Search Results (347)

Rechargeable zinc–air batteries (ZABs) are still impeded by the intrinsically sluggish kinetics of oxygen reduction and evolution reactions (ORR/OER) and by the instability or prohibitive price of state-of-the-art noble metal catalysts. Metal–organic frameworks (MOFs) have recently emerged as versatile sacrificial templates for next-generation air–cathode electrocatalysts. By programming pyrolytic or chemical conversion pathways, MOFs can be quantitatively transformed into hierarchically porous, heteroatom-doped carbon scaffolds that embed uniform metal, alloy, or metal-oxide nanodomains. The resulting architectures couple metallic conductivity with molecular-scale active site tunability, delivering exceptional ORR/OER activity, stability, and mass transport properties. This review critically examines the most recent advances in MOF-derived electrocatalysts for ZABs, establishing quantitative structure–composition–performance relationships across mono-, bi-, and multi-metallic systems. Emphasis is placed on deciphering how framework topology, metal–ligand coordination, and post-synthetic parameters dictate the density, electronic structure, and accessibility of surface-active moieties during catalyst evolution. We further dissect engineering strategies that enhance intrinsic activity via electronic modulation, bolster durability through encapsulation effects, and optimize hierarchical porosity for rapid O₂/water transport. This article concludes by outlining unresolved challenges and future research directions, including atomically precise active site construction, multi-scale compositional control, long-term reversibility under realistic ZABs cycles, scalable and green synthesis, providing a roadmap for translating MOF-derived catalysts from laboratory curiosities to commercially viable air–cathode materials. Full article

With the deployment of Hydrogen-enriched Compressed Natural Gas (HCNG) technology, establishing market mechanisms adapted to its physical characteristics is crucial for renewable energy accommodation. However, existing studies lack HCNG pricing mechanisms that reflect calorific value fluctuations and often overlook the dynamic carbon emission characteristics of Hydrogen Mixed Gas Turbines (HMGTs). To address these gaps, this paper proposes a hierarchical optimization framework for Integrated RES-NG Providers (IRNPs) participating in multi-type markets. In the upper level, a bidding model involving electricity, HCNG, hydrogen, and CEP-GEC joint markets is established. A dynamic HCNG pricing mechanism based on the Wobbe Index is introduced to capture composition variations, and a refined HMGT model based on the modified Arrhenius equation is employed to quantify combustion-emission physicochemical kinetics. The lower level formulates market clearing models for social welfare maximization, which are transformed into a Mathematical Program with Equilibrium Constraints (MPEC) via KKT conditions. Case studies demonstrate that: (1) the refined HMGT model captures the dynamic fluctuation of the carbon emission factor between 0.6074 and 0.6216, correcting the bias of traditional static models; (2) the introduction of the dynamic HCNG pricing mechanism significantly enhances flexibility, increasing the renewable energy accommodation rate from 90.47% to 100%; (3) IRNPs maximize profits through multi-market arbitrage, achieving a daily total revenue of ¥2.231 million, a 30.9% increase compared to participating only in electricity–gas markets; (4) The critical thresholds for cross-market arbitrage are identified, and hydrogen is diverted to the hydrogen market when prices exceed 9.6 ¥/kg and completely prioritized over HCNG blending when prices surpass 15.6 ¥/kg. Full article

In this study, magnetic porous glycidyl methacrylate and ethylene glycol dimethacrylate copolymer (mP) grafted with tetraethylenepentamine (mP-TEPA) obtained in a two-step procedure was tested as the CO₂ sorbent. The morphological, textural, structural, and thermal characterization of the sample was determined by scanning electron microscopy with energy-dispersive X-ray analysis (SEM-EDS), mercury intrusion porosimetry (MIP), nitrogen physisorption at 77 K, Fourier transform infrared spectroscopy in ATR mode (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), elemental analysis, and thermogravimetric analysis (TGA). The effects of thermodynamic and kinetic parameters, as well as the adsorption/desorption mechanism on the CO₂ sorption ability of mP-TEPA, were investigated using a pulse gas chromatographic method. Under optimal adsorption conditions, the CO₂ sorption capacity reached 6.20 mmol CO₂/g (6.20 × 10⁻² mmol CO₂/m²). Temperature-programmed desorption (TPD) experiments were conducted to calculate the activation energy of CO₂ desorption. The low desorption activation energy of 18.80 kJ/mol and high desorption rate, with stable CO₂ uptake after ten adsorption/desorption cycles, suggest that mP-TEPA is a potentially excellent sorbent for CO₂ adsorption. Full article

