Search Results (265)

Pharmaceutical packaging materials play a crucial role in ensuring the safety and efficacy of medications. This mini-review examines the properties of common packaging materials (glass, plastics, metals, and rubber) and their implications for drug safety. By analyzing 127 research articles from PubMed, Web of Science, and CNKI databases (2000–2025), we also discuss recent regulatory updates in China and highlight emerging technologies, including nanomaterials, sustainable packaging solutions, and intelligent packaging systems that present new opportunities for the pharmaceutical industry. Key findings include the following: (1) The physicochemical properties of packaging materials and potential microbial contamination risks during production significantly impact drug quality and safety, underscoring the need for enhanced research and regulatory oversight. (2) Each material exhibits distinct advantages and limitations: glass demonstrates superior chemical stability but may leach ions; plastics offer versatility but risk plasticizer migration; metals provide exceptional strength yet have limited applications; rubber ensures effective sealing but may release additives compromising drug quality. (3) The pharmaceutical packaging sector is evolving toward intelligent systems and sustainable solutions to address contemporary healthcare challenges. This review can aid pharmaceutical companies in selecting drug packaging and guide manufacturers in developing innovative packaging solutions. Full article

The inclusion of adsorption thermodynamic analysis and performance benchmarking with existing adsorbents reinforces both the theoretical significance and practical applicability of this study. The modified rubber-derived carbon demonstrated a remarkably high DBT adsorption capacity of 254.45 mg/g. These results establish it as a promising alternative to conventional materials such as commercial activated carbon, zeolites, and even metal–organic framework materials. In addition to confirming the superior performance of the adsorbent, the findings provide a deeper understanding of the DBT adsorption mechanism and offer a solid scientific basis for large-scale fuel desulfurization applications. This research highlights the potential of transforming end-of-life tire waste into value-added functional materials and contributes to the advancement of sustainable and efficient desulfurization technologies. Future work should focus on optimizing surface functionalization and regeneration strategies to further improve long-term adsorption stability and practical deployment. Full article

This paper aimed to evaluate the effect of cross-linking temperature on the rheological, mechanical, and thermal properties of CR/BR compositions cross-linked with zinc oxide, iron(III) oxide, or copper(II) oxide. Properties of CR/BR compounds were studied at four temperatures: 140, 160, 180, and 200 °C. The lowest activation energy of vulcanization was shown by blends cross-linked with ZnO, and the highest activation energy of vulcanization was shown by samples with Fe₂O₃. Blends cured with ZnO or Fe₂O₃ showed higher cross-linking activity than CuO. Higher temperatures enhanced the degree of cross-linking in the CR/BR composite cured with ZnO or CuO but slightly reduced it for the CR/BR/Fe₂O₃ vulcanizates. The highest tensile strength was observed for the CR/BR/Fe₂O₃ product. However, compositions cured with ZnO exhibited the best aging resistance. The CR/BR compounds cured with ZnO at high temperatures had the highest tear strength (16.8 N/mm), while samples containing CuO as a curing agent showed declining tear strength with temperature. DSC confirmed a single glass transition (~36 °C), indicating good elastomers dispersion. Infrared and SEM analyses confirmed effective cross-linking and blend compatibility. Full article

Self-healing hydrogels hold promise for smart sensors in bioengineering and intelligent systems, yet balancing self-healing ability with mechanical strength remains challenging. In this study, a self-healing hydrogel exhibiting superior stretchability was developed by embedding a combination of hydrogen bonding and dynamic metal coordination interactions, introduced by modified fenugreek galactomannan, ferric ions, and lignin silver nanoparticles, into a covalent polyacrylic acid (PAA) matrix. Synergistic covalent and multiple non-covalent interactions enabled the hydrogel with high self-healing ability and enhanced mechanical property. In particular, due to the introduction of multiple energy dissipation mechanisms, particularly migrative dynamic metal coordination interactions, the hydrogel exhibited ultra-high stretchability of up to 2000%. Furthermore, with the incorporation of lignin silver nanoparticles and ferric ions, the hydrogel demonstrated excellent strain sensitivity (gauge factor ≈ 3.94), with stable and repeatable resistance signals. Assembled into a flexible strain sensor, it effectively detected subtle human motions and organ vibrations, and even replaced conductive rubber in gaming controllers for real-time inputs. This study provides a versatile strategy for designing multifunctional hydrogels for advanced sensing applications. Full article

