Search Results (7,027)

Large soil pores critically influence water and solute transport in soils. The presence of preferential flow paths created by soil macropores can profoundly impact water quality, underscoring the necessity of accurately assessing the characteristics of these macropores. However, it remains unclear whether variations in macropore structure exist between different altitudes and positions of terraced paddy fields. The primary objective of this research was to utilize X-ray computed tomography (CT) and image analysis techniques to characterize the soil pore structure at both the inner field and ridge positions across different altitude levels (high, medium, and low altitude) within terraced paddy fields. The results indicate that there are significant differences in the distribution of large soil pores at different altitudes, with large pores concentrated in the surface layer (0–10 cm) in low-altitude areas, while in high-altitude areas, the distribution of large pores is more uniform. Additionally, as altitude increases, the porosity of large pores shows an increasing trend. The three-dimensional equivalent diameter and large pore volume are primarily characterized by large pores ranging from 1 to 2 mm and 0 to 5 mm³, respectively, with their morphology predominantly appearing spherical or ellipsoidal. The connectivity of large pores in the surface layer of paddy soil is stronger than that in the bunds. However, this connectivity gradually weakens with increasing soil depth. The findings from this study provide valuable quantitative insights into the unique characteristics of soil macropores that vary according to the altitude and position in terraced paddy fields. Moreover, this study emphasizes the necessity for future research that encompasses a broader range of soil types, altitudes, and terraced paddy locations to validate and further explore the identified relationships between altitude and macropore characteristics. Full article

Effective building operation requires a careful balance between energy conservation and indoor environmental comfort. Although numerous methods have been developed to reduce energy consumption during the operational phase, their objectives and applications vary widely. However, the complexity of building energy management makes it challenging to identify the most suitable methods that simultaneously achieve both comfort and efficiency goals. Existing studies often lack a systematic framework that supports integrated decision-making under comfort constraints. This research aims to address this gap by proposing a decision-making tree for selecting energy conservation methods during building operation with an explicit consideration of indoor environmental comfort. A comprehensive literature review is conducted to identify four main energy-consuming components during building operation: the building envelope, HVAC systems, lighting systems, and plug loads and appliances. Three key comfort indicators—thermal comfort, lighting comfort, and air quality comfort—are defined, and energy conservation methods are categorized into three strategic groups: passive strategies, control optimization strategies, and behavioural intervention strategies. Each method is assessed using a defined set of evaluation criteria. Subsequently, a questionnaire survey is administered for the calibration of the decision tree, incorporating stakeholder preferences and expert judgement. The findings contribute to the advancement of understanding regarding the co-optimization of energy conservation and occupant comfort in building operations. Full article

Background/Objectives: Pulmonary vein isolation (PVI) via cryoballoon ablation (CBA) is a recommended therapeutic strategy for patients with symptomatic paroxysmal and persistent atrial fibrillation (AF) who are refractory to antiarrhythmic drugs. Although PVI has demonstrated efficacy in reducing AF recurrence and improving patients’ quality of life, its impact on respiratory function is not well understood, particularly in patients with comorbid conditions. The aim of the study was to search for functional predictors of the respiratory system in the process of evaluating the efficiency of clinical assessment of CBA in patients with AF. Methods: We conducted a prospective study on 42 patients with symptomatic AF who underwent CBA, assessing their respiratory function through spirometry before and 30 days after the procedure. Exclusion criteria included pre-existing lung disease and cardiac insufficiency. The impact of variables such as body mass index (BMI), coronary artery disease (CAD) and heart failure (HF) on spirometry parameters was analyzed using statistical tests. Results: No significant changes were observed in overall post-PVI spirometry parameters for the full cohort. However, post hoc analyses revealed a significant decline in ΔMEF₇₅ in patients with CAD and BMI ≥ 30 kg/m², whereas ΔFEV₁/FVCex was significantly increased in patients with HF, as well as in patients with ejection fraction (EF) < 50%. Conclusions: CBA for AF does not universally affect respiratory function in the short term, but specific subgroups, including patients with CAD and a higher BMI, may require post-procedure respiratory monitoring. In addition, PVI may improve lung function in patients with HF and reduced EF. Full article

