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Search Results (595)

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Keywords = life extension strategy

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19 pages, 29727 KiB  
Review
A Review of Methods for Increasing the Durability of Hot Forging Tools
by Jan Turek and Jacek Cieślik
Materials 2025, 18(15), 3669; https://doi.org/10.3390/ma18153669 - 4 Aug 2025
Abstract
The article presents a comprehensive review of key issues and challenges related to enhancing the durability of hot forging tools. It discusses modern strategies aimed at increasing tool life, including modifications to tool materials, heat treatment, surface engineering, tool and die design, die [...] Read more.
The article presents a comprehensive review of key issues and challenges related to enhancing the durability of hot forging tools. It discusses modern strategies aimed at increasing tool life, including modifications to tool materials, heat treatment, surface engineering, tool and die design, die geometry, tribological conditions, and lubrication. The review is based on extensive literature data, including recent publications and the authors’ own research, which has been implemented under industrial conditions at the modern forging facility in Forge Plant “Glinik” (Poland). The study introduces original design and technological solutions, such as an innovative concept for manufacturing forging dies from alloy structural steels with welded impressions, replacing traditional hot-work tool steel dies. It also proposes a zonal hardfacing approach, which involves applying welds with different chemical compositions to specific surface zones of the die impressions, selected according to the dominant wear mechanisms in each zone. General guidelines for selecting hardfacing material compositions are also provided. Additionally, the article presents technological processes for die production and regeneration. The importance and application of computer simulations of forging processes are emphasized, particularly in predicting wear mechanisms and intensity, as well as in optimizing tool and forging geometry. Full article
(This article belongs to the Section Manufacturing Processes and Systems)
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37 pages, 1202 KiB  
Article
Exploring Service Needs and Development Strategies for the Healthcare Tourism Industry Through the APA-NRM Technique
by Chung-Ling Kuo and Chia-Li Lin
Sustainability 2025, 17(15), 7068; https://doi.org/10.3390/su17157068 - 4 Aug 2025
Abstract
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism [...] Read more.
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism and medical services, which is health tourism. This growing demand has prompted many service providers to see it as a business opportunity and enter the market. Tourism can help travelers release work stress and restore physical and mental balance; meanwhile, health check-ups and disease treatment can help them regain health. Consumers have long favored health and medical tourism because it helps relieve stress and promotes overall well-being. As people age, some consumers experience a gradual decline in physical functions, making it difficult for them to participate in regular travel services provided by traditional travel agencies. Therefore, this study aims to explore the service needs of health and medical tourism customers (tourists/patients) and the interrelationships among these service needs, so that health and medical tourism service providers can develop more customized and diversified services. This study identifies four key drivers of medical tourism services: medical services, medical facilities, tour planning, and hospitality facilities. This study uses the APA (attention and performance analysis) method to assess each dimension and criterion and utilizes the DEMATEL method with the NRM (network relationship map) to identify network relationships. By combining APA and NRM techniques, this study develops the APA-NRM technique to evaluate adoption strategies and identify suitable paths for health tourism services, providing tailored development strategies and recommendations for service providers to enhance the service experience. Full article
(This article belongs to the Special Issue Inclusive Tourism and Its Place in Sustainable Development Concepts)
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17 pages, 2459 KiB  
Article
Comparative Life Cycle Assessment of Rubberized Warm-Mix Asphalt Pavements: A Cradle-to-Gate Plus Maintenance Approach
by Ana María Rodríguez-Alloza and Daniel Garraín
Coatings 2025, 15(8), 899; https://doi.org/10.3390/coatings15080899 (registering DOI) - 1 Aug 2025
Viewed by 173
Abstract
In response to the escalating climate crisis, reducing greenhouse gas emissions (GHG) has become a top priority for both the public and private sectors. The pavement industry plays a key role in this transition, offering innovative technologies that minimize environmental impacts without compromising [...] Read more.
