Search Results (11,928)

Saline-affected soils exhibit poor mechanical properties and are prone to durability degradation under environmental disturbances, severely hindering infrastructure development in saline-affected regions. This study adopted a synergistic consolidation treatment for sulfate-salinized soils using a guar gum (GG) and Portland cement composite system, formulating 25 mix designs with GG content ranging from 0% to 2% and cement content from 0% to 12%. The unconfined compressive strength (UCS), dry–wet cycle durability, and repeated load fatigue performance of the stabilized soils were systematically tested. Combined with microstructural characterization techniques including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and CT scanning, the evolution patterns of the solidified soil’s mechanical properties and the macro-micro interaction mechanisms were revealed. Results indicate that cement is the primary strength source in cement-stabilized soil: at a cement dosage of 12%, the UCS reaches 2.53 MPa, a 41-fold increase compared to the native soil. A significant synergistic strengthening effect exists between cement and GG at the optimal GG dosage of 0.5%–1.0%, with the optimal mixture ratio being 6%–9% cement blended with 0.5%–1.0% GG. With this optimized ratio, the stabilized soil shows a strength retention rate of 87.2% after 10 dry–wet cycles, and its fatigue life extends to 1986 cycles (a 42.6% increase compared to pure cement-stabilized specimens). Microstructural analysis suggests that the stabilization process is fundamentally governed by interfacial micro-coating mechanisms. The reaction between cement aluminates and soil sulfates generates abundant ettringite, which is hypothesized to form a rigid skeletal framework. Simultaneously, GG forms a hydrogel network that acts as a dense, protective organic–inorganic micro-coating on the surface of soil aggregates and cement phases. This interfacial encapsulation optimizes the pore structure, reducing porosity to 1.43% and fundamentally blocking inward water infiltration pathways at the aggregate interface. However, excessive GG (>1.5%) coats cement particles, hinders hydration reactions and induces structural defects, ultimately leading to performance degradation. This study elucidates the macro-micro coupled mechanism of GG-cement composite consolidation for saline–alkali soils, providing theoretical foundations and technical solutions for saline–alkali soil consolidation engineering. Full article

Glioblastoma (GBM) remains the most lethal primary brain tumor in adults, with a median overall survival of approximately 15–20 months despite multimodal treatment including surgery, chemoradiation, and Tumor Treating Fields (TTFields). While the survival benefit of TTFields was established by the EF-14 phase III trial, their biological effects extend well beyond the canonical anti-mitotic mechanism and encompass extensive interactions with the GBM tumor microenvironment (TME). This review provides an integrated mechanistic analysis of TTFields–TME interactions in GBM, with a distinctive focus on their convergence with radiotherapy. We examine how TTFields activate innate immune sensing through cGAS/STING and AIM2 inflammasome pathways, drive immunogenic cell death, reprogram tumor-associated macrophages, and prime adaptive T cell responses. We further address TTFields effects on glioma stem cells, blood–brain barrier permeability, and intracellular signaling governing invasion, angiogenesis, and autophagy. Critically, we develop the mechanistic and clinical case for TTFields-radiotherapy combinations, highlighting convergent mechanisms of DNA repair impairment, mitotic catastrophe, and innate immune activation. Practical considerations for concurrent clinical implementation are discussed alongside a research agenda centered on optimal timing, hypofractionation, and predictive biomarkers. Available evidence—largely preclinical—suggests that TTFields may act as a TME-remodeling platform whose potential is most likely to be realized through mechanistically informed combinations. Full article

School peace, or Schulfrieden, is often portrayed in German education as a neutral condition enabling learning. Yet this study interrogates how peace itself becomes a tool of governance, selectively policing who can safely occupy the classroom. Examining the Berlin Senate’s October 2023 directive, which banned symbols showing solidarity with Palestine, we show that school peace is less about conflict resolution than about shaping affective hierarchies. Fear, anticipation, and symbolic association circulate to mark some bodies as threats while leaving others unexamined. Through the lens of Sara Ahmed’s affective economies and Zembylas’s affective ideology, we argue that the directive transforms political expression into a site of emotional correction, preemptively disciplining marginalized students and rendering their solidarity politically suspect. Peace, in this framing, is primarily rule and order: it secures institutional comfort while curtailing engagement with global injustice. The classroom becomes a laboratory of anticipatory governance, where ethical awareness is unevenly distributed, and dissent is contained before it emerges. By tracing how school peace operates affectively, the study reveals the subtle mechanics by which liberal education reproduces racialized hierarchies under the guise of neutrality. Full article

