Search Results (24,885)

Cardiovascular diseases (CVDs), which remain globally one of the most common causes of death, are usually diagnosed based on the electrocardiogram (ECG) signal. To support human experts, modern deep-learning models are used for CVD classification problems as an early warning. This article proposes a novel multi-branch architecture focused on processing various modalities of the ECG signal in parallel branches, replacing typical single-input architectures. Each branch is given separate input in the form of the raw signal, domain knowledge, the wavelet transform of the signal, or the signal with drift removed. The proposed method is based on deep-learning core models that can incorporate various modern neural networks. It was thoroughly tested on N-BEATS, LSTM, and GRU neural networks. The proposed architecture allows the retention of the speed of the neural network. At the same time, the combination of independently computed branches improves model performance, which finally exceeds the performance obtained by classical single-branch architectures. Full article

A novel adaptive intelligent control system (AICS) with learning-while-controlling capability is developed for a highly nonlinear single-input single-output plant by redesigning the conventional model reference adaptive control (MRAC) framework, originally based on first-order Lyapunov stability, and employing customized neural networks. The AICS is designed with a simple structure, consisting of two main subsystems: a meta-learning-triggered mechanism-based physics-informed neural network (MLTM-PINN) for plant identification and a self-tuning neural network controller (STNNC). This structure, featuring the triggered mechanism, facilitates a balance between high controllability and control efficiency. The MLTM-PINN incorporates the following: (I) a single self-supervised physics-informed neural network (PINN) without the need for labelled data, enabling online learning in control; (II) a meta-learning-triggered mechanism to ensure consistent control performance; (III) transfer learning combined with meta-learning for finely tailored initialization and quick adaptation to input changes. To resolve the conflict between streamlining the AICS’s structure and enhancing its controllability, the STNNC functionally integrates the nonlinear controller and adaptation laws from the MRAC system. Three STNNC design scenarios are tested with transfer learning and/or hyperparameter optimization (HPO) using a Gaussian process tailored for Bayesian optimization (GP-BO): (scenario 1) applying transfer learning in the absence of the HPO; (scenario 2) optimizing a learning rate in combination with transfer learning; and (scenario 3) optimizing both a learning rate and the number of neurons in hidden layers without applying transfer learning. Unlike scenario 1, no quick adaptation effect in the MLTM-PINN is observed in the other scenarios, as these struggle with the issue of dynamic input evolution due to the HPO-based STNNC design. Scenario 2 demonstrates the best synergy in controllability (best control response) and efficiency (minimal activation frequency of meta-learning and fewer trials for the HPO) in control. Full article

As people with cystic fibrosis (PwCF) live longer, kidney disease is emerging as a significant comorbidity that is increasingly linked to cardiovascular complications and progression to end-stage kidney disease. In our recent review, we proposed the unifying term CF-related kidney disease (CFKD) to encompass the spectrum of kidney dysfunction observed in this population. Early detection of kidney injury is critical for improving long-term outcomes, yet remains challenging due to the limited sensitivity of conventional laboratory tests, particularly in individuals with altered muscle mass and unique CF pathophysiology. Emerging approaches, including novel blood and urinary biomarkers, urinary extracellular vesicles, and genetic risk profiling, offer promising avenues for identifying subclinical kidney damage. When integrated with machine learning algorithms, these tools may enable the development of personalized risk stratification models and targeted therapeutic strategies. This precision medicine approach has the potential to transform kidney disease management in PwCF, shifting care from reactive treatment of late-stage disease to proactive monitoring and early intervention. Full article

Distributed acoustic sensing shows great potential for pipeline monitoring. However, internally deployed and unfixed sensing cables are highly susceptible to disturbances from water flow noise, severely challenging impact source localization. This study proposes a novel two-step method to address this. The first step employs Variational Mode Decomposition (VMD) combined with Short-Time Energy Entropy (STEE) for the adaptive extraction of impact signal from noisy data. STEE is introduced as a stable metric to quantify signal impulsiveness and guides the selection of the relevant intrinsic mode function. The second step utilizes the Pruned Exact Linear Time (PELT) algorithm for accurate signal segmentation, followed by an unsupervised learning method combining Dynamic Time Warping (DTW) and clustering to identify the impact segment and precisely pick the arrival time based on shape similarity, overcoming the limitations of traditional pickers under conditions of complex noise. Field tests on an operational water pipeline validated the method, demonstrating the consistent localization of manual impacts with standard deviations typically between 1.4 m and 2.0 m, proving its efficacy under realistic noisy conditions. This approach offers a reliable framework for pipeline safety assessments under operational conditions. Full article

