeneration: Link to Parkinson’s Disease

  • Marcello Serra,
  • Annalisa Pinna,
  • Giulia Costa,
  • Alessandro Usiello,
  • Massimo Pasqualetti,
  • Luigi Avallone,
  • Micaela Morelli and
  • Francesco Napolitano

Rhes is one of the most interesting genes regulated by thyroid hormones that, through the inhibition of the striatal cAMP/PKA pathway, acts as a modulator of dopamine neurotransmission. Rhes mRNA is expressed at high levels in the dorsal striatum, wi...