Background/Objectives: Oral cancer resection often leads to maxillofacial defects and dentition loss, compromising patients’ quality of life. Implant-supported prosthetic rehabilitation offers a reliable solution to restore function, though factors such as bone reconstruction, radiotherapy, and timing of implant placement (immediate vs. delayed) may influence outcomes. This study aimed to evaluate long-term implant survival and rehabilitation timelines in oncologic patients, comparing two cohorts (2005–2014 and 2015–2024) to assess the impact of evolving clinical practices. Methods: A retrospective cohort study was conducted at Hospital General Universitario Gregorio Marañón (Madrid, Spain), including 304 patients who underwent ablative oral cancer surgery and subsequent implant-based rehabilitation between 2005 and 2024. Data on demographics, oncologic treatment, reconstruction, implant timing, and prosthetic rehabilitation were collected. Outcomes were compared using Kaplan–Meier analysis and appropriate statistical tests between the 2005–2014 (n = 122) and 2015–2024 (n = 182) cohorts. Results: A total of 2341 Ticare Implants^® were placed, supporting 281 prostheses. Implant placement during primary surgery increased from 41% to 71% (p < 0.001). The median time from surgery to prosthesis significantly decreased from 24 to 15 months (p < 0.001). Five-year implant survival was 95% in the early cohort versus 97% in the later cohort. Implant survival was comparable between irradiated and non-irradiated patients (~94–96%). Fixed prostheses became more frequent (92% vs. 79%, p = 0.002). Conclusions: Implant-supported rehabilitation in oncologic patients is highly feasible and durable, with improved timelines and functional outcomes associated with early implant placement and modern digital planning strategies. Full article

Objective: The objective of this study was to assess changes in body composition, with a specific focus on fat mass (FM) and fat-free mass (FFM), in obese adults with type 2 diabetes (T2D) treated with once-weekly (OW) subcutaneous (s.c.) semaglutide. Methods: This was a single-center, 12-month, real-world, ambispective study (6-month prospective and 6-month retrospective). Body composition parameters were assessed via segmental multifrequency bioelectrical impedance analysis (SMF-BIA). Results: A total of 117 patients with DM2, with a median age of 56 years, a median HbA1c level of 9.4%, and a median body weight of 102.5 kg, were included in the study. The median body weight, body fat mass, and visceral fat significantly decreased at 6 months, with values of −9.3, −7.5, and −1.8 kg, respectively. There were further reductions from 6 to 12 months, albeit at a slower rate. The median skeletal muscle mass significantly decreased at 6 months (−1.2 kg), although no further significant reductions were observed at 12 months. Conclusions: OW s.c. semaglutide for 12 months significantly improved body composition parameters, mainly at the expense of fat mass loss, with the preservation of skeletal muscle mass. These changes are clinically meaningful, since they impact general metabolic health and are associated with improvements in metabolic control and clinical parameters associated with renal and CV risks, as well as presumable improvements in quality of life. Full article

Background/Objectives: Cannabidiol (CBD) is a non-intoxicating cannabinoid touted for a variety of medical benefits, including alleviation of anxiety. While legalization of hemp-derived products in the United States (containing ≤0.3% delta-9-tetrahydrocannabinol [d9-THC] by weight) has led to a rapid increase in the commercialization of hemp-derived CBD products, most therapeutic claims have not been substantiated using clinical trials. This trial aimed to assess the impact of 6 weeks of treatment with a proprietary hemp-derived, full-spectrum, high-CBD sublingual solution similar to those available in the marketplace in patients with anxiety. Methods: An open-label pilot clinical trial (NCT04286594) was conducted in 12 patients with at least moderate levels of anxiety. Patients self-administered a hemp-derived, high-CBD sublingual solution twice daily during the 6-week trial (target daily dose: 30 mg/day CBD). Clinical change over time relative to baseline was assessed for anxiety, mood, sleep, and quality of life, as well as changes in cognitive performance on measures of executive function and memory. Safety and tolerability of the study product were also evaluated. Results: Patients reported significant reductions in anxiety symptoms over time. Concurrent improvements in mood, sleep, and relevant quality of life domains were also observed, along with stable or improved performance on all neurocognitive measures. Few side effects were reported, and no serious adverse events occurred. Conclusions: These pilot findings provide initial support for the efficacy and tolerability of the hemp-derived, high-CBD product in patients with moderate-to-severe levels of anxiety. Double-blind, placebo-controlled studies are indicated to obtain robust data regarding efficacy and tolerability of these types of products for anxiety. Full article