This study addresses a real-world logistics problem in forestry operations: the distribution of plants from cultivation centers to planting sites under strict delivery time windows and limited depot resources. We introduce the Coordinated Truck Loading and Routing Problem (CTLRP), an extension of the classical Vehicle Routing Problem with Time Windows (VRPTW) that integrates routing decisions with truck loading schedules at a single depot with constrained capacity. To solve this NP-hard problem, we develop a metaheuristic algorithm based on Ant Colony Optimization (ACO), enhanced with a global memory system and a novel stochastic return rule that allows trucks to return to the depot when additional deliveries are suboptimal. Parameter calibration experiments are conducted to determine optimal values for the return probability and ant population size. The algorithm is tested on a real forestry dispatch scenario over six working days. The results show that an Ant Colony System (ACS–CTLRP) algorithm reduces total distance traveled by 23%, travel time by 22%, and the number of trucks used by 13 units, while increasing fleet utilization from 54% to 83%. These findings demonstrate that the proposed method significantly outperforms current company planning and offers a transferable framework for depot-constrained routing problems in time-sensitive distribution environments. Full article

Traffic safety is a significant global concern, and traffic sign recognition (TSR) is essential for the advancement of intelligent transportation systems. Traditional YOLO11s-based methods often struggle to balance detection accuracy and processing speed, particularly in the context of small traffic signs within complex environments. To address these challenges, this study presents Ghost-YOLO-GBH, an innovative lightweight model that incorporates three key enhancements: (1) the integration of a GhostNet backbone, which substitutes the conventional YOLO11s architecture and utilizes Ghost modules to exploit feature redundancy, resulting in a 40.6% reduction in computational load while ensuring effective feature extraction for small targets; (2) the development of a HybridFocus module that combines large separable kernel attention with multi-scale pooling, effectively minimizing background interference and improving contextual feature aggregation by 4.3% in isolated tests; and (3) the implementation of a Bidirectional Dynamic Multi-Scale Feature Pyramid Network (BiDMS-FPN) that allows for bidirectional cross-stage feature fusion, significantly enhancing the accuracy of small target detection. Experimental results on the TT100K dataset indicate that Ghost-YOLO-GBH achieves an impressive 81.10% mean Average Precision (mAP) at a threshold of 0.5, along with an 11.7% increase in processing speed (45 FPS) and an 18.2% reduction in model parameters (7.74 M) compared to the baseline YOLO11s. Overall, Ghost-YOLO-GBH effectively balances accuracy, efficiency, and lightweight deployment, demonstrating superior performance in real-world applications characterized by small signs and cluttered backgrounds. This research provides a novel framework for resource-constrained TSR applications, contributing to the evolution of intelligent transportation systems. Full article

Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men worldwide. Although traditionally considered a disease of older men, the incidence of early-onset PCa (diagnosis < 55 years) is steadily rising. Advances in screening and therapy have significantly improved survival, creating a growing cohort of younger survivors for whom post-treatment quality of life—notably reproductive function—is paramount. Curative treatments such as radical prostatectomy, pelvic radiotherapy, androgen-deprivation therapy (ADT), and chemotherapy often cause irreversible infertility via multiple mechanisms, including surgical disruption of the ejaculatory tract, endocrine suppression of spermatogenesis, direct gonadotoxic injury to the testes, and oxidative sperm DNA damage. Despite these risks, fertility preservation is frequently overlooked in pre-treatment counseling, leaving many patients unaware of their options. This narrative review synthesizes current evidence on how PCa therapies impact male fertility, elucidates the molecular and physiological mechanisms of iatrogenic infertility, and evaluates both established and emerging strategies for fertility preservation and restoration. Key interventions covered include sperm cryopreservation, microsurgical testicular sperm extraction (TESE), and assisted reproductive technologies (ART). Psychosocial factors influencing decision-making, novel biomarkers predictive of post-treatment spermatogenic recovery, and long-term offspring outcomes are also examined. The review underscores the urgent need for timely, multidisciplinary fertility consultation as a routine component of PCa care. As PCa increasingly affects men in their reproductive years, proactively integrating preservation into standard oncologic practice should become a standard survivorship priority. Full article

Background: Clinical assessment of balance and postural disorders is usually carried out through several common practices including tests such as the Subjective Visual Vertical (SVV) and Limit of Stability (LOS). Nowadays, several cutting-edge technologies have been proposed as supporting tools for stability evaluation. Extended Reality (XR) emerges as a powerful instrument. This proof-of-concept study aims to assess the feasibility and potential clinical utility of a novel MR-based framework integrating HoloLens 2, Wii Balance Board, and Azure Kinect for multimodal balance assessment. An innovative test is also introduced, the Innovative Dynamic Balance Assessment (IDBA), alongside an MR version of the SVV test and the evaluation of their performance in a cohort of healthy individuals. Results: All participants reported SVV deviations within the clinically accepted ±2° range. The IDBA results revealed consistent sway and angular profiles across participants, with statistically significant differences in posture control between opposing target directions. System outputs were consistent, with integrated parameters offering a comprehensive representation of postural strategies. Conclusions: The MR-based framework successfully delivers integrated, multimodal measurements of postural control in healthy individuals. These findings support its potential use in future clinical applications for balance disorder assessment and personalized rehabilitation. Full article

