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Dietary Interventions for Functional Gastrointestinal Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 4717

Special Issue Editor


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Guest Editor
School of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, Japan
Interests: immunology; allergy; inflammatory bowel disease; non-IgE-mediated gut allergic reaction

Special Issue Information

Dear Colleagues,

Functional gastrointestinal disorders (FGIDs) are prevalent in adults, adolescents, and children. They are also known as disorders of gut–brain interactions. These disorders impair the body’s movement of the intestines, the sensitivity of the nerves of the intestines, or the way the brain controls some of these functions. Interest is growing in elucidating the environmental and nutritional factors that have contributed to the significant increase in the prevalence of FGIDs. Recent scientific evidence has shown that dietary interventions do present as an independent self-management approach for patients with FGIDs.

This Special Issue aims to cover, in the form of either original research articles or reviews, the most recent advances in the development of new nutritional strategies and dietary regimens in gastrointestinal disorders management.

Dr. Kanami Orihara
Guest Editor

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Keywords

  • inflammatory bowel disease
  • nutrition
  • parenteral and enteral nutrition
  • irritable bowel syndrome
  • gastrointestinal disorders
  • celiac disease
  • eosinophilic esophagitis (EoE)
  • eosinophilic gastrointestinal disorders (EGID)
  • food protein-induced enterocolitis syndrome (FPIES)
  • functional dyspepsia
  • gastroesophageal reflux disease (GERD)
  • short bowel syndrome (SBS)

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Published Papers (2 papers)

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Research

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16 pages, 3354 KiB  
Article
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation
by Yao Du, Xinyue Chen, Susumu Kajiwara and Kanami Orihara
Nutrients 2024, 16(14), 2263; https://doi.org/10.3390/nu16142263 - 13 Jul 2024
Cited by 3 | Viewed by 2669
Abstract
Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammation. However, the relationship between intestinal microbiota metabolites and the circadian rhythm of the [...] Read more.
Circadian rhythm plays an important role in intestinal homeostasis and intestinal immune function. Circadian rhythm dysregulation was reported to induce intestinal microbiota dysbiosis, intestinal barrier disruption, and trigger intestinal inflammation. However, the relationship between intestinal microbiota metabolites and the circadian rhythm of the intestinal barrier was still unclear. Urolithin A (UA), a kind of intestinal microbial metabolite, was selected in this study. Results showed UA influenced on the expression rhythm of the clock genes BMAL1 and PER2 in intestinal epithelial cells. Furthermore, the study investigated the effects of UA on the expression rhythms of clock genes (BMAL1 and PER2) and tight junctions (OCLN, TJP1, and CLND1), all of which were dysregulated by inflammation. In addition, UA pre-treatment by oral administration to female C57BL/6 mice showed the improvement in the fecal IgA concentrations, tight junction expression (Clnd1 and Clnd4), and clock gene expression (Bmal1 and Per2) in a DSS-induced colitis model induced using DSS treatment. Finally, the Nrf2-SIRT1 signaling pathway was confirmed to be involved in UA’s effect on the circadian rhythm of intestinal epithelial cells by antagonist treatment. This study also showed evidence that UA feeding showed an impact on the central clock, which are circadian rhythms in SCN. Therefore, this study highlighted the potential of UA in treating diseases like IBD with sleeping disorders by improving the dysregulated circadian rhythms in both the intestinal barrier and the SCN. Full article
(This article belongs to the Special Issue Dietary Interventions for Functional Gastrointestinal Disorders)
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Review

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30 pages, 601 KiB  
Review
Natural Products in the Management of Gastroesophageal Reflux Disease: Mechanisms, Efficacy, and Future Directions
by Kayode Komolafe, Titilope Ruth Komolafe, Olamide Olajusi Crown, Basiru Ajiboye, Felicite Noubissi, Ifedayo Victor Ogungbe and Barbara Graham
Nutrients 2025, 17(6), 1069; https://doi.org/10.3390/nu17061069 - 19 Mar 2025
Viewed by 2293
Abstract
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that is defined by the reflux of gastric contents into the esophagus, and it results in symptoms such as esophageal inflammation, regurgitation, and indigestion. Although proton pump inhibitors (PPIs) and histamine-2 receptor antagonists are [...] Read more.
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that is defined by the reflux of gastric contents into the esophagus, and it results in symptoms such as esophageal inflammation, regurgitation, and indigestion. Although proton pump inhibitors (PPIs) and histamine-2 receptor antagonists are frequently employed to treat GERD, their prolonged administration is associated with adverse effects, necessitating the development of alternative therapeutic strategies. Natural products are now recognized as promising candidates for the management of GERD due to their bioactive compounds, which possess antioxidant, anti-inflammatory, and mucosal-protective properties. The potential of natural products in the treatment of GERD is comprehensively examined in this review, with a focus on their mechanisms of action, which include acid suppression, esophageal mucosal regeneration, anti-inflammatory activity, and gut microbiota modulation. Also, the efficacy and safety of key natural products, including flavonoids, polyphenols, plant-derived oils, herbal extracts, probiotics, and dietary components, in preclinical and clinical studies, are assessed. Additionally, this review addresses the barriers confronting the translation of natural therapies into clinical practice, such as regulatory obstacles, variability in bioavailability, and the need for dosage standardization. The integration of natural products into the management of GERD has the potential to enhance conventional therapies, providing a more comprehensive and secure approach for patients. Full article
(This article belongs to the Special Issue Dietary Interventions for Functional Gastrointestinal Disorders)
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