Search Results (1,632)

Microneedle arrays (MNAs) are becoming increasingly popular due to their ease of use and effectiveness in drug delivery and diagnostic applications. Improvements in three-dimensional (3D) printing techniques have made it possible to fabricate MNAs with high precision, intricate designs, and customizable properties, expanding their potential in medical applications. While most studies have focused on transdermal applications, non-transdermal uses remain relatively underexplored. This review summarizes recent developments in 3D-printed MNAs intended for non-transdermal drug delivery and diagnostic purposes. It includes a literature review of studies published in the past ten years, organized by the target delivery site—such as the brain and central nervous system (CNS), oral cavity, eyes, gastrointestinal (GI) tract, and cardiovascular and reproductive systems, among other emerging areas. The findings show that 3D-printed MNAs are more adaptable than skin-based delivery, opening up exciting new possibilities for use in a variety of organs and systems. To guarantee the effective incorporation of polymeric non-transdermal MNAs into clinical practice, additional research is necessary to address current issues with materials, manufacturing processes, and regulatory approval. Full article

Brain cancer is a heterogeneous collection of malignant neoplasms, such as glioblastoma multiforme (GBM), astrocytomas and medulloblastomas, with high morbidity and mortality. Its treatment is complicated by the tumor’s site, infiltrative growth mode and selective permeability of the blood–brain barrier (BBB). During tumor formation, the BBB dynamically remodels into the blood–brain tumor barrier (BBTB), disrupting homeostasis and preventing drug delivery. Furthermore, the TME (Tumor Micro Environment) supports drug resistance, immune evasion and treatment failure. This review points out the ways in which nanomedicine overcomes these obstacles with custom-designed delivery systems, sophisticated diagnostics and personalized therapies. Traditional treatments fail through a lack of BBB penetration, non-specific cytotoxicity and swift tumor adaptation. Nanomedicine provides greater drug solubility, protection against enzymatic degradation, target drug delivery and control over the release. Nanotheranostics’ confluence of therapeutic and diagnostic modalities allows for dynamic adjustment and real-time monitoring. Nanotechnology has paved the way for the initiation of a new era in precision neuro-oncology. Transcending the limitations of conventional therapy protocols, nanomedicine promises to deliver better outcomes by way of enhanced targeting, BBB penetration and real-time monitoring. Multidisciplinary collaboration, regulatory advancements and patient-centered therapy protocols customized to the individual patient’s tumor biology will be necessary to facilitate translation success in the future. Full article

Addressing the urgent need for lightweight and reusable energy-absorbing materials in aviation impact resistance, this study introduces an innovative multi-directional braided metamaterial design enabled by 4D printing technology. This approach overcomes the dual challenges of intricate manufacturing processes and the limited functionality inherent to traditional textile preforms. Six distinct braided structural units (types 1–6) were devised based on periodic trigonometric functions (Y = A sin(12πX)), and integrated with shape memory polylactic acid (SMP-PLA), thereby achieving a synergistic combination of topological architecture and adaptive response characteristics. Compression tests reveal that reducing strip density to 50–25% (as in types 1–3) markedly enhances energy absorption performance, achieving a maximum specific energy absorption of 3.3 J/g. Three-point bending tests further demonstrate that the yarn amplitude parameter A is inversely correlated with load-bearing capacity; for instance, the type 1 structure (A = 3) withstands a maximum load stress of 8 MPa, representing a 100% increase compared to the type 2 structure (A = 4.5). A multi-branch viscoelastic constitutive model elucidates the temperature-dependent stress relaxation behavior during the glass–rubber phase transition and clarifies the relaxation time conversion mechanism governed by the Williams–Landel–Ferry (WLF) and Arrhenius equations. Experimental results further confirm the shape memory effect, with the type 3 structure fully recovering its original shape within 3 s under thermal stimulation at 80 °C, thus addressing the non-reusability issue of conventional energy-absorbing structures. This work establishes a new paradigm for the design of impact-resistant aviation components, particularly in the context of anti-collision structures and reusable energy absorption systems for eVTOL aircraft. Future research should further investigate the regulation of multi-stimulus response behaviors and microstructural optimization to advance the engineering application of smart textile metamaterials in aviation protection systems. Full article

