Search Results (248)

Pseudomonas aeruginosa is a highly adaptable opportunistic pathogen with significant clinical relevance in both human and veterinary medicine. Despite its well-documented role in hospital-acquired infections in human healthcare settings, its persistence and transmission within veterinary clinics remain underexplored. This review highlights the overlooked status of veterinary facilities as environmental reservoirs and amplification points for multidrug-resistant (MDR) P. aeruginosa, emphasizing their relevance to One Health surveillance. We examine the bacterium’s environmental survival strategies, including biofilm formation, resistance to disinfectants, and tolerance to nutrient-poor conditions that facilitate the long-term colonization of moist surfaces, drains, medical equipment, and plumbing systems. Common transmission vectors are identified, including asymptomatic animal carriers, contaminated instruments, and the hands of veterinary staff. The review synthesizes current data on antimicrobial resistance in environmental isolates, revealing frequent expression of efflux pumps and mobile resistance genes, and documents the potential for zoonotic transmission to staff and pet owners. Key gaps in environmental monitoring, infection control protocols, and genomic surveillance are identified, with a call for standardized approaches tailored to the veterinary context. Control strategies, including mechanical biofilm disruption, disinfectant cycling, effluent monitoring, and staff hygiene training, are evaluated for feasibility and impact. The article concludes with a One Health framework outlining cross-species and environmental transmission pathways. It advocates for harmonized surveillance, infrastructure improvements, and intersectoral collaboration to reduce the risk posed by MDR P. aeruginosa within veterinary clinical environments and beyond. By addressing these blind spots, veterinary facilities can become proactive partners in antimicrobial stewardship and global resistance mitigation. Full article

Steam is widely used in industry as a heat carrier for thermal processes and is primarily generated by gas-fired steam boilers. The decarbonization of industrial thermal demand relies on the capability of clean and renewable technologies to provide steam through reliable and cost-effective systems. Concentrating solar thermal technologies are attracting attention as a heat source for industrial steam generation. In addition, electricity-driven high-temperature heat pumps can provide heat using either renewable or grid electricity by upgrading ambient or waste heat to the required temperature level. In this study, linear Fresnel solar collectors and high-temperature heat pumps driven by photovoltaics are considered heat sources for steam generation in industrial processes. Energetic and economic analyses are performed across the European countries to assess and compare their performances. The results demonstrate that for a given available area for the solar field, solar thermal systems provide a higher annual energy yield in southern countries and at lower costs than heat pumps. On the other hand, heat pumps driven by photovoltaics provide higher annual energy for decreasing solar radiation conditions (central and northern Europe), although it leads to higher costs than solar thermal systems. A hybrid scheme combining the two technologies is the favorable option in central Europe, allowing a trade-off between the costs and the energy yield per unit area. Full article

Background/Objectives: The association between sexual dysfunction and diabetes is well known, but few studies have investigated its prevalence in type 1 diabetes (T1D). The aim of this study was to evaluate the prevalence of sexual dysfunction in a group of women with T1D, regardless of their age, and to compare its different prevalences in women treated with different insulin regimens. Methods: The population included 77 women affected by T1D, of which 16 were on Multiple Daily Injections (MDI) and 61 on Continuous Subcutaneous Insulin Infusion (45 on Advanced Hybrid Closed Loop System with catheter and 16 on patch pump). All participants completed the Female Sexual Function Index (FSFI), a questionnaire that evaluates several aspects of sexual function. Another questionnaire that evaluated general features, diabetes-specific features and sexual-specific features was proposed to every participant. Results: The overall prevalence of female sexual dysfunction was 49.3%. A correlation was demonstrated between the prevalence of female sexual dysfunction and age; another correlation was found between the prevalence of female sexual dysfunction and dyadic status. No correlation between glycemic control and sexual dysfunction was found. Conclusions: Women with T1D presented a high prevalence of sexual dysfunction, independently from glycometabolic disease control and insulin regimens; on the other hand, a significant correlation was demonstrated with age and dyadic status. Evaluation of sexual function in women with T1D appears to be important in clinical settings independently from disease control. Full article