Background: This study examined the acute effects of post-run plantar fascia recovery training (PFRT) on dorsal kinetic chain performance (DKCP) in adolescent long-distance runners. Methods: Thirty-four adolescent runners were randomly assigned to a PFRT group (n = 17) or a control group (n = 17). Following a standardized running session, the PFRT group received bilateral PFRT. Assessments were performed on the dominant side at three time points: pre-training, post-training, and post-PFRT. DKCP was evaluated using the Bunkie Test for the posterior stabilization line (PSL) and posterior power line (PPL), Myoton measurements of the latissimus dorsi, erector spinae, hamstrings, and gastrocnemius, the Sit-and-Reach Test for hamstring/lumbar flexibility, and the Modified Schober Test for lumbar mobility. Results: No significant group × time interactions were observed for any outcome except lumbar mobility. PSL performance increased significantly following PFRT compared with post-training (p = 0.016), whereas PPL performance did not change. Lumbar mobility improved significantly over time (p < 0.05). Although latissimus dorsi stiffness and hamstring and gastrocnemius stiffness were lower in the PFRT group at baseline, no significant within-group changes were observed following PFRT. Conclusions: PFRT may acutely improve lumbar mobility as a recovery intervention in adolescent runners. Further research is needed to clarify its short- and long-term effects within structured recovery programs during adolescence. Full article

Silica spicules provide a natural transdermal conduit but require a linker that binds strongly under physiological conditions and releases payloads selectively in response to biological cues. Existing silane chemistries or polydopamine coatings lack enzyme responsiveness and show limited control over release. We created a 180-member peptide library with the motif L–X1–X2–[Y–F–Y]–A–L–G–P–H–C and screened for silica binding. Biophysical assays (circular dichroism, ζ-potential, quartz crystal microbalance, atomic force microscopy) and molecular dynamics identified high-affinity binders. The lead, P176, was tested for matrix metalloprotease (MMP)-responsive cleavage. Conjugation and release of Vitamin C and Stigmasterol were analyzed by HPLC and Franz diffusion cells. P176 showed high silica affinity (~55 µg mg⁻¹), robust biophysical signals (Δf −35 to −38 Hz; rupture force ~154 pN; ζ shift −22 to−11.5 mV), and favorable adsorption energy (−48.5 kcal mol⁻¹, contact 4.5 nm², 8.5 H-bonds). The MMP gate displayed efficient kinetics (Vmax 117.9 RFU·min⁻¹, Km 5.0 µM) with >90% cleavage at 60 min, reduced to 26% by inhibitor. Conjugation yields reached 87% (Vitamin C) and 77% (Stigmasterol). Franz diffusion showed MMP-dependent release (24 h: Vitamin C 90–96%, Stigmasterol 80–85%) with minimal basal leakage. Released Vitamin C enhanced collagen I to ~250% in fibroblasts, while Stigmasterol attenuated LPS-induced macrophage morphology; keratinocytes retained normal marker expression. This study demonstrates that a single amphipathic, sequence-programmed peptide can couple strong silica anchoring with protease-responsive release and broad payload compatibility, establishing a versatile platform for spicule-based transdermal and regenerative delivery. Full article

Fibrin hydrogels are biocompatible but often lack instructive cues needed to sustain chondrocyte phenotype and cartilage-like matrix formation; therefore, we investigated whether a tricomposite fibrin hydrogel incorporating decellularized articular cartilage matrix (dACM) and decellularized amniotic membrane matrix (dAMM) enhances human articular chondrocyte performance in vitro. Human articular chondrocytes were encapsulated in tricomposite or fibrin-only hydrogels and cultured for 28 days, evaluating degradation kinetics, viability and cell density, histological remodeling (H&E, Masson’s trichrome, Safranin O), immunohistochemistry for type II collagen, aggrecan, and type I collagen, and qPCR of SOX9, COL2A1, ACAN, RUNX2, COL1A2, and COL10A1. The tricomposite remained cytocompatible (~99% viability), supported marked cell expansion (~250% by day 28), and degraded more slowly than fibrin controls. It increased chondrogenic gene expression (SOX9 >3-fold vs. control by day 28; sustained COL2A1 at 1.5–2-fold; early ACAN at 3–5-fold) while attenuating off-target transcriptional programs (RUNX2 ~50% of control, reduced COL1A2, and negligible COL10A1). Consistently, histology showed progressive lacuna-like morphology and proteoglycan-rich matrix accumulation, accompanied by strong type II collagen and aggrecan immunoreactivity and reduced type I collagen. Overall, adding dACM and dAMM to fibrin improved hydrogel biofunctionality and promoted hyaline-like extracellular matrix assembly, supporting further evaluation of this cell-instructive platform for focal articular cartilage repair. Full article