Evaluating grouting effectiveness in deep shafts remains difficult because water-control performance is jointly governed by hydraulic response, seepage-path sealing, grout-body quality, and surrounding rock stability under complex hydrogeological conditions. In this study, an integrated evaluation and seepage analysis framework was developed for the Lianhuashan Phosphate Mine shaft project in Zhongxiang City, Hubei Province, China. Multi-source engineering data from hydrogeological observations, geophysical detection, construction records, and laboratory tests were used to evaluate six representative working faces, and a two-dimensional Darcy flow model was established to interpret the seepage-control mechanism. The evaluation results show differences among the treated sections: the auxiliary shaft at the −29.8 m outlet achieved the highest comprehensive score of 74.79, whereas the main shaft at +13 m showed the weakest performance, with a score of 50.16. Overall, three sections were rated as good, two as moderate, and one as poor. The dominant controls on grouting effectiveness are total shaft inflow, surrounding rock integrity/stability, seepage point number, and sealing-related indices. Numerical simulations further show that grouting reduced total shaft inflow from 6.6080 to 2.0198 m³/h, corresponding to a reduction of 69.43%, and shifted the main hydraulic-gradient concentration from the shaft wall to the outer boundary of the grouted ring. Reducing grouting ring permeability from 5.10 × 10⁻¹³ to 1.00 × 10⁻¹⁴ m² further lowered shaft inflow to 0.2929 m³/h and increased water-control efficiency to 95.57%, whereas increasing ring thickness from 8 to 16 m reduced shaft inflow from 2.7063 to 1.7260 m³/h. In addition, moving the water-rich zone away from the shaft reduced total inflow from 2.5503 m³/h at X_f = 10 m to 2.0079 m³/h at X_f = 26 m. These results indicate that effective shaft grouting depends on the coordinated control of inflow suppression, conductive-path sealing, and structural stabilization. The proposed framework provides a practical basis for grouting evaluation and water hazard control in deep shafts under complex hydrogeological conditions. Full article

Urban–rural integration (URI) represents a pivotal pathway to realizing sustainable development within urban–rural spatial systems. It is of paramount importance in addressing the challenge of reconciling ecological conservation with high-quality development in the Yellow River Basin. Leveraging panel data from 78 cities in the Yellow River Basin spanning the years 2006–2023, this research constructs an evaluation index system that encompasses five dimensions: population, economy, society, ecology, and space. Through the comprehensive application of kernel density estimation, exploratory spatiotemporal data analysis, and panel quantile regression models, a systematic analysis of the spatiotemporal evolution patterns and transition mechanisms of URI is conducted. The results disclose that URI in the Yellow River Basin demonstrates a trend of “overall enhancement with regional disparities”. From 2006 to 2023, the URI of the basin witnessed an average annual growth rate of 2.86%. Spatially, it presented distinct features: high-level agglomeration in the lower reaches, accelerating-growth path dependency accompanied by internal divergence in the middle reaches, and balanced yet low-level development in the upper reaches. The local spatial evolution of URI follows a pattern characterized as “predominant stability and limited transitions”. In detail, high-level regions sustain their advantages, low-level regions encounter obstacles in achieving breakthroughs, and the spillover effects between adjacent regions remain relatively restricted. The driving mechanisms exhibit significant “phase-spatial” dual heterogeneity, with four distinct patterns identified. In light of these findings, policy recommendations are put forward, including the establishment of a multi-scale, coordinated spatial governance system. Full article

This work examines the machining responses of dry turning in ultrasonic-assisted stir-squeeze cast A356 hybrid nanocomposites reinforced with zirconia (ZrO₂) and graphene oxide (GO). Accordingly, flank wear (VBc) ranged from 0.061 to 0.238 mm, influenced by abrasion, adhesion, built-up edge (BUE) formation, and diffusion mechanisms. Cutting speed had the most significant effect on flank wear (65.65%), followed by depth of cut (18.2%) and feed rate (11.13%), supported by a well-fitted regression model (R² = 0.987; p < 0.05). Surface roughness (Ra) ranged from 1.733 to 7.012 μm, with cutting speed, feed rate, and depth of cut contributing 70.42%, 15.43%, and 9.56%, respectively. The cutting temperature was limited to 127 °C, primarily influenced by cutting speed (60.68%), whereas cutting power varied between 0.353 and 0.644 kW, mainly governed by cutting speed (68.71%) and depth of cut (25.92%). The chip morphology showed a segmented sawtooth pattern due to cyclic fracture initiation during material removal. Multi-criteria optimization using complex proportional assessment (COPRAS) identified v = 90 m/min, f = 0.06 mm/rev, and d = 0.1 mm as the optimal parameters, yielding a tool life of 22.6 min and a machining cost of INR 58.69 per item. This research is further focused on the implementation of different cooling lubrication techniques utilizing environmentally friendly cutting fluids, including Minimum-Quantity Lubrication and nano-MQL, among other types of environments. Full article