The integration of new technologies in Industry 4.0 has modernised agriculture, fostering the concept of smart agriculture (Agriculture 4.0). Higher education institutions are incorporating digital technologies into agricultural curricula, equipping students in agriculture, agronomy, and engineering with essential skills. The implementation of targeted STEM activities has the potential to enhance the teaching of Agriculture 4.0 through the utilisation of practical applications that stimulate student interest, thereby facilitating more accessible and effective teaching. In this context, this study presents a system comprising retrofitted real-scale components that facilitate the understanding of digital technologies and automations in agriculture. The specific system utilises a typical centrifugal electric pump and a water tank and adds logic to it, so that its flow follows various user-defined setpoints, given and monitored via a smartphone application, despite the in-purpose disturbances invoked via intermediating valves. This setup aims for students to gain familiarity with concepts such as closed-loop systems and PID controllers. Going further, fertile ground is provided for experimentation on the efficiency of the PID controller via testing different algorithmic variants incorporating non-linear methods as well. Feedback collected from the participating students via a corresponding survey highlights the importance of integrating similar hands-on interdisciplinary activities into university curricula to foster engineering education. Full article

Fontan circulation is a fragile system in which imperfections at any of multiple levels may compromise the quality of life, produce secondary pathophysiology, and shorten life span. Increased inferior vena caval pressure itself may play a role in “Fontan failure”. This study describes a mock flow loop model (MFL) designed to quantitatively estimate pulmonary flow entrainment induced by continuous and pulsed flow injections. A patient generic 3D-printed phantom model of the total cavopulmonary connection (TCPC) with average dimensions matching those of a 2–4-year-old patient was inserted in an MFL derived from a reduced lumped parameter model (LPM) representing cardiovascular circulation. The LPM comprises four 2-element Windkessel compartments (compliance and resistance), approximating the upper and lower systemic circulations and the right and left pulmonary circulations. The prescribed cardiac output is about 2.3 L/min for a body surface area of $0.675{ \mathrm{m}}^2$. The injections originate from an external pump through a 7–9 fr catheter, following a strict protocol suggested by the clinical team, featuring a variation in injection rate (flow rate), injection volume, and injection modality (continuous or pulsed). The key measurements in this study are the flow rates sampled at the distal pulmonary arteries, as well as at the upper and lower body boundaries. These measurements were then used to calculate effective entrainment as the difference between the measured and expected flow rates, as well as jet relaxation (rise and fall time of injection). The results show that for continuous or pulsed injections, varying the total volume injected has no significant influence on the entrainment rate across all injection rates. On the other hand, for both injection modalities, increasing the injection rate results in a reduction in entrainment that is consistent across all injected volumes. This study demonstrates the effectiveness of a high-speed injection jet entraining a slow co-flow while determining the potential for fluid buildup, which could ultimately cause an increase in caval pressure. To avoid the increase in caval pressure due to mass accumulation, we added a fenestration to our proposed injection jet shunt-assisted Fontan models. It was found that for a set of well-defined parameters, the jet not only can be beneficial to the local flow, but any adverse effect can be obviated by careful tuning. These results were also cross-validated with similar in silico findings. Full article