This study focuses on producing and processing highly aligned tapes from recycled carbon fibers (rCFs). The rCFs are processed with a modified carding machine, oriented through a specialized subsequent process and consolidated into a semi-finished product. These rCF-tapes are placed onto a two-dimensional tool using an adapted automated fiber placement (AFP) technology to demonstrate a novel approach of producing composites from highly oriented recycled materials. The semi-finished stacks are consolidated in a heating press and test coupons are tested according to corresponding standards. The rCF-tapes are evaluated using methods such as tensile and flexural testing and determination of fiber volume content. Mechanical values are assessed by processing various generations of rCF-tapes and comparing them to each other and to virgin fiber tapes (vCF-tapes) made of the same type of carbon fiber and matrix. Microscopic imaging is also performed to analyze the quality of the resulting composites. In this study, a tensile strength of up to 1100 MPa in the fiber direction and stiffness of up to 80 GPa at a fiber volume content (FVC) of approximately 40% were achieved. The results highlight the strong potential and benefits of using highly oriented rCF-tapes and demonstrate the suitability of fiber placement technologies for those recycled materials. Full article

Alagille syndrome (ALGS) is a multisystem disorder characterized by a paucity of intrahepatic bile ducts and cholestasis, often requiring liver transplantation before adulthood. Due to the lack of genotype–phenotype correlation, case series are essential to understand disease presentation and prognosis. Data on Mexican ALGS patients are limited. Therefore, we aimed to characterize a large series of Mexican patients by consolidating cases from major institutions and independent geneticists, with the goal of generating one of the most comprehensive cohorts in Latin America. We retrospectively analyzed clinical records of pediatric ALGS patients, focusing on demographics, clinical features, laboratory and imaging results, biopsy findings, and transplant status. Genetic testing was performed for all cases without prior molecular confirmation. We identified 52 ALGS cases over 13 years; 22 had available clinical records. Of these, only 6 had molecular confirmation at study onset, prompting genetic testing in the remaining 16. We identified six novel JAG1 variants and several previously unreported phenotypic features. A liver transplantation rate of 13% was observed in the cohort. This study represents the largest molecularly confirmed ALGS cohort in Mexico to date. Novel genetic and clinical findings expand the known spectrum of ALGS and emphasize the need for improved therapies, such as IBAT inhibitors, which may alleviate symptoms and reduce the need for transplantation. Full article

Objective: The accurate visualization of root canal systems on periapical radiographs is critical for successful endodontic treatment. This study aimed to evaluate and compare the effectiveness of several image enhancement algorithms—including a novel Total Variation–Contrast-Limited Adaptive Histogram Equalization (TV-CLAHE) technique—in improving the detectability of root canal configurations in mandibular incisors, using cone-beam computed tomography (CBCT) as the gold standard. A null hypothesis was tested, assuming that enhancement methods would not significantly improve root canal detection compared to original radiographs. Method: A retrospective analysis was conducted on 60 periapical radiographs of mandibular incisors, resulting in 420 images after applying seven enhancement techniques: Histogram Equalization (HE), Contrast-Limited Adaptive Histogram Equalization (CLAHE), CLAHE optimized with Pelican Optimization Algorithm (CLAHE-POA), Global CLAHE (G-CLAHE), k-Caputo Fractional Differential Operator (KCFDO), and the proposed TV-CLAHE. Four experienced observers (two radiologists and two dentists) independently assessed root canal visibility. Subjective evaluation was performed using an own scale inspired by a 5-point Likert scale, and the detection accuracy was compared to the CBCT findings. Quantitative metrics including Peak Signal-to-Noise Ratio (PSNR), Signal-to-Noise Ratio (SNR), image entropy, and Structural Similarity Index Measure (SSIM) were calculated to objectively assess image quality. Results: Root canal detection accuracy improved across all enhancement methods, with the proposed TV-CLAHE algorithm achieving the highest performance (93–98% accuracy), closely approaching CBCT-level visualization. G-CLAHE also showed substantial improvement (up to 92%). Statistical analysis confirmed significant inter-method differences (p < 0.001). TV-CLAHE outperformed all other techniques in subjective quality ratings and yielded superior SNR and entropy values. Conclusions: Advanced image enhancement methods, particularly TV-CLAHE, significantly improve root canal visibility in 2D radiographs and offer a practical, low-cost alternative to CBCT in routine dental diagnostics. These findings support the integration of optimized contrast enhancement techniques into endodontic imaging workflows to reduce the risk of missed canals and improve treatment outcomes. Full article