In response to the escalating climate crisis, reducing greenhouse gas emissions (GHG) has become a top priority for both the public and private sectors. The pavement industry plays a key role in this transition, offering innovative technologies that minimize environmental impacts without compromising performance. Among these, the incorporation of recycled tire rubber and warm-mix asphalt (WMA) additives represents a promising strategy to reduce energy consumption and resource depletion in road construction. This study conducts a comparative life cycle assessment (LCA) to evaluate the environmental performance of an asphalt pavement incorporating recycled rubber and a WMA additive—referred to as R-W asphalt—against a conventional hot-mix asphalt (HMA) pavement. The analysis follows the ISO 14040/44 standards, covering material production, transport, construction, and maintenance. Two service-life scenarios are considered: one assuming equivalent durability and another with a five-year extension for the R-W pavement. The results demonstrate environmental impact reductions of up to 57%, with average savings ranging from 32% to 52% across key impact categories such as climate change, land use, and resource use. These benefits are primarily attributed to lower production temperatures and extended maintenance intervals. The findings underscore the potential of R-W asphalt as a cleaner engineering solution aligned with circular economy principles and climate mitigation goals. Full article
(This article belongs to the Special Issue Surface Protection of Pavements: New Perspectives and Applications)
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12 pages, 3315 KiB  
Article
NeRF-RE: An Improved Neural Radiance Field Model Based on Object Removal and Efficient Reconstruction
by Ziyang Li, Yongjian Huai, Qingkuo Meng and Shiquan Dong
Information 2025, 16(8), 654; https://doi.org/10.3390/info16080654 - 31 Jul 2025
Viewed by 124
Abstract
High-quality green gardens can markedly enhance the quality of life and mental well-being of their users. However, health and lifestyle constraints make it difficult for people to enjoy urban gardens, and traditional methods struggle to offer the high-fidelity experiences they need. This study [...] Read more.
High-quality green gardens can markedly enhance the quality of life and mental well-being of their users. However, health and lifestyle constraints make it difficult for people to enjoy urban gardens, and traditional methods struggle to offer the high-fidelity experiences they need. This study introduces a 3D scene reconstruction and rendering strategy based on implicit neural representation through the efficient and removable neural radiation fields model (NeRF-RE). Leveraging neural radiance fields (NeRF), the model incorporates a multi-resolution hash grid and proposal network to improve training efficiency and modeling accuracy, while integrating a segment-anything model to safeguard public privacy. Take the crabapple tree, extensively utilized in urban garden design across temperate regions of the Northern Hemisphere. A dataset comprising 660 images of crabapple trees exhibiting three distinct geometric forms is collected to assess the NeRF-RE model’s performance. The results demonstrated that the ‘harvest gold’ crabapple scene had the highest reconstruction accuracy, with PSNR, LPIPS and SSIM of 24.80 dB, 0.34 and 0.74, respectively. Compared to the Mip-NeRF 360 model, the NeRF-RE model not only showed an up to 21-fold increase in training efficiency for three types of crabapple trees, but also exhibited a less pronounced impact of dataset size on reconstruction accuracy. This study reconstructs real scenes with high fidelity using virtual reality technology. It not only facilitates people’s personal enjoyment of the beauty of natural gardens at home, but also makes certain contributions to the publicity and promotion of urban landscapes. Full article
(This article belongs to the Special Issue Extended Reality and Its Applications)
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33 pages, 799 KiB  
Review
The Ten Dietary Commandments for Patients with Irritable Bowel Syndrome: A Narrative Review with Pragmatic Indications
by Nicola Siragusa, Gloria Baldassari, Lorenzo Ferrario, Laura Passera, Beatrice Rota, Francesco Pavan, Fabrizio Santagata, Mario Capasso, Claudio Londoni, Guido Manfredi, Danilo Consalvo, Giovanni Lasagni, Luca Pozzi, Vincenza Lombardo, Federica Mascaretti, Alice Scricciolo, Leda Roncoroni, Luca Elli, Maurizio Vecchi and Andrea Costantino
Nutrients 2025, 17(15), 2496; https://doi.org/10.3390/nu17152496 - 30 Jul 2025
Viewed by 527
Abstract
Irritable bowel syndrome (IBS) is a gut–brain axis chronic disorder, characterized by recurrent abdominal pain and altered bowel habits in the absence of organic pathology. Nutrition plays a central role in symptom management, yet no single dietary strategy has demonstrated universal effectiveness. This [...] Read more.