Tyre wear particles (TWPs), generated from tyre-road abrasion, are a pervasive and under-regulated environmental pollutant, accounting for a significant share of global microplastic contamination. Recent estimates indicate that 1.3 million metric tons of TWPs are released annually in Europe, dispersing via atmospheric transport, stormwater runoff, and sedimentation to contaminate air, water, and soil. TWPs are composed of synthetic rubber polymers, reinforcing fillers, and chemical additives, including heavy metals such as zinc (Zn) and copper (Cu) and organic compounds like polycyclic aromatic hydrocarbons (PAHs) and N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD). These constituents confer persistence and bioaccumulative potential. While TWP toxicity in aquatic systems is well-documented, its ecological impacts on terrestrial environments, particularly in agricultural soils, remain less understood despite global soil loading rates exceeding 6.1 million metric tons annually. This review synthesizes global research on TWP sources, environmental fate, and ecotoxicological effects, with a focus on soil–plant systems. TWPs have been shown to alter key soil properties, including a 25% reduction in porosity and a 20–35% decrease in organic matter decomposition, disrupt microbial communities (with a 40–60% reduction in nitrogen-fixing bacteria), and induce phytotoxicity through both physical blockage of roots and Zn-induced oxidative stress. Human exposure occurs through inhalation (estimated at 3200 particles per day in urban areas), ingestion, and dermal contact, with epidemiological evidence linking TWPs to increased risks of respiratory, cardiovascular, and developmental disorders. Emerging remediation strategies are critically evaluated across three tiers: (1) source reduction using advanced tyre materials (up to 40% wear reduction in laboratory tests); (2) environmental interception through bioengineered filtration systems (60–80% capture efficiency in pilot trials); and (3) contaminant degradation via novel bioremediation techniques (up to 85% removal in recent studies). Key research gaps remain, including the need for long-term field studies, standardized mitigation protocols, and integrated risk assessments. This review emphasizes the importance of interdisciplinary collaboration in addressing TWP pollution and offers guidance on sustainable solutions to protect ecosystems and public health through science-driven policy recommendations. Full article

Polybutadiene (PB) and polyisoprene (PI) rubbers are indispensable synthetic elastomeric materials widely used in tires, footwear, hose, belts, sealants, electricity, construction, and other applications. Nowadays, PB and PI elastomers are produced from butadiene (BD) and isoprene (IP) monomers via transition-metal-mediated coordination polymerization. Transition metal catalytic systems consist of a precise characteristic structural unit at the molecular level: well known as “single-site catalysts” (SSCs). These have experienced a revolutionary advance in the recently developed conjugated dienes synthetic rubber method. Among the SSCs, a class of rare-earth, metal-centered half-sandwich molecule has been identified as a high-performance catalytic system for conjugated dienes polymerization. These novel half-sandwich rare-earth (HSRE) catalytic systems exhibit several irreplaceable advantages compared with the conventional Ziegler–Natta-type catalytic systems. These HSRE catalytic systems can create novel conjugated diene rubbers (CDRs) with high catalytic reactivity, high stereoselectivity, an adjustable polymer chain microstructure, and high molecular weights and are considered to be the next generation of ecofriendly and economic catalytic systems for industrial applications. This paper delivers a concise review of some important synthetic methods for representative HSRE complexes with characteristic structures and of the utilization of some HSRE catalytic systems for the preparation of high-performance CDRs, especially highly stereoregular PI and PB materials. Full article