As a key component in the hydraulic brake system of automobiles, the brake joint directly affects the braking performance and driving safety of the vehicle. Therefore, improving the quality of brake joints is crucial. During the processing, due to the complexity of the welding material and welding process, the weld seam is prone to various defects such as cracks, pores, undercutting, and incomplete fusion, which can weaken the joint and even lead to product failure. Traditional weld seam detection methods include destructive testing and non-destructive testing; however, destructive testing has high costs and long cycles, and non-destructive testing, such as radiographic testing and ultrasonic testing, also have problems such as high consumable costs, slow detection speed, or high requirements for operator experience. In response to these challenges, this article proposes a defect detection and classification method for laser welding seams of automotive brake joints based on machine vision inspection technology. Laser-welded automotive brake joints are subjected to weld defect detection and classification, and image processing algorithms are optimized to improve the accuracy of detection and failure analysis by utilizing the high efficiency, low cost, flexibility, and automation advantages of machine vision technology. This article first analyzes the common types of weld defects in laser welding of automotive brake joints, including craters, holes, and nibbling, and explores the causes and characteristics of these defects. Then, an image processing algorithm suitable for laser welding of automotive brake joints was studied, including pre-processing steps such as image smoothing, image enhancement, threshold segmentation, and morphological processing, to extract feature parameters of weld defects. On this basis, a welding seam defect detection and classification system based on the cascade classifier and AdaBoost algorithm was designed, and efficient recognition and classification of welding seam defects were achieved by training the cascade classifier. The results show that the system can accurately identify and distinguish pits, holes, and undercutting defects in welds, with an average classification accuracy of over 90%. The detection and recognition rate of pit defects reaches 100%, and the detection accuracy of undercutting defects is 92.6%. And the overall missed detection rate is less than 3%, with both the missed detection rate and false detection rate for pit defects being 0%. The average detection time for each image is 0.24 s, meeting the real-time requirements of industrial automation. Compared with infrared and ultrasonic detection methods, the proposed machine-vision-based detection system has significant advantages in detection speed, surface defect recognition accuracy, and industrial adaptability. This provides an efficient and accurate solution for laser welding defect detection of automotive brake joints. Full article

As an emerging energy-saving approach, bio-inspired drag reduction technology has become a key research direction for reducing energy consumption and greenhouse gas emissions. This study introduces the latest research progress on bio-inspired microstructured surfaces in the field of underwater drag reduction, focusing on analyzing the drag reduction mechanism, preparation process, and application effect of the three major technological paths; namely, bio-inspired non-smooth surfaces, bio-inspired superhydrophobic surfaces, and bio-inspired modified coatings. Bio-inspired non-smooth surfaces can significantly reduce the wall shear stress by regulating the flow characteristics of the turbulent boundary layer through microstructure design. Bio-inspired superhydrophobic surfaces form stable gas–liquid interfaces through the construction of micro-nanostructures and reduce frictional resistance by utilizing the slip boundary effect. Bio-inspired modified coatings, on the other hand, realize the synergistic function of drag reduction and antifouling through targeted chemical modification of materials and design of micro-nanostructures. Although these technologies have made significant progress in drag reduction performance, their engineering applications still face bottlenecks such as manufacturing process complexity, gas layer stability, and durability. Future research should focus on the analysis of drag reduction mechanisms and optimization of material properties under multi-physical field coupling conditions, the development of efficient and low-cost manufacturing processes, and the enhancement of surface stability and adaptability through dynamic self-healing coatings and smart response materials. It is hoped that the latest research status of bio-inspired drag reduction technology reviewed in this study provides a theoretical basis and technical reference for the sustainable development and energy-saving design of ships and underwater vehicles. Full article