Irritable bowel syndrome (IBS) is a gut–brain axis chronic disorder, characterized by recurrent abdominal pain and altered bowel habits in the absence of organic pathology. Nutrition plays a central role in symptom management, yet no single dietary strategy has demonstrated universal effectiveness. This narrative review critically evaluates current nutritional approaches to IBS. The low-Fermentable Oligo-, Di-, Mono-saccharides and Polyols (FODMAP) diet is the most extensively studied and provides short-term symptom relief, but its long-term effects on microbiota diversity remain concerning. The Mediterranean diet, due to its anti-inflammatory and prebiotic properties, offers a sustainable, microbiota-friendly option; however, it has specific limitations in the context of IBS, particularly due to the adverse effects of certain FODMAP-rich foods. A gluten-free diet may benefit individuals with suspected non-celiac gluten sensitivity, although improvements are often attributed to fructan restriction and placebo and nocebo effects. Lactose-free diets are effective in patients with documented lactose intolerance, while a high-soluble-fiber diet is beneficial for constipation-predominant IBS. IgG-based elimination diets are emerging but remain controversial and require further validation. In this review, we present the 10 dietary commandments for IBS, pragmatic and easily retained recommendations. It advocates a personalized, flexible, and multidisciplinary management approach, avoiding rigidity and standardized protocols, with the aim of optimizing adherence, symptom mitigation, and health-related quality of life. Future research should aim to evaluate, in real-world clinical settings, the impact and applicability of the 10 dietary commandments for IBS in terms of symptom improvement and quality of life Full article
(This article belongs to the Special Issue Dietary Interventions for Functional Gastrointestinal Disorders)
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15 pages, 1837 KiB  
Article
Cost-Effectiveness of Youth-Friendly Health Services in Health Post Settings in Jimma Zone, Ethiopia
by Geteneh Moges Assefa, Muluken Dessalegn Muluneh, Sintayehu Abebe, Genetu Addisu and Wendemagegn Yeshanehe
Int. J. Environ. Res. Public Health 2025, 22(8), 1179; https://doi.org/10.3390/ijerph22081179 - 25 Jul 2025
Viewed by 233
Abstract
Background: Adolescents in Ethiopia, particularly in rural areas, face significant barriers to accessing comprehensive sexual and reproductive health (SRH) services, resulting in poor health outcomes. The youth-friendly health services (YFHS) initiative addresses these challenges by training Health Extension Workers (HEWs) to deliver tailored, [...] Read more.
Background: Adolescents in Ethiopia, particularly in rural areas, face significant barriers to accessing comprehensive sexual and reproductive health (SRH) services, resulting in poor health outcomes. The youth-friendly health services (YFHS) initiative addresses these challenges by training Health Extension Workers (HEWs) to deliver tailored, age-appropriate care at the primary care level. This study evaluates the cost-effectiveness of YFHS implementation in rural health posts in the Jimma Zone, Ethiopia. Methods: Using an ingredient-based costing approach, costs were analyzed across six health posts, three implementing YFHS and three offering routine services. Health outcomes were modeled using disability-adjusted life years (DALYs) averted, and incremental cost-effectiveness ratios (ICERs) were calculated. Results: Results showed that YFHS reached 9854 adolescents annually at a cost of USD 29,680, compared to 2012.5 adolescents and USD 7519 in control sites. The study showed the ICER of USD 25.50 per DALY averted. The intervention improved health outcomes, including a 27% increase in antenatal care uptake, a 34% rise in contraceptive use, and a 0.065% reduction in abortion-related mortality, averting 52.11 DALYs versus 26.42 in controls. Conclusions: The ICER was USD 25.50 per DALY averted, well below Ethiopia’s GDP per capita, making it highly cost-effective by WHO standards. Scaling YFHS through HEWs offers a transformative, cost-effective strategy to advance adolescent SRH equity and achieve universal health coverage in Ethiopia. Full article
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29 pages, 2251 KiB  
Article
Embedding Circular Operations in Manufacturing: A Conceptual Model for Operational Sustainability and Resource Efficiency
by Antonius Setyadi, Suharno Pawirosumarto and Alana Damaris
Sustainability 2025, 17(15), 6737; https://doi.org/10.3390/su17156737 - 24 Jul 2025
Viewed by 409
Abstract
In response to growing environmental pressures and material constraints, circular economy principles are gaining traction across manufacturing sectors. However, most existing frameworks emphasize design and supply chain considerations, with limited focus on how circularity can be operationalized within internal manufacturing systems. This paper [...] Read more.
