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Keywords = multi-stage loading

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25 pages, 8423 KB  
Article
Analysis of Dynamic Load Tests on Reinforced Foundations Under the Influence of Karst Soil Cavity Collapse
by Jia Lu, Jia-Quan Wang, Xiao-Yan Yang and Heng-Tong Wang
Buildings 2026, 16(4), 828; https://doi.org/10.3390/buildings16040828 - 18 Feb 2026
Viewed by 50
Abstract
Karst soil caves are prone to induce insufficient bearing capacity and excessive settlement of engineering foundations, which in turn trigger sudden ground surface collapse. In this study, multi-stage cyclic loads were designed to simulate traffic loads, and model tests were conducted to measure [...] Read more.
Karst soil caves are prone to induce insufficient bearing capacity and excessive settlement of engineering foundations, which in turn trigger sudden ground surface collapse. In this study, multi-stage cyclic loads were designed to simulate traffic loads, and model tests were conducted to measure and analyze the variation laws of foundation settlement, peak vertical earth pressure within the foundation, and reinforcement strain at different positions under cyclic dynamic loading. The results show that the following: ① under cyclic dynamic loading, the collapse of soil caves significantly reduces the bearing capacity of reinforced foundations with an influence range of up to 3B; ② affected by karst soil caves, reinforced foundations only experience a short elastic compaction stage under cyclic loading, followed by rapid deformation until failure; ③ a critical value exists in the earth pressure distribution at a distance of 1B–2B from the soil cave to the foundation center, which governs the abrupt pressure drop behavior in the collapse zone; ④ under the same level of cyclic loading, the height and number of soil arches are independent of the number of loading cycles, and the soil arching effect exerts the most significant influence on the bearing capacity of reinforced foundations at the initial stage of loading application. Full article
(This article belongs to the Special Issue Advances in Soil–Geosynthetic Composite Materials)
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15 pages, 4021 KB  
Article
Reevaluating Fracture Forming Limits in Bulk Forming Under Non-Monotonic Strain Loading Paths
by Rui F. V. Sampaio, João P. M. Pragana, Guilherme P. Joaquim, Ivo M. F. Bragança, Carlos M. A. Silva and Paulo A. F. Martins
J. Manuf. Mater. Process. 2026, 10(2), 66; https://doi.org/10.3390/jmmp10020066 - 17 Feb 2026
Viewed by 131
Abstract
This paper examines the applicability of the fracture forming limits (FFLs) derived from conventional monotonic upset compression tests for assessing the formability of non-monotonic strain loading paths. The work uses a simple test specimen subjected to various non-monotonic deformation histories, and combines experimental [...] Read more.
This paper examines the applicability of the fracture forming limits (FFLs) derived from conventional monotonic upset compression tests for assessing the formability of non-monotonic strain loading paths. The work uses a simple test specimen subjected to various non-monotonic deformation histories, and combines experimental force measurements, digital image correlation, finite element analysis, and scanning electron microscopy (SEM) to characterize strain loading paths and crack opening mechanisms under varying testing parameters. Results demonstrate that non-monotonic strain loading paths can result in fracture strains that differ from those obtained through conventional monotonic bulk formability tests in the effective strain versus stress triaxiality space, depending on the considerations made in the transition between different loading stages. Consequently, reliance on monotonic test data may lead to inaccurate predictions of cracking in multi-stage industrial bulk forming processes. Full article
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21 pages, 1639 KB  
Article
Coordinated Optimal Scheduling of Transmission Grid and Multi-Parks Considering Source-Load Uncertainties with Multi-Spatial–Temporal Scales
by Zhenghong Tu, Fangzong Wang and Jin Wang
Energies 2026, 19(4), 1033; https://doi.org/10.3390/en19041033 - 15 Feb 2026
Viewed by 181
Abstract
With the ongoing transformation of energy systems and the expanding scale of multi-park integrated energy systems, this paper proposes a novel multi-spatiotemporal scale scheduling framework that integrates robust optimization with distributed coordination to address the challenges of complex spatiotemporal coupling and significant uncertainties [...] Read more.