Objective: To evaluate the effect of Physitrack^® on jump performance in handball players through performance, kinematic, and kinetic variables. Material and Methods: A pilot, randomized clinical trial was conducted with male handball players (n = 28). Participants were allocated to either an intervention group (IG), which completed a specific jump-training program, or a control group (CG), which followed a general strengthening program. Both programs were delivered via Physitrack^® over an 8-week period. Vertical jump variables were assessed using force platforms (Hawkin Dynamics^®), along with adherence questionnaires, the Telemedicine Satisfaction and Usefulness Questionnaire (TSUQ), and the System Usability Scale (SUS). Results: Both groups showed significant improvements in jump height, flight time, and peak velocity (p < 0.05), without differences between groups. The IG, additionally, demonstrated improvements not statistically significant in the modified Reactive Strength Index (mRSI), Rate of Force Development (RFD), and power. Mean adherence was moderate, slightly higher in the IG (52.13% vs. 48.98%), with no significant differences between groups (p = 0.74). Physitrack^® received an excellent usability rating (SUS: 83.3/100) and good satisfaction (TSUQ: 3.68/5). These findings should be interpreted with caution given the pilot nature of the study and the limited sample size, which restrict statistical power and the generalizability of results. Conclusions: Physitrack^® is a feasible tool for prescribing home-based exercises and is well rated by users. It does not directly improve adherence but facilitates the implementation of effective programs although the content of the program has a greater influence on performance improvements than the platform itself. Full article

Purpose: This study investigated the contribution of lower limb kinetics to punch performance in amateur boxing and examined the effects of fatigue on biomechanical efficiency. Methods: Ten male amateur boxers performed six punch types (jab, cross, left hook, right hook, left uppercut, right uppercut) under non-fatigued and post-fatigue conditions. Ground reaction force (GRF) and rate of force development (RFD) were measured using dual force plates, while punch outputs were assessed via a boxing force sensor. Fatigue was induced using a 9.5 min lower-body circuit. Results: Pre-fatigue, the cross punch generated the highest outputs for punch force (1475.42 N), GRF (947.54 N), and RFD (3973.38 N/s). Post-fatigue, punch force declined significantly across all punches (–4.26%, p = 0.027), with the greatest reductions in the cross and left hook. RFD responses were variable, with compensatory increases observed in some punches. Intra-individual analysis revealed greater fatigue-induced declines in the weakest punches (–9.84%, p = 0.001) compared with the strongest (–4.63%, p = 0.027). Conclusions: Lower limb force generation, particularly rear-leg drive, is critical to punch effectiveness and fatigue resilience. Conditioning programs should prioritise lower limb endurance while addressing performance variability across punch types. Full article

Despite the groundbreaking impact of currently approved CAR T-cell therapies, substantial unmet clinical needs remain. This highlights the need for CAR T treatments that are easier to tune, combine, and program with logic rules, in oncology and autoimmunity. Modular CAR T cells use a two-part system: the CAR on the T cell binds an adaptor molecule (AM), and that adaptor binds the tumour-associated antigen (TAA). This design separates recognition of the target antigen and activation of the T cells, resulting in a cellular therapy concept with better control, flexibility, and safety compared to established direct-targeting CAR T-cell systems. The key advantage of the system is the adaptor molecule, often an antibody-based reagent, that targets the TAA. Adaptors can be swapped or combined without re-engineering the T cells, enabling straightforward multiplexing and logic-gated control. The CAR itself is designed to recognise the AM via a unique tag on the adaptor. Only when the CAR, AM, and antigen-positive target cell assemble correctly is T-cell effector function activated, leading to cancer cell lysis. This two-component system has several features that need to be considered when designing a modular CAR: First, the architecture of the CAR, i.e., how the binding domain and the backbone are designed, can influence tonic signalling and activation/exhaustion parameters. Second, the affinity of CAR–AM and AM–TAA will mostly define the engagement kinetics of the system. Third, the valency of the AM has an impact on exhaustion and non-specific activation of CAR T cells. And lastly, the architecture of the AM, especially the size, defines the pharmacokinetics and, consequently, the dosing scheme of the AM. The research conducted on direct-targeting CAR T cells have generated in-depth knowledge of the advantages and disadvantages of the technology in its current form, with remarkable clinical success in relapsed/refractory disease and long-term survival in otherwise difficult-to-treat patient populations. On the other hand, CAR T-cell therapy poses the risk of severe adverse events and antigen loss coupled with antigen-negative relapse which remains the main reason for failed therapies. Addressing these issues in the traditional setting of one CAR targeting one antigen will always be difficult due to the heterogeneous nature of most oncologic diseases, but the flexibility to change target antigens and the modulation of CAR T response by dosing the AM in a modular CAR system might be pivotal to mitigate these hurdles of direct CAR T cells. Since the first conception of modular CARs in 2012, there have been more than 30 constructs published, and some of those have been translated into phase I/II clinical trials with early signs of success, but whether these will progress into a late-stage clinical trial and gain regulatory approval remains to be seen. Full article

In this study, experiments and numerical simulations were conducted to investigate the oscillation phenomena in a pressure swirl injector. The flow field was captured using high-speed photography, and the gray values were analyzed using the Matlab image processing program. The oscillation frequency was recorded using FFT transform. Additionally, the flow field of the pressure swirl injector was simulated based on the volume of fluid (VOF) interface-tracking method. Both the experimental and numerical results revealed periodic oscillations in the pressure swirl injector, with a corresponding frequency of several hundred Hertz. The oscillation frequency is closely related to the behavior of the central gas core, which has greater turbulent kinetic energy than the liquid phase. As the mass flow rate increases, the velocity of the gas core is increased. The turbulent kinetic energy of the central gas core increased, which led to an increase in the oscillation frequency. Finally, the relationship between Re and the oscillation frequency was obtained. Full article

Tetracycline (TC), commonly utilized in medicine and aquaculture, frequently enters aquatic environments, raising ecological concerns. This study examined TC-contaminated wastewater treated through ultraviolet (UV), potassium persulfate (PS), and combined UV/PS disinfection processes. The degradation of TC followed pseudo-first-order kinetics, with removal efficiency ranked as UV/PS > UV > PS. High-performance liquid chromatography–mass spectrometry (HPLC-MS) identified 20 disinfection byproducts (DBPs) across all processes. Based on the identified intermediates, the degradation pathways of TC under different disinfection processes (UV, PS, and UV/PS) were elucidated. Using the ECOSAR program, both acute and chronic aquatic toxicities of TC and its DBPs were predicted. The biological effects on Chlorella were also investigated. DBPs from UV and PS treatments inhibited algal growth, reducing it by 4.8–9.4% relative to the control. Conversely, DBPs formed under UV/PS disinfection stimulated growth, increasing rates by 3.4–6.6%. To counteract oxidative stress from TC and its DBPs, Chlorella enhanced superoxide dismutase (SOD) and catalase (CAT) activities. These findings highlight that while TC degradation occurs efficiently, the nature of DBPs and their ecological impacts vary significantly depending on the disinfection method. Overall, the UV/PS process not only improved TC removal but also reduced harmful effects on microalgal growth compared with UV or PS alone. Full article

Eight diffusion couples were fabricated to systematically investigate the composition-dependent interdiffusion behavior in hcp Dy-Y, Dy-Nd, Sm-Nd, and Sm-Tb binary alloys. The interdiffusion coefficients were determined at two representative temperatures using the Sauer–Freise method based on concentration–distance profiles measured by electron probe microanalysis (EPMA). These experimentally obtained diffusivities, together with available thermodynamic data, were subsequently employed to assess the atomic mobilities of each system by means of the CALTPP (CALculation of Thermo Physical Properties) program within the CALPHAD (CALculation of PHAse Diagrams) framework. The optimized mobility parameters provide a reliable description of the diffusion behavior in all investigated alloys. This reliability is confirmed by the close agreement between the calculated and experimentally measured interdiffusion coefficients, as well as by the strong consistency between the model-predicted and experimental concentration profiles. The present work thus establishes the first set of critically evaluated atomic mobility parameters for these hcp rare-earth binary systems. These results fill an important gap in the kinetic database of rare-earth alloys and lay a robust foundation for future multi-component CALPHAD-based simulations, thereby supporting the design and optimization of advanced rare-earth permanent magnets with improved coercivity and thermal stability. Full article

