Search Results (1,009)

Aqueous magnesium-ion batteries (AMIBs) are promising for next-generation energy storage technologies due to their high safety, low cost, high theoretical energy density, and environmental friendliness. In particular, manganese-based oxides have attracted much attention due to the abundant resources, high theoretical capacity, and environmental friendliness. This paper provides a comprehensive overview of manganese-based oxide cathode materials for AMIBs, including the crystal structure, electrochemical performance, optimization strategies, and electrode reaction mechanisms. Meanwhile, recent research progress of AMIB full cells based on Mn-based oxide cathode materials is summarized. Finally, the challenges and future perspectives of Mn-based oxide cathode materials for AMIBs are discussed. This review will provide a valuable reference and source of inspiration for future research of manganese-based oxide cathode materials for AMIBs. Full article

Magnesium is an extremely important macromineral in the human body. In recent years, magnesium and its alloys have been widely used in the biomedical field due to their excellent biocompatibility, degradability, and mechanical properties similar to those of human bone. Magnesium-based materials can degrade completely within the human body, releasing magnesium ions, hydrogen gas, hydroxides, insoluble particles, and other bioactive substances, thereby influencing the microenvironment and the biochemical states of various cell types. This review systematically summarizes the biological effects of magnesium alloys in various microenvironments, analyzes the molecular mechanisms underlying the interactions between various bioactive components and their respective microenvironments, and finally explores strategies for optimizing magnesium alloy devices, thereby providing a reference for further research on the synergistic use of magnesium-based implants and drugs. Full article

Despite extensive research, formation and properties of protein corona (PC) remain largely unknown. The composition and properties of PC are unique to each particle type. Our research focuses on multilevel nanoconstructs (MLNCs) containing a core (AuNP coated with oligonucleotide) encapsulated in lipid envelope (LE). We are developing particles of this type as nucleic acid delivery systems and platforms for studying PC on lipid surfaces. The goal of this work is to optimize the assembly of MLNCs with a negatively charged LE encapsulating a negatively charged core. Magnesium ions successfully acted as electrostatic bridges between like-charged components to facilitate self-assembly. The resulting particles were characterized using DLS (hydrodynamic diameter of ~36 nm) and TEM, which revealed stable LE. However, we encountered a critical issue: mechanical strength of the phosphatidylcholine/phosphatidic acid/cholesterol envelope proved to be highly sensitive to centrifugation forces and interactions with proteins. Incubation with albumin destabilized the LE, resulting in core release. In contrast, exposure to serum maintained the integrity of LE, allowing isolation of MLNC particles bearing PC. These results demonstrate that the assembly protocol can be adapted to negatively charged lipid compositions. However, stability of MLNCs during isolation is strictly dependent on medium protein composition. Thus, MLNCs represent a valuable platform for studying the interactions of LE with the PC. Full article

Magnesium-based membranes are promising biomaterials for guided bone regeneration due to their unique properties of mechanical strength, biocompatibility, and controlled biodegradation. This scoping review aimed to map and synthesize the available evidence regarding the use of magnesium-based membranes and fixation screws in alveolar ridge regeneration and guided bone regeneration procedures. Relevant studies were identified through a literature search conducted from November 2025 to May 2026, using several databases following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Thirty-nine studies met the inclusion criteria, including in vitro studies, preclinical animal studies, clinical case reports and case series, and narrative or systematic reviews. In vitro studies demonstrated cytocompatibility and fibroblast adhesion, while moderate magnesium ion concentrations increased markers of osteogenic differentiation. Preclinical animal studies reported controlled degradation, biocompatible tissue responses, maintenance of barrier function during early healing, and findings suggesting potential osteogenic stimulation. Clinical evidence, limited to case reports and small case series, described the use of magnesium membranes in horizontal and vertical ridge augmentation, sinus lift procedures, immediate dentoalveolar regeneration, periodontal defects, and cystic lesions, with generally uneventful healing outcomes and preserved bone volume. Reported complications were mainly minor and included transient soft tissue reactions, membrane exposure, and localized gas cavity formation. However, the available evidence remains limited to low-level studies without controlled clinical trials. Current findings are insufficient to establish clinical efficacy or superiority over conventional membranes, highlighting the need for larger prospective controlled studies. The review’s findings could help researchers advance the understanding of bone regeneration and help develop new strategies to improve and further investigate bone regeneration. Full article