Background/Objectives: Intrarenal pressure (IRP) plays a critical role in ensuring the safety of retrograde intrarenal surgery (RIRS), as elevated IRP is associated with complications such as pyelovenous backflow, infection, and renal injury. LithoVue™ Elite (LVE) is the first commercially available ureteroscope (URS) capable of providing real-time IRP measurements. Conventionally, IRP has been measured via a percutaneous nephrostomy catheter (PNC), which may not accurately reflect dynamic changes during endoscopic procedures. Recently, small ureteral access sheaths (UASs) have been increasingly used to minimize ureteral injury risk. This study aimed (1) to assess the accuracy of LVE compared with that of IRP measured by a PNC and (2) to evaluate appropriate irrigation settings suitable for small UASs using porcine kidney models and LVE. Methods: An 11/13-Fr UAS and a 10/12-Fr UAS were inserted into each model, and an automatic irrigation pump (AIP) and hand pumping (HP) with a 20-cc syringe were used. IRP was measured at various LVE tip positions (renal pelvis and upper, middle, and lower calyces) with different irrigation settings, repeated four times in each. Simultaneously, the IRP via the PNC located in the upper calyx and renal pelvis was measured. Results: LVE showed high concordance with the PNC across the upper, middle, and lower calyces (p > 0.05). However, at the renal pelvis, LVE measured IRP values that were significantly higher than the PNC by a mean of 1.93 ± 0.93 mmHg (p < 0.001). For the 11/13-Fr UAS, the IRP remained below 30 mmHg across all irrigation settings with an AIP and HP. In contrast, the 10/12-Fr UAS maintained 30 mmHg only with limited AIP settings, while HP resulted in high IRP, exceeding 100 mmHg at any location. Intergroup comparisons demonstrated that the IRP with the 10/12-Fr UAS was significantly higher than that with the 11/13-Fr UAS at any irrigation pressure setting across all URS tip positions (p < 0.05). Intragroup comparisons indicated a significant pressure difference between the upper, middle, and lower calyces and the renal pelvis in both models at all irrigation settings (p < 0.05). Conclusions: LVE provided accurate IRP measurements compared to the PNC. The IRP was significantly influenced by UAS size, irrigation setting, and URS tip position. When using small UASs, selecting appropriate irrigation settings is essential to maintain the safe threshold. Full article

Background/Objectives: Breastfeeding multiple birth infants (MBIs) poses unique challenges that require tailored support; however, research on these mothers’ experiences is limited. This study explored the breastfeeding journeys of Australian mothers of MBIs, highlighting barriers, facilitators, and support needs. Methods: Data were collected via an online survey (May–August 2024) and included quantitative data on breastfeeding initiation, duration, and challenges, as well as qualitative insights into mothers’ experiences. Thematic analysis was used to identify key themes, and statistical analyses were used to compare breastfeeding outcomes by parity. Results: While most mothers (87%) had an antenatal intention to breastfeed, they faced barriers such as latching difficulties (56%), inadequate milk supply (49%), and sore nipples (47%). Preterm births (58%) and neonatal unit admissions delayed the breastfeeding initiation. Most mothers (99%) used electric breast pumps to boost milk supply (68%) and enable expressed breast milk feeding by other caregivers (65% of mothers). While 72% were satisfied with hospital breastfeeding support and some mothers received excellent hands-on support, others felt neglected due to busy staff or conflicting advice. Mothers frequently reported that breastfeeding guidance was geared toward singletons, leaving them unprepared for the challenges of feeding multiples. Mothers’ suggestions for improving care included specialised guidance, better access to lactation support, and in-home practical support to alleviate the burden of feeding and expressing. Additionally, mothers reported that healthcare professionals should be trained to offer practical, non-judgemental support to help mothers navigate the elaborate challenges of breastfeeding MBIs. Conclusions: This study underscores the need for early postpartum support and tailored guidelines to enhance MBI breastfeeding outcomes and maternal-infant well-being. Full article

Within the field of physiology, it is widely recognized that the constant flow of mobile ions across the plasma membrane generates membrane potential in living cells. This understanding is a part of the membrane theory. Despite this, membrane theory does not account for the role of ion adsorption (or desorption) processes in generating membrane potential, even though ion adsorption is a key concept in basic thermodynamics. Presently, the study of physiology lacks integration with thermodynamic principles. The membrane theory posits that living cells can differentiate between Na⁺ and K⁺ by means of channels and pumps. Thus, Na⁺ and K⁺ differentially impact the membrane potential. On the other hand, the Hofmeister effect, an older and less prominent thermodynamic theory, proposes that Na⁺ and K⁺ have varying adsorption levels to biomolecules, potentially accounting for their distinct effects on membrane potential even without the involvement of channels and pumps. This concept, distinct from the traditional membrane theory and grounded in ion adsorption (desorption) alongside the Hofmeister effect, might elucidate the process of membrane potential formation. This ion adsorption (desorption) and Hofmeister effect-based idea relates to the previously overlooked Association-Induction Hypothesis (AIH). Our experimental measurements of membrane potentials using artificial cell models highlight that ion adsorption activity and the Hofmeister effect have a comparable impact on the generation of membrane potential as ion flow in the conventional physiological model, assisted by channels and pumps. Full article