With the ongoing transformation of energy systems and the expanding scale of multi-park integrated energy systems, this paper proposes a novel multi-spatiotemporal scale scheduling framework that integrates robust optimization with distributed coordination to address the challenges of complex spatiotemporal coupling and significant uncertainties in the coordinated operation of transmission grids and multi-park integrated energy systems under high renewable energy penetration. The proposed framework establishes a hierarchical optimization model encompassing day-ahead, intra-day rolling, and real-time scheduling stages, incorporating multi-energy coupling constraints and accounting for load uncertainty. Robust optimization is employed to effectively manage source-load fluctuations arising from renewable intermittency. For solution implementation, the analytical target cascading (ATC) method is adopted to enable distributed collaborative optimization between the transmission system and individual park-level systems. Simulation results demonstrate that the proposed approach significantly enhances both the economic efficiency and operational reliability of the integrated energy system. Full article
(This article belongs to the Section F1: Electrical Power System)
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15 pages, 3781 KB  
Article
Experimental Study on a Dual Compensation Chamber Multi-Evaporator Loop Heat Pipe System
by Deqing Huang, Yuankun Zhang, Huajie Li and Chunsheng Guo
Eng 2026, 7(2), 84; https://doi.org/10.3390/eng7020084 - 13 Feb 2026
Viewed by 141
Abstract
To meet the requirements of high-efficiency thermal management without external power in long-distance and distributed multi-heat source scenarios, this paper proposes a dual compensation chamber multi-evaporator loop heat pipe system (DCCME-LHP). The system uses a capillary pump to provide capillary driving force, and [...] Read more.
To meet the requirements of high-efficiency thermal management without external power in long-distance and distributed multi-heat source scenarios, this paper proposes a dual compensation chamber multi-evaporator loop heat pipe system (DCCME-LHP). The system uses a capillary pump to provide capillary driving force, and through the step-by-step advancement of multiple condenser-evaporator combination, it achieves heat transfer and long-distance transportation among multi-heat sources. The experimental system investigates the effects of working fluid charge ratio, time interval, and heat load on the system’s hydrodynamic stability and heat transfer limit. The results show the optimal comprehensive performance of startup and steady state can be achieved with the charge ratio of 75% and a time interval of 8–10 min. The system operates stably under a total heat load of 270 W (90 W for the capillary pump and 60 W for each of the three evaporators). When the heat load of a single-stage evaporator rises to 70 W, the system enters the operation failure zone, and the steady-state temperature plateau jumps. This study provides a theoretical basis and experimental support for the design and stable operation strategy of long-distance multi-heat source thermal control systems. Full article
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24 pages, 18171 KB  
Article
CFD-DEM-Based Simulation Study on Lateral Sudden Sediment Supply and Riverbed Evolution in a Mountainous Stream Channel Induced by Multi-Stage Slope Slumps
by Ming Lei, Liang Zhang, Sen Wang and Chen Ye
Water 2026, 18(4), 481; https://doi.org/10.3390/w18040481 - 13 Feb 2026
Viewed by 132
Abstract
Under dynamic loading (e.g., earthquakes, extreme rainfall), multi-stage slope slumps occur as downstream slopes lose anti-sliding stability, triggering intensive lateral sediment supply that governs mountainous channel evolution. This study uses a coupled CFD-DEM model to simulate how water–sediment conditions regulate sediment transport and [...] Read more.