In response to growing environmental pressures and material constraints, circular economy principles are gaining traction across manufacturing sectors. However, most existing frameworks emphasize design and supply chain considerations, with limited focus on how circularity can be operationalized within internal manufacturing systems. This paper proposes a conceptual model that embeds circular operations at the core of production strategy. Grounded in circular economy theory, operations management, and socio-technical systems thinking, the model identifies four key operational pillars: circular input management, looping process and waste valorization, product-life extension, and reverse logistics. These are supported by enabling factors—digital infrastructure, organizational culture, and leadership—and mediated by operational flexibility, which facilitates adaptive, closed-loop performance. The model aims to align internal processes with long-term sustainability outcomes, specifically resource efficiency and operational resilience. Practical implications are outlined for resource-intensive industries such as automotive, electronics, and FMCG, along with a readiness assessment framework for guiding implementation. This study offers a pathway for future empirical research and policy development by integrating circular logic into the structural and behavioral dimensions of operations. The model contributes to advancing the Sustainable Development Goals (SDGs), particularly SDG 9 and SDG 12, by positioning circularity as a regenerative operational strategy rather than a peripheral initiative. Full article
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35 pages, 5898 KiB  
Article
A Unified Machine Learning Framework for Li-Ion Battery State Estimation and Prediction
by Afroditi Fouka, Alexandros Bousdekis, Katerina Lepenioti and Gregoris Mentzas
Appl. Sci. 2025, 15(15), 8164; https://doi.org/10.3390/app15158164 - 22 Jul 2025
Viewed by 238
Abstract
The accurate estimation and prediction of internal states in lithium-ion (Li-Ion) batteries, such as State of Charge (SoC) and Remaining Useful Life (RUL), are vital for optimizing battery performance, safety, and longevity in electric vehicles and other applications. This paper presents a unified, [...] Read more.
The accurate estimation and prediction of internal states in lithium-ion (Li-Ion) batteries, such as State of Charge (SoC) and Remaining Useful Life (RUL), are vital for optimizing battery performance, safety, and longevity in electric vehicles and other applications. This paper presents a unified, modular, and extensible machine learning (ML) framework designed to address the heterogeneity and complexity of battery state prediction tasks. The proposed framework supports flexible configurations across multiple dimensions, including feature engineering, model selection, and training/testing strategies. It integrates standardized data processing pipelines with a diverse set of ML models, such as a long short-term memory neural network (LSTM), a convolutional neural network (CNN), a feedforward neural network (FFNN), automated machine learning (AutoML), and classical regressors, while accommodating heterogeneous datasets. The framework’s applicability is demonstrated through five distinct use cases involving SoC estimation and RUL prediction using real-world and benchmark datasets. Experimental results highlight the framework’s adaptability, methodological transparency, and robust predictive performance across various battery chemistries, usage profiles, and degradation conditions. This work contributes to a standardized approach that facilitates the reproducibility, comparability, and practical deployment of ML-based battery analytics. Full article
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24 pages, 3928 KiB  
Article
Performance Degradation and Fatigue Life Prediction of Hot Recycled Asphalt Mixture Under the Coupling Effect of Ultraviolet Radiation and Freeze–Thaw Cycle
by Tangxin Xie, Zhongming He, Yuetan Ma, Huanan Yu, Zhichen Wang, Chao Huang, Feiyu Yang and Pengxu Wang
Coatings 2025, 15(7), 849; https://doi.org/10.3390/coatings15070849 - 19 Jul 2025
Viewed by 484
Abstract
In actual service, asphalt pavement is subjected to freeze–thaw cycles and ultraviolet radiation (UV) over the long term, which can easily lead to mixture aging, enhanced brittleness, and structural damage, thereby reducing pavement durability. This study focuses on the influence of freeze–thaw cycles [...] Read more.
