Search Results (427)

Background/Objectives: Effective teamwork is crucial for minimizing human error in healthcare settings. Medical teams, typically composed of physicians and nurses, supported by auxiliary professionals, achieve better outcomes when they possess strong collaborative competencies. High-quality teamwork is associated with fewer adverse events and complications and lower mortality rates. Based on this background, the objective of this study is to analyze the perception of non-technical skills and immediate learning outcomes in interprofessional simulation settings based on E-CRM items. Methods: A cross-sectional observational study was conducted involving participants from the official postgraduate Medicine and Nursing programs at the Catholic University of Murcia (UCAM) during the 2024–2025 academic year. Four interprofessional E-CRM simulation sessions were planned, involving randomly assigned groups with proportional representation of medical and nursing students. Teams worked consistently throughout the training and participated in clinical scenarios observed via video transmission by their peers. Post-scenario debriefings followed INACSL guidelines and employed the PEARLS method. Results: Findings indicate that 48.3% of participants had no difficulty identifying the team leader, while 51.7% reported minor difficulty. Role assignment posed moderate-to-high difficulty for 24.1% of respondents. Communication, situation awareness, and early help-seeking were generally managed with ease, though mobilizing resources remained a challenge for 27.5% of participants. Conclusions: This study supports the value of interprofessional education in developing essential competencies for handling urgent, emergency, and high-complexity clinical situations. Strengthening interdisciplinary collaboration contributes to safer, more effective patient care. Full article

This study conducted uniaxial creep tests on coal samples under both natural and water-saturated conditions for durations of about 180 days per sample to study the stability of coal pillar dams of the Daliuta Coal Mine underground reservoir. Combined with synchronized acoustic emission (AE) monitoring, the research systematically revealed the time-dependent deformation mechanisms and damage evolution laws of coal under prolonged water immersion and natural conditions. The results indicate that water-immersed coal exhibits a unique negative creep phenomenon at the initial stage, with the strain rate down to −0.00086%/d, attributed to non-uniform pore compaction and elastic rebound effects. During the steady-state creep phase, the creep rates under water-immersed and natural conditions were comparable. However, water immersion led to an 11.4% attenuation in elastic modulus, decreasing from 2300 MPa to 2037 MPa. Water immersion would also suppress AE activity, leading to the average daily AE events of 128, which is only 25% of that under natural conditions. In the accelerating creep stage, the AE event rate surged abruptly, validating its potential as an early warning indicator for coal pillar instability. Based on the identified long-term strength of the coal sample, it is recommended to maintain operational loads below the threshold of 9 MPa. This research provides crucial theoretical foundations and experimental data for optimizing the design and safety monitoring of coal pillar dams in CMURs. Full article

Agroecological transitions in collective urban gardens in Toulouse region were studied through the prism of global health (2011–2022). The specific meaning of “global health” in the context of urban gardens concerns the health of gardeners (well-being and physical health), plants, soil, and animals, as well as the interactions between humans and non-humans, which are crucial for gardeners. A sociotechnical research project was developed on four different collective gardening sites, consisting of the following: 1. surveys issued to 100 garden stakeholders to highlight issues and practices, participation in meetings with the social centers in charge of events, and focus groups; 2. participative agronomic and environmental measurements and field observations, including soil quality analyses; and 3. analysis of the available documentary corpus. In order to produce the results, these three research methods (surveys, agronomy, document analysis) were combined through a transdisciplinary approach, in that both the field experimentation outcomes and retrieved scientific publications and technical documents informed the discussions with gardeners. Consideration of the four different sites enabled the exploration of various contextual factors—such as soil or air quality—affecting the production of vegetables. A rise in the concerns of gardeners about the impacts of their activities on global health was observed, including aspects such as creating and enjoying landscapes, taking care of the soil and biodiversity, developing social connections through the transmission of practices, and regular outside physical activity and healthier eating. The increased consideration for global health issues by all stakeholders promotes the implementation of agroecological practices in gardens to improve biodiversity and adherence to circular economy principles. Four concepts emerged from the interviews: health, production of vegetables, living soil, and social interactions. Notably, nuances between the studied sites were observed, according to their history, environment, and organization. These collective gardens can thus be considered as accessible laboratories for social and agroecological experimentation, being areas that can strongly contribute to urban ecosystem services. Full article