The successful realization of a circular economy in the cement industry, coupled with a substantial reduction in carbon emissions, relies on the development of sustainable alternative binder systems. This study investigated the physicomechanical performance and sulfate resistance of composites produced by alkali activation of natural perlite and blast furnace slag. The aim of the research was to improve mechanical properties under low- and medium-alkalinity conditions (5–10 M NaOH). The samples were cured at an ambient temperature of 20 °C and then treated with heat at 60 °C. These samples were then mechanically processed and subjected to five soak–dry cycles in 5% and 10% Na₂SO₄ solutions. The results showed that heat treatment resulted in the formation of a dense C-A-S-H gel, increasing compressive strength approximately eightfold, from 11.64 MPa to 92 MPa. However, perlite’s porous and brittle structure limits its flexural strength to 0.27 MPa; this value is insufficient for structural applications. Under severe sulfate attack (10% Na₂SO₄), samples cured at ambient temperature showed a 12% mass increase in the first cycle due to solution infiltration into capillary voids. As a consequence of extensive ettringite and gypsum formation, the specimens experienced severe deterioration, resulting in a complete loss of mechanical integrity and a residual compressive strength of 0 MPa. In contrast, heat-treated samples showed limited ion diffusion due to a denser matrix and an improved aggregate interface transition zone, resulting in a 2.6% mass increase and a residual compressive strength of 5.17 MPa. Consequently, the obtained findings indicate that thermally treated alkali-activated slag–perlite composites exhibit high resistance against sodium sulfate attack and may have potential for use in specific industrial environments with high sulfate concentrations. However, the performance of these materials under more complex aggressive conditions, such as mining environments involving magnesium sulfate exposure and acidic drainage waters, should be further validated through future studies. Full article

In the performed studies, microsomal fractions from Arabidopsis plants were used as a source of enzymes that esterify free fatty acids to free alcohols (both fatty alcohols and short-chain alcohols). The existence of two isoforms of tested enzymes is postulated. These putative isoforms, characterized by apparent peak activities at pH 6.0 and pH 7.2, respectively, appeared to differ in their responses to environmental conditions, e.g., in their temperature dependence; in their responses to calcium and magnesium ions’ presence in assays; or in retaining activity after membrane solubilization with 4% detergent CHAPS (only the postulated isoforms most active at pH 6.0 kept their activity). Differences were also annotated in the preferences of the apparent enzymatic activities toward different fatty alcohols (although both putative isoforms showed the highest activity toward phytol) and different fatty acids (in reactions with both fatty alcohols and short-chain alcohols). Two apparent enzymatic activities were inhibited by tetrahydrolipstatin, which may suggest their lipase nature. Based on the high activity of the tested enzymes in the membrane of the microsomal fractions, the authors speculate that their physiological function might be associated with maintaining membrane integrity against the harmful effects of excess free fatty acids and/or free fatty alcohols. Full article

Background/Objectives: Osteoporosis poses significant obstacles as it causes an imbalance between osteoblasts and adipocytes, which results in the disruption of bone homeostasis. Although various magnesium-based scaffolds have been deployed for the treatment of osteoporotic bone defects, whether this can be achieved by alleviating bone–fat imbalance still requires further elucidation. Methods: We designed magnesium phosphate-based platforms (GMPCs), based on magnesium photopolymerized methacrylated gelatin (GelMA) and phosphate (K-struvite, MPC), and used them to deliver magnesium ions (Mg²⁺) for alleviating bone–fat imbalance locally. Results: The in vivo results demonstrated that the GMPCs not only improved osteogenic behavior at the implanted site, but also reduced the proportion of adipose tissues in a femoral defect model in 18-month-old SD rats. Moreover, by promoting the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts in a concentration-dependent manner, GMPCs significantly reduced adipogenic differentiation in vitro. Also, 5GMPC demonstrated the best comprehensive biologic properties compared to other platforms. Conclusions: GMPCs have great potential in the treatment of age-related osteoporosis via the effective delivery of Mg²⁺. Full article