Unsustainable groundwater extraction for domestic and agricultural purposes, particularly crop irrigation, is leading to dramatic reductions in the quantity and quality of groundwater in many developing countries, including Ethiopia. Assessing and predicting groundwater responses to hydraulic stress caused by overexploitation related to anthropogenic activities and climate change are crucial for informing water management decisions. The aim of this study is to develop a three-dimensional steady-state groundwater flow model for the Golina River Sub-Basin to understand the relationship between groundwater recharge and groundwater pumping and their impacts under steady-state conditions from the perspective of groundwater management. The model was created using MODFLOW 6 and discretized into 345 rows and 444 columns with a grid resolution of 100 m by 100 m. The subsurface was modeled as two layers: a clastic alluvial layer overlying a weathered and fractured bedrock. The surface-water divide of the Golina River Sub-Basin was treated as a no-flow boundary. The initial values of horizontal hydraulic conductivity ranged from 0.001 m/day for rhyolite to 27.26 m/day for alluvial deposits. The aquifer recharge rates from the WetSpass model ranged from 1.08 × 10⁻³ to 2.25 × 10⁻⁴ m/day, and the discharge rates from the springs, hand-dug wells, and boreholes were 2.79 × 10⁴ m³/day, known flux boundaries. Sensitivity analysis revealed that the model is very sensitive to hydraulic conductivity, moderately sensitive to aquifer recharge, and less sensitive to groundwater pumping. Calibration was performed to match observed and simulated hydraulic heads of selected wells and achieved a correlation coefficient of 0.998. The calibrated hydraulic conductivity ranged from 1.2 × 10⁻⁴ m/day for rhyolite to 20 m/day for gravel-dominated alluvial deposits. The groundwater flow direction is toward the southeast, and the water balance indicates a negligible difference between the total recharge (207,775.8297 m³/day, which is the water entering the aquifer system) and the total pumped volume (207,775.9373 m³/day, which is the water leaving the aquifer system). The scenario analysis showed that an increase in the pumping rate of 25%, 50%, and 75% would result in a decrease in the hydraulic head by 4.64 m, 10.18 m, and 17.38 m, respectively. A decrease in recharge of 25%, 50%, and 75% would instead result in hydraulic-head declines of 6 m, 15.29 m, and 46.97 m, respectively. Consequently, the findings of this study suggest that decision-makers should prioritize enhancing integrated groundwater management strategies to improve recharge rates within the aquifer system of the study area. Full article

Due to climate change, water scarcity, and overexploitation of aquifers, the sustainable management and protection of groundwater resources will be one of the main challenges in the future. Therefore, the knowledge of hydrogeological characteristics, which must be as robust as possible, becomes crucial for defining groundwater management plans. On the other hand, the earliest evidence of the fertile plains and abundant water resources of Skydra and its surroundings dates back to the Neolithic period (6500–3200 B.C.), confirming the area’s current agricultural vocation and productivity. In this perspective, the aim of the present study is to define the conceptual hydrogeological model of a complex confined multi-aquifer system characterizing the volcano-sedimentary deposits of the Skydra area, northern Greece. In particular, the architecture of the hydrostratigraphic units, the hydraulic parameters, and the hydrodynamic behavior of the multi-aquifer system were analyzed. The geological, geomorphological, and structural evolution affecting the area has influenced the geometric and hydraulic characteristics of the aquifer, and consequently its productivity. The thickness of the multi-aquifer system varies between 25.0 and 94.5 m and the hydraulic conductivity, calculated through the analysis of data from 72 pumping tests, and the application of empirical method (42 wells), ranges between 2.2 · 10⁻⁶ and 2.5 · 10⁻³ m/s. Higher hydraulic conductivity values are calculated in areas where tuffaceous formations are fractured and/or interlayered with sandy layers; while lower values occur where tuffs present only primary porosity and are interspersed with frequent clay layers. In the central area, due to overexploitation of the aquifer, an annual piezometric level drop of approximately 6 m has been recorded. The information acquired could serve as the basis for the sustainable development of groundwater resources in the test area and could also be applied in other similar hydrogeological settings. Full article

This study assessed the status of water, sanitation, and hygiene (WASH) services at (49) selected primary schools in uMfolozi Local Municipality, which is situated in the province of Kwa-Zulu Natal in South Africa. Data were collected using an observational checklist tool and by conducting a walk-through survey to inspect the conditions of sanitary facilities, observe the hand-washing practices of the school learners, and analyse the accessibility to safe drinking water in school premises. The data were analysed with the Statistical Package for Social Science Version 29. This study revealed that there is easy access to safe drinking water in all but one school. The dependability of the water supply seemed to be one of the most urgent problems in every school, even though all of them have some kind of drinking water infrastructure on their grounds. Municipal water (n = 25, 36%) and rainwater (n = 25, 36%) were the most common type of water used in schools compared to borehole (n = 15, 22%) and tanker truck water (n = 4, 6%). Schools must have a reserved water supply because of the inconsistent supply of municipal water, and because rainwater is a seasonal harvest while borehole water may be affected by factors like load-shedding. The UNICEF-described ratio of one tap or disperser per fifty learners suggests that the water taps in the schoolyard were insufficient in some schools (n = 25, 36%). Rainwater is collected through a gutter system in the school building roofs and stored in 5000–10,000 Jojo tanks. Borehole water is pumped into Jojo tanks at an elevated position where it is stored, and learners receive the water through taps connected to the borehole tanks. During an emergency when there is no water supply from other sources, tanker trucks are hired to fill tanks that are also used to store rainwater. The borehole and rainwater quality appeared to be clear, but water treatment had not been performed, and the microbial quality was unknown. This shows that the Sustainable Development Goal (SGD) 6, clean water and sanitation, is still far from being met. According to national norms and standards for domestic water and sanitation services, people who do not use water treatment or purification techniques fall in the ‘no service’ category and contribute to the water backlog. Pit latrines (n = 46, 94%) and flush toilet (n = 3, 6%) were found to be the only convenient toilet systems used. The number of toilets is not sufficient according to the guidelines. There are (n = 46, 94%) of the schools in the study area using pit latrine due to insufficient or no water supply. In 89.8% of primary schools, sanitation facilities are in working condition in terms of repair and hygiene, while 10.2% are not usable in terms of hygiene, and these are mostly boy’s toilets. All schools (n = 46, 94%) that have flush toilets is because they received sponsorship from non-government stakeholders that funded them in achieving piped water systems that permit the functionality of flush toilets. For the purposes of this study, hygiene was evaluate based on the items found in toilets and handwashing practices. The hygiene aspects of toilets included tissues, cleanness, and toilet seat. For handwashing practices we looked the number of washing basins, the colour of water, and having soaps to use. In the schools that did provide handwashing facilities, some of the toilets were broken, there was no water, or there was no drainage system in place to allow them to function. However, according to the school act, the handwash basins should be inside the facilities. A total of (n = 7, 14%) of handwash basins were inside the toilets. Only (n = 2, 4%) of schools had handwashing facilities which were Jojo tanks with taps near toilets, which were outside of the toilet, with no soap provided. Additionally, (n = 40, 82%) of learners used drinking points for handwashing, which can possibly transmit microbes among them. The findings revealed that, in general, (n = 32, 64%) of school toilets were clean, while, in general, the girls’ toilets were cleaner than the boys’ toilets. In all the schools, the cleaning services were from the people who were involved in school nutrition. In conclusion, there were water sources available for access to water inside schools; however, the situation can be improved by increasing the number of water source points. Pit latrines were the main used toilets, which were in a majority of the schools, and did not have the necessary terms for hygiene such as handwashing basin, tissues, and others. The lack of the main aspect, i.e., access to water and sanitation items, results in an impact on hygiene to learners as they will fail to practice proper hygiene. However, improvement can still be made by keeping the boys’ toilets clean while increasing the number of handwashing basins inside the toilets, so that they do not use taps outside the toilets. Schools should work towards meeting the required number of handwashing basins to increase access to handwashing facilities. Full article