With the large-scale application and high-quality development demands of optical fiber cables, higher requirements have been placed on the corresponding measurement technologies. In recent years, optical fiber testing has played a crucial role in evaluating cable performance, as well as in the deployment, operation, maintenance, fault repair, and upgrade of optical networks. The Optical Time-Domain Reflectometer (OTDR) is a fiber fault diagnostic tool recommended by standards such as the International Telecommunication Union and the International Electrotechnical Commission. It is used to certify the performance of new fiber links and monitor the status of existing ones, detecting and locating fault events with advantages including simple operation, rapid response, and cost-effectiveness. First, this paper introduces the working principle and system architecture of OTDR, along with a brief discussion of its performance evaluation metrics. Next, a comprehensive review of improved OTDR technologies and systems is provided, categorizing different performance enhancement methods, including the enhanced measurement distance with simple structure and low cost in 2024, and the high spatial resolution measurement of optical fiber reflection events and non-reflection events in 2025. Finally, the development trends and future research directions of OTDR are outlined, aiming to achieve the development of low-cost, high-performance OTDR systems. Full article

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons. One of its major genetic causes is C9ORF72, where mutations lead to hexanucleotide repeat expansions in the C9ORF72 gene. These expansions drive disease progression through mechanisms, including the formation of toxic RNAs and the accumulation of damaged proteins such as dipeptide repeats (DPRs). This review highlights these pathogenic mechanisms, focusing on RNA foci formation and the accumulation of toxic DPRs, which contribute to neuronal damage. It also discusses promising targeted therapies, including small molecules and biological drugs, designed to counteract these specific molecular events. Small molecules such as G-quadruplex stabilizers, proteasome and autophagy modulators, and RNase-targeting chimeras show potential in reducing RNA foci and DPR accumulation. Furthermore, targeting enzymes involved in repeat-associated non-AUG (RAN) translation and nucleocytoplasmic transport, which are crucial for disease pathogenesis, opens new therapeutic avenues. Even some anti-viral drugs show encouraging results in preclinical studies. Biological drugs, such as antisense oligonucleotides and gene-editing technologies like CRISPR-Cas, were explored for their potential to specifically target C9ORF72 mutations and modify the disease’s molecular foundations. While preclinical and early clinical data show promise, challenges remain in optimizing delivery methods, ensuring long-term safety, and improving efficacy. This review concludes by emphasizing the importance of continued research and the potential for these therapies to alter the disease trajectory and improve patient outcomes. Full article

Background/Objectives: Non-invasive spinal cord transcutaneous stimulation (scTS) has expanded the therapeutic landscape of spinal cord injury (SCI) rehabilitation, offering potential benefits beyond compensatory approaches to paralysis. Children with SCI are particularly susceptible to developing neuromuscular scoliosis due to trunk muscle paralysis and ongoing skeletal growth, making targeted interventions crucial. As demonstrated in adults and pediatrics with SCI, the ability of scTS to acutely and safely enable an upright posture and trunk control could be leveraged as a therapeutic adjunct. Activity-based locomotor training (AB-LT) alone significantly improves trunk control in children with SCIs; combining it with scTS may enhance outcomes. This pilot study evaluated the safety, feasibility, and cumulative effects of AB-LT combined with scTS on trunk control in children with SCI. Methods: Three children with SCI completed 19 to 64 sessions of combined AB-LT and scTS. Adverse effects were monitored session to session, and trunk control was assessed pre- and post-intervention. Results: Across 130 interventions in three participants, 88.5% of sessions were free from adverse effects. Reported adverse events included autonomic dysreflexia (5.4%), skin redness at electrode sites (4.6%), and headaches (1.5%). No significant impact of scTS on fatigue or central hemodynamic parameters was observed. Post-intervention, all participants demonstrated improved trunk control during quiet and perturbed sitting. Conclusions: These findings provide the first evidence supporting the safety and feasibility of this combinatorial approach in pediatric SCI rehabilitation while emphasizing the importance of monitoring skin integrity and signs of autonomic dysreflexia. This intervention shows potential synergistic benefits, warranting further research to confirm efficacy and optimize therapeutic protocols. Full article

This study used event-related potentials (ERPs) to examine how candidates’ educational background (elite vs. non-elite universities) and prior internship experience (Fortune 500 vs. non-Fortune 500 enterprises) influence recruitment evaluations. Thirty-two participants completed a 2 × 2 within-subjects design task. Behavioral data indicated that applicants with Fortune 500 internships and graduates from elite universities received higher evaluation scores. ERP results revealed that Fortune 500 experience elicited larger P200 amplitudes (reflecting early attention). Crucially, this effect was modulated by educational background as only candidates from elite universities showed both enhanced P200 and reduced N300 amplitudes (suggesting efficient later processing). These findings indicate that recruiters dynamically allocate attention based on academic prestige (P200) and evaluate semantic congruence between education and employer reputation (N300), providing neurophysiological evidence for educational bias in hiring. Full article

Asthma exacerbations are acute worsening episodes in individuals with bronchial asthma, frequently necessitating emergency hospital care. Early differentiation between eosinophilic (≥150 eosinophils/mm³) and non-eosinophilic (<150 eosinophils/mm³) subtypes plays a crucial role in treatment decisions and identifying patients eligible for biologic therapies. The ExBA Study explored variations in complete blood count (CBC) parameters and derived cellular ratios—namely the neutrophil-to-lymphocyte (NLR), thrombocyte-to-lymphocyte (TLR), and eosinophil-to-leukocyte ratios (ELR)—in adults hospitalized with severe asthma exacerbations. Ninety patients were enrolled and categorized into eosinophilic (n = 38) and non-eosinophilic (n = 52) groups. Significant statistical differences were observed in the neutrophil and lymphocyte levels, as well as in all three ratios. ROC analysis highlighted the ELR as the most specific indicator of the eosinophilic phenotype (specificity 100%, AUC 0.938, cut-off 0.003), whereas the NLR and TLR showed stronger associations with the non-eosinophilic group (AUC 0.733 and 0.676). No meaningful differences emerged regarding arterial blood gas levels, length of hospital stay, treatment costs, or mortality. A notable association was found between a personal or family history of atopy and the eosinophilic subtype (p = 0.0181). This study underscores the relevance of CBC-based ratios in asthma phenotyping during exacerbation events. Full article

Landslides are a significant geological hazard with substantial socio-economic and environmental consequences, particularly in northwestern Sichuan, SW China, where complex geological and climatic conditions contribute to their occurrence. This study examines 1629 recorded landslide events, including 240 active landslides that have undergone substantial changes over the past two decades. By analyzing multi-temporal satellite imagery, this research investigates the relationship between landslide occurrence and key environmental factors such as annual rainfall and the Normalized Difference Vegetation Index (NDVI). The results reveal that landslides are most frequent on southwest-, south-, east-, and southeast-facing slopes, where the Föhn effect interacts with rainfall and vegetation patterns, thereby increasing landslide susceptibility. Rainfall intensity is identified as a critical factor, with landslide areas expanding significantly when annual rainfall exceeds 650 mm, while minimal changes are observed when rainfall is below 550 mm. The relationship between the NDVI and landslide occurrence is non-linear; higher vegetation cover does not necessarily correlate with reduced landslide frequency. Notably, landslide expansion is more pronounced when NDVI values are below 0.82, with a suppression effect occurring beyond this threshold. A threshold model based on the interaction between the NDVI and rainfall provides valuable insights into landslide dynamics, offering a framework for improved risk management. Slope characteristics are crucial in landslide evolution, with steeper slopes leading to greater vertical drops and more frequent events, making slope zone identification key for predicting future expansion. Full article