Under dynamic loading (e.g., earthquakes, extreme rainfall), multi-stage slope slumps occur as downstream slopes lose anti-sliding stability, triggering intensive lateral sediment supply that governs mountainous channel evolution. This study uses a coupled CFD-DEM model to simulate how water–sediment conditions regulate sediment transport and riverbed deformation. Results show that during the first sediment supply event, particle motion is initially slower under wet than dry conditions but accelerates due to buoyancy, with the peak average particle velocity along the gully axis decreasing by 11.5% and exhibiting negligible flow rate dependence. In the channel, higher flow rates raise particle velocity and downstream sediment flux, while a prolonged supply interval elevates peak velocity and delays its occurrence. For subsequent events, peak gully axis and vertical velocities increase with sediment supply mass, with weak dependence on flow rate or interval. Post-peak particle motion accelerates with these three factors, enhancing sediment entrainment effects. Increasing flow rate from 1.7 to 2.2 L/s, supply mass from 0.75 to 1.50 kg, and interval from 4 to 6 s significantly strengthens substrate dynamic response, with the peak average velocity rising by 78.3%, 33.3%, 67.0% and maximum displacement by 80.7%, 51.2%, 67.6%, respectively. Channel particle velocity is more sensitive to flow rate but suppressed by greater sediment mass and shorter intervals. The deposited riverbed has three zones: first-supply-dominated, mixed, and subsequent-supply-dominated. Higher flow rates restrict depositional area expansion but increase thickness, whereas greater subsequent sediment expands its dominant zone while reducing thickness, with minimal influence from supply intervals. This study offers theoretical insights for preventing water–sediment disasters in mountainous areas. Full article
(This article belongs to the Special Issue Water-Related Disaster Assessments and Prevention)
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30 pages, 7886 KB  
Article
Detection and Precision Application Path Planning for Cotton Spider Mite Based on UAV Multispectral Remote Sensing
by Hua Zhuo, Mei Yang, Bei Wu, Yuqin Xiao, Jungang Ma, Yanhong Chen, Manxian Yang, Yuqing Li, Yikun Zhao and Pengfei Shi
Agriculture 2026, 16(4), 424; https://doi.org/10.3390/agriculture16040424 - 12 Feb 2026
Viewed by 139
Abstract
Cotton spider mites pose a significant threat to cotton production, while traditional manual investigation and blanket pesticide application are inefficient for precision pest management in large-scale cotton fields. To address this challenge, this study developed an integrated UAV multispectral remote sensing system for [...] Read more.
Cotton spider mites pose a significant threat to cotton production, while traditional manual investigation and blanket pesticide application are inefficient for precision pest management in large-scale cotton fields. To address this challenge, this study developed an integrated UAV multispectral remote sensing system for spider mite monitoring and precision spraying. Multispectral imagery was acquired from cotton fields in Shaya County, Xinjiang using UAV-mounted cameras, and vegetation indices including RDVI, MSAVI, SAVI, and OSAVI were selected through feature optimization. Comparative evaluation of three machine learning models (Logistic Regression, Random Forest, and Support Vector Machine) and two deep learning models (1D-CNN and MobileNetV2) was conducted. Considering classification performance and computational efficiency for real-time UAV deployment, Random Forest was identified as optimal, achieving 85.47% accuracy, an 85.24% F1-score, and an AUC of 0.912. The model generated centimeter-level spatial distribution maps for precise spray zone delineation. An improved NSGA-III multi-objective path optimization algorithm was proposed, incorporating PCA-based heuristic initialization, differential evolution operators, and co-evolutionary dual population strategies to optimize deadheading distance, energy consumption, operation time, turning frequency, and load balancing. Ablation study validated the effectiveness of each component, with the fully improved algorithm reducing IGD by 59.94% and increasing HV by 5.90% compared to standard NSGA-III. Field validation showed 98.5% coverage of infested areas with only 3.6% path repetition, effectively minimizing pesticide waste and phytotoxicity risks. This study established a complete technical pipeline from monitoring to application, providing a valuable reference for precision pest control in large-scale cotton production systems. The framework demonstrated robust performance across multiple field sites, though its generalization is currently limited to one geographic region and growth stage. Future work will extend its application to additional cotton varieties, growth stages, and geographic regions. Full article
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22 pages, 10320 KB  
Article
Design and Buffering Performance Study of a 3D-Printed Labyrinth Buffer Sleeve for High-Speed Heavy-Load Hydraulic Cylinders
by Haitao Pan, Xiaoguang Liu, Shudong Tao, Yangxin Ren, Wei Wang, Kaixiong Hu, Mingxing Han and Yun Chen
Appl. Sci. 2026, 16(4), 1827; https://doi.org/10.3390/app16041827 - 12 Feb 2026
Viewed by 116
Abstract
In the hydraulic hoist design for a water conservancy hub project in western China, the vertically positioned, high-speed, heavy-load hydraulic cylinder is required to achieve closing speeds of up to 16 m/min, which is 4–5 times faster than conventional hydraulic hoists. Traditional buffer [...] Read more.