Background: Appetite regulation is governed by a complex neuroendocrine network that integrates peripheral peptide signals with hypothalamic and brainstem circuits to coordinate energy intake and maintain energy homeostasis. Disruption of these pathways contributes to obesity and other disorders characterised by dysregulated feeding behaviour. Objective: To map and synthesise the current evidence on the role of appetite-regulating peptide hormones and central neural pathways in appetite control, obesity pathophysiology, and emerging therapeutic approaches. Methods: A scoping review of the literature was conducted to identify and synthesise evidence relating to the physiological and pathological mechanisms of appetite regulation. The review examined the actions of key peptide hormones, including ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), leptin, and insulin, their interactions within the gut–brain axis, and their effects on central appetite-regulating circuits. Results The evidence highlights the central role of the arcuate nucleus in integrating peripheral hormonal signals with neural pathways controlling feeding behaviour. Appetite regulation is mediated by the balance between orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons and anorexigenic pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons, with further modulation by the paraventricular, lateral, and ventromedial hypothalamic nuclei. The literature identifies hormone resistance, impaired satiety signalling, and altered neuroendocrine feedback as major contributors to obesity. Evidence on therapeutic interventions demonstrates the potential of GLP-1 receptor agonists, including liraglutide and semaglutide, and the dual incretin agonist tirzepatide, while also highlighting challenges related to treatment durability, adverse effects, and weight regain following discontinuation. Conclusions: Current evidence demonstrates that appetite regulation involves highly interconnected peripheral and central signalling pathways. The reviewed literature supports the development of multi-target and precision-based therapeutic strategies for obesity and identifies important areas for future research, including mechanisms of treatment resistance, long-term efficacy, and inter-individual variability in neuroendocrine responses. Full article

To elucidate the scale-dependent response and interfacial evolution of liquid capillary rise in glass capillaries under an electric field, capillaries with different inner diameters were used as model channels. The equilibrium capillary-rise behavior of NaCl solutions without an electric field was investigated, and the coupled effects of capillary diameter, temperature, and concentration were analyzed using response surface methodology. The additional rise of the liquid column under a direct-current electric field was examined, and the interfacial evolution mechanism was explored through meniscus visualization. The results show that, without an electric field, the equilibrium capillary height is governed mainly by capillary inner diameter, followed by temperature, whereas concentration has a relatively weak effect. The developed quadratic regression model shows high fitting accuracy. Under the applied electric field, the electrocapillary response exhibits clear scale selectivity. No significant additional rise was observed in the 0.1 mm and 0.3 mm capillaries, whereas the liquid-column height increased markedly in the 0.5 mm capillary. At 30 °C and 0.75 kV, the additional rise reached 8.2 mm, corresponding to a relative increase of 15.30%. The enhancement at 0.75 kV was stronger than that at 1.5 kV, indicating a non-monotonic voltage response. Meniscus experiments further show that 0.32% NaCl and 5% ethanol solutions respond more evidently to the electric field, with stronger interfacial restructuring for NaCl solution at 0.75 kV. These results indicate that the electric field modifies capillary pressure by altering the force balance near the three-phase contact region and the meniscus curvature, thereby inducing additional liquid-column rise. Full article

The Engineering-Procurement-Construction (EPC) general contracting model has emerged as the dominant delivery method for large-scale infrastructure and industrial projects in China. However, contemporary EPC project cost control remains plagued by critical industry challenges, including fragmented cross-stage coordination, pervasive data silos, and the shallow integration of digital technologies into core management processes. This study considers three key stakeholders—government regulators, project owners, and EPC general contractors—and develops a tripartite evolutionary game model to analyze the strategic interactions underlying intelligent cost control in EPC projects. We examine the evolutionary stability of each stakeholder’s strategy selection, explore how various factors influence tripartite strategic choices, and further investigate the stability of equilibrium points in the game system. The key findings are summarized as follows: (1) Strengthening government incentives and penalties simultaneously promotes owners’ investment in intelligent cost control systems and general contractors’ active collaborative cost management. However, excessive incentive intensity undermines the government’s regulatory effectiveness. (2) Establishing a revenue-sharing mechanism for excess cost savings fully stimulates the spontaneous cooperation willingness of owners and general contractors, serving as the cornerstone for market-oriented operation of intelligent cost control. (3) Reducing owners’ intelligent construction investment costs and general contractors’ collaborative control costs effectively addresses practical implementation barriers and accelerates the digital upgrading of engineering cost management. Finally, numerical simulations are performed using MATLAB R2020b to validate theoretical findings. Full article