Experimental and theoretical design on thermal and structural properties of Cu-Zn-Al alloys are established. As such, from an experimental point of view, differential thermal analysis has been performed with the help of a DSC Netzsch STA 449 F1 Jupiter calorimeter with high levels of sensitivity, and the structural analysis has been accomplished through X-ray diffraction and SEM analysis. An unusual specific property for a metallic material has been discovered, which is known as “rubber-type behavior”, a characteristic determined by micro-structural changes. From the theoretical point of view, the thermal transfer in Cu-Zn-Al is presented by assimilating this alloy, both structurally and functionally, with a multifractal, situation in which the order–disorder transitions assimilated with thermal “dynamics” of Cu-Zn-Al, are mimed through transitions from non-multifractal to multifractal curves. In such a context, the thermal expansion velocity contains both the propagation speed of the phase transformation (be it a direct one: austenitic–martensitic transformation, or an indirect one: martensitic–austenitic transformation) and the thermal diffusion speed. Then, through self-modulations of the thermal field, the Cu-Zn-Al alloy will self-structure in channel-type or cellular-type thermal patterns, which can be linked to obtained experimental data. Consequently, since the thermal conductivity becomes a function of the observation scale, and heat transfer is modified to reflect the multifractal, non-differentiable paths in the material, it leads to anomalous diffusion and complex thermal behaviors. Full article

Waste fires are significant sources of atmospheric pollutants that contribute to environmental degradation and public health risks. They also lead to considerable losses in recyclable materials and energy. In Poland, waste fire incidents have increased in recent years, peaking in 2018–2019. This study quantifies the volume and mass of waste burned and assesses the associated losses in material and energy potential. A detailed incident inventory was compiled, including waste types and burned volumes, which were converted to mass values. This study estimates the potential fate of this waste under proper waste management scenarios. Recyclable materials, such as plastics, metals, paper, textiles, and rubber, are permanently removed from circulation, increasing the reliance on virgin resources. Energy losses were calculated using the lower heating values of each waste type, assuming a full energy recovery potential. In 2018, large and very large fires resulted in an estimated 170,000–1,016,640 m³ of burned waste, with corresponding energy losses of 495–2970 TJ. In 2019, estimates ranged from 68,000–410,000 m³ and 139–831 TJ. Plastics, refuse-derived fuel (RDF), and tires accounted for the majority of these losses. These findings highlight the relevance of waste fires in undermining recycling or energy recovery efforts and slowing progress toward a circular economy. Full article

Marine litter threatens ocean ecosystems, and nautical tourism, as a source of litter, contributes significantly. This paper presents a qualitative and quantitative study of seafloor litter in the Bay of Selehovica in the northern Adriatic Sea. The bay is accessible only by sea and is attractive to nautical tourism vessels. The survey was conducted using a remotely operated vehicle across 22,100 m² of seafloor, before and after the tourist season (summer) in 2024. The analysis shows a 25.90% increase in litter items after one season. The predominant litter category is plastic, followed by glass, metal, rubber, and textiles. The abundance of marine litter increased from 1.3 to 1.7 items per 100 m² in the post-season, reflecting a measurable rise in litter density. Due to non-normal data distribution (Shapiro–Wilk test, p < 0.001), the Wilcoxon Signed-Rank Test was used, revealing a statistically significant increase in marine litter (W = 0, p < 0.001) with a large effect size (Cohen’s d = 0.89). A strong positive correlation between the pre- and post-season values was observed (Spearman’s r = 0.96, p < 0.001), suggesting that areas with higher initial litter levels tend to accumulate more over time. The results point to the necessity of targeted management strategies to reduce the pressure of nautical tourism on marine ecosystems and to protect the marine environment. Full article