Electromagnetic articulography is a technique developed for recording three-dimensional movements. It is based on magnetic induction, where small currents are induced in miniature receiver coils acting as motion sensors by means of electromagnetic fields generated by transmitter coils. This technology has been applied in dental research to record mandibular movements during mastication, Posselt’s envelope of motion, and micromovements of dental prostheses. The AG501 electromagnetic articulograph (Carstens Medizinelektronik GmbH, Bovenden, Germany) provides a Head Correction (HC) procedure to eliminate head movement, which requires the reference sensors to be firmly attached to the subject’s head. If the sensors shift during the recordings, it becomes necessary to reposition them and repeat the head correction procedure. The aim of this study was to develop a 3D-printed helmet to securely fix the reference sensors to the head of a subject in the context of performing a series of recordings involving the mastication of 36 foods and the execution of Posselt’s envelope of motion. The number of HCs required was recorded for a group using the helmet and for a control group in which the sensors were attached to the subject’s head using tissue adhesive. A total of 29 recordings were conducted with and without the helmet. Without the helmet 44 HCs were required; on the other hand, with the helmet 36 HCs were required. On average, 1.5 HCs were required per session without the helmet and 1.2 HCs with the helmet, showing a non-significant difference (p < 0.05). A reduction in the number of HCs required per session was observed. However, more than one HC was still needed to complete a session. This could be addressed in future research by designing a series of helmets that adapt to different head sizes. Full article

We present a new method for trend analysis that integrates traditional foresight techniques with advanced data processing and artificial intelligence. It addresses the challenge of analyzing large volumes of information while preserving expert insight. The hybrid methodology combines computational analysis with expert validation across four phases: literature review, information systematization, trend identification, and analysis. Tools like Voyant Tools 2.6.18 and NotebookLMare used for semantic and statistical exploration. Among them, we highlight the use of the Defly Compass tool, a natural language processing tool based on semantic projections and developed by our team. The method produces mixed results, including both conceptual conclusions and quantifiable, reproducible outcomes adaptable to diverse contexts. Comparative case studies in agriculture, education, and public health identified key patterns within and across sectors. Cross-domain validation revealed universal trends such as digital infrastructure, data integration, and equity. Designed for accessibility, the method enables small, non-specialized teams to combine computational tools with expert knowledge for strategic decision making in complex environments. Full article

Traditional cuff-based blood pressure (BP) monitoring methods provide only intermittent readings, while invasive alternatives pose clinical risks. Recent studies have demonstrated feasibility of estimating continuous non-invasive cuff-less BP using photoplethysmogram (PPG) signals alone. However, existing approaches rely on complex manual feature engineering and/or multiple model architectures, resulting in inefficient epoch training numbers and limited performance. This research proposes cBP-Tnet, an efficient single-channel and model multi-task Transformer network designed for PPG signal automatic feature extraction. cBP-Tnet employed specialized hyperparameters—integrating adaptive Kalman filtering, outlier elimination, signal synchronization, and data augmentation—leveraging multi-head self-attention and multi-task learning strategies to identify subtle and shared waveform patterns associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP). We used the MIMIC-II public dataset (500 patients with 202,956 samples) for experimentation. Results showed mean absolute errors of 4.32 mmHg for SBP and 2.18 mmHg for DBP. For the first time, both SBP and DBP meet the Association for the Advancement of Medical Instrumentation’s international standard (<5 mmHg, >85 subjects). Furthermore, the network efficiently reduces the epoch training number by 13.67% when compared to other deep learning methods. Thus, this establishes cBP-Tnet’s potential for integration into wearable and home-based healthcare devices with continuous non-invasive cuff-less blood pressure monitoring. Full article

