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1,299 Results Found

  • Article
  • Open Access
21 Citations
6,147 Views
30 Pages

20 May 2022

As powerful economic and cultural centers, fortified sites played an important role in early medieval society. In Central Europe, early medieval fortified site research has been an essential topic for several generations. However, gradual changes in...

  • Article
  • Open Access
4 Citations
3,792 Views
17 Pages

3 December 2021

The development of artillery in Europe at the end of the Middle Ages brought a necessary change in military architecture. This change was a radical rethinking of the entire geometry and architectural design of city walls which required an increase in...

  • Review
  • Open Access
20 Citations
11,097 Views
20 Pages

The Impact and Efficacy of Vitamin D Fortification

  • Ruyuf Y. Alnafisah,
  • Atheer S. Alragea,
  • Mona K. Alzamil and
  • Amani S. Alqahtani

14 December 2024

Vitamin D deficiency is a global health issue linked to various chronic diseases and overall mortality. It primarily arises from insufficient sunlight exposure, compounded by dietary limitations. Vitamin D fortification of commonly consumed foods has...

  • Article
  • Open Access
53 Citations
21,057 Views
13 Pages

18 January 2020

The United States implemented mandatory fortification of cereal grains with folic acid in 1998 to prevent neural tube defects (NTDs) during pregnancy. The health benefits of folate (vitamin B9) are well documented; however, there are potential risks...

  • Review
  • Open Access
259 Citations
37,464 Views
12 Pages

Food Fortification: The Advantages, Disadvantages and Lessons from Sight and Life Programs

  • Rebecca Olson,
  • Breda Gavin-Smith,
  • Chiara Ferraboschi and
  • Klaus Kraemer

29 March 2021

Deficiencies in one or more micronutrients such as iron, zinc, and vitamin A are widespread in low- and middle-income countries and compromise the physical and cognitive capacity of millions of people. Food fortification is a cost-effective strategy...

  • Article
  • Open Access
4 Citations
1,919 Views
11 Pages

8 December 2022

Food fortification is a strategy to increase low vitamin D intake. In order to avoid the intake of a population exceeding the upper tolerable intake level, the right choice of food groups to fortify is of crucial importance. An automated fortificatio...

  • Review
  • Open Access
33 Citations
7,814 Views
14 Pages

Regulatory and Policy-Related Aspects of Calcium Fortification of Foods. Implications for Implementing National Strategies of Calcium Fortification

  • Gabriela Cormick,
  • Ana Pilar Betrán,
  • Fletcher Metz,
  • Cristina Palacios,
  • Filiberto Beltrán-Velazquez,
  • María de las Nieves García-Casal,
  • Juan Pablo Peña-Rosas,
  • G. Justus Hofmeyr and
  • José M. Belizán

8 April 2020

Daily calcium intake is well below current recommendations in most low- and middle-income countries (LMICs). Calcium intake is usually related to bone health, however an adequate calcium intake has also been shown to reduce hypertensive disorders of...

  • Review
  • Open Access
715 Views
27 Pages

Vitamin D Fortification Strategies and Policy Landscape in Selected European Countries

  • Bartłomiej Czyżniewski,
  • Jolanta Chmielowiec,
  • Krzysztof Chmielowiec and
  • Magdalena Gibas-Dorna

10 April 2026

Background: Vitamin D deficiency remains a widespread public health issue in Europe, despite the availability of sunlight, dietary sources, supplements, and food fortification. National fortification strategies differ substantially in their regulator...

  • Article
  • Open Access
3 Citations
4,326 Views
28 Pages

5 January 2022

This paper is focused on selected units of casemates with enhanced fortification in the military fortification complex of the Czech borderlands landscape as specific forms of brownfields. They represent a functional system that interacts with surroun...

  • Review
  • Open Access
61 Citations
14,346 Views
23 Pages

12 September 2014

Vitamin D deficiency is widely prevalent in India, despite abundant sunshine. Fortification of staple foods with vitamin D is a viable strategy to target an entire population. Vitamin D fortification programs implemented in the United States and Cana...