In actual service, asphalt pavement is subjected to freeze–thaw cycles and ultraviolet radiation (UV) over the long term, which can easily lead to mixture aging, enhanced brittleness, and structural damage, thereby reducing pavement durability. This study focuses on the influence of freeze–thaw cycles and ultraviolet aging on the performance of recycled asphalt mixtures. Systematic indoor road performance tests were carried out, and a fatigue prediction model was established to explore the comprehensive effects of recycled asphalt pavement (RAP) content, environmental action (ultraviolet radiation + freeze–thaw cycle), and other factors on the performance of recycled asphalt mixtures. The results show that the high-temperature stability of recycled asphalt mixtures decreases with the increase in environmental action days, while higher RAP content contributes to better high-temperature stability. The higher the proportion of old materials, the more significant the environmental impact on the mixture; both the flexural tensile strain and flexural tensile strength decrease with the increase in environmental action time. When the RAP content increased from 30% to 50%, the bending strain continued to decline. With the extension of environmental action days, the decrease in the immersion Marshall residual stability and the freeze–thaw splitting strength became more pronounced. Although the increase in RAP content can improve the forming stability, the residual stability decreases, and the freeze–thaw splitting strength is lower than that before the freeze–thaw. Based on the fatigue test results, a fatigue life prediction model with RAP content and freeze–thaw cycles as independent variables was constructed using the multiple nonlinear regression method. Verification shows that the established prediction model is basically consistent with the change trend of the test data. The research results provide a theoretical basis and optimization strategy for the performance improvement and engineering application of recycled asphalt materials. Full article
(This article belongs to the Special Issue Novel Cleaner Materials for Pavements)
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14 pages, 5696 KiB  
Article
Growth Patterns of Reef-Building Porites Species in the Remote Clipperton Atoll Reef
by Ania Ochoa-Serena, J. J. Adolfo Tortolero-Langarica, Fabián A. Rodríguez-Zaragoza, Juan P. Carricart-Ganivet, Eric Clua and Alma P. Rodríguez-Troncoso
Diversity 2025, 17(7), 492; https://doi.org/10.3390/d17070492 - 18 Jul 2025
Viewed by 1145
Abstract
Remote reefs offer insights into natural coral dynamics, influenced by regional environmental factors and climate change fluctuations. Clipperton Atoll is the eastern tropical Pacific’s most isolated reef, where coral reef growth and life strategies have been poorly studied so far. Recognizing the coral [...] Read more.
Remote reefs offer insights into natural coral dynamics, influenced by regional environmental factors and climate change fluctuations. Clipperton Atoll is the eastern tropical Pacific’s most isolated reef, where coral reef growth and life strategies have been poorly studied so far. Recognizing the coral species’ growth response might help understand ecological dynamics and the impacts of anthropogenic stressors on coastal reefs. The present study evaluates annual coral growth parameters of the most abundant coral reef-building species, Porites australiensis, Porites arnaudi, Porites lutea, and Porites lobata. The results showed that during 2015–2019, corals exhibited the lowest annual linear extension (0.65 ± 0.29 cm yr−1), skeletal density (1.14 ± 0.32 g cm−3), and calcification rates (0.78 ± 0.44 g cm−2 yr−1) for the genera along the Pacific. Differences in growth patterns among species were observed, with Porites lutea and Porites lobata showing a higher radial extension, developing massive-hemispherical morphologies, and acting as structural stabilizers; meanwhile, P. arnaudi and P. australiensis exhibited more skeletal compaction but also with a high plasticity on their morphologies, contributing to benthic heterogeneity. These differences are particularly important as each species fulfills different ecological functions within the reef, contributing to the ecosystem balance and enhancing the relevance of the massive species in the physical structure of remote reef systems, such as Clipperton Atoll. Full article
(This article belongs to the Special Issue Eco-Physiology of Shallow Benthic Communities)
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20 pages, 9405 KiB  
Article
Developing a Hybrid Model to Enhance the Robustness of Interpretability for Landslide Susceptibility Assessment
by Xiao Yan, Dongshui Zhang, Yongshun Han, Tongsheng Li, Pin Zhong, Zhe Ning and Shirou Tan
ISPRS Int. J. Geo-Inf. 2025, 14(7), 277; https://doi.org/10.3390/ijgi14070277 - 16 Jul 2025
Viewed by 361
Abstract
Landslide is one of the most damaging natural hazards, causing extensive damage to the infrastructure and threatening human life. Although advances have been made in landslide susceptibility assessment by objective explainable machine learning, the interpretability robustness of traditional single landslide susceptibility model is [...] Read more.