Background: Sapropelic mud from Techirghiol Lake has been used therapeutically under medical supervision for more than 170 years; however, its comprehensive physicochemical characterization under application-relevant conditions remains insufficiently documented. This study aimed to evaluate the physicochemical properties, mineral and organic composition, ion-exchange capacity, and potential therapeutic mechanisms of Techirghiol sapropelic mud. Methods: Mud samples were analyzed using standardized physicochemical and analytical techniques to determine pH, water content, granulometry, mineral composition, organic fraction, and trace elements. Results: The results indicate that Techirghiol mud is a highly hydrated alkaline peloid characterized by a complex mineral–organic system. Major elements included sodium, calcium, and magnesium, while trace elements such as manganese, iron, and zinc were present in relevant concentrations. The organic fraction, composed of humic substances, lipids, and proteins, reflected advanced but incomplete humification processes. Conclusions: The findings demonstrate the complex physicochemical composition of Techirghiol sapropelic mud and provide a scientific basis for further studies regarding its properties and applications. Full article

Soil cadmium (Cd) pollution has emerged as one of the key environmental issues threatening the safety of agricultural products worldwide, yet clean and low-cost intervention strategies that reduce Cd accumulation in edible crops without disrupting agricultural production remain scarce. Grafting onto tolerant rootstocks represents an emerging clean agronomic technology that achieves in situ Cd risk reduction within a single growing season. However, the molecular mechanisms by which rootstocks regulate scion phenotypes remain poorly understood. MicroRNAs (miRNAs) act as critical long-distance signals in plants, yet their roles in rootstock-mediated growth promotion and Cd reduction remain largely unclear. In this study, we used Solanum torvum as rootstock and purple eggplant (Solanum melongena) as scion to investigate growth, fruit quality, Cd accumulation, and miRNA-mediated regulatory mechanisms. Grafting significantly increased plant height (by 18%), stem diameter (by 12%), and yield without obvious effects on fruit quality. Under Cd stress, the Cd content in grafted eggplant fruits was reduced by 76%, whereas leaf potassium (K), calcium (Ca), and magnesium (Mg) contents were elevated by 21%, 17%, and 10%, respectively. High-throughput sequencing and quantitative real-time polymerase chain reaction identified five key differentially expressed miRNAs, including miR164a and miR166b, four of which were related to Cd stress. Gene Ontology (GO) enrichment analyzes that their target genes were mainly involved in hormone signal transduction and ion transport. Further validation suggested that grafting improved growth and reduced Cd accumulation by regulating genes of the NAC, SPL, and HD-ZIP III families. These results suggested that suitable rootstocks can enhance crop productivity and reduce toxic metal accumulation in edible parts through miRNA-mediated regulation. Full article

Bottled drinking water is widely consumed in Saudi Arabia; however, the chemical composition of these products and the accuracy of the information presented on their labels remain insufficiently characterized. This study evaluated the composition of 41 still bottled waters purchased from major supermarkets in Riyadh, Saudi Arabia, with emphasis on fluoride, calcium, magnesium, sodium, potassium, hardness, and pH, and examined their potential contributions to dietary mineral intake and caries-preventive fluoride exposure. Products were categorized according to label descriptions, and elemental analyses were performed using a fluoride ion-selective electrode for fluoride and ICP-MS for calcium, magnesium, sodium, and potassium. The pH was measured using a calibrated multiparameter analyzer, and hardness was calculated from calcium and magnesium concentrations. Mineral and purified waters accounted for 75.6% of the sampled products. Fluoride concentrations were generally modest (mean 0.76 ppm; median 0.74 ppm), indicating that the potential contribution of bottled water to caries prevention may vary substantially by brand, and only one product would provide the adult adequate intake for fluoride at a hypothetical intake of 2 L/day. Mean concentrations of calcium, magnesium, sodium, and potassium were 15.10, 7.19, 12.08, and 3.55 mg/L, respectively, indicating limited nutritional significance for most products. Most waters were soft to moderately hard, and pH values were close to neutral. Agreement between label declarations and measured values was inconsistent for fluoride, calcium, and pH. These findings show that bottled waters sold in Riyadh differ considerably in composition and that product labels do not always provide a reliable estimate of fluoride content, mineral content, or pH. From a water quality and public health perspective, bottled water can contribute to daily intake of selected constituents, but in most cases, this contribution is modest and highly brand dependent. Full article