In the hydraulic hoist design for a water conservancy hub project in western China, the vertically positioned, high-speed, heavy-load hydraulic cylinder is required to achieve closing speeds of up to 16 m/min, which is 4–5 times faster than conventional hydraulic hoists. Traditional buffer structures in hydraulic cylinders are insufficient to meet these performance demands. To address this challenge, a labyrinth buffer sleeve with multi-stage labyrinth buffer channels was designed and manufactured using additive manufacturing technology. The feasibility and effectiveness of the labyrinth buffer sleeve were evaluated through numerical simulations and experimental testing. Results demonstrate that the sleeve offers superior flow capacity, speed control, and pressure reduction capabilities. The maximum flow velocity within the labyrinth flow field reaches 111.7–166.5 m/s at the narrowest section of the flow path. The pressure ranges from 9.95 MPa at the inlet to 0.5 MPa at the outlet. Upon entering the buffer stage, the cylinder’s velocity smoothly decreases from 8 to 9 m/min to 2 m/min. Compared to traditional spiral groove buffer sleeves, the 3D-printed labyrinth design enables staged buffering, reducing peak pressures by 80%, with peak values only 1/16 to 1/5 of those seen in conventional sleeves. This results in an 80% reduction in pressure impacts, eliminating the need for frequent on-site disassembly and reassembly for fit clearance adjustments. Full article
(This article belongs to the Section Mechanical Engineering)
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16 pages, 3206 KB  
Article
A Multi-Port Converter for Energy-Harvesting Systems
by Dante Miraglia, Carlos Aguilar, Jaime E. Arau, Jesús D. Mina, Rodolfo A. Vargas and Gloria L. Osorio
Eng 2026, 7(2), 80; https://doi.org/10.3390/eng7020080 - 11 Feb 2026
Viewed by 191
Abstract
In energy-harvesting storage systems, in order to guarantee the correct operation and integration of its parts into the system, different power converters must be used. Using several stages increases energy processing and therefore decreases the overall efficiency of the system. In this paper, [...] Read more.
In energy-harvesting storage systems, in order to guarantee the correct operation and integration of its parts into the system, different power converters must be used. Using several stages increases energy processing and therefore decreases the overall efficiency of the system. In this paper, an integrated multi-port converter with galvanic isolation is proposed. It allows the transfer of energy between the solar panel, the battery, and the user using the fewest possible stages, thus maximizing efficiency. Operating in three modes depending on the battery’s state of charge, solar radiation and load conditions, the converter can conduct electric power between its ports. The proposal was validated in a 1 kW prototype performing the different modes of operation. It should be noted that a PV emulator (ETS150X5.6C-PVF) was used in the experimental setup; by means of this device, conditions such as solar irradiance and temperature, which affect the energy generation of PV panels, were controlled. In addition, the transformer employed in the prototype implementation was handmade; therefore, its design could be improved to obtain better performance. The experimental results show efficiencies exceeding 94%, and an analysis of the distribution of losses in the circuit was carried out. Also, a comparison with previous proposals is presented, showing competitive features. Full article
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18 pages, 3577 KB  
Article
Design and Comparative Analysis of a Cryo-Cooling System of a Performance Evaluation System for a HTS Field Coil
by Byeong-Soo Go and Seok-Ju Lee
Energies 2026, 19(4), 912; https://doi.org/10.3390/en19040912 - 9 Feb 2026
Viewed by 193
Abstract
High-temperature superconducting (HTS) technologies continue to advance as promising solutions for large-capacity rotating electrical machinery. However, the cryogenic architecture required to maintain superconducting states remains a critical design challenge, particularly for performance evaluation systems (PESs). Conventional helium–neon (He–Ne) circulation-based cooling enables stable low-temperature [...] Read more.
