Search Results (5,504)

The use of miniscrews as Temporary Skeletal Anchorage Devices (TSAD) in orthodontics has allowed clinicians to perform challenging tooth movements by dissipating undesired forces into the bone structure; thus, avoiding unwanted movement of the adjacent teeth. It is essential for miniscrews to be highly resistant to fracture during clinical use. While many studies have analysed torsional loads, none have measured the changes in flexural and bending strength of miniscrews before and after an ageing process. This study aims to analyse the resistance to orthogonal forces of miniscrews with different diameters, focusing on both new and aged materials, the latter subjected to thermocycling and autoclaving laboratory processes to simulate a 3- and a 6-month exposure to the oral environment. A total of 105 pristine miniscrews have been tested; specimens were divided into seven groups based on the different endosseous body diameters. Each group was further subdivided into three subgroups, according to the simulated ageing of the miniscrews (intact, 3 months of ageing and 6 months of ageing, respectively). An Instron Universal Testing Machine has been used to measure deflection at 0.1 mm and 0.2 mm, as well as maximum load at fracture. The results evidenced that miniscrews respond differently to cutting forces; in particular, the resistance to orthogonal loads increases as the diameter of the miniscrews increases. Linear regression analysis revealed a significant influence between all the dependent variables—maximum load, 0.1 mm deflection load, and 0.2 mm deflection load—and the independent variables, such as diameter and thermocycling (p < 0.05). Both new and aged miniscrews are suitable for orthodontic and orthopaedic loads; moreover, ageing up to 6 months does not seem to significantly decrease the resistance to shear forces for the same diameter. Linear regression analysis of the miniscrews subjected to experimental ageing showed a slight but significant decrease in resistance to orthogonal loading. Full article

Background: Chronic low back pain (cLBP) with kinesiophobia is difficult to treat, and traditional graded activity approaches often show limited adherence and short-term effects. Virtual reality (VR) may enhance treatment engagement by providing immersive game-based environments that encourage therapeutic movement. This randomized controlled trial aimed to examine the effects of VR interventions designed to promote lumbar spine flexion in individuals with cLBP and elevated movement-related fear. Methods: Participants were randomized to one of two nine-week VR game conditions that differed only in the amount of lumbar flexion required. Primary outcomes were changes in pain intensity and disability from baseline to one-week post-treatment. Secondary analyses examined lumbar flexion and expectations of pain/harm as potential mediators. Follow-up assessments were conducted at multiple time points through 48 weeks to assess maintenance of treatment gains. Results: Both VR groups showed significant and clinically meaningful reductions in pain and disability at post-treatment. Improvements were maintained throughout the 48-week follow-up period. Depression symptoms continued to improve during follow-up. Expectations of pain and harm decreased significantly during treatment and remained reduced, whereas objective lumbar flexion did not change appreciably over time. Mediator analyses indicated that improved expectations of pain/harm, rather than increased lumbar flexion, were more closely associated with treatment response. Conclusions: Immersive VR gaming produced sustained reductions in pain, disability, and movement-related fear in individuals with cLBP and kinesiophobia. Findings suggest that VR may enhance rehabilitation outcomes by modifying maladaptive expectations rather than altering lumbar motion. VR-based interventions represent a promising and engaging approach for long-term cLBP management. Full article

Background/Objectives: Motion artifacts significantly distort fluorescence measurements during surgical perfusion assessment, potentially leading to incorrect clinical decisions. This study evaluates the efficacy of automated motion compensation (MC) in quantitative indocyanine green (q-ICG) imaging to improve the accuracy of perfusion assessment. Methods: Frames from ICG perfusion assessment during 17 pancreaticoduodenectomies were analyzed. Regions of interest (ROIs) were systematically placed on each frame series, and automated MC was applied to track tissue movement. Performance was evaluated by comparing MC with surgeon-adjusted placement using multiple image quality metrics and analyzing perfusion metrics on time–intensity curves. Principal Component Analysis (PCA) was applied to explore whether image patterns could distinguish between successful and unsuccessful motion compensation. Results: Automated motion compensation successfully corrected motion artifacts in 67.5% of frame sequences, achieving comparable performance to surgeon-guided adjustments. PCA demonstrated clear separation between sufficient and insufficient corrections (AUC = 0.80). At the population level, MC did not significantly change perfusion slope (t(59) = 1.60, p = 0.11) or time-to-peak (Tmax; t(58) = 0.81, p = 0.42). Bland–Altman analysis showed a mean bias of −0.54 (SD = 3.32) for slope and 24.95 (SD = 238.40) for Tmax. At the individual level, 86.7% of slope and 79.7% of Tmax values differed by ≥10% after MC, with mean absolute percentage changes of 108.5% (median 37.8%) and 431.5% (median 65.9%), respectively. Conclusions: MC effectively reduces motion artifacts in fluorescence-guided perfusion assessment. By improving the precision of ICG-derived parameters, this technology enhances measurement reliability and represents an enabler for accurate intraoperative perfusion quantification. Full article