In prokaryotes, translation initiation orchestrates protein synthesis through a network of dynamic interactions among the ribosome, mRNA, initiator tRNA^fMet, and initiation factors (IFs). Traditional approaches that rely on radioactive labeling or surface immobilization are hindered by inherent safety risks and methodological constraints. We present a fluorescence-based analytical platform that integrates microscale thermophoresis (MST) as a unified, multiparametric toolkit for comprehensive interrogation of bacterial translation initiation at the molecular level. By systematically applying MST to a panel of fluorescently labeled components—initiator tRNA^fMet, mRNAs, and initiation factors—we quantify assembly pathways and equilibria as initiation progresses from simple bimolecular interactions to higher-order, multicomponent complexes. To broaden the fluorescence toolbox for ribosomal studies, we developed a robust BODIPY-labeling protocol for 70S ribosomes and confirmed preservation of structural integrity and function by nano differential scanning fluorimetry, stopped-flow kinetic assays, and peptide-synthesis activity tests. Our microscale fluorescent system facilitates probing initiation at a variety of steps, since the role of magnesium ions and initiation factors upon 30S initiation complex formation. The same platform can be applied to investigate the effects of different compounds on translation initiation, as demonstrated for a number of antibiotics, aptamers, and antimicrobial peptides. Using this approach, we determined the antibiotic streptomycin dissociation constant for both 30S and 70S ribosomes, which proved identical at 0.3 ± 0.1 μM, and demonstrated the effect of the antimicrobial peptide rumicidin-1 on translation initiation. Offering a cost-effective and high-sensitivity alternative to conventional methods, this approach advances mechanistic understanding of prokaryotic translation and provides a versatile framework for the discovery of novel protein synthesis inhibitors. Full article

To elucidate the corrosion behavior of cracked reinforced concrete under pressurized permeation at 0.3 MPa, three exposure conditions were established, namely a low-concentration chloride-sulfate solution, a high-concentration chloride-magnesium sulfate solution, and a high-concentration chloride-magnesium sulfate-carbonate composite solution, and cyclic permeation tests were conducted. Based on the chloride ion (Cl⁻) content distribution, permeation behavior, and steel half-cell potential measurements, together with XRD and SEM microstructural analyses, the results showed that Cl⁻ transport was significantly enhanced. At a depth of 15 mm, the Cl⁻ content increased from 0.011% under unpressurized conditions to 0.211% at 90 d and further to 0.322% at 365 d, while it remained close to zero at depths of 35 mm and below. Under the low-concentration condition, permeation ceased after about 3 months, and the half-cell potential recovered from −550 to −580 at 46 d and stabilized at −250 to −340 in the later stage, indicating a certain self-healing capacity of the cracks. Under the high-concentration and composite conditions, permeation persisted throughout the 12-month period, and the half-cell potential dropped to −800 to −900 at 34–40 d and remained at −580 to −840 in the later stage, indicating that the steel remained in an active corrosion state for a long time. XRD and SEM results further showed that corrosion products such as AFt increased, and the internal concrete structure gradually deteriorated. Full article

Neutralization residue results from the hydrometallurgical extraction of magnesium in serpentine, and contains abundant Fe³⁺, Mg²⁺, and Al³⁺. The recovery of these metals involves acid leaching and precipitation. Fe³⁺ often causes co-precipitation and makes separation difficult. The reduction of Fe³⁺ into Fe²⁺ can separate iron from other metals. The reduction kinetics of Fe³⁺ by SO₂ in the acidic leachate from the neutralization residue was studied systematically within the temperature range of 323 to 363 K. The results indicate that SO₂ reduction follows first-order kinetics with respect to Fe³⁺ and 0.71-order with respect to SO₂. SO₂ reduction undergoes dissolution, hydrolysis, complex and reduction. SO₂ dissolution is an exothermic process with ΔH_sol = −42.88 kJ mol⁻¹, the reduction step has an activation energy of 14.52 kJ mol⁻¹. The reduction process is controlled by dissolution and hydrolysis. High pH accelerate the reduction while the co-existing Al³⁺, Mg²⁺ and Ni²⁺ ions inhibit the reduction. A multi-factor-controlled kinetic equation for the reduction of Fe³⁺ by SO₂ was built. This study provides a reference for the establishment of a multi-factor control system dynamics model. Full article

A relative humidity (RH) of 30–40% was considered optimal for the ‘sick’ glasses of the Veste Coburg Art Collections to prevent further corrosion at higher humidity values and crizzling on drying of the gel layer at lower levels. This has been achieved since 1993 by using saturated solutions of magnesium chloride in display cases, providing a constant humidity of 33%. These solutions also absorb volatile harmful ‘carbonyl’ and other pollutants. A visual survey of the glasses and recent ion chromatographic measurements of alkalis on their surfaces confirmed their stable condition after three decades: no crystals, no new haze, no tears, no fragmentation, and no further growth of crizzling. Full article