Search Results (4,013)

Social media engagement drives both individual behavior and content dissemination, yet traditional analytics often reduce interactions to simple counts, obscuring the complex structures underlying user activity. In the highly competitive digital landscape, understanding how users interact with content is crucial for businesses aiming to optimize social media campaigns and maximize return on investment (ROI). Traditional engagement metrics, such as likes and shares, fail to capture the underlying structure and dynamics of user behavior. This study investigates the latent patterns of engagement by combining topological data analysis (TDA) with behavioral clustering across 100,000 posts on multiple platforms. Using persistent homology and k-nearest neighbour graphs, we reveal a primary bifurcation between Active (validation-focused) and Passive (consumption/propagation) users, nested four-strain substructures, and over 650 significant $H_1$ loops indicating recurring feedback cycles. Active users exhibit strong cluster cohesion and high engagement rates, while Passive users contribute broadly to content diffusion with slightly higher loop counts, highlighting distinct functional roles in social media dynamics. These findings provide a principled framework for targeting content, reinforcing feedback loops, and leveraging hub posts to amplify engagement. By linking topological structure to behavioral patterns, this work advances both the theoretical understanding of digital interaction and the practical design of more effective social media campaigns. Full article

The impact of oncological diseases extends far beyond the clinical patient, profoundly affecting the mental health of caregivers, family members, and volunteers who navigate complex emotional landscapes of grief, anxiety, and trauma. While the domain of digital health has seen a proliferation of serious games aimed at pediatric patient education and treatment adherence, the specific perspective of the “second-order patient”, the caregiver or survivor, remains significantly under-explored. The primary objective of this study is to systematically review the current state of interactive narratives in oncology, palliative care, and grief support, identifying research gaps to inform the broader design space of empathy-driven serious games. Following the PRISMA guidelines, 31 articles were selected from an initial query of 116 records. Interventions were categorized into Serious Games, Games, and Gamification. The analysis reveals a critical thematic transition: early interventions relied heavily on biological “battle” metaphors to empower patients, whereas the current literature advocates for “thanatosensitive” designs that foster empathy. However, a distinct research gap persists regarding narratives that explore post-loss meaning reconstruction and the hospital volunteer experience. Synthesizing these findings, this paper establishes an evidence-based theoretical framework demonstrating a significant opportunity for games that prioritize dialogue and emotional processing over traditional winning conditions. As a practical application of these findings, we also briefly outline the conceptualization of a prototype simulating a widower’s experience volunteering in a palliative ward, shifting the ludic focus from defeating a disease to navigating loss. Full article

This study presents a comprehensive bibliometric analysis of research on 2xxx series aluminum–copper (Al–Cu) alloys published between 2020 and 2025. A complete analysis of 4380 documents from 747 sources indexed in Scopus reveals sustained research growth, with publications rising from 603 in 2020 to 948 in 2025 at a compound annual growth rate of 9.5%. China dominates global output, contributing 35.7% of publications with Central South University as the leading institution (548 articles). However, China’s international collaboration rate (12.2%) remains notably lower than Western counterparts such as the United Kingdom (62.5%) and Canada (53.2%). Core journals including the Journal of Alloys and Compounds, Materials Science and Engineering: A, and Journal of Materials Research and Technology collectively account for 11.4% of total publications, conforming to Bradford’s Law concentration patterns. Keyword co-occurrence analysis revealed five distinct thematic clusters centered on microstructure–property relationships, friction stir welding and joining technologies, corrosion mechanisms, Al–Cu–Li aerospace alloys, and additive manufacturing. While life cycle modeling (K = 5993; tm = 2022.84) indicates the field is approaching maturity, by identifying emerging frontiers such as machine learning-assisted alloy design, sustainable processing routes, and multi-material joining for electric vehicles, this study offers researchers a quantitative roadmap of the Al–Cu alloy knowledge landscape and highlights strategic opportunities for future investigation. Full article

This paper introduces the Quantum-Inspired Impulsive Continuous Hopfield Network (Q-ICHN), a novel hybrid control framework designed to handle non-smooth, high-energy perturbations in nonlinear dynamical systems. Standard Continuous Hopfield Networks (CHNs) rely on sigmoidal activation functions that are prone to gradient saturation, which leads to an insufficient corrective response when the system undergoes large deviations from equilibrium. To overcome this shortcoming, the proposed Q-ICHN adopts a wave-packet-based activation function grounded in the stationary Schrödinger equation, yielding a non-monotonic and oscillatory activation profile that sustains effective compensatory dynamics across a broad range of states. Furthermore, the proposed framework incorporates Madelung’s quantum potential into the control architecture, thereby enabling a fundamental reshaping of the system’s energy landscape. Specifically, this induces a tunneling-like mechanism that allows the system to circumvent local minima and rapidly recover from impulsive disturbances, manifested as a sharpened attractor structure in the phase-space domain. Together, these properties yield enhanced convergence behavior and improved robustness over traditional neural control approaches. To rigorously assess its merits, the performance of the Q-ICHN is evaluated through a large-scale benchmark involving 20 established control methods, including Sliding Mode Control (SMC), Model Predictive Control (MPC), and Backstepping. The experimental results obtained across 20 heterogeneous scenarios demonstrate that the proposed model achieves a 48% reduction in Mean Squared Error (MSE) relative to the classical ICHN. In addition, the Q-ICHN exhibits improved smoothness, reflected in a 30% reduction in jerk with respect to high-gain robust controllers, and enhanced reliability, validated by superior spectral purity and a 34% reduction in integrated variance under stochastic perturbations. Collectively, these results underscore the potential of quantum-inspired activation mechanisms to favorably balance control responsiveness and harmonic stability, providing a robust framework for handling both continuous dynamics and impulsive effects. Full article

Robotic technologies are increasingly investigated for craniofacial and dental surgical procedures where sub-millimeter positional accuracy and stable instrument trajectories are essential. This structured review evaluates the current landscape of robotic systems applied to craniofacial surgical interventions and analyzes their technical architectures, validation approaches, and reported surgical accuracy. A structured literature search of PubMed and IEEE Xplore identified 27 studies published between 2015 and 2025 that met predefined inclusion criteria. The included systems were analyzed with respect to robotic control architecture, surgical application domain, validation model, and quantitative performance metrics. To facilitate cross-study interpretation, the review introduces a unified engineering classification framework linking robotic control paradigms, mechanical configurations, and clinical application domains. Most platforms employed master–slave teleoperation, image-guided hybrid control, task-autonomous execution, or cooperative haptic-guided architectures designed to stabilize surgical trajectories and reduce surgeon-dependent variability. Across representative investigations, robotic systems demonstrated entry-point deviations typically ranging from approximately 0.6–1.5 mm and angular deviations between 1.2° and 3.5°, indicating improved reproducibility compared with conventional freehand techniques. Dental implant robotics currently represents the most clinically mature application, whereas sinus, skull base, and microsurgical systems remain largely in experimental or early translational stages. Overall, craniofacial surgical robotics demonstrates substantial potential to enhance surgical precision and procedural standardization; however, broader clinical validation and improved workflow integration remain necessary for widespread clinical adoption. Full article

“Can ChatGPT become a general purpose technology?” “How does the “privacy paradox” play a role in adopting ubiquitous AI technologies in a humane AI ecosystem?” To answer these research questions, this study examined the roles of AI equality, trust in the large language model (LLM) ChatGPT, the need to belong, perceived benefits of ubiquitous AI, and privacy concerns about potentially ubiquitous generative artificial intelligence (GenAI) in a human-centered AI ecosystem. Drawing from the emerging literature on the AI divide (vs. AI equality) and AI-powered digital transformation, cross-sectional survey data were collected from current ChatGPT users. The results of testing PROCESS macro models with 5000 bootstrap samples showed the relationship between AI equality and purchase intention is mediated by trust in ChatGPT and is moderated by the need to belong. Privacy concerns about ChatGPT moderate the relationship between AI equality and perceived benefits of ubiquitous GenAI, which, in turn, mediates the relationship between AI equality and purchase intention. Ethical dilemmas in developing an equitable AI ecosystem, practical implications of the “privacy paradox” for designing trustworthy and ubiquitous AI interfaces in the dynamically evolving AI-powered digital transformation landscape and electronic marketplaces, and theoretical implications of the ChatGPT epidemic in a humane AI ecosystem for the literature on general purpose technology (GPT) are discussed. Full article

The heritagisation of cultural landscapes is often understood as a state-led administrative process. At the same time, the discursive origins and adaptive mechanisms that precede formal designation remain underexplored, especially in relation to cultural sustainability. This study examines the pre-heritagisation of Suzhou’s classical gardens during China’s modern transformation by analysing periodical discourse published between 1870 and 1948. Using a mixed-methods approach that combines quantitative content analysis and Critical Discourse Analysis (CDA), it investigates 699 historical texts from the Index to Chinese Newspapers & Periodicals database. The findings reveal a dual discursive process. On the one hand, reports portrayed the gardens as accessible, multifunctional civic spaces through narratives of public use. On the other hand, literati discourse reinforced their classical value through historical memory and aesthetic preservation. Together, these tendencies show how the gardens were materially refunctioned and symbolically re-anchored under modern conditions. Rather than directly producing later heritage designation, this process helped create the socio-cultural conditions through which the gardens acquired broader public intelligibility, cultural legitimacy, and heritage-like meanings before formal institutional recognition. Full article

The development of metro-led urban underground public spaces (UUPSs) provides urban residents with extensive pedestrian-friendly activity areas sheltered from rain, snow, strong winds, and other extreme weather conditions. Although an increasing number of people are engaging in daily commercial and leisure activities within UUPSs, problems such as inconvenient transfer, poor visibility, and a lack of natural light, which indicate poor environmental quality, have led to an uneven distribution of user behavior, thereby reducing the efficiency of space utilization. Our aim in this study was to predict UUPS utilization rates by investigating the relationship between UUPS environmental attributes and user behavior characteristics and preferences. Six typical UUPSs in Wuhan were selected as case studies. User behavior data were collected using panoramic camera recordings, on-site observations, and space syntax methods, while spatial environmental factors were quantified. The correlation between various factors and multi-dimensional user behavior characteristics was discussed, and a Random Forest model was established to predict behavioral preferences. Our results indicate that accessibility and visibility are fundamental factors influencing user behavior characteristics, while the impact of landscape elements is relatively low. Regarding behavioral preference prediction, UUPS environmental features achieved the highest prediction accuracy for leisure behaviors, whereas the predictive performance for sports activities was lower. In this study, we reveal the influence of UUPS environmental factors on user behavior characteristics and predict preference patterns of different behaviors for space types. Focusing on the behavioral needs of space users, we provide a reference for the subsequent human-centered design of UUPSs. Full article

The increasing integration of Virtual Reality (VR) technologies in cultural and historical contexts has significantly transformed the way heritage and legacy are preserved, studied, and experienced. This study provides a bibliometric analysis of the current research landscape surrounding the use of VR in heritage and legacy research. The results obtained highlight a research environment dominated by European institutions—primarily Italian and Spanish—complemented by Asian and French contributions that demonstrate a trend toward progressive internationalization. This field of research combines immersive technologies, photogrammetry for 3D digitization and user-centered designs, moving from conservationist approaches to holistic approaches that prioritize accessibility, educational dissemination and tourism. The results reveal a duality between digital documentation and immersive experience, while, among the countries with the most World Heritage sites, Italy leads in terms of quantity and average citations, China in terms of total volume, and Spain shows underutilized bibliometric potential despite its rich historical heritage. This analysis aims to trace the evolution of this field of research, uncover gaps, and suggest directions for future work that leverages virtual reality to safeguard and disseminate cultural heritage in an immersive and impactful way. Full article

Work-related stress is a significant concern among employees in multinational corporations, where workloads and performance expectations are high. This study examines pre–post changes associated with a Virtual Reality (VR)-based mindfulness intervention designed to support stress management after a workday. A sample of 134 corporate employees from multinational companies reporting moderate to high stress participated in the study. Physiological indicators, including heart rate and skin conductance, were recorded before and after the VR session, alongside self-reported measures of perceived stress and relaxation. The intervention consisted of immersive VR environments integrating guided breathing, calming narration, and natural landscapes. Results indicated significant reductions in physiological stress markers following the intervention compared to baseline levels, accompanied by improvements in self-reported relaxation, reduced tension, and enhanced mental clarity. These findings suggest that VR-based mindfulness is associated with short-term reductions in both physiological and perceived stress. VR-based mindfulness may represent a complementary and non-invasive approach to stress management in individuals exposed to high occupational demands. Future research using controlled designs and longitudinal approaches is needed to evaluate the sustained effects of repeated VR sessions and their integration into corporate wellness programs. Full article

Rail-trail corridors in the agricultural Midwest exhibit layered ecological conditions influenced by the material legacy of railroad infrastructure and contemporary land use pressures. This study uses a mixed-methods approach integrating GIS analysis, field documentation, and open-response surveys with trail managers to characterize the structural and ecological heterogeneity of two rail-trails within the Corn Belt. Spatial methods quantify variation in right of way width, land cover context, connectivity, and patterns of fragmentation, revealing that corridors shift in response to agricultural edges, successional woodlands, riparian zones, and urban conditions. Field visits and on-site sketching provide fine-grained insight into vegetative structure, topography, and edge dynamics, while the thematic analysis of survey responses highlights how management regimes, resource limitations, invasive species, and adjacent land uses shape ecological patterns along the trail. Together, these methods support the development of a typology of rail-trails based on their vegetative, hydrological, and disturbance patterns. We argue that design and management should work with the nuance of the corridors, noting the potential for landscape experimentation. Novel design approaches can support the performance of rail-trails as ecological infrastructure while enabling meaningful human–environment interactions within the right of way. Full article

In today’s energy landscape, defined by the growing demand for sustainable energy generation technologies and the parallel need to advance internal combustion engine (ICE) architectures toward cleaner and more efficient solutions, the adoption of Free-Piston Linear Generator (FPLG) engines emerges as a highly promising approach. This innovative system enables the direct conversion of combustion-induced piston motion into electrical energy, eliminating the need for traditional crankshaft and connecting rod mechanisms. The FPLG concept facilitates efficient utilization of a broad spectrum of fuels—including methane, ethanol, LPG, gasoline, biodiesel, and hydrogen—by supporting variable compression ratio operation. This feature enhances operational flexibility and fuel adaptability, positioning the technology as a viable candidate for future energy transition scenarios. The absence of rotating mechanical components significantly reduces frictional losses, contributing to an overall increase in system efficiency. To accurately characterize and optimize engine performance, an extensive series of one-dimensional (1D) numerical simulations was performed under both free and controlled operating conditions. The resulting data enabled the development of semi-empirical models capable of predicting the dynamic behavior of the engine across a wide range of working scenarios. Finally, through a detailed parametric analysis, the optimal operating conditions were identified to maximize both net electric efficiency and electrical power output. These findings provide a solid ground for the design and implementation of FPLG engine systems in advanced power generation applications. Full article

Background/Objectives: Early detection through minimally invasive approaches is critical for timely patient stratification and optimal therapeutic decision-making in colorectal cancer (CRC). Liquid biopsy, based on the analysis of tumor-derived components in blood and other body fluids, has emerged as a promising strategy to overcome current limitations in CRC diagnosis and follow-up. This review evaluates the current landscape of liquid biopsy clinical trials in CRC, focusing on predictive biomarker detection, prognostic assessment, and disease monitoring. Methods: ClinicalTrials.gov was searched using the terms “colorectal cancer” and “liquid biopsy” yielding 153 registered trials. After manual screening, 44 trials were excluded for not using liquid biopsy for CRC management, leaving 109 trials for analysis. Of these, 25 were completed, and 13 had publicly available results related to liquid biopsy. Results: The included trials were conducted across 27 countries on four continents. Overall, 119 biomolecules assessments and 167 different endpoints were reported across 109 clinical trials. Because individual trials could evaluate multiple biomolecules and endpoints, counts exceed the total number of trials. Cell-free DNA (cfDNA) was evaluated in 92/109 trials (84%) and accounting for 77% of all biomolecule assessments. Circulatingtumor cells (CTCs) were analyzed in 9/109 trials (8%, representing 8% of all the biomolecules analyzed), and microRNAs (miRNAs) in 8/109 (7%, representing 7% of all the biomolecules analyzed). Treatment sensitivity was the most common endpoint (57/109, 52% of the clinical trials; representing 34% of all the 167 different endpoints analyzed), followed by disease progression (28/109, 26%; representing 17% of all the different endpoints analyzed) and diagnostic applications (21/109, 19%; representing 12% of all the different endpoints analyzed). Among the 25 completed studies, 10/25 (40%) were interventional and 15/25 (60%) observational, spanning 14 countries. The majority of completed trials (21/25, 84%) used cfDNA. Interventional studies were predominantly phase II (5/10), with fewer phase III trials (2/10), primarily evaluating treatment response, particularly in relation to EGFR inhibitors and RAS/BRAF mutation status. Four observational studies (4/15) investigated emerging biomarkers, including long noncoding RNAs and miRNAs. Conclusions: Current clinical trials highlight cfDNA as the dominant and most clinically advanced liquid biopsy biomarker in CRC, primarily used for treatment guidance and disease monitoring. In contrast, CTCs and RNA-based biomarkers remain underrepresented. The limited number of randomized late-phase trials, heterogeneity in study design, and technical challenges associated with emerging biomarkers underscore the need for standardized methodologies and robust validation before routine clinical implementation. Full article

Microbiome-based therapies are reshaping the therapeutic landscape for ulcerative colitis (UC), offering new avenues for disease management beyond conventional immunomodulatory and biologic treatments. UC remains a chronic, relapsing condition with significant unmet clinical needs, as many patients fail to achieve sustained remission or experience adverse effects with current therapies. The gut microbiome has emerged as a central contributor to UC pathogenesis, influencing epithelial barrier integrity, immune homeostasis, and metabolic signaling. Interventions such as fecal microbiota transplantation (FMT) and defined microbial consortia have demonstrated proof-of-concept efficacy in early-phase clinical trials, each leveraging distinct mechanistic strategies. FMT, as a broad ecological intervention, restores microbial diversity and functional redundancy, potentially addressing multiple pathogenic mechanisms simultaneously. In contrast, defined consortia enable precise targeting of specific metabolic and immunological pathways, including short-chain fatty acid production, bile-acid remodeling, epithelial barrier reinforcement, immune modulation, and succinate degradation. Recent clinical evidence suggests that consortia with broader mechanistic coverage may achieve more consistent biological activity than narrowly focused designs. This review synthesizes mechanistic and clinical insights across broad and defined microbial consortia, integrates evidence from randomized controlled trials and early-phase LBP studies, and outlines a precision-medicine framework to guide therapy selection. We highlight the importance of aligning therapeutic mechanisms with patient-specific microbial, metabolic, and immune profiles, and discuss future directions including biomarker-guided stratification, hybrid consortia, and adaptive trial designs. Advancing both broad and defined approaches, while incorporating ecological principles, mechanistic understanding, and patient stratification, will be essential to realizing the full therapeutic potential of microbiome-based therapies in UC. Full article

Anticipating the socio-environmental impacts of spatial planning strategies is a prerequisite for sustainable development pathways. Land change models are increasingly employed to evaluate the impacts of spatial planning on land use and land cover, and their subsequent effects on ecosystem services and environmental resources. Nevertheless, modelling land use and land cover changes, and their interactions, at a fine scale to preserve future landscape patterns has been identified as a key challenge in the land change science community. This paper presents an innovative process-based model—the FORecasting landscapE SCEnarios Model (FORESCEM)—designed to spatially simulate fine-scale future land use and land cover changes (LUCC) based on narratives developed through participatory or expert-driven approaches. By clearly distinguishing land covers and land uses as two different but related inputs, its conception and architecture enable the assessment of interactions among LUCC within human-managed landscapes. It relies on conventional functions and properties of LUCC models, and aims at completing the existing land change models. Applied on a French case study, the validation results demonstrate the model’s capability to replicate LUCC dynamics, effectively simulating trend-based and trend-breaking LUCC trajectories under contrasting scenarios. More broadly, this paper questions and discusses the validation of land change models used for simulating future LUCC. Full article