Accurate electricity wholesale price (EWP) forecasting is crucial for advancing sustainability in the energy sector, as it supports more efficient utilization and integration of renewable energy by informing when and how it should be consumed, dispatched, curtailed, or stored. However, high fluctuations in EWP, often resulting from demand–supply imbalances typically caused by sudden surges in electricity usage and the intermittency of renewable energy generation, and unforeseen external events, pose a challenge for accurate forecasting. Incorporating local temporal information (LTI) in time series, such as hourly price changes, is essential for accurate EWP forecasting, as it helps detect rapid market shifts. However, existing methods remain limited in capturing LTI, either relying on point-wise input sequences or, for fixed-length, non-overlapping segmentation methods, failing to effectively model dependencies within and across segments. This paper proposes the Local-Temporal Convolutional Transformer (LT-Conformer) model for day-ahead EWP forecasting, which addresses the challenge of capturing fine-grained LTI using Local-Temporal 1D Convolution and incorporates two attention modules to capture global temporal dependencies (e.g., daily price trends) and cross-feature dependencies (e.g., solar output influencing price). An initial evaluation in the Australian market demonstrates that LT-Conformer outperforms existing state-of-the-art methods and exhibits adaptability in forecasting EWP under volatile market conditions. Full article

Atherosclerosis, a chronic inflammatory disease driving cardiovascular events, involves complex molecular networks where long non-coding RNAs (lncRNAs) are key regulators. This review synthesizes current knowledge on lncRNA Growth Arrest-Specific 5 (GAS5) in atherosclerosis, covering its expression, multifaceted roles in vascular cells, and molecular mechanisms. GAS5 is significantly upregulated in atherosclerotic plaques, exerting complex, cell-specific effects on vascular smooth muscle cells, macrophages, and endothelial cells. GAS5 modulates crucial pathophysiological processes like cell proliferation, apoptosis, inflammation, lipid metabolism, and foam cell formation, primarily by acting as a competing endogenous RNA (ceRNA) and through direct protein interactions. While promising as a biomarker, circulating GAS5 levels require further validation. Therapeutic strategies targeting GAS5, including antisense oligonucleotides (ASO) and small-molecule compounds, are under investigation. In conclusion, lncRNA GAS5 is a critical regulatory node in atherosclerosis pathobiology, offering significant opportunities for novel diagnostic and therapeutic interventions. Further research is vital to elucidate its intricate roles and translate these findings into clinical applications for atherosclerotic cardiovascular disease. Full article

Non-intrusive load monitoring (NILM) enables the disaggregation of appliance-level energy consumption from aggregate electrical signals, offering a scalable solution for improving efficiency. This study compared the performance of traditional NILM algorithms (Mean, CO, Hart85, FHMM) and deep neural network-based approaches (DAE, RNN, Seq2Point, Seq2Seq, WindowGRU) under various experimental conditions. Factors such as sampling rate, harmonic content, and the application of power filters were analyzed. A key aspect of the evaluation was the difference in testing conditions: while traditional algorithms were evaluated under multiple experimental configurations, deep learning models, due to their extremely high computational cost, were analyzed exclusively under a specific configuration consisting of a 1-s sampling rate, with harmonic content present and without applying power filters. The results confirm that no universally superior algorithm exists, and performance varies depending on the type of appliance and signal conditions. Traditional algorithms are faster and more computationally efficient, making them more suitable for scenarios with limited resources or rapid response requirements. However, significantly more computationally expensive deep learning models showed higher average accuracy (MAE, RMSE, NDE) and event detection capability (F1-SCORE) in the specific configuration in which they were evaluated. These models excel in detailed signal reconstruction and handling harmonics without requiring filtering in this configuration. The selection of the optimal NILM algorithm for real-world applications must consider a balance between desired accuracy, load types, electrical signal characteristics, and crucially, the limitations of available computational resources. Full article