High-temperature superconducting (HTS) technologies continue to advance as promising solutions for large-capacity rotating electrical machinery. However, the cryogenic architecture required to maintain superconducting states remains a critical design challenge, particularly for performance evaluation systems (PESs). Conventional helium–neon (He–Ne) circulation-based cooling enables stable low-temperature operation and has been experimentally validated in previous PES implementations, but it introduces substantial limitations due to installation complexity, flow-induced instability, and limited adaptability to different coil configurations. To address these constraints, this study proposes a conduction-cooled PES architecture optimized for HTS field coil testing and examines its thermal and structural characteristics through comprehensive design and finite element method (FEM)-based analysis. A multi-stage conduction cooling pathway using a cryocooler, thermal straps, and copper heat plates was designed to achieve uniform temperature distribution and reduce thermal gradients across the HTS winding. Three-dimensional FEM simulations were performed to evaluate the steady-state temperature distribution and heat-transfer characteristics of the proposed conduction-cooled PES under representative thermal load conditions, and the predicted cooling performance was comparatively assessed against the He–Ne cooled PES. The conduction-cooled PES was analyzed by comparing its predicted performance with previously obtained experimental results from the He–Ne cooled PES. The proposed conduction cooling architecture achieved a significant reduction in total heat load, decreasing from 177 W in the He–Ne system to approximately 78 W in the conduction-cooled configuration while also improving thermal efficiency and simplifying system integration. In addition, conduction cooling enhances compatibility with a wider range of HTS coil geometries by eliminating the constraints associated with fluid-based circulation. While the proposed conduction-cooled PES has not yet been physically fabricated, the numerical framework was established based on experimentally confirmed operating conditions of the previously implemented He–Ne-cooled PES, and future work will include fabrication and experimental validation of the conduction-cooled configuration. These findings demonstrate that conduction cooling represents a practical and scalable alternative for next-generation PES platforms and provide essential design guidelines for the development of high-field HTS coils and large-capacity superconducting rotating machines. Full article
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20 pages, 3203 KB  
Article
A Data-Driven Multi-Scale Source–Grid–Load–Storage Collaborative Dispatching Method for Distribution Systems
by Wenbiao Xia, Xin Chen, Fuguo Jin, Lu Li, Meizhu Lu, Zhuo Yang and Ning Yan
Processes 2026, 14(4), 603; https://doi.org/10.3390/pr14040603 - 9 Feb 2026
Viewed by 152
Abstract
Currently, distribution system scheduling faces significant uncertainty and dynamic complexity due to the large-scale integration of diverse heterogeneous entities, while conventional approaches suffer from limited capability in modeling user behavior responses and ensuring dispatch accuracy, making them inadequate for source–grid–load–storage collaborative optimization. To [...] Read more.
Currently, distribution system scheduling faces significant uncertainty and dynamic complexity due to the large-scale integration of diverse heterogeneous entities, while conventional approaches suffer from limited capability in modeling user behavior responses and ensuring dispatch accuracy, making them inadequate for source–grid–load–storage collaborative optimization. To address this, this paper proposes a data-driven multi-scale coordinated scheduling method for distribution systems, in which distributed generation outputs, load responses, and energy storage states are extracted and modeled using an improved exponential smoothing technique; a hierarchical and time-divided optimization framework is then developed by combining machine learning and probabilistic modeling with spatial correlation analysis to enhance renewable generation and load forecasting accuracy; and finally, a two-stage robust optimization model considering scenario uncertainties is established through typical scenario generation and uncertainty set constraints to achieve dispatch strategies that balance economic efficiency and low-carbon objectives and supply reliability under fluctuating renewable outputs and dynamic load variations. Simulation results demonstrate that the proposed method reduces total operating cost by 16.4%, decreases carbon emissions by 10.7%, and lowers electricity purchase fluctuation by 8.75%, thereby significantly enhancing system flexibility and adaptability to renewable energy uncertainties and providing a novel pathway for the development of active and intelligent distribution systems. Full article
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15 pages, 3863 KB  
Article
Simplification of Low-Cycle Creep–Fatigue Load Spectrum of Combustion Chamber and Life Assessment for Feature Simulation Specimens
by Dingnan Cheng, Honghua Zhao, Qiang Zhang, Minmin Chen, Hao Zhao and Cheng Hou
Materials 2026, 19(3), 620; https://doi.org/10.3390/ma19030620 - 5 Feb 2026
Viewed by 218
Abstract
Based on the damage equivalence principle, simplification of the low-cycle creep–fatigue original load spectrum of a combustion chamber under multi-stage flight conditions, such as low speed, takeoff, climb, and cruise states, and experimental verification were carried out in this study. The low-cycle creep–fatigue [...] Read more.
Based on the damage equivalence principle, simplification of the low-cycle creep–fatigue original load spectrum of a combustion chamber under multi-stage flight conditions, such as low speed, takeoff, climb, and cruise states, and experimental verification were carried out in this study. The low-cycle creep–fatigue life of the combustion chamber feature simulation specimens was predicted. The results showed that compared with the original load spectrum, the simplified load spectrum had an average life error of 6.13% in the low-cycle creep–fatigue tests of flat-plate specimens with a single hole. The simplified load spectrum test results and the original load spectrum test results were both within the double dispersion band of their average values. The low-cycle creep–fatigue test results of the flat specimens with single or multiple holes were both within the double dispersion band of the predicted results, while the test results of circular tube specimens with multiple holes were basically within the fourfold dispersion band of the predicted results. In addition, after passing cooling gas inside the circular tube test specimens with multiple holes, the temperature near the gas film holes was reduced, thereby improving their low-cycle creep–fatigue test life. Full article
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26 pages, 13529 KB  
Article
Study on Wind-Induced Response of Multi-Row Large-Span Cable Flexible Photovoltaic Panels
by Jinzhi Wu, Zhongya Yuan, Guojun Sun and Zhaohui Lu
Buildings 2026, 16(3), 599; https://doi.org/10.3390/buildings16030599 - 1 Feb 2026
Viewed by 182
Abstract
With its benefits of high efficiency and cheap cost, solar photovoltaic is rebuilding the energy supply and demand system as the world’s energy structure shifts to a clean one. This research investigates the wind-induced vibration response of a multi-row flexible photovoltaic system using [...] Read more.
With its benefits of high efficiency and cheap cost, solar photovoltaic is rebuilding the energy supply and demand system as the world’s energy structure shifts to a clean one. This research investigates the wind-induced vibration response of a multi-row flexible photovoltaic system using large eddy simulation and the two-way fluid–solid coupling approach. Firstly, the two-way coupling and the standard shape coefficient are compared to verify the reliability of the simulation method. Then, the model of multi-row flexible photovoltaics is analyzed to determine the natural frequency and vibration mode of the photovoltaic system. Finally, the vertical displacement of the photovoltaic system and the internal force of the cable are studied by investigating different wind direction angles and initial pretension. It is discovered that the natural frequency of the flexible photovoltaic system exhibits a stepwise increase in three distinct stages. Both the internal force in the load-bearing cable and the vertical displacement of the photovoltaic system decrease with increasing wind direction angle, with the cable force lagging behind at the peak time. The internal force and vertical displacement of the first row of load-bearing cables are at their highest at the 0° direction angle. The difference between the cable’s internal force’s peak and valley values grows when the pretension is low. The cable pretension significantly affects the vibration response of the flexible photovoltaic more than the angle of direction. The response law of direction angle and pretension to multi-row flexible photovoltaic wind-induced vibration is revealed, which provides a basis for wind-resistant design. Full article
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18 pages, 961 KB  
Article
An Evidential Reasoning-Enhanced African Vulture Optimization Algorithm for Two-Stage Optimization of Integrated Energy Systems Under Uncertainty
by Chao Zhang and Qiming Sun
Algorithms 2026, 19(2), 109; https://doi.org/10.3390/a19020109 - 1 Feb 2026
Viewed by 170
Abstract
With the aim of mitigating the impact of wind power integration and source-load-side uncertainties on an integrated energy system, we initially employed the Monte Carlo simulation in this study to randomly generate multiple wind power output/load scenarios in accordance with probability distribution functions. [...] Read more.