Emerging research indicates that neuronal activity is maintained by an architectural system of protons in a multi-scale fashion. Proton architecture is formed when organelles (such as mitochondria, endoplasmic reticulum, lysosomes, synaptic vesicles, etc.) are coupled together to produce dynamic energy domains. Techniques have been developed to visualize protons in neurons; recent advances include near-atomic structural imaging of organelle interfaces using cryo-tomography and nanoscale resolution imaging of organelle interfaces and proton tracking using ultra-fast spectroscopy. Results of these studies indicate that protons in neurons do not diffuse randomly throughout the neuron but instead exist in organized geometric configurations. The cristae of mitochondrial cells create oscillating proton micro-domains that are influenced by the curvature of the cristae, hydrogen bonding between molecules, and localized changes in dielectric properties that result in time-patterned proton signals that can be used to determine the metabolic load of the cell and the redox state of its mitochondria. These proton patterns also communicate to the rest of the cell via hydrated aligned proton-conductive pathways at the mitochon-dria-endoplasmic reticulum junctions, through acidic lipid regions, and through nano-tethered contact sites between mitochondria and other organelles, which are typically spaced approximately 10–25 nm apart. Other proton architectures exist in lysosomes, endosomes, and synaptic vesicles. In each of these organelles, the V-ATPase generates steep concentration gradients across their membranes, controlling the rate of cargo removal from the lumen of the organelle, recycling receptors from the surface of the membrane, and loading neurotransmitters into the vesicles. Recent super-resolution pH mapping has indicated that populations of synaptic vesicles contain significant heterogeneity in the amount of protons they contain, thereby influencing the amount of neurotransmitter released per vesicle, the probability of vesicle release, and the degree of post-synaptic receptor protonation. Additionally, proton gradients in each organelle interact with the cytoskeleton: the protonation status of actin and microtubules influences filament stiffness, protein–protein interactions, and organelle movement, resulting in the formation of localized spatial structures that may possess some type of computational significance. At multiple scales, it appears that neurons integrate the proton micro-domains with mechanical tension fields, dielectric nanodomains, and phase-state transitions to form distributed computing elements whose behavior is determined by the integration of energy flow, organelle geometry, and the organization of soft materials. Alterations to the proton landscape in neurons (e.g., due to alterations in cristae structure, drift in luminal pH, disruption in the hydration-structure of the cell, or imbalance in the protonation of cytoskeletal components) could disrupt the intracellular signaling network well before the onset of measurable electrical or biochemical pathologies. This article will summarize evidence indicating that proton–organelle interaction provides a previously unknown source of energetic substrate for neural computation. Using an integrated approach combining nanoscale proton energy, organelle interface geometry, cytoskeletal mechanics, and AI-based multiscale models, this article outlines current principles and unresolved questions related to the subject area as well as possible new approaches to early detection and precise intervention of pathological conditions related to altered intracellular energy flow. Full article

Premenstrual syndrome (PMS) negatively affects women’s physical performance, emotional balance, and quality of life. Although pharmacological therapies exist, their side effects and limited effectiveness highlight the need for alternatives. This partially controlled, non-blinded, non-randomized prospective pilot study included 34 women aged 18–40 years and examined the effects of an eight-week structured yoga program. Participants met the same eligibility criteria and were comparable at baseline in age, sociodemographic characteristics, and PMS severity. The study group attended two weekly 90-min hatha yoga sessions and completed a 15-min daily home practice, while controls maintained their usual physical activity. Outcome measures included body composition, hip range of motion, spinal mobility (flexion and lateral flexion), and Premenstrual Symptoms Screening Tool (PSST) scores. After eight weeks, the yoga group showed significant reductions in body weight and fat mass and an increase in muscle mass. Hip external rotation improved significantly among yoga participants, while changes in spinal mobility did not reach statistical significance. The intervention group showed a significant reduction in PMS symptom severity, while the control group showed no significant change. The findings suggest that regular yoga practice can enhance physical functioning and alleviate PMS-related symptoms, supporting its role as a movement-based approach for improving women’s health. Full article

The vision of Albert Maria Weiß on Catholic anti-modernism and his bitter fight against the tendency of adapting Catholic doctrine to the changing world’s expectations was esteemed by Pius X, but his legacy was long forgotten by the Holy See. His rediscovery is due to the 21st-century traditionalist movement, but his vision on modernism is still problematic because of his explication of the corruption that had emerged in Catholic theology. To him, Protestantism is the origine of all heresy, liberalism being its descendant which represents the greatest threat to Catholic doctrine ever: Catholic modernity. His anti-liberal and anti-Protestant visions made him unacceptable to later the mainstream Catholic thought, which supported democratic ideals and oecumenism instead. Full article

The maturation and motility of epididymal sperm (ES) cells are largely driven by changes in protein expression. This study aimed to analyze the proteomic profile of canine (Canis lupus familiaris) ES across groups characterized by different progressive motility (PMOT) values to identify motility-related sperm proteins (MRSPs). ES were obtained from the epididymal semen of 19 dogs. The motility and movement parameters of ejaculated sperm (ES) were evaluated using computer-assisted semen analysis (CASA). Samples were classified into two groups: good sperm motility (GSM), defined as PMOT% ≥ 55%, and poor sperm motility (PSM), defined as PMOT < 55%. Principal component analysis (PCA) of the first two components could explain 88.1% of the total variance between the GSM and PSM groups. Protein profiling of ES was performed using NanoUPLC-Q-TOF/MS. Significant statistical differences were demonstrated between the GSM and PSM groups for the TMOT (p = 0.039) and PMOT (p < 0.001). For five common proteins, their abundance was estimated to be higher in the GSM group than in the PSM group: ACTB (p = 0.2732), CRISP2 (p = 0.1558), LTF (p = 0.2661) and significantly higher: ce10 (p = 0.009) and NPC2 (p < 0.0044). These findings may be used to develop diagnostic MRSP-based tests related to ES quality in assisted reproduction techniques in dogs. Full article

To date, there is extensive scientific evidence affirming that physical exercise plays a fundamental role in both the prevention and treatment of various pathological conditions in humans as well as in animals. It is understood that the advantages of movement and exercise have a multifactorial origin and they depend on a category of bioactive molecules vehicolated by extracellular microvesicles known as exosomes. The exosomes act as potential delivery systems for messages within the organism. These findings have drawn significant attention, leading researchers to further investigate the role of exosomes, delving into the study of microRNAs (miRNAs). In particular, these molecules are found inside exosomes and play a key role in cellular communication, with an impact on numerous physiological functions of the organism. It has been suggested that during physical exercise, the expression levels of miRNAs increase in parallel with those of exosomes, and their release enables intercellular communication in multicellular organisms, thereby regulating both cell growth and division. Studies have not only been carried out in humans, but also in laboratory animals and in mammals following exercise. Specifically, a change in exosome expression has been found in athletic horses following physical exercise. The aim of the current review was to highlight what is known about the role played by exosomes and miRNAs during physical exercise in equine species by considering, on a broad scale, the published data on this topic, including comparative data from humans and rodent models. Full article