The article aims to identify consumer types based on their attitudes and behaviors toward phygital tools and solutions. The analysis was based on the authors’ empirical research. The research was conducted on a sample of 2160 Polish consumers. The study employed an online survey technique. To determine the types of consumers, a 20-item scale was used, allowing the respondents to express their attitudes toward solutions and tools that improve shopping in the phygital space. The extraction of types was carried out in two steps. The first was cluster analysis, conducted using the hierarchical Ward method with the square of the Euclidean distance, and the second was non-hierarchical cluster analysis using the k-means method. As a result of the analyses, three relatively homogeneous types of consumers were distinguished: phygital integrators, digital frequenters, and physical reality anchors. The behaviours of consumers from each type were examined in the context of their impact on sustainable consumption and the sustainable development of the planet. The proposed typology contributes to developing consumer behavior theory in sustainable consumption environments. It provides practical implications for designing customer experiences that are more inclusive, resource-efficient, and aligned with responsible consumption patterns. Understanding how different consumer groups engage with phygital tools allows businesses and policymakers to tailor strategies that support equitable access to digital services and foster more sustainable, adaptive consumption journeys in an increasingly digitized marketplace. Full article

In computer vision, the performance of detectors trained under optimal lighting conditions is significantly impaired when applied to infrared domains due to the scarcity of labeled infrared target domain data and the inherent degradation in infrared image quality. Progress in cross-domain pedestrian re-identification is hindered by the lack of labeled infrared image data. To address the degradation of pedestrian recognition in infrared environments, we propose a framework for zero-shot infrared domain adaptation. This integrated approach is designed to mitigate the challenges of pedestrian recognition in infrared domains while enabling zero-shot domain adaptation. Specifically, an advanced reflectance representation learning module and an exchange–re-decomposition–coherence process are employed to learn illumination invariance and to enhance the model’s effectiveness, respectively. Additionally, the CLIP (Contrastive Language–Image Pretraining) image encoder and DINO (Distillation with No Labels) are fused for feature extraction, improving model performance under infrared conditions and enhancing its generalization capability. To further improve model performance, we introduce the Non-Local Attention (NLA) module, the Instance-based Weighted Part Attention (IWPA) module, and the Multi-head Self-Attention module. The NLA module captures global feature dependencies, particularly long-range feature relationships, effectively mitigating issues such as blurred or missing image information in feature degradation scenarios. The IWPA module focuses on localized regions to enhance model accuracy in complex backgrounds and unevenly lit scenes. Meanwhile, the Multi-head Self-Attention module captures long-range dependencies between cross-modal features, further strengthening environmental understanding and scene modeling. The key innovation of this work lies in the skillful combination and application of existing technologies to new domains, overcoming the challenges posed by vision in infrared environments. Experimental results on the SYSU-MM01 dataset show that, under the single-shot setting, Rank-1 Accuracy (Rank-1) andmean Average Precision (mAP) values of 37.97% and 37.25%, respectively, were achieved, while in the multi-shot setting, values of 34.96% and 34.14% were attained. Full article

The escalating threat of infectious diseases necessitates the development of diagnostic technologies that are not only rapid and sensitive but also deployable at the point of care. Electrochemical impedance spectroscopy (EIS) has emerged as a leading technique for the label-free detection of pathogens, offering a unique combination of sensitivity, non-invasiveness, and adaptability. This review provides a comprehensive overview of the design and application of EIS-based biosensors tailored for pathogen detection, focusing on critical components such as biorecognition elements, electrode materials, nanomaterial integration, and surface immobilization strategies. Special emphasis is placed on the mechanisms of signal generation under Faradaic and non-Faradaic modes and how these underpin performance characteristics such as the limit of detection, specificity, and response time. The application spectrum spans bacterial, viral, fungal, and parasitic pathogens, with case studies highlighting detection in complex matrices such as blood, saliva, food, and environmental water. Furthermore, integration with microfluidics and point-of-care systems is explored as a pathway toward real-world deployment. Emerging strategies for multiplexed detection and the utilization of novel nanomaterials underscore the dynamic evolution of the field. Key challenges—including non-specific binding, matrix effects, the inherently low ΔR_ct/decade sensitivity of impedance transduction, and long-term stability—are critically evaluated alongside recent breakthroughs. This synthesis aims to support the future development of robust, scalable, and user-friendly EIS-based pathogen biosensors with the potential to transform diagnostics across healthcare, food safety, and environmental monitoring. Full article