With the aim of mitigating the impact of wind power integration and source-load-side uncertainties on an integrated energy system, we initially employed the Monte Carlo simulation in this study to randomly generate multiple wind power output/load scenarios in accordance with probability distribution functions. Additionally, we proposed a two-stage optimization method. In the first stage of our study, an enhanced African vulture optimization algorithm was applied to perform multi-objective optimization targeting fuel cost and carbon emissions across various scenarios, thereby solving the Pareto frontier to obtain multiple candidate solutions. In the study’s second stage, comprehensively considering fuel cost, carbon emission, and wind power penetration rate, evidential reasoning was utilized to determine the optimal operation strategy among the candidates. Finally, a combined heat and power system composed of the IEEE 30-bus system and a 32-node heating network was simulated. The results demonstrate that this decision-making approach can effectively reflect the merits of candidate solutions, thus validating the feasibility of the designed research methodology. Full article
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22 pages, 5215 KB  
Article
Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer’s Disease
by Iliannis Yisel Roa-Bruzón, Celeste Patricia Gazcón-Rivas, Asbiel Felipe Garibaldi-Ríos, Luis Félix Duany-Almira, Martha Patricia Gallegos-Arreola, Claudia Azucena Palafox-Sánchez, Daniel Ortuño-Sahagún, Luis Eduardo Figuera, Manuel Alejandro Rico-Méndez and Yeminia Valle
Genes 2026, 17(2), 186; https://doi.org/10.3390/genes17020186 - 31 Jan 2026
Viewed by 354
Abstract
Background/Objectives: Alzheimer’s disease (AD) exhibits marked genetic heterogeneity between early-onset (EOAD) and late-onset (LOAD) forms. EOAD is typically associated with highly penetrant variants, whereas LOAD follows a polygenic architecture dominated by non-coding variation. However, the tissue-specific regulatory consequences of these variants remain insufficiently [...] Read more.