Extreme precipitation events severely impact agriculture, reducing yields and land use efficiency. The spatiotemporal distribution of Total Column Water Vapor (TCWV), the primary gaseous form of water, directly influences sustainable agricultural management. This study, through multi-source data fusion, employs methods including the Mann–Kendall test, sliding change-point detection, wavelet transform, pixel-scale trend estimation, and linear regression to analyze the spatiotemporal dynamics of global TCWV from 1959 to 2023 and its impacts on agricultural systems, surpassing the limitations of single-method approaches. Results reveal a global TCWV increase of 0.0168 kg/m²/year from 1959–2023, with a pivotal shift in 2002 amplifying changes, notably in tropical regions (e.g., Amazon, Congo Basins, Southeast Asia) where cumulative increases exceeded 2 kg/m² since 2000, while mid-to-high latitudes remained stable and polar regions showed minimal content. These dynamics escalate weather risks, impacting sustainable agricultural management with irrigation and crop adaptation. To enhance prediction accuracy, we propose a novel hybrid model combining wavelet transform with LSTM, TCN, and GRU deep learning models, substantially improving multidimensional feature extraction and nonstationary trend capture. Comparative analysis shows that WT-TCN performs the best (MAE = 0.170, R² = 0.953), demonstrating its potential for addressing climate change uncertainties. These findings provide valuable applications for precision agriculture, sustainable water resource management, and disaster early warning. Full article

This study focuses on optimizing track and grouser structural parameters to enhance UATV drawbar pull, particularly under soft soil conditions. A numerical soil thrust model for single-track shoes was developed based on track–soil interaction mechanics, revealing distinct mechanistic roles: track structural parameters (length/width) govern pressure–sinkage relationships at the track base, while grouser structural parameters (height, spacing, V-shaped angle) dominate shear stress–displacement dynamics on grouser shear planes. A novel DEM-MBD coupling simulation framework was established through soil parameter calibration and multi-body dynamics modeling, demonstrating that soil thrust increases with grouser height and V-shaped angle, but decreases with spacing, with grouser height exhibiting the highest sensitivity. A soil bin test validated the numerical model’s accuracy and the coupling method’s efficacy. Parametric optimization via the Whale Optimization Algorithm (WOA) achieved a 55.86% increase in drawbar pull, 40.38% reduction in ground contact pressure and 57.33% improvement in maximum gradability. These advancements substantially improve the tractive performance of UATVs in soft beach terrains. The proposed methodology provides a systematic framework for amphibious vehicle design, integrating numerical modeling, high-fidelity simulation, and experimental validation. Full article

With the increasing size of datasets in data mining applications, feature selection has become critical for enhancing classification accuracy and reducing computational complexity. In this study, a novel binary feature selection algorithm, called bWSO-log, is proposed based on the White Shark Optimizer (WSO). Unlike the commonly used S-shaped and V-shaped transfer functions in the literature, the WSO algorithm is converted into a binary form for the first time using a logarithmic transfer function. The performance of the proposed method was tested on nineteen benchmark datasets and compared with eight widely used metaheuristic algorithms. The results show that the bWSO-log algorithm demonstrates superior or competitive performance in terms of classification accuracy and the number of selected features. These findings reveal the effectiveness of the proposed logarithmic function and highlight the potential of WSO-based binary optimization in feature selection problems. Full article

Rapid data growth in large systems has introduced significant challenges in real-time monitoring and analysis. One of these challenges is detecting anomalies in time series data with high-dimensional inputs that contain complex inter-correlations between them. In addition, the lack of labeled data leads to the use of unsupervised learning that relies on daily system data to train models, which can contain noise that affects feature extraction. To address these challenges, we propose PCA-AAE, a novel anomaly detection model for time series data using an Adversarial Autoencoder integrated with Principal Component Analysis (PCA). PCA contributes to analyzing the latent space by transforming it into uncorrelated components to extract important features and reduce noise within the latent space. We tested the integration of PCA into the model’s phases and studied its efficiency in each phase. The tests show that the best practice is to apply PCA to the latent code during the adversarial training phase of the AAE model. We used two public datasets, the SWaT and SMAP datasets, to compare our model with state-of-the-art models. The results indicate that our model achieves an average F1 score of 0.90, which is competitive with state-of-the-art models, and an average of 58.5% faster detection speed compared to similar state-of-the-art models. This makes PCA-AAE a candidate solution to enhance real-time anomaly detection in high-dimensional datasets. Full article