The Sylhet Division of Bangladesh, highly susceptible to monsoon flooding, requires effective flood risk management to reduce socio-economic losses. Flood frequency analysis is an essential aspect of flood risk management and plays a crucial role in designing hydraulic structures. This study applies regional flood frequency analysis (RFFA) using L-moments to identify homogeneous hydrological regions and estimate extreme flood quantiles. Records from 26 streamflow gauging stations were used, including streamflow data along with corresponding physiographic and climatic characteristic data, obtained from GIS analysis and ERA5 respectively. Most stations showed no significant monotonic trends, temporal correlations, or spatial dependence, supporting the assumptions of stationarity and independence necessary for reliable frequency analysis, which allowed the use of cluster analysis, discordancy measures, heterogeneity tests for regionalization, and goodness-of-fit tests to evaluate candidate distributions. The Generalized Logistic (GLO) distribution performed best, offering robust quantile estimates with narrow confidence intervals. Multiple Non-Linear Regression models, based on catchment area, elevation, and other parameters, reasonably predicted ungauged basin peak discharges (R² = 0.61–0.87; RMSE = 438–2726 m³/s; MAPE = 41–74%) at different return periods, although uncertainty was higher for extreme events. Four homogeneous regions were identified, showing significant differences in hydrological behavior, with two regions yielding stable estimates and two exhibiting greater extreme variability. Full article

(1) Background: postoperative surgical-site infections are a significant complication in small-animal surgical procedures, with detected rates ranging from 0.8% to 18.1%, depending on the type of surgery. The sterilization process of surgical instruments is a crucial factor in infection control, but the shelf life of surgical instruments and the best packaging method are not precisely defined due to the multiple variables that influence them. This study aimed to assess the shelf life of surgical instruments stored under controlled environmental conditions in a veterinary hospital and compare two packaging methods: using a self-sealing single pouch versus a self-sealing double pouch. (2) Methods: a sample of 400 non-sterile screws was divided into three groups: Group 1 (175 screws in single pouches), Group 2 (175 screws in double pouches), and Group 3 (50 non-sterile screws as a control group to verify the microbial culture efficiency). Microbiological tests were conducted at 1, 7, 15, 30, 60, 182, and 390 days post-sterilization. (3) Results: no bacterial growth was detected on screws packaged in single and double pouches up to 182 days. However, after 390 days, bacterial growth was observed in one screw packaged in a single pouch. In Group 3, only two screws turned out to be bacteriologically positive. (4) Conclusions: no statistical difference was found between the two groups; however, the detection of a single positive screw in the single-pouch group raised a potential clinical consideration, suggesting the need for further studies based on events and time. Full article

Objectives: The ability to efficiently regulate body temperature is crucial during endurance activities such as trail running, especially during competitive events in hot conditions. Over the past decade, passive hyperthermia exposure has grown significantly in popularity as a means of improving acclimatization and performance in hot environments. The present study aims to compare the physiological changes that occur in a group of professional athletes due to passive sauna exposure (80–90 °C) and their own response to maximal aerobic performance. Methods: Twelve professional trail runners (eight men and four women) were tested in three conditions: (i) baseline; (ii) before; and (iii) after (a) passive dry sauna exposure and (b) a maximal endurance test. In both cases, physiological parameters such as heart rate, tympanic temperature, arterial and muscle oxygen saturation, and blood concentrations of glucose, total cholesterol, high-density lipoprotein (HDL) and hemoglobin were measured. Results: Sauna exposure produced similar trends in cardiovascular and metabolic responses to those occurring during exercise, but at a much lower physiological level. Glucose and HDL levels were both significantly elevated (or tended to be so) after sauna and exercise (p < 0.03 and p < 0.01, respectively). Athletes who mobilized the sum of substrates (glucose and HDL) performed the exercise test faster (r = −0.76; p < 0.004). The response of arterial oxygen saturation (decreased) was similar during sauna and exercise, but opposite at the muscular level (increased during sauna and decreased during exercise). Additionally, inter-individual variability in responses was noted for most of the other parameters, suggesting the existence of ‘responders’ and ‘non-responders’ to thermal stimuli. Conclusions: The physiological responses of trained endurance athletes are moderately impacted by passive sauna use. However, individual changes could be correlated with endurance performance and optimizing individualization. Heat stimuli promote different physiological responses in terms of cardiac function, oxygen kinetics and substrate mobilization, albeit to a lesser extent than exercise. Greater substrate mobilization during maximal endurance exercise was found to be correlated with better performance. Further studies are needed to explore the concepts of metabolic flexibility, as described here, and how heat exposure may improve systemic health and performance. Full article