Background/Objectives: Alzheimer’s disease (AD) exhibits marked genetic heterogeneity between early-onset (EOAD) and late-onset (LOAD) forms. EOAD is typically associated with highly penetrant variants, whereas LOAD follows a polygenic architecture dominated by non-coding variation. However, the tissue-specific regulatory consequences of these variants remain insufficiently characterized. This study aimed to compare the regulatory genomic architectures underlying EOAD and LOAD using a multi-tissue integrative approach. Methods: GWAS-associated variants for EOAD and LOAD were retrieved from the GWAS Catalog using a relaxed significance threshold (p < 1 × 10−5). Variants were functionally annotated and integrated with GTEx v8 eQTL data across 13 neurologically relevant tissues and peripheral blood. Regulatory effects were evaluated using eQTL slope estimates. Basal gene expression patterns were assessed using GTEx RNA-seq data, and protein–protein interaction and functional enrichment analyses were performed using the STRING database. Results: A total of 287 variants were analyzed (32 EOAD, 255 LOAD), with minimal overlap. EOAD exhibited a highly focal regulatory profile, identifying GSE1 as the sole eQTL-regulated gene, restricted to the dorsolateral prefrontal cortex (BA9). In contrast, LOAD displayed a broad multi-tissue regulatory architecture involving APH1B, APOE, CEP63, and HAVCR2, with heterogeneous tissue-specific effects. LOAD-regulated genes converged on pathways related to γ-secretase activity, amyloid precursor protein processing, and Notch signaling, whereas GSE1-associated interactions were enriched for chromatin organization and epigenetic repression. Conclusions: EOAD and LOAD exhibit distinct regulatory genomic architectures, with EOAD characterized by focal, region-specific regulation and LOAD by widespread, tissue-dependent effects, highlighting stage-specific molecular mechanisms contributing to AD heterogeneity. Full article
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28 pages, 4717 KB  
Article
Collaborative Multi-Sensor Fusion for Intelligent Flow Regulation and State Monitoring in Digital Plunger Pumps
by Fang Yang, Zisheng Lian, Zhandong Zhang, Runze Li, Mingqi Jiang and Wentao Xi
Sensors 2026, 26(3), 919; https://doi.org/10.3390/s26030919 - 31 Jan 2026
Viewed by 326
Abstract
To address the technical challenge where traditional high-pressure, large-flow emulsion pump stations cannot adapt to the drastic flow rate changes in hydraulic supports due to the fixed displacement of their quantitative pumps—leading to frequent system unloading, severe impacts, and damage—this study proposes an [...] Read more.
To address the technical challenge where traditional high-pressure, large-flow emulsion pump stations cannot adapt to the drastic flow rate changes in hydraulic supports due to the fixed displacement of their quantitative pumps—leading to frequent system unloading, severe impacts, and damage—this study proposes an intelligent flow control method based on the digital flow distribution principle for actively perceiving and matching support demands. Building on this method, a compact, electro-hydraulically separated prototype with stepless flow regulation was developed. The system integrates high-speed switching solenoid valves, a piston push rod, a plunger pump, sensors, and a controller. By monitoring piston position in real time, the controller employs an optimized combined regulation strategy that integrates adjustable duty cycles across single, dual, and multiple cycles. This dynamically adjusts the switching timing of the pilot solenoid valve, thereby precisely controlling the closure of the inlet valve. As a result, part of the fluid can return to the suction line during the compression phase, fundamentally achieving accurate and smooth matching between the pump output flow and support demand, while significantly reducing system fluctuations and impacts. This research adopts a combined approach of co-simulation and experimental validation to deeply investigate the dynamic coupling relationship between the piston’s extreme position and delayed valve closure. It further establishes a comprehensive dynamic coupling model covering the response of the pilot valve, actuator motion, and backflow control characteristics. By analyzing key parameters such as reset spring stiffness, piston cylinder diameter, and actuator load, the system reliability is optimized. Evaluation of the backflow strategy and delay phase verifies the effectiveness of the multi-mode composite regulation strategy based on digital displacement pump technology, which extends the effective flow range of the pump to 20–100% of its rated flow. Experimental results show that the system achieves a flow regulation range of 83% under load and 57% without load, with energy efficiency improved by 15–20% due to a significant reduction in overflow losses. Compared with traditional unloading methods, this approach demonstrates markedly higher control precision and stability, with substantial reductions in both flow root mean square error (53.4 L/min vs. 357.2 L/min) and fluctuation amplitude (±3.5 L/min vs. ±12.8 L/min). The system can intelligently respond to support conditions, providing high pressure with small flow during the lowering stage and low pressure with large flow during the lifting stage, effectively achieving on-demand and precise supply of dynamic flow and pressure. The proposed “demand feedforward–flow coordination” control architecture, the innovative electro-hydraulically separated structure, and the multi-cycle optimized regulation strategy collectively provide a practical and feasible solution for upgrading the fluid supply system in fully mechanized mining faces toward fast response, high energy efficiency, and intelligent operation. Full article
(This article belongs to the Section Industrial Sensors)
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