  • Article
  • Open Access
13 Citations
5,786 Views
14 Pages

Enablers and Barriers of Zinc Fortification; Experience from 10 Low- and Middle-Income Countries with Mandatory Large-Scale Food Fortification

  • Ann Tarini,
  • Mari S. Manger,
  • Kenneth H. Brown,
  • Mduduzi N. N. Mbuya,
  • Laura A. Rowe,
  • Frederick Grant,
  • Robert E. Black and
  • Christine M. McDonald

15 June 2021

Adequate zinc nutrition is important for child growth, neurodevelopment, immune function, and normal pregnancy outcomes. Seventeen percent of the global population is estimated to be at risk for inadequate zinc intake. However, zinc is not included i...

  • Review
  • Open Access
19 Citations
7,980 Views
13 Pages

17 October 2014

‘Discretionary fortification’ refers to the addition of vitamins and minerals to foods at the discretion of manufacturers for marketing purposes, but not as part of a planned public health intervention. While the nutrients added may correspond to nee...

  • Review
  • Open Access
39 Citations
7,931 Views
16 Pages

21 September 2022

Zinc, through its structural and cofactor roles, affects a broad range of critical physiological functions, including growth, metabolism, immune and neurological functions. Zinc deficiency is widespread among populations around the world, and it may,...

  • Review
  • Open Access
91 Citations
15,704 Views
19 Pages

The Unfinished Agenda for Food Fortification in Low- and Middle-Income Countries: Quantifying Progress, Gaps and Potential Opportunities

  • Penjani Mkambula,
  • Mduduzi N. N. Mbuya,
  • Laura A. Rowe,
  • Mawuli Sablah,
  • Valerie M. Friesen,
  • Manpreet Chadha,
  • Akoto K. Osei,
  • Corinne Ringholz,
  • Florencia C. Vasta and
  • Jonathan Gorstein

29 January 2020

Large-scale food fortification (LSFF) is a cost-effective intervention that is widely implemented, but there is scope to further increase its potential. To identify gaps and opportunities, we first accessed the Global Fortification Data Exchange (GFD...

  • Article
  • Open Access
29 Citations
11,423 Views
13 Pages

19 January 2015

Micronutrient deficiencies remain a significant public health issue in Southeast Asia, particularly in vulnerable populations, such as women of reproductive age and young children. An important nutrition-specific intervention to address micronutrient...

  • Article
  • Open Access
11 Citations
7,614 Views
13 Pages

Awareness and Attitudes Regarding Industrial Food Fortification in Mongolia and Harbin

  • Sabri Bromage,
  • Enkhmaa Gonchigsumlaa,
  • Margaret Traeger,
  • Bayarbat Magsar,
  • Qifan Wang,
  • Jorick Bater,
  • Hewei Li and
  • Davaasambuu Ganmaa

19 January 2019

This study assessed awareness and attitudes regarding industrial food fortification among adults in urban and rural Mongolia, and the city of Harbin, China. Between 2014 and 2017, surveys were collected from healthy men and women aged ≥18 years (1...

  • Study Protocol
  • Open Access
7 Citations
4,681 Views
10 Pages

Adequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition...

  • Article
  • Open Access
8 Citations
5,537 Views
13 Pages

Vitamin A Fortification Quality Is High for Packaged and Branded Edible Oil but Low for Oil Sold in Unbranded, Loose Form: Findings from a Market Assessment in Bangladesh

  • Svenja M. Jungjohann,
  • Gulshan Ara,
  • Catia Pedro,
  • Valerie M. Friesen,
  • Mansura Khanam,
  • Tahmeed Ahmed,
  • Lynnette M. Neufeld and
  • Mduduzi N. N. Mbuya

28 February 2021

Although mandatory fortification of oil with vitamin A is efficacious, its effectiveness can be compromised by suboptimal compliance to standards. In this study, we assessed (1) the availability of oil brands across the eight divisions of Bangladesh,...

  • Article
  • Open Access
10 Citations
7,270 Views
15 Pages

Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths—A Modeling Study

  • Tobias Niedermaier,
  • Thomas Gