Search Results (1,751)

Background/objective: Despite the fact that almost 87% of children with Autism Spectrum Disorder (ASD) have physical coordination issues, motor skills are not the primary concern when ASD is diagnosed. An aquatic environment can provide multisensory stimuli that might assist these children; however, studies related to hydrotherapy with children with ASD have not yet examined whether this environment has an effect on balance and coordination. Methods: A control vs. research group examined the effect of a weekly, three-month hydrotherapy program on the balance and coordination abilities of male children and adolescents diagnosed with high-functioning ASD. Children (N = 22) between the ages of 6 and 17 years (mean: 8.4 ± 2.4), participated in this study. Each participant’s coordination and balance abilities were evaluated using the Movement Assessment Battery for Children-Second Edition (M-ABC-II). The initial evaluation (test one) was repeated (test two) after two months to establish improvement prior to intervention. The final evaluation (test three) was conducted at intervention termination. Individual functional goals were set for each patient using the Goal Attainment Scale (GAS). Results: No improvement was noted within the pre-intervention period (between tests one and two), yet there was a statistically significant improvement in the M-ABC-II Total Test score (p = 0.0133), in Manual Dexterity (p = 0.0181), and balance (p = 0.0053) post-intervention, between tests two and three. The mean GAS score for this study was 52.1, suggesting the achievement of prespecified functional goals. Conclusions: This study demonstrated a positive impact of a 12-week hydrotherapy program on balance and coordination and manual dexterity among children with ASD. A positive impact was also noted in patients’ individual functional abilities. Full article

Purpose: This study assessed the adaptations resulting from implementing an experimental, integrated training program tailored to sex-specific traits. The aim was to enhance motor abilities, aerobic capacity, and metabolic variables in female and male rugby sevens athletes. Methods: Employing a combined observational and experimental design, initial and post-intervention assessments were conducted over three months (March–June 2023) with 24 elite professional players, divided equally by sex (12 females, 12 males). The protocol consisted of 12 micro-cycles, each lasting 7 days and comprising 12 training sessions. The evaluations included sprint and jumping tests, as well as functional assessments such as resting metabolic rate and cardiopulmonary exercise testing. Results: Using one-way repeated measures ANOVA, significant improvements were noted across all performance parameters (p < 0.001), with effect sizes ranging from small to very large. Sex-specific differences were evident, with females demonstrating consistent improvements in aerobic capacity and jumping ability, while males excelled in explosive power and longer sprints. Despite initial performance disparities, both sexes improved in short-distance sprints (10 m and 40 m). Cardiovascular efficiency improved as indicated by reduced maximum heart rates and lower respiratory quotients. Conclusions: Males showed superior progress in strength and explosive power tests, reflecting distinct physiological traits. These findings underscore the need for individualized and sex-specific training programs to optimize performance in high-intensity sports, such as rugby sevens. Full article

Background/Objectives: Post-traumatic epileptogenesis is a frequent and clinically relevant consequence of traumatic brain injury (TBI), often contributing to worsened neurological and functional outcomes. In patients experiencing early post-injury seizures, rehabilitative strategies that support recovery while considering increased epileptogenic risk are needed. This case study explores the potential benefits of combining neurofeedback (NFB) with motor therapy on cognitive and motor recovery. Methods: A patient hospitalized for severe TBI who experienced an acute symptomatic seizure in the early post-injury phase underwent baseline quantitative EEG (qEEG), neuromotor, functional, and neuropsychological assessments. The patient then completed a three-week rehabilitation program (five days/week) including 30 sensorimotor rhythm (SMR) NFB sessions (35 min each) combined with daily one-hour motor therapy. qEEG and clinical assessments were repeated post-intervention and at 6-month follow-up. Results: Post-intervention qEEG showed significant reductions in Delta and Theta power, reflecting decreased cortical slowing and enhanced neural activation. Relative power analysis indicated reduced Theta activity and Alpha normalization, suggesting improved cortical stability. Increases were observed in Beta and High-beta activity, alongside significant reductions in the Theta/Beta ratio, consistent with improved attentional regulation. Neuropsychological outcomes revealed reliable improvements in global cognition, memory, and visuospatial abilities, mostly maintained or enhanced at follow-up. Depressive and anxiety symptoms decreased markedly. Motor and functional assessments demonstrated meaningful improvements in motor performance, coordination, and functional independence. Conclusions: Findings suggest that integrating NFB with motor therapy may support recovery processes and be associated with sustained neuroplastic changes in the early post-injury phase after TBI, a condition associated with elevated risk for post-traumatic epilepsy. Full article