Correcting an illegal bowling action in cricket through technical intervention involves modifying a movement pattern. This study evaluated the success of an intervention aimed at correcting the suspect actions of two off-spin bowlers and assessed whether it influenced other movement patterns and performance parameters that were not directly targeted by the intervention (the “side-effects” of the intervention). For this purpose, a smart cricket ball equipped with three high-speed gyroscopes was used. This technology not only detects illegal bowling actions but also measures five physical and five skill performance parameters, along with ratios within and across these two parameter groups. Additionally, it tracks the position of the centre of pressure, where torque is applied to the ball, and identifies the type of delivery based on the direction of the angular velocity vector in the global coordinate system. The significant reduction of 15–27% in the integral of the precession signal before the torque spike provided the required evidence for the success of the intervention. Among the performance parameters not targeted by the intervention, skill parameters improved by 7–53% after the intervention relative to before the intervention, while physical performance parameters (spin rate, torque, angular acceleration) decreased (≈10%) significantly after the intervention. The position and vector of the centre of pressure shifted significantly distally and closer to the palm in both bowlers (33.3° and 47.5° in participants A and B, respectively) after the intervention. Although the basic average type of delivery (sidespin plus half swerve, and top-spin plus half swerve) did not change, the yaw angle of the angular velocity vector in the global coordinate system moved significantly counterclockwise by 18–20°. This study demonstrated that while the intervention successfully corrected illegal bowling actions, the smart cricket ball also revealed changes in other performance measures, which aligns with the understanding that the bowling action operates as an integrated, dynamic system. Full article

The growing demand for personalized healthcare is driving the development of Wireless Body Area Networks (WBANs). These networks enable continuous monitoring of physiological parameters. In WBANs, routing protocols are essential for ensuring reliable data delivery. However, designing efficient protocols is challenging due to the specific environment of the human body. Key issues include limited energy, frequent topology changes caused by movement, and diverse Quality of Service needs. In this review, we investigate, summarize, and analyze state-of-the-art WBAN routing protocols. Specifically, we outline the architecture of WBAN-based eHealth systems and review major design challenges. We then present a categorized survey of recent protocols. Subsequently, we examine the distribution across protocol categories and compare their performance. Finally, we identify open challenges and discuss future research directions. Full article

In naturally ventilated dairy barns, many questions regarding airflow, indoor air quality, and emissions are still unanswered, often resulting in inaccurate environmental control of the housing. Particularly, limited understanding of the implications of the constantly changing outdoor weather conditions in interaction with the building design and the role of the characteristics of the animals’ movement inside the building enhances uncertainties in the estimation of airflows within and across the barns. Computational fluid dynamics (CFD) have been used in the past to better understand the dynamics of barn climate, but the models are typically too slow to be used for real-time prediction and control. We investigated the effect of animal characteristics (i.e., animal location, orientation, body posture, and dimensions) on the pressure drop in the animal occupied zone considering inlet wind speed from 0.1 m s⁻¹ to 5 m s⁻¹ and wind direction of 0° and 90° in a CFD model. The cow position in general had little impact on the pressure drop at low wind speeds, but became relevant at higher wind speeds. Cows distributed in a more organized alignment showed less airflow resistance, and, therefore, a lower pressure drop and higher air velocities. Moreover, the cow breed affected the pressure drop, with higher withers resulting in a higher pressure drop and air resistance. In contrast, the effects of cow lying–standing ratio on the pressure drop and airflow resistance coefficients were negligible for both investigated wind directions. Our study aims to provide guidance for optimizing parametrizations of the animal occupied zone in order to enhance the speed of simulations without significant loss in model accuracy. In addition, the conclusions drawn from our study may support the adaption of building design and herd management to improve the effectiveness of ventilation concepts of naturally ventilated dairy barns. Full article

Background/Objectives: The ability to maintain movement quality despite muscle fatigue is essential for daily activities and preserving independence after motor impairments. Many real-life situations involve asymmetrical muscle activation, leading to unilateral muscle fatigue. Repeated unilateral handgrip contractions at submaximal force have been linked to neural changes in both contralateral and ipsilateral motor areas, as well as improved contralateral response times in a button-press task. However, it remains unclear whether these improvements in response latency extend to higher-level benefits in overall arm movement quality. Methods: Thirty healthy participants performed unilateral handgrip fatiguing tasks at 5%, 50%, and 75% of maximum voluntary contraction (MVC) force. Subsequently, bilateral upper-limb movement quality was assessed in an object-hit task using a Kinarm robot. Results: The 50% and 75% MVC protocols elicited muscle fatigue as evidenced by declines in force output, post-exercise MVC, electromyography magnitude changes, and increased perceived exertion compared to the 5% MVC control condition. However, no significant changes in kinematic measures of the object-hit task were observed for either the fatigued (ipsilateral) or non-fatigued (contralateral) arm, indicating that unilateral handgrip fatigue did not affect higher-level movement quality. Conclusions: Previously reported improvements on contralateral response latency in a button-press task were not found to translate into advanced arm movement quality benefits. Full article