This manuscript addresses an application study by employing a mathematical model of a thermoelastic plate weakened by multi-curved holes under the effect of stress forces in the presence of heat conduction. When the initial heat flow is directed to the plate system, complex variable procedures are used to compute the basic Goursat functions, taking into account the time-dependent variables through conformal mapping, which transfers the domain to the exterior of a unit circle. The problem reduces to a general form of a contact problem in two dimensions, which is called an integrodifferential equation of the second type with the Cauchy kernel. Additionally, different hole shapes are generated using Maple 2023. Computational simulations are performed to determine the normal and shear stress components in the presence and absence of heat effects at various times. Furthermore, numerical calculations of Goursat functions are carried out and graphically displayed for some specific materials. This investigation provides valuable information about industries, such as those regarding ceramic tile, glass, rubber, paint, ceramic pigment, and metal alloys. Full article

Urban minerals are secondary resources with economic value that can be recycled and utilized, including iron and steel, non-ferrous metals, rubber, and others. Accurately estimating the quantities of various components is a critical element in the urban mining operations that support sustainable resource management. To achieve this, ontology construction was employed to systematically define and structure the relationships among different entities in the domain. Knowledge graphs were developed to identify the constituent elements and mineralization process of iron and steel, contributing to improved sustainability in urban resource utilization. The knowledge graphs were constructed using a top-down approach and stored in a Neo4j database. When a knowledge graph of iron and steel components is constructed, the iron and steel products are classified into 5 major categories and 14 subcategories. The knowledge graph of the iron and steel mineralization process is divided into five iron and steel mineralization stages and combines industrialization and urbanization to represent the factors that play a role in the iron and steel mineralization process. By leveraging ontology construction, the knowledge graph can improve the efficiency of refining and analyzing data in urban mineral-related fields. This, in turn, provides an essential data basis for establishing a circular economic system for iron and steel industry resources and advancing sustainability-oriented urban mining practices. Full article

In recent decades, the application of composite materials in aerostructures has significantly increased, with modern commercial aircraft progressively replacing aluminum alloys with composite components. This shift is exemplified by comparing the material compositions of the Boeing 777 and the Boeing 787 (Dreamliner). The Boeing 777 incorporates approximately 50% aluminum alloy and 12% composite materials, whereas the Dreamliner reverses this ratio, utilizing around 50% composites and 12% aluminum alloy. While metals remain advantageous due to their availability and ease of machining, composites offer greater potential for property tailoring to meet specific performance requirements. They also provide superior strength-to-weight ratios and enhanced resistance to corrosion and fatigue. To ensure the reliability of composites in aerospace applications, comprehensive testing under various loading conditions, particularly impact, is essential. Impacts were performed on quasi-isotropic (QIT) carbon-fiber reinforced epoxy panels with stainless steel, round-nosed and flat-ended impactors with rubber discs of 1-, 1.5- and 2 mm thickness, adhered to the flat-ended impactor to simulate the transition between hard and soft impact loading conditions. QIT composite panels were tested in this research employing similar lay-ups often being implemented in aircraft wings and other structures. The rubber discs were applied in the flat-ended impactor case but not for the round-nosed impactor due to the limited adhesion between the rubber and the rounded stainless-steel surface. Impact energies of 7.5, 15 and 30 J were investigated, and the performance of the panels was evaluated using force-time and force-displacement data alongside post-impact ultrasonic C-scan imaging to assess the damaged area. Damage was observed at all three energy values for the round-nosed impacts but only at the highest impact energy when using the flat-ended impactor, leading to the hardness study with adhered rubber discs being performed at 30 J. The most noticeable difference with the addition of rubber discs was the reduction in the damage in the plies nearest the top (impacted) surface. This suggests that the rubber reduces the severity of the impact, but increasing the thickness of the rubber from 1 to 2 mm does not notably increase this effect. Indentation clearly plays a significant role in promoting delamination at low-impact energies for the round-nosed impactors. Full article