This study, through a hybrid approach to post-occupancy evaluation (POE) of four types of high-energy-efficiency housing in rural Scotland, explores the manifestation, formation mechanism, and mitigation pathways of energy risks in high-energy-efficiency housing from environmental and socioeconomic dimensions. The findings reveal a “high-efficiency paradox”: better fabric performance and lower heating demand do not guarantee reduced carbon emissions, fuel poverty alleviation, or energy resilience. Actual energy risks are formed by the combined effects of multiple factors, including building size, energy infrastructure, resident characteristics, energy prices, and policy, exhibiting a clear systemic coupling characteristic. The study further verifies that, in the context of rural Scotland, relying solely on indicators such as EPC may lead to misjudgements of housing sustainability. Heating demand, total energy consumption, carbon emissions, and energy expenditure exhibit a partially decoupled relationship. Thus, rural housing sustainability should shift from a technically efficient approach to a comprehensive strategy integrating design, infrastructure, affordability, and social equity. The study proposes context-specific mitigation pathways including multi-source energy systems, place-sensitive policies, socio-economic support, and a multi-criteria assessment framework, providing empirical references for rural housing energy transition and energy risk governance. Full article

Hidden hunger and grassland degradation represent interconnected governance challenges in northern China’s pastoral areas. Nutrition-sensitive agriculture (NSA) has been conceptualised largely around crop-based systems, with limited attention to grassland grazing systems, where nutritional value is shaped by ecology, feeding practices, seasonality, local knowledge, and market institutions. Drawing on five rounds of fieldwork (2019–2025) across meadow, typical, and desert steppes in Inner Mongolia, this study employs a multi-case comparative design involving 92 semi-structured interviews, 58 policy documents, and long-term observations. Using reflexive thematic analysis, we develop an ecology–nutrition synergy framework to explain local practices and institutional constraints in nutrition-sensitive livestock farming. Three pathways are identified: grass–livestock nutritional balancing, scientific valorisation of native forage, and market experimentation linking ecological origin to nutritional quality. These pathways operate through three mechanisms: ecological mediation of nutritional quality, endogenous quality fluctuation as an inherent feature, and scientific codification of traditional pastoral knowledge. Four structural dilemmas constrain scaling: incompatibility between natural quality fluctuation and industrial standardisation; absence of institutional trust in nutritional premiums; short-term trade-offs between stocking control and nutritional enhancement; and fragmented cross-sectoral governance. The study extends NSA to grassland systems and offers a framework for integrating ecological protection, livestock quality, and nutrition-oriented governance in arid and semi-arid rangelands. Three theoretical contributions are advanced: (i) extending NSA’s conceptual boundary from cropping systems to natural grassland pastoral systems; (ii) embedding a nutrition-output dimension within Ostrom’s SES framework, thereby creating a triple-nested ecology–nutrition synergy framework; and (iii) specifying three grazing-system-specific mechanisms that distinguish grassland livestock systems from both crop-based and confined animal production systems. Full article

This study investigates the mechanical properties and corrosion behavior of a Co-free Fe₄₀Ni₃₀Cr₂₀V₈Mo₂ (at.%) multi-principal elements alloy (MPEA) designed for potential applications in aggressive environments. The alloy exhibits a balanced combination of strength and ductility, with a yield strength of approximately 258 MPa, an ultimate tensile strength of about 647 MPa, and a fracture elongation of around 52%, of which deformation is primarily governed by dislocation-mediated plasticity. In terms of corrosion performance, the alloy demonstrates excellent resistance in chloride-containing environments. Potentiodynamic polarization tests reveal a wide and stable passive region of approximately 1.28 V_SCE and a high pitting potential of about 0.975 V_SCE, indicating exceptional stability of the passive film. Electrochemical impedance spectroscopy (EIS) further confirms the high impedance and protective nature of the surface layer. X-ray photoelectron spectroscopy (XPS) analysis reveals that the superior anti-corrosion property is attributed to the formation of a passive film enriched with protective Cr₂O₃ and V, Mo oxides, which collectively construct an effective barrier against chloride-induced attack by reducing donor density. This work provides valuable insights for the development of alternative alloys to replace Co-containing systems in demanding corrosive applications. Full article