The difficulty and manual nature of procuring human evaluators for ranking the quality of images affected by various types of degradations, and of those cleaned up by developed algorithms, has lead to the widespread adoption of automated metrics, like the Peak Signal-to-Noise Ratio (PSNR) and the Structural Similarity Index Metric (SSIM). However, disparities between rankings given by these metrics and those given by human evaluators have encouraged the development of improved image quality assessment (IQA) metrics that are a better fit for this purpose. These methods have been previously used solely for quality assessments and not as objectives in the training of neural networks for high-level vision tasks, despite the potential improvements that may come about by directly optimizing for desired metrics. This paper examines the adequacy of ten recent IQA metrics, compared with standard loss functions, within two trained dehazing neural networks, with observed broad improvement in their performance. Full article

Context: Many patients at the end of life receive antibiotics to alleviate symptoms and improve quality of life; however, clear guidelines supporting decision making about the use of antibiotics are still lacking. Objectives: This study aimed to evaluate the benefits and harms of antibiotic use among patients under a palliative care community support team in Portugal. Methods: An observational, cross-sectional, retrospective study was conducted on 249 patients who died over a two-year period, having been followed for at least 30 days prior to their death. Data included patient demographics, clinical diagnoses, antibiotic prescriptions, and symptomatic outcomes. The effects of commonly prescribed antibiotics—amoxicillin + clavulanic acid, cefixime, ciprofloxacin, and levofloxacin—were compared using statistical analyses to assess survival, symptom intensity, and functional scales. Results: Adverse events, primarily infections and secretions, occurred in 57.8% of cases, with 33.7% receiving antibiotics. No significant difference in survival was observed across the antibiotic groups (p = 0.990). Symptom intensity significantly reduced after 72 h of treatment (p < 0.05), with ciprofloxacin demonstrating the greatest symptom control. The Palliative Outcome Scale decreased uniformly, with higher scores associated with amoxicillin + clavulanic acid (p = 0.004). The Palliative Performance Scale declined post-treatment, with significant changes noted for cefixime and ciprofloxacin (p < 0.05). Conclusions: Antibiotics may improve symptom control and quality of life in the end-of-life stage. While second-line antibiotics may offer additional benefits, the heterogeneity of the sample and limited adverse effect data underscore the need for further research to guide appropriate prescription practices in palliative care. Full article

Background/Objectives: Cardiovascular diseases (CVDs) are frequently associated with psychiatric and cognitive comorbidities. These conditions have been shown to significantly impact quality of life and clinical outcomes. This study aims to evaluate the prevalence of anxiety, depression, and cognitive deficits in patients with CVD and to compare the results with existing evidence in the literature. Methods: A total of 74 patients were assessed using the following standardized screening tools: Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI). A systematic review was then conducted to compare the findings with those reported in the literature. Results: Most previous studies using the MoCA reported an over 70% absence of cognitive impairment, whereas this study shows a balanced distribution between the absence of (32.4%) and mild (35%) or moderate (32%) impairment. Studies with the MMSE indicated high rates of absence of cognitive deficits (74–79%), but here, the rate of absence was lower (58%), with an increase in mild impairment (42%). Regarding depression, compared with studies showing only absence or moderate/severe forms, this study reveals a more balanced profile, with 57% without depression and with varying severity levels (22% mild, 19% moderate, and 3% severe). Finally, for anxiety, unlike previous asymmetric distributions, greater variability was observed, with 58% without anxiety and significant percentages of mild (26%), moderate (12%), and severe (4%) anxiety. Conclusions: The results highlight a significant and varied prevalence of anxiety, depression, and cognitive deficits, emphasizing the importance of a multidimensional assessment to improve clinical management and therapeutic outcomes. Full article