Bis-(o-dipheylphosphinophenyl)amine, a tridentate (PNP) chelating ligand, and several of their Rare Earth (RE) metal complexes, [bis-(o-dipheylphosphinophenyl)amido]-RER₂, {[(C₆H₅)₂P-o-(C₆H₄)]₂NMR₂ (R = -CH₂-o-(C₆H₄)NMe₂: M = Y, 1; Nd, 2; Gd, 3;), are prepared in high yields. When activated with the strong Lewis acid MMAO-7, all these complexes exhibit catalytic activity toward the polymerization of isoprene (IP) in non-protic hydrocarbons. While the Nd complex (2) showed moderate activity and stereoselectivity, the Y and Gd complexes (1 and 3) exhibited extremely high catalytic efficiency in IP homo-polymerization, and produced polyisoprene rubber (PI) with 95% to over 99% cis-1,4 stereoselectivity and narrow polydispersity indices (<2.0). Moreover, under industrially relevant conditions, complex 3 can catalyze IP to produce ultrahigh molecular weight PI (UHMW-PI, MW up to 1200–2600 kg/mol) rubber with a very narrow polydispersity index (PDI ca. 1.1–1.6), a high-performance elastomeric material mimic of natural rubber (NR). Full article

Vibration is a prevalent phenomenon in mechanical systems, often adversely affecting equipment performance and operational stability. To address this issue, this study proposes a novel three-directional vibration absorber, which provides stiffness in three orthogonal directions. The mechanical properties of the isolator are theoretically analyzed, focusing on its load-bearing capacity and working stroke, which are influenced by the initial configuration angle of the spring assembly. The dynamic characteristics of the proposed isolator are evaluated by comparing its peak dynamic displacement and force transmissibility rate with those of a conventional linear vibration isolator. The results indicate that under low excitation amplitudes, the three-directional isolator achieves a lower peak force transmissibility but exhibits a higher dynamic displacement peak compared to the linear isolator. Furthermore, a dynamic model incorporating Coulomb friction damping is developed to assess its impact on the system’s dynamic response. The findings reveal that increasing the equivalent Coulomb friction factor effectively reduces the dynamic response amplitude and force transmission rate below the resonance frequency but exacerbates these parameters beyond the resonance point. Finally, experimental studies were conducted on the isolator prototype. The results show that the static theoretical model can well reflect the static characteristics of the isolator and the dynamic theoretical model can effectively fit the dynamic test curves of the isolator. This research provides a theoretical foundation for the further optimization and practical application of three-directional vibration isolators. Full article

Natural rubber is widely used in various engineering fields due to its excellent properties, particularly as an anti-corrosion and wear-resistant lining for metal pipelines. The defects in rubber linings are typically detected using the electrical spark test. Carbon black can enhance the strength, modulus, and wear resistance of natural rubber. However, conventional carbon black-filled natural rubber composites exhibit a certain level of electrical conductivity, making them unsuitable for defect detection via the electrical spark test. In this study, a silica/carbon black hybrid filler system was selected, and different types of amino-terminated poly(propylene oxide) were employed as novel interfacial dispersants to develop a low-conductivity natural rubber composite suitable for electrical spark testing while meeting general industrial mechanical performance requirements. The role of amino-terminated poly(propylene oxide) was first explored in a pure carbon black system, and then the optimized types and dosages of amino-terminated poly(propylene oxide) were added into a mixed filler system of silica and carbon black to explore the silica dosage that could balance the resistivity and mechanical properties. The results showed that the amino-terminated poly(propylene oxide) could improve the dispersion of carbon black and silica, thus increasing the mechanical properties of natural rubber composites. In the pure carbon black system, the tensile strength of natural rubber composites increased by 18.2%, the 300% modulus increased by 74.6%, and the Akron abrasion decreased by 42.7%. In the mixed filler system, the tensile strength of the natural rubber composites with 20 phr of silica and 30 phr of carbon black was 24.03 MPa, the 300% modulus was 15.16 MPa, and the Akron abrasion was 0.223 cm³. In addition, the volume resistivity was 5.52 × 10⁹ Ω·cm, which is suitable for detecting defects with the spark test. Full article