Landslide is one of the most damaging natural hazards, causing extensive damage to the infrastructure and threatening human life. Although advances have been made in landslide susceptibility assessment by objective explainable machine learning, the interpretability robustness of traditional single landslide susceptibility model is still low. The proposed interpretable hybrid model in this study overcomes these challenges and aims to enhance the stability of landslide susceptibility interpretability. The model integrates three base machine learning models—LightGBM, XGBoost, and Random Forest—using a heterogeneous category strategy, thereby enhancing the robustness of model interpretability. The hybrid model is interpreted using SHAP (Shapley Additive Explanations) values, which quantify feature contributions. A 10-fold cross-validation with the coefficient of variation (CV) metric reveals that the hybrid model outperforms individual base models in terms of interpretive robustness, yielding a lower CV value of 0.175 compared to 0.208 for LightGBM, 0.240 for XGBoost, and 0.207 for the Random Forest model. Although predictive accuracy remains comparable to the baseline models, the hybrid model provides more stable and reliable interpretability results for landslide susceptibility. It identifies the slope, elevation, and LS factor as the three most important factors for landslide susceptibility in Xi’an city. Furthermore, the quantitative nonlinear relationships between these predisposing factors and susceptibility were identified, providing empowering knowledge for the landslides risk prevention and urban planning in the regions vulnerable to landslides. Full article
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19 pages, 2160 KiB  
Article
Genetic Diversity and Phylogenetic Analysis Among Multidrug-Resistant Pseudomonas spp. Isolated from Solid Waste Dump Sites and Dairy Farms
by Tuhina Das, Arkaprava Das, Neha Das, Rittika Mukherjee, Mousumi Saha, Dipanwita Das and Agniswar Sarkar
Acta Microbiol. Hell. 2025, 70(3), 30; https://doi.org/10.3390/amh70030030 - 16 Jul 2025
Viewed by 357
Abstract
The excessive use of antimicrobials drives the emergence of multidrug resistance (MDR) in bacterial strains, which harbor resistance genes to survive under diverse drug pressures. Such resistance can result in life-threatening infections. The predominance of MDR Pseudomonas spp. poses significant challenges to public [...] Read more.