Background/Objectives: To investigate associations between Follistatin (FST) gene polymorphisms (SNPs) and baseline musculoskeletal traits, and their interactions with 16-week exercise interventions. Methods: A cohort of 470 untrained Northern Han Chinese adults (208 males, 262 females), sourced from the “Research on Key Technologies for an Exercise and Fitness Expert Guidance System” project, was analyzed. These participants were previously randomly assigned to one of four exercise groups (Hill, Running, Cycling, Combined) or a non-exercising Control group, and completed their respective 16-week protocols. Body composition, bone mineral content (BMC), bone mineral density (BMD), and serum follistatin levels were all assessed pre- and post-intervention. Dual-energy X-ray absorptiometry (DXA) was utilized for the body composition, BMC, and BMD measurements. FST SNPs (rs3797296, rs3797297) were genotyped using matrix assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) or microarrays. To elucidate the biological mechanisms, we performed in silico functional analyses for rs3797296 and rs3797297. Results: Baseline: In females only, the rs3797297 T allele was associated with higher muscle mass (β = 1.159, 95% confidence interval (CI): 0.202–2.116, P_{_adj} = 0.034) and BMC (β = 0.127, 95% CI: 0.039–0.215, P_{_adj} = 0.009), with the BMC effect significantly mediated by muscle mass. Exercise Response: Interventions improved body composition, particularly in females. Gene-Exercise Interaction: A significant interaction occurred exclusively in women undertaking hill climbing: the rs3797296 G allele was associated with attenuated muscle mass gains (β = −1.126 kg, 95% CI: −1.767 to −0.485, P_{_adj} = 0.034). Baseline follistatin correlated with body composition (stronger in males) and increased post-exercise (primarily in males, Hill/Running groups) but did not mediate SNP effects on exercise adaptation. Functional annotation revealed that rs3797297 is a likely causal variant, acting as a skeletal muscle eQTL for the mitochondrial gene NDUFS4, suggesting a mechanism involving muscle bioenergetics. Conclusions: Findings indicate that FST polymorphisms associate with musculoskeletal traits in Northern Han Chinese. Mechanistic insights from functional annotation reveal potential pathways for these associations, highlighting the potential utility of these genetic markers for optimizing training program design. Full article

This study introduces a novel control strategy tailored to nonlinear systems with non-minimum phase (NMP) characteristics. The framework leverages reinforcement learning within a cascade control architecture that integrates an Actor–Critic structure. Controlling NMP systems poses significant challenges due to the inherent instability of their internal dynamics, which hinders effective output tracking. To address this, the system is reformulated using the Byrnes–Isidori normal form, allowing the decoupling of the input–output pathway from the internal system behavior. The proposed control architecture consists of two nested loops: an inner loop that applies input–output feedback linearization to ensure accurate tracking performance, and an outer loop that constructs reference signals to stabilize the internal dynamics. A key innovation in this design lies in the incorporation of symmetry principles observed in both system behavior and control objectives. By identifying and utilizing these symmetrical structures, the learning algorithm can be guided toward more efficient and generalized policy solutions, enhancing robustness. Rather than relying on classical static optimization techniques, the method employs a learning-based strategy inspired by previous gradient-based approaches. In this setup, the Actor—modeled as a multilayer perceptron (MLP)—learns a time-varying control policy for generating intermediate reference signals, while the Critic evaluates the policy’s performance using Temporal Difference (TD) learning. The proposed methodology is validated through simulations on the well-known Inverted Pendulum system. The results demonstrate significant improvements in tracking accuracy, smoother control signals, and enhanced internal stability compared to conventional methods. These findings highlight the potential of Actor–Critic reinforcement learning, especially when symmetry is exploited, to enable intelligent and adaptive control of complex nonlinear systems. Full article

Unmanned Aerial Vehicles (UAVs) face a significant challenge in balancing high accuracy and high efficiency when performing real-time object detection tasks, especially amidst intricate backgrounds, diverse target scales, and stringent onboard computational resource constraints. To tackle these difficulties, this study introduces YOLO-SRMX, a lightweight real-time object detection framework specifically designed for infrared imagery captured by UAVs. Firstly, the model utilizes ShuffleNetV2 as an efficient lightweight backbone and integrates the novel Multi-Scale Dilated Attention (MSDA) module. This strategy not only facilitates a substantial 46.4% reduction in parameter volume but also, through the flexible adaptation of receptive fields, boosts the model’s robustness and precision in multi-scale object recognition tasks. Secondly, within the neck network, multi-scale feature extraction is facilitated through the design of novel composite convolutions, ConvX and MConv, based on a “split–differentiate–concatenate” paradigm. Furthermore, the lightweight GhostConv is incorporated to reduce model complexity. By synthesizing these principles, a novel composite receptive field lightweight convolution, DRFAConvP, is proposed to further optimize multi-scale feature fusion efficiency and promote model lightweighting. Finally, the Wise-IoU loss function is adopted to replace the traditional bounding box loss. This is coupled with a dynamic non-monotonic focusing mechanism formulated using the concept of outlier degrees. This mechanism intelligently assigns elevated gradient weights to anchor boxes of moderate quality by assessing their relative outlier degree, while concurrently diminishing the gradient contributions from both high-quality and low-quality anchor boxes. Consequently, this approach enhances the model’s localization accuracy for small targets in complex scenes. Experimental evaluations on the HIT-UAV dataset corroborate that YOLO-SRMX achieves an ${\mathrm{mAP}}_{50}$ of 82.8%, representing a 7.81% improvement over the baseline YOLOv8s model; an F1 score of 80%, marking a 3.9% increase; and a substantial 65.3% reduction in computational cost (GFLOPs). YOLO-SRMX demonstrates an exceptional trade-off between detection accuracy and operational efficiency, thereby underscoring its considerable potential for efficient and precise object detection on resource-constrained UAV platforms. Full article

In response to challenges around student engagement and teacher technological proficiency, this paper looks at the impact of gamification on students’ mathematical resilience whilst monitoring their mathematical anxiety plus investigating teachers’ experiences, willingness, and professional development ambitions to utilise gamified instructional tools in the mathematics classroom. Drawing on strategies to motivate students, the aim of this paper is to unbundle gamification in enacting curriculum change and the role of teacher professional development in using the pedagogical approach in mathematics in Ireland. Ireland is currently experiencing second-level curriculum reforms that are placing particular emphasis on digital competence and technological fluency from both teachers and students. With teachers highlighting the gap in educators’ pedagogical skills for the smooth roll out of recent curriculum reform due to the lack of knowledge and competency in technological teaching strategies, this study is both relevant and timely. Games have been used in multiple industries aiming to motivate participants and increase engagement on a particular matter. However, the term “gamification” has been coined by Pelling as the use of games in a non-gaming context. Current students are very technologically savvy due to the exposure of software applications from a young age and the integration of technological appliances in all walks of life. Traditional teaching and learning strategies are potentially seen as monotonous and somewhat boring to today’s students. Utilising game-based design such as leaderboards, points, and badges encourages motivation and enhances engagement of students. With this in mind, and the rate of change in mathematics curricula globally in recent years, there is a significant emphasis on the necessity of professional development initiatives to adapt at the same rate. Full article