Improving the efficiency of lasers without complex structures, expensive elements, and precise optimization will lead to cost reductions and increased practicality. Here, it is first shown theoretically that the dependence of the optical-to-optical conversion efficiency on the laser beam waist (minimum laser spot) radii for a Yb:YAG laser with a simple structure decreases extremely with increasing pump intensity and efficiency. Not only is the optimum range for highest efficiency wide, but even if the radii are doubled, the efficiency decreases by only a few percentage points or less at the maximum pump intensity of 450 kW/cm². Therefore, it is possible to achieve sufficiently high efficiencies without precise optimization by high-intensity pumping. In the experiment, at a pump wavelength of 940 nm, corresponding to pump-level pumping, the maximum efficiency was 75.2% for the incident pump power at the corresponding maximum intensity. On the other hand, at a pump wavelength of 968 nm, corresponding to direct pumping of the upper laser level, the maximum efficiency was 76.0% at about 60% of the maximum. Although the pump focus is slightly off from the optimum, these efficiencies are close to the theoretical maximum at the corresponding pump intensities. Since no complex gain medium is used, there is almost no efficiency reduction due to parasitic oscillations, despite the high pump intensities. These results demonstrate the high practicality of high-intensity pumping for high-efficiency lasers. Full article

The cosmetic industry is an important economic sector with expected growth in the upcoming years and a noticeable trend towards sustainable products and product packaging options. A critical aspect of packaging sustainability is the amount of product residue left in emptied containers, as this contributes to both economic losses for consumers and environmental waste. In this study, the emptiability of different packaging systems for shampoo, hair gel, hand cream, body lotion, face cream, eye cream, and serum is assessed by developing novel testing methods. The results show a significant dependence of emptiability on the packaging system and product properties. While jars and airless pump dispensers retain less than 1% of product residues for hand cream products, pump dispensers’ values of up to 26% were found. These results underline the importance of optimal packaging choices adapted to different products to avoid economic losses for the consumer, environmental impact due to wasted products, and a negative influence on the recyclability of packaging and quality of the recyclate. Manufacturers can use these insights to design packaging that not only reduces leftover product but also aligns with circular economy principles, ultimately lowering environmental impacts and improving consumer satisfaction. Full article

Rare-earth doped transparent glass-ceramic waveguides are playing a very crucial role in integrated optics. We fabricated ZnO-HfO₂ hybrid nanocrystals embedded with 70 SiO₂–(30-x) HfO₂–x ZnO (x = 0, 2, 5 and 7 mol %) ternary transparent glass-ceramic waveguides doped with 1 mol % Eu-ions. The formation and size of the nanocrystals evolved with an increase in ZnO concentration in the glass-ceramic waveguides. In this context, key factors of such nanocrystals embedded active glass-ceramic waveguides were optical losses and transparency. A lab-built m-line experimental set-up was used for the characterization of the waveguides. On the other hand, optical gain measurements of the Eu-doped hybrid nanocrystals embedded glass-ceramic waveguides were performed using the variable stripe length method. The optical amplification of the waveguides was investigated on the red emission line (⁵D₀ → ⁷F₂) of Eu-ions pumped by a 532 nm laser in a stripe-like geometry generated by a cylindrical lens. Here, we report, the optical gain in rare-earth activated glass-ceramic waveguides with nanocrystals of varying sizes formed in the waveguides with increasing ZnO concentration. Full article

The rotating pump of pipelines are susceptible to damage based on extended operations in a complex environment of high temperature and high pressure, which leads to abnormal vibrations and noises. Currently, the method for detecting the conditions of pipelines and rotating pumps primarily involves identifying their abnormal sounds and vibrations. Due to complex background noise, the performance of condition monitoring is unsatisfactory. To overcome this issue, a pipeline and rotating pump condition monitoring method is proposed by extracting and fusing sound and vibration features in different ways. Firstly, a hand-crafted feature set is established from two aspects of sound and vibration. Moreover, a convolutional neural network (CNN)-derived feature set is established based on a one-dimensional CNN (1D CNN). For the hand-crafted and CNN-derived feature sets, a feature selection method is presented for significant features by ranking features according to their importance, which is calculated by ReliefF and the random forest score. Finally, pipeline and rotating pump condition monitoring is applied by fusing the significant sound and vibration features at the feature level. According to the sound and vibration signals obtained from the experimental platform, the proposed method was evaluated, showing an average accuracy of 93.27% for different conditions. The effectiveness and superiority of the proposed method are manifested through comparison and ablation experiments. Full article