Background/Objectives: Children with Down Syndrome (DS) exhibit difficulties in maintaining balance and coordination in addition to limitations in functional mobility. The Cognitive–Motor Dual-Task Exercise Program (CMDT) has shown the ability to improve balance and functional mobility. This study aimed to compare the effect of CMDT versus exergaming on the balance and functional mobility of children with Down Syndrome aged 8–14 years. Methods: A randomized comparative trial was conducted, dividing participants’ children with DS into two intervention groups: CMDT group and exergaming group. Participants were recruited using convenience sampling methods from the Voice of Down Syndrome Association and the Down Syndrome Charitable Association in Riyadh, Saudi Arabia. Both interventions were implemented over a period of six weeks. Outcome measures included the Timed Up and Go (TUG), Four Square Step Test (FSST), and Pediatric Balance Scale (PBS). Results: A total of 23 children with DS participated in the study. A mixed repeated measures ANCOVA shows a significant effect of time across the two groups (p < 0.001) for TUG, FSST, and PBS, indicating improvements in balance and functional mobility. There were no significant differences between the two group interventions. Conclusions: CMDT and exergaming were equally effective in improving balance and functional mobility in children with DS. Trial Registration: Clinicaltrials.gov with ID NCT06146907. Full article

Acquired brain injury (ABI) often results in cognitive and motor impairments that can compromise driving ability, an essential aspect of independence and social participation. This study utilized a custom-designed driving simulator to compare driving performance between individuals with ABI and controls, and to examine the relationship between cognitive performance and driving behavior within the control group. All participants completed a series of standardized driving simulation tasks of varying complexity. The control group also completed a neuropsychological battery that assessed attention, processing speed, executive function, and visuospatial abilities. Simulator data were analyzed using generalized linear mixed models to evaluate group differences and, for the control group, cognitive predictors of performance. Results showed that individuals with ABI performed comparably to controls in basic operational tasks but demonstrated reduced performance in cognitively demanding scenarios requiring sustained attention, visuospatial monitoring, and adaptive control, such as rural driving, vehicle following, and parking. In the control group, strong associations were found between simulator outcomes and measures of attention, processing speed, and spatial orientation. The findings support the use of simulator-based assessment as an objective tool sensitive to post-injury impairments and highlight its links to cognitive domains relevant to driving. Full article

Background/Objectives: Down Syndrome (DS) is frequently associated with oral-motor dysmorphologies, like oral hypotonia, tongue protrusion, short palate, and malocclusion, compromising the oral functions of sucking, chewing, swallowing, and speech production. Therapeutic interventions with stimulating palatal plates (SPP) have been proposed to prevent and improve oral-motor dysmorphologies in DS. This study proposes a new digital workflow for the manufacturing and use of a modified SPP. Methods: We report the application of the new workflow to five clinical cases, all infants with DS showing oral-motor disorders, aged between 5 and 11 months. The workflow is described step-by-step, from the mouth scanning protocol and model printing to SPP manufacturing and delivering, and assessment of oral-morphological features and language abilities via video captures and parental questionnaires. Key novel features include an SPP with an acrylic extension with a pacifier terminal and, importantly, the use of an infant-friendly intraoral scanner. Results: The new workflow had good acceptability by infants and parents, offering a safe, easy-to-implement, and feasible solution for SPP design, as it avoided the high risks associated with impression materials. It also supported the use of the SPP to promote tongue stimulation, retraction, and overall oral-muscle function in oral-motor disorders in children with DS, especially in infants. Conclusions: Within the limitations of the current study, it was shown that the proposed digital workflow constitutes a viable and infant-friendly approach to the production and use of a modified SPP, and thus promises to contribute to improving oral morphology and auditory-motor language abilities. Full article

Background/Objectives: Despite athletes initiating sprints from dynamic starts during gameplay, sprint performance is traditionally measured from a static position. This article aimed to determine whether static start or “pickup” acceleration are related or relatively independent motor qualities by assessing their relationship and examining how athletes’ rank order changes between static and pickup conditions. Methods: Thirty-one male athletes (20.3 ± 5.3 years) completed two 30 m sprints from a static start and two 30 m pickup accelerations following 20 m paced entries at 1.5 and 3.0 m/s⁻¹, regulated by an LED system. Peak acceleration (a_max) was measured via a horizontal linear position encoder (LPE; 1080 Sprint). Results: The shared variance between a_max from the static and pickup starts was R² = 11.6–39.6%, indicating, for the most part, a great amount of unexplained variance. The shared variance between pickup acceleration entry velocities was R² = 16.8%. A visual analysis of an individualized rank-order table confirmed that, for the most part, the fastest static-start athletes differed from the fastest pickup athletes. Conclusions: In summary, static and pickup acceleration appear to be distinct motor abilities, most likely requiring a paradigm shift in strength and conditioning practices for acceleration assessment and development. Full article

Juggling is a complex motor skill that requires multiple sub-skills and cannot be mastered without extensive practice. Although prior studies have quantified performance differences between novice and expert jugglers, none have attempted to quantitatively decompose these components or model their contribution to juggling performance. This longitudinal study presents a multimodal evaluation system that integrates computer vision, motion capture, and biosensing to quantify three key elements of juggling ability: Sequencing, Prediction, and Accuracy. Twenty beginners completed a 10-day, three-ball juggling experiment combining visuo-haptic virtual reality (VR) and real-world practice, with half training in reduced gravity, previously shown to enhance early-stage motor learning. The fitted Gamma-Log generalized linear model (GLM) indicated that Sequencing is the dominant factor of early skill acquisition, followed by Prediction and Accuracy. This study provides the first computational decomposition of juggling, demonstrates how multiple elements jointly contribute to performance, and results in a principled approach to characterizing motor learning in complex real-world tasks. Full article

Objective: This study investigated the efficacy and neural mechanisms of robot-assisted mirror therapy (RMT) for post-stroke upper limb rehabilitation. RMT integrates the multimodal feedback of mirror therapy with robotic precision and repetition to enhance cortical activation and neuroplasticity. Methods: Seventy-eight stroke patients were randomly assigned to control, mirror therapy (MT), or RMT groups. All received conventional rehabilitation; the MT group additionally underwent mirror therapy, and the RMT group received robot-assisted mirror therapy combined with functional electrical stimulation. The primary outcome was the Fugl–Meyer Assessment for Upper Extremity (FMA-UE), with secondary measures including spasticity, dexterity, daily living, and quality of life. Functional near-infrared spectroscopy (fNIRS) was applied to assess cortical activation and connectivity at baseline, post-intervention, and one-month follow-up. Results: All groups showed significant time effects, though between-group differences were limited. Subgroup analysis revealed that patients at Brunnstrom stages I–II in the MT group achieved greater improvements in upper limb function, dexterity, and daily living ability. fNIRS findings showed enhanced activation in the right sensory association cortex and increased prefrontal–sensory connectivity. Conclusions: While all interventions improved motor outcomes, MT yielded slightly superior recovery associated with neuroplastic changes. RMT demonstrated high safety, compliance, and potential benefit for patients with severe motor deficits. Full article

Background: Preterm infants are at risk of growth faltering at term age. Our primary objective is to assess post-discharge growth patterns in these infants and investigate the association between growth faltering and neurodevelopment. Methods: We divided the sample into two groups according to growth during the initial hospital stay: infants who suffered from growth faltering (GF, loss of >1 weight z-score from birth to 36 weeks postmenstrual age, n = 115) and infants who did not suffer from GF (non-growth faltering, NGF, n = 85). Results: The NFG group weight z-score was significantly lower at 36 postmenstrual ages (PMA) compared to birth (p < 0.001), at 1-year corrected age (CA), it was significantly higher than at birth (p = 0.0026), and by 2 years CA, there were no differences compared to the birth z-scores. In the GF infants’ group, statistical differences were found at all time points. At 3 and 6 months, CA GF infants were still in weight z-score values lower than −1 point compared to the birth median value. At 12 and 24 months CA, they still had not achieved birth z-score values (p < 0.001). In the Parent Report of Children’s Abilities-Revised (PARCA), NGF infants had a higher score in the language development scale at 2 years than GF infants (88.5 [78.5; 96.5] vs. 84.5 [69.5; 91.5], p = 0.03). The Bayley-III test was available for 35 infants. We found a significant difference in motor development, with a higher score in the NGF group (94 [88; 100] vs. 85 [79; 91], p = 0.03). Conclusions: In this cohort study, GF is associated with growth differences till 2 years CA, and with lower scores in neurodevelopment assessment. Full article

Background/Objectives: The ability to maintain movement quality despite muscle fatigue is essential for daily activities and preserving independence after motor impairments. Many real-life situations involve asymmetrical muscle activation, leading to unilateral muscle fatigue. Repeated unilateral handgrip contractions at submaximal force have been linked to neural changes in both contralateral and ipsilateral motor areas, as well as improved contralateral response times in a button-press task. However, it remains unclear whether these improvements in response latency extend to higher-level benefits in overall arm movement quality. Methods: Thirty healthy participants performed unilateral handgrip fatiguing tasks at 5%, 50%, and 75% of maximum voluntary contraction (MVC) force. Subsequently, bilateral upper-limb movement quality was assessed in an object-hit task using a Kinarm robot. Results: The 50% and 75% MVC protocols elicited muscle fatigue as evidenced by declines in force output, post-exercise MVC, electromyography magnitude changes, and increased perceived exertion compared to the 5% MVC control condition. However, no significant changes in kinematic measures of the object-hit task were observed for either the fatigued (ipsilateral) or non-fatigued (contralateral) arm, indicating that unilateral handgrip fatigue did not affect higher-level movement quality. Conclusions: Previously reported improvements on contralateral response latency in a button-press task were not found to translate into advanced arm movement quality benefits. Full article

Zebrafish is emerging as a model animal for phenotype-based drug screening. Drugs screened from the zebrafish platform have advanced into clinical trials, underscoring their translational potential. Amyotrophic lateral sclerosis is a progressive motor neurons (MN) degenerative disease with few approved drugs. Previously, supplementation with exogenous recombinant phosphoglycerate kinase 1 (Pgk1) was found to improve MN growth through its interaction with receptor Eno2. To bypass the high complexity and cost of full-length Pgk1 production, a short segment within Pgk1 (M08) was predicted as the key motif interacting with Eno2, and a zebrafish phenotypic screening platform was established to find the most neurotrophic compound(s) among M08 and its mutants. We first found that M08-injected zebrafish embryos significantly increased branched caudal primary MNs (CaPMNs). However, compared to M08 (59.20 ± 1.80%), M039, among 17 mutants further screened, showed even more improvement of branched CaPMNs, up to 74.54 ± 3.73%. Next, when we administered the M039 peptide to C9ORF72-knockdown ALS-like zebrafish embryos, it improved axonal growth and swimming ability. Then, we employed a cellular model as a secondary screen, and M039 exhibited improved neurite outgrowth of MN (NOMN) and reduced p-Cofilin in NSC34 neural cells grown in ALS-like condition. Therefore, by using a zebrafish MN phenotype as a primary screening platform, we identified a mutated short peptide M039 having the most pronounced positive effect on improving neurite growth among all 17 mutants in comparison to parental M08, demonstrating the feasibility of zebrafish screening as a cost-effective strategy for finding promising neuroprotective short peptides that serve as neurotherapeutic potentials. Full article

Neuroplasticity-based active movement opens an avenue for functional recovery in post-stroke patients. Active rehabilitation techniques have attracted wide attention based on their abilities to enhance patient involvement, facilitate precise personalized intervention, and provide comprehensive treatment via cross-domain approaches. Emerging evidence suggests that active rehabilitation methods can respond to patients’ motor intentions in real-time and significantly increase motivation and engagement, leading to efficient utilization of critical recovery windows and better rehabilitation outcomes. In this review, we focus on the physiological basis of active rehabilitation, including mechanisms of neuroplasticity, and discuss recent advances in intent detection and feedback devices. We also examine treatment options for different stages of stroke recovery, providing a comprehensive reference for engineers to design optimized rehabilitation techniques and for clinicians to select appropriate rehabilitation protocols. These developments create new opportunities to improve the lives of stroke patients and offer greater hope for their recovery. Full article

Cerebral palsy (CP) is a neuromotor disorder that affects movement and posture, causing functional limitations and musculoskeletal deformities that persist into adulthood. Variability in motor expression makes identifying the functional level a clinical challenge; achieving greater accuracy in this assessment enables detection of risk factors for postural deterioration. This study analysed a sample of 56 adults with CP to evaluate the ability of different machine learning (ML) models to discriminate between levels IV and V of the Gross Motor Function Classification System (GMFCS), using a total of 78 clinical variables such as spasticity, range of motion, deformities, and postural asymmetries. Different supervised learning models were compared, and a relabelling procedure was applied to improve classification consistency. The results indicate that there is valuable information in the collected standardised variables for classifying levels IV and V. The best performances were subsequently obtained by the neural network and the linear logistic regression, achieving the latter, which has explanatory properties interesting for clinicians, accuracy, F1-score and AUC metrics of 92.83%, 93.44% and 99.35%, respectively. These findings suggest that ML could emerge as a useful and explanatory tool for functional assessment of CP in adults and for the design of personalised rehabilitation strategies. Full article

The switched reluctance motors (SRMs) are an attractive solution for electric vehicles (EVs) and hybrid electric vehicles (HEVs). However, the main drawbacks of SRMs are their highly nonlinear magnetic characteristics, complicated control algorithms, and the inherent torque ripples. This paper presents a simple structure average torque control (ATC) technique with a better ability to reduce torque ripples. Based on the detailed analysis of an inductance profile, this paper introduces a novel current compensation mechanism (CCM) that has the ability to profile the phase current and, hence, reduce the torque ripple. The proposed CCM is meant for the minimum inductance zone (MIZ) to profile the current of the ongoing phase. Over the MIZ, the inductance is independent of the phase current that helps to simplify the deduced mathematical formulations and provides a simple structure ATC with a lower computational burden, making it a feasible solution for real-time implementations and future developments. A series of experimental results are achieved to show the feasibility and effectiveness of the proposed ATC technique. The results show the superior performance of the proposed ATC, providing better torque profiles and reducing the torque ripples with an average value of 30% compared to conventional ATC. Full article