The excessive use of antimicrobials drives the emergence of multidrug resistance (MDR) in bacterial strains, which harbor resistance genes to survive under diverse drug pressures. Such resistance can result in life-threatening infections. The predominance of MDR Pseudomonas spp. poses significant challenges to public health and environmental sustainability, particularly in ecosystems affected by human activities. Characterizing MDR Pseudomonas spp. is crucial for developing effective diagnostic tools and biosecurity protocols, with broader implications for managing other pathogenic bacteria. Strains were diagnosed through 16S rRNA PCR and sequencing, complemented by phylogenetic analysis to evaluate local and global evolutionary connections. Antibiotic susceptibility tests revealed extensive resistance across multiple classes, with MIC values surpassing clinical breakpoints. This study examined the genetic diversity, resistance potential, and phylogenetic relationships among Pseudomonas aeruginosa strain DG2 and Pseudomonas fluorescens strain FM3, which were isolated from solid waste dump sites (n = 30) and dairy farms (n = 22) in West Bengal, India. Phylogenetic analysis reveals distinct clusters that highlight significant geographic linkages and genetic variability among the strains. Significant biofilm production under antibiotic exposure markedly increased resistance levels. RAPD-PCR profiling revealed substantial genetic diversity among the isolates, indicating variations in their genetic makeup. In contrast, SDS-PAGE analysis provided insights into the protein expression patterns that are activated by stress, which are closely linked to MDR. This dual approach offers a clearer perspective on their adaptive responses to environmental stressors. This study underscores the need for vigilant monitoring of MDR Pseudomonas spp. in anthropogenically impacted environments to mitigate risks to human and animal health. Surveillance strategies combining phenotypic and molecular approaches are essential to assess the risks posed by resilient pathogens. Solid waste and dairy farm ecosystems emerge as critical reservoirs for the evolution and dissemination of MDR Pseudomonas spp. Full article
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85 pages, 6138 KiB  
Review
Beyond Latency: Chronic Toxoplasma Infection and Its Unveiled Behavioral and Clinical Manifestations—A 30-Year Research Perspective
by Ashkan Latifi and Jaroslav Flegr
Biomedicines 2025, 13(7), 1731; https://doi.org/10.3390/biomedicines13071731 - 15 Jul 2025
Viewed by 710
Abstract
Over the past three turbulent decades, research has profoundly reshaped our understanding of chronic Toxoplasma gondii infection—traditionally regarded as harmless in immunocompetent individuals—unveiling its surprising impact on human health, performance, and behavior. This review emphasizes the effects of chronic Toxoplasma infection on physical [...] Read more.
Over the past three turbulent decades, research has profoundly reshaped our understanding of chronic Toxoplasma gondii infection—traditionally regarded as harmless in immunocompetent individuals—unveiling its surprising impact on human health, performance, and behavior. This review emphasizes the effects of chronic Toxoplasma infection on physical and mental health, cognitive performance, and behavioral changes, highlighting key findings from studies investigating these domains, with a particular focus on both ultimate and proximate mechanisms underlying the observed effects. To this end, the primary focus will be on human studies; however, animal model studies will also be thoroughly considered when necessary and appropriate, to provide context and additional important information. Research demonstrates that chronic Toxoplasma infection may contribute to a broad spectrum of physical health issues. Ecological studies have revealed correlations between toxoplasmosis prevalence and increased morbidity and mortality from various conditions, including cardiovascular diseases, neurological disorders, and certain cancers. Large-scale cross-sectional studies have further shown that infected individuals report a higher incidence of numerous health complaints and diagnosed diseases, suggesting a significant impact on overall physical well-being. In addition to physical health, lifelong Toxoplasma infection (subclinical toxoplasmosis) has been implicated in cognitive impairments and behavioral changes. Studies have reported associations between infection and poorer performance in areas such as reaction time, processing speed, working memory, and executive function. Many of these behavioral changes likely relate to worsened health and a shift towards a “fast life history strategy.” These cognitive deficits can have significant implications for daily functioning and performance. Furthermore, the role of Toxoplasma infection in the development or exacerbation of mental health disorders has been extensively investigated. Meta-analyses, ecological studies, and large-scale observational studies have demonstrated associations between Toxoplasma infection and an increased risk of disorders such as schizophrenia and obsessive–compulsive disorder. While the precise mechanisms underlying these associations remain under investigation, research suggests that neuroinflammation and alterations in neurotransmitter systems are likely to play a role. Far from being harmless, subclinical toxoplasmosis is increasingly recognized as a hidden factor influencing human health, behavior, and cognitive performance—with implications that extend well beyond the individual to public health at large. Further research is warranted to elucidate the complex interplay between Toxoplasma infection, host physiology, and the development of various physical, cognitive, behavioral, and mental health conditions. Full article
(This article belongs to the Section Microbiology in Human Health and Disease)
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36 pages, 2939 KiB  
Systematic Review
A Systematic Review and Bibliometric Analysis for the Design of a Traceable and Sustainable Model for WEEE Information Management in Ecuador Based on the Circular Economy
by Marlon Copara, Angel Pilamunga, Fernando Ibarra, Silvia-Melinda Oyaque-Mora, Diana Morales-Urrutia and Patricio Córdova
Sustainability 2025, 17(14), 6402; https://doi.org/10.3390/su17146402 - 12 Jul 2025
Viewed by 595
Abstract
The rapid increase in waste electrical and electronic equipment (WEEE) creates major environmental and governance issues in developing countries like Ecuador struggle because they with minimal formal collection and recycling rates. This research presents a potential sustainable management approach that tracks products through [...] Read more.