Mitigating climate change through the reduction of atmospheric CO₂ emissions remains a critical global priority. Solid adsorbents, particularly shales, have become promising options for CO₂ storage due to their favorable structural and chemical properties. In this study, a solid sorbent was developed by pyrolyzing shale at 800 °C under a nitrogen (N₂) atmospheric condition, yielding spent shale. The key physicochemical properties influencing CO₂ sorption were characterized using X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Brunauer–Emmett–Teller (BET) surface area analysis, and Temperature-Programmed Desorption (TPD). Mineralogical analysis revealed the presence of quartz, feldspars, clays, and carbonate minerals. The spent shale exhibited surface areas of 30–34 m²/g and pore diameters ranging from 3 to 10 nm. TPD results confirmed the presence of active adsorption sites, with a maximum CO₂ sorption capacity of about 1.62 mmol/g—surpassing several commercial sorbents. Adsorption behavior was best described by the Sips and Toth isotherm models (R² > 0.99), indicating multilayer and heterogeneous adsorption processes. Kinetic modeling using both pseudo-first-order and pseudo-second-order equations revealed that CO₂ uptake was governed by both diffusion and chemisorption mechanisms. These findings positioned spent shale as a low-cost, efficient sorbent for CO₂ storage, promoting circular resource utilization and advancing sustainable carbon management strategies. This novel shale-derived material offers a competitive pathway for carbon capture, storage, and sequestration applications. Full article

Background/Objectives: This study assessed the chemical and physical stability of ascorbic acid in pediatric total parenteral nutrition (TPN) admixtures under conditions reflecting both hospital compounding and home administration. Methods: Two storage protocols were examined: (A) refrigerated storage (15 days, 4 ± 2 °C) followed by addition of ascorbic acid and a 24-h period of storage at room temperature, and (B) vitamin supplementation within 24 h after composing and storage at 21 ± 2 °C. A validated high-performance liquid chromatography (HPLC) method was used to quantify ascorbic acid degradation. Physical stability was evaluated via optical microscopy, dynamic light scattering (DLS), laser diffraction (LD), zeta potential, and pH measurement. Results: Ascorbic acid content remained above 90% of the declared value in both protocols, although gradual degradation was observed with increasing storage time and temperature. Emulsion droplet sizes remained within pharmacopeial limits (<500 nm), and no coalescence or phase separation was detected. Zeta potential values (−20 to −40 mV) confirmed kinetic stability, while pH ranged from 5.8 to 6.2, remaining within acceptable safety margins. Conclusions: Vitamin C in pediatric TPN admixtures is stable under refrigerated conditions for up to 15 days. However, the additional 24 h at room temperature resulted in measurable loss of ascorbic acid content, suggesting a need for improved guidance in home-based parenteral nutrition, particularly regarding transport and handling. The study underscores the importance of strict cold-chain maintenance and highlights the role of emulsion matrix and packaging in protecting labile vitamins. This research provides practical implications for hospital pharmacists and caregivers, supporting better formulation practices and patient safety in pediatric home TPN programs. Full article

Recent studies have identified the hip joint as a central component of the human kinetic chain, playing a pivotal role in optimizing force transmission during movement. Enhancing its functional capacity represents an effective strategy for enhancing overall physical well-being and preventing injuries. This study investigates the effects of an eight-week hip joint functional training program on the health-related physical fitness, hip joint function, and factors associated with injury risk in university students from a track and field elective class. A total of 56 participants were randomly assigned to an experimental group (n = 28) or a control group (n = 28). The experimental group incorporated hip joint functional training, which comprising dynamic stretching and activation exercises, into their standard physical education (PE) class activities, while the control group continued with the regular physical education curriculum. Pre-intervention and post-intervention assessments included hip joint range of motion (ROM), functional movement screening (FMS), a 50 m sprint, standing long jump, sit-and-reach test, and spinal health evaluations. Results indicated that the experimental group demonstrated significant improvements in multi-directional hip range of motion (ROM), with examples including flexion increasing by 10° and external rotation by 9°. These improvements were accompanied by significant gains in functional movement screen (FMS) scores, with significant improvements in the Hurdle Step, whose median score increased to 3.0, Active Straight Leg Raise, and Rotary Stability components (all p < 0.05) compared to the control group. Furthermore, the training significantly reduced spinal asymmetry (axial trunk rotation reduced from 3.86° to 3.43°) and enhanced performance in the 50 m sprint (−0.26 s) and standing long jump (+0.08 m) (all p < 0.05). These objective improvements in functional movement patterns, postural alignment, and physical performance are associated with key biomechanical factors known to influence injury risk, such as the demonstrated gains in joint mobility and movement efficiency. Therefore, incorporating hip joint functional training into college physical education programs may effectively enhance students’ fundamental movement quality, improve joint stability, and promote postural health, thereby mitigating key biomechanical risk factors. This approach offers a practical strategy for educators to improve student physical health in general PE settings. Full article