The transition towards carbon-neutral construction materials requires innovative solutions that combine reduced embodied energy, enhanced durability and improved building energy efficiency. This study investigates and compares two novel bioaerated low-density composites—BAAC and BIOAERMAC—developed through biologically driven aeration processes incorporating industrial byproducts. BAAC is produced using Saccharomyces cerevisiae and hydrogen peroxide, replacing conventional aluminum powder and improving safety while enabling the valorization of waste-derived yeast. BIOAERMAC is a gypsum-based composite incorporating synthetic anhydrite, microorganisms, peroxides, and recycled rubber from end-of-life tires. The materials were characterized in terms of hygrothermal behavior and dimensional stability, and compared with commercial autoclaved aerated concrete under equivalent mechanical strength conditions. The results highlight significant differences in moisture transport and shrinkage, primarily governed by pore structure and connectivity. BAAC exhibits behavior comparable to conventional AAC, whereas BIOAERMAC shows reduced capillary and hygroscopic absorption, indicating limited pore connectivity, but higher drying shrinkage. These findings demonstrate the effectiveness of bioaeration in tailoring pore structure and controlling the trade-off between moisture transport, durability, and dimensional stability, highlighting the potential of bioaerated composites for low-carbon and energy-efficient building applications. Full article

Natural lacquer, a bio-based polymer derived from Toxicodendron vernicifluum, has attracted renewed scientific interest as a sustainable coating material with exceptional mechanical durability, chemical resistance, and aesthetic qualities. This review synthesizes current knowledge on the chemical composition, enzymatic curing mechanisms, and structure–property relationships of lacquer-based polymer systems, with particular focus on recent advances in functional modification and processing technology. Key findings indicate that laccase-catalyzed oxidative polymerization, operating optimally at pH 6.0–7.5 and 20–30 °C, governs the formation of a highly cross-linked urushiol network whose properties are fundamentally determined by side-chain unsaturation and emulsion stability. Mechanistic analysis reveals that polyurethane hybridization improves weathering resistance by introducing flexible aliphatic segments and additional hydrogen-bonding cross-links, while graphene oxide incorporation enhances anticorrosion performance through a physical barrier mechanism that prolongs ionic diffusion pathways. UV-curable LPEA derivatives achieve an 83% reduction in curing time relative to ambient-cured lacquer, enabling integration with industrial spray-coating lines. Despite these advances, several critical limitations remain inadequately resolved. Allergen reduction strategies have not yet achieved sufficient quantitative efficiency for large-scale commercial deployment, and the long-term stability of nanocomposite lacquer films under sustained UV exposure and hydrothermal conditions is not well established. Furthermore, most high-performance modification systems reported in the literature are demonstrated only on laboratory scale, with scalability, substrate compatibility, and lifecycle performance remaining largely unvalidated. The review identifies the absence of standardized performance evaluation protocols and the fragmentation of structure–property data across studies as key barriers to systematic progress, and proposes that future work prioritize the development of integrated processing–modification–performance frameworks to guide the rational design of next-generation lacquer-based functional materials. Full article

Time-resolved visualization of local structural dynamics driven by external fields is essential for understanding structure–property relationships in functional materials and devices. Conventional ultrafast methods primarily capture femtosecond-to-picosecond photoinduced dynamics, yet they lack real-space access to spatially inhomogeneous processes occurring at their intrinsic mesoscopic timescales that govern material and device performance—particularly electrically driven processes that closely mimic actual device operating conditions. Here, we report a multifunctional ultrafast transmission electron microscopy (UTEM) platform targeting reversible structural dynamics spanning nanoseconds to microseconds under stroboscopic multi-field excitation. Our system employs photoelectron pulses generated by nanosecond UV laser illumination as the probe, alongside optical and electric pulses as pump excitation. A unified electronic synchronization scheme based on a high-speed photodiode and a digital delay generator enables precise timing control among the optical pump, electrical pump, and photoelectron pulses across the nanosecond-to-microsecond range. Using vanadium dioxide (${\mathrm{VO}}_2$) as a model system, we demonstrate a combined spatiotemporal resolution with measurable signals on the order of 10 nm–10 ns, allowing real-space mapping of spatially inhomogeneous dynamics. Electrical-pump experiments further reveal Joule-heating-induced non-uniform structural phase transitions and thermal-shock-excited megahertz-range mechanical oscillations. These results establish the developed multi-field UTEM platform as a practical tool for probing local structural dynamics in functional materials under optical and electrical excitation. Full article