The rapid increase in waste electrical and electronic equipment (WEEE) creates major environmental and governance issues in developing countries like Ecuador struggle because they with minimal formal collection and recycling rates. This research presents a potential sustainable management approach that tracks products through their life cycles while following circular economy principles that include product extension and material extraction and waste minimization. A systematic literature review (SLR) using the PRISMA methodology combined with a bibliometric analysis found essential global strategies and technological frameworks and regulatory frameworks. The analysis of articles demonstrates that information management systems (IMSs) together with digital technologies and consistent regulations serve as essential elements for enhancing traceability and material recovery and formal recycling processes. A WEEE management IMS model was developed for the Ecuadorian market through an analysis of the findings; it follows a five-stage development process, starting from the technological infrastructure setup to complete data visualization integration. The proposed model is designed to enable public–private–community partnerships using digital tools that promote sustainable practices. The combination of circular strategies with traceability technologies and strong regulatory frameworks leads to improved WEEE governance, which supports sustainable system transitions in emerging economies. Full article
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19 pages, 2134 KiB  
Article
Valorization of Rice-Bran and Corn-Flour Hydrolysates for Optimized Polyhydroxybutyrate Biosynthesis: Statistical Process Design and Structural Verification
by Gaurav Shrimali, Hardik Shah, Kashyap Thummar, Esha Rami, Rajeshkumar Chaudhari, Jens Ejbye Schmidt and Ajit Gangawane
Polymers 2025, 17(14), 1904; https://doi.org/10.3390/polym17141904 - 10 Jul 2025
Viewed by 461
Abstract
The extensive environmental pollution caused by petroleum-based plastics highlights the urgent need for sustainable, economically viable alternatives. The practical challenge of enhancing polyhydroxybutyrate (PHB) production with cost-effective agro-industrial residues—rice-bran and corn-flour hydrolysates—has been demonstrated. Bacillus bingmayongensis GS2 was isolated from soil samples collected [...] Read more.
The extensive environmental pollution caused by petroleum-based plastics highlights the urgent need for sustainable, economically viable alternatives. The practical challenge of enhancing polyhydroxybutyrate (PHB) production with cost-effective agro-industrial residues—rice-bran and corn-flour hydrolysates—has been demonstrated. Bacillus bingmayongensis GS2 was isolated from soil samples collected at the Pirana municipal landfill in Ahmedabad, India, and identified through VITEK-2 biochemical profiling and 16S rDNA sequencing (GenBank accession OQ749793). Initial screening for PHB accumulation was performed using Sudan Black B staining. Optimization via a sequential one-variable-at-a-time (OVAT) approach identified optimal cultivation conditions (36 h inoculum age, 37 °C, pH 7.0, 100 rpm agitation), resulting in a PHB yield of 2.77 g L−1 (66% DCW). Further refinement using a central composite response surface methodology (RSM)—varying rice-bran hydrolysate, corn-flour hydrolysate, peptone concentration, and initial pH—significantly improved the PHB yield to 3.18 g L−1(74% DCW), representing more than a threefold enhancement over unoptimized conditions. Structural validation using Fourier Transform Infrared spectroscopy (FTIR) and Proton Nuclear Magnetic Resonance spectroscopy (1H-NMR) confirmed the molecular integrity of the produced PHB. That Bacillus bingmayongensis GS2 effectively converts low-cost agro-industrial residues into high-value bioplastics has been demonstrated, indicating substantial industrial potential. Future work will focus on bioreactor scale-up, targeted metabolic-engineering strategies, and comprehensive sustainability evaluations, including life-cycle assessment. Full article
(This article belongs to the Section Biobased and Biodegradable Polymers)
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