Behavioral individuality, often termed animal personality, reflects consistent patterns of behavioral variability across individuals. In fruit flies (Drosophila melanogaster), pharmacological and dietary manipulations affecting neuromodulatory systems have been shown to alter behavior, but their effects on behavioral predictability remain incompletely understood. Here, we investigated whether developmental dietary exposure to tryptophan (a serotonin precursor) or escitalopram (a selective serotonin reuptake inhibitor, SSRI) is associated with changes in lateralized turning behavior. Flies were reared from larval stages on supplemented media and tested in a Y-maze assay to assess movement predictability. Flies exposed to escitalopram displayed significantly reduced behavioral variability compared to controls, indicated by a lower median absolute deviation (MAD) of turning behavior, whereas tryptophan supplementation did not significantly affect variability. Because both compounds were tested at a single dietary dose and serotonergic activity was not directly measured, these findings should be interpreted as dose-specific behavioral effects rather than evidence of altered serotonergic tone or mechanism. Our results demonstrate that chronic developmental exposure to escitalopram is associated with increased behavioral predictability in fruit flies, highlighting the utility of high-throughput behavioral assays for detecting subtle pharmacologically induced changes in individual variability. Future studies incorporating dose–response designs and physiological validation will be required to establish underlying mechanisms. Full article

Background: Cognitive and physical functions share certain age-related patterns of change, including slowed processing speed and movement. Both functions are multifaceted, and the association between them can be affected by the type of measurement considered. This study examined one-to-one relationships between cognitive and physical functions, using data from the Compostela Aging Study. Methods: A total of 267 middle-aged and older individuals without cognitive impairment were included in the study (mean age 65.57, 75.7% women). The relationship between cognitive and physical performance was examined using Spearman’s rho, adjusted for age and sex. Results: Standing up, sitting down and total times in the Timed-Up and Go test were significantly correlated with performance on the Trail-Making and phonological fluency tests. Turning time in the Timed-Up and Go test and self-reported physical activity were correlated with performance on the Spanish version of the California Verbal Learning Test. Grip strength was correlated with performance on the Counting Span task. Conclusions: This study adds evidence to the one-to-one relationship between cognitive and physical function in a subclinical cohort of middle-aged and older adults. Full article

Glacier mass loss driven by climate change has increased glacier-related hazards, including glacier debris flows, and poses growing threats to downstream communities. The Badswat Basin in northern Karakoram has experienced repeated glacier debris flows in recent years but lacks systematic disaster analysis and detailed monitoring. This study reconstructs and analyzes three glacier debris flows from 2015, 2018, and 2021 using multi-source remote sensing data and high-resolution DEMs. Results show that three events were triggered by tributary glaciers, with the 2015 event creating the initial dammed lake, and the 2018 and 2021 events further enlarging it (up to 0.72 km² and 40 million m³). These events transported glacier mass downstream, expanded alluvial fans, and caused net glacier erosion. The 2018 event was the most destructive, damaging 75 buildings, flooding 0.28 km² of farmland, and destroying 4.95 km of roads. Analysis suggests that topography influences environmental vulnerability and glacier stability. High temperatures, which accelerate glacier melting, are the primary drivers of the hazard. The bidirectional link between glacier movement and debris flows is a key factor in triggering or intensifying events. Under future climate scenarios, both tributary and main glaciers are expected to continue losing mass, further increasing downstream risks. This study details the evolutionary process of recurring periodic debris flows in the Badswat Basin, providing scientific insights into glacier–landform interactions and hazard management in high-mountain socio-ecological systems. Full article