Background/Objectives: Additive manufacturing (AM) technology has emerged as an innovative approach in dentistry. Recently, manufacturers have developed permanent resins engineered explicitly for the fabrication of definitive prostheses using AM techniques. This systematic review evaluated the mechanical and physical properties of 3D-printed permanent resins in comparison to milled resins and hybrid ceramics for the fabrication of indirect dental restorations. Methods: Three electronic databases—Scopus, Web of Science, and PubMed—were searched for English-language articles. Two independent researchers conducted study selection, data extraction, quality assessment, and the evaluation of the certainty of evidence. In vitro studies assessing the mechanical and physical properties of the permanent resins were included in this review. Results: A total of 1779 articles were identified through electronic databases. Following full-text screening and eligibility assessment, 13 studies published between 2023 and 2024 were included in this qualitative review. The investigated outcomes included physical properties (surface roughness, color changes, water sorption/solubility) and mechanical properties (flexural strength, elastic modulus, microhardness). Conclusions: Three-dimensionally printed permanent resins show promising potential for fabricating indirect dental restorations. However, the current evidence regarding their mechanical and physical properties remain limited and inconsistent, mainly due to variability in study methodologies. Full article

Strawberries are highly perishable fruits prone to postharvest losses due to defects, diseases, and uneven ripening. This study proposes a deep learning-based approach for automated quality assessment using the YOLOv8n object detection model. A custom dataset of 5663 annotated strawberry images was compiled, covering eight quality categories, including anthracnose, gray mold, powdery mildew, uneven ripening, and physical defects. Data augmentation techniques, such as rotation and Gaussian blur, were applied to enhance model generalization and robustness. The model was trained over 100 and 200 epochs, and its performance was evaluated using standard metrics: Precision, Recall, and mean Average Precision (mAP). The 200-epoch model achieved the best results, with a mAP50 of 0.79 and an inference time of 1 ms per image, demonstrating suitability for real-time applications. Classes with distinct visual features, such as anthracnose and gray mold, were accurately classified. In contrast, visually similar categories, such as ‘Good Quality’ and ‘Unripe’ strawberries, presented classification challenges. Full article

Background: Environmental enrichment is a promising strategy to improve the welfare of dairy goats and sheep. However, studies in this field remain scattered, and its effects on productivity are unclear. Objectives: To evaluate the effects of environmental enrichment on behavioral, physiological, and productive parameters in dairy goats and sheep. Data sources: Scopus and Web of Science were searched for studies published from 2010 to 2025. Study eligibility criteria: Experimental or observational peer-reviewed studies comparing enriched vs. non-enriched housing in dairy goats or sheep, reporting on welfare or productivity outcomes. Methods: This review followed PRISMA 2020 guidelines and the PICO framework. Two independent reviewers screened and extracted data. Risk of bias was assessed with the SYRCLE tool. Results: Thirteen studies were included, mostly with goats. Physical, sensory, and social enrichments showed benefits for behavior (e.g., activity, fewer stereotypies) and stress physiology. However, results varied by social rank, enrichment type, and physiological stage. Only three studies assessed productive parameters (weight gain in kids/lambs); none evaluated milk yield or quality. Limitations: Most studies had small samples and short durations. No meta-analysis was conducted due to heterogeneity. Conclusions: Environmental enrichment can benefit the welfare of dairy goats and sheep. However, evidence on productivity is scarce. Long-term studies are needed to evaluate its cost-effectiveness and potential impacts on milk yield and reproductive performance. Full article

Background/Objective: The most effective strategy for addressing users’ prosthetic needs is a comprehensive clinical assessment that provides a holistic understanding of the individual’s symptoms, health, function, and environmental barriers and facilitators. A standardized evaluation form would provide guidance for a structured approach to comprehensive clinical assessments of people with LLA. The objective of this study was to determine a list of relevant elements to be included in prosthetic evaluation for adults with lower limb amputation. Methods: Three independent focus group discussions were conducted with prosthetists (n = 15), prosthesis users (n = 11), and decision makers (n = 4) to identify all relevant elements that should be included in the clinical assessment of prosthetic services. The final content was then determined using the Delphi technique, with 35 panelists (18 prosthetists and decision makers, and 17 prosthesis users) voting in each round. Results: A total of 91 elements were identified through the focus group, of which 78 were included through the Delphi process. The identified elements are mostly related to the physical health of the prosthesis user (e.g., mobility, pain, and medical information), while others address personal or psychosocial aspects (e.g., activities of daily living, goals, and motivation) or technical aspects (prosthesis-related). Conclusions: Through a Delphi consensus, a list of relevant elements to be included in a prosthetic evaluation was generated. These results will inform the development of a standardized clinical prosthetic assessment form. This form has the potential to improve the quality of clinical evaluations, guide interventions, and enhance the well-being of prosthetic users. Full article

Objectives: The aim of this study was to examine the impact of physical activity levels and body mass index (BMI) on the quality of life among university students. Methods: The sample consisted of 495 students (176 males and 319 females). Physical activity was assessed using the International Physical Activity Questionnaire—Short Form (IPAQ-SF), while quality of life was measured using the WHOQOL-BREF questionnaire. Pearson’s correlation coefficient and regression analysis were employed to determine relationships and predictive influence. Data were analyzed using SPSS version 20, with the level of significance set at p < 0.05. Results: The results indicated that male students reported significantly higher levels of moderate and vigorous intensity physical activity compared to female students (p = 0.015 and p = 0.001, respectively), as well as higher scores in the physical health and social relationships domains of quality of life (p = 0.002 and p = 0.001, respectively). Both physical activity and BMI had a statistically significant impact on the physical health (p = 0.040 for males; p = 0.024 for females) and psychological health (p = 0.047 for males; p = 0.000 for females) domains. Specifically, moderate-intensity PA positively influenced physical health (β = 0.21, p = 0.005), while BMI was a predictor of psychological health in males (β = 0.18, p = 0.016). Among females, BMI negatively influenced physical health (β = −0.18, p = 0.002), and both low-intensity PA (β = 0.17, p = 0.002) and BMI (β = −0.21, p = 0.000) significantly affected psychological health. Conclusions: These findings underscore the importance of promoting diverse forms of physical activity and maintaining a healthy BMI in student populations, with consideration for gender-specific approaches to maximize quality of life outcomes. Full article

(1) Background and objectives: Large language models (LLMs) such as GPT, Mistral, and LLaMA exhibit strong capabilities in text generation, yet assessing the quality of their reasoning—particularly in open-ended and argumentative contexts—remains a persistent challenge. This study introduces Dialectical Agent, an internally developed modular framework designed to evaluate reasoning through a structured three-stage process: opinion, counterargument, and synthesis. The framework enables transparent and comparative analysis of how different LLMs handle dialectical reasoning. (2) Methods: Each stage is executed by a single model, and final syntheses are scored via two independent LLM evaluators (LLaMA 3.1 and GPT-4o) based on a rubric with four dimensions: clarity, coherence, originality, and dialecticality. In parallel, a rule-based semantic analyzer detects rhetorical anomalies and ethical values. All outputs and metadata are stored in a Neo4j graph database for structured exploration. (3) Results: The system was applied to four open-weight models (Gemma 7B, Mistral 7B, Dolphin-Mistral, Zephyr 7B) across ten open-ended prompts on ethical, political, and technological topics. The results show consistent stylistic and semantic variation across models, with moderate inter-rater agreement. Semantic diagnostics revealed differences in value expression and rhetorical flaws not captured by rubric scores. (4) Originality: The framework is, to our knowledge, the first to integrate multi-stage reasoning, rubric-based and semantic evaluation, and graph-based storage into a single system. It enables replicable, interpretable, and multidimensional assessment of generative reasoning—supporting researchers, developers, and educators working with LLMs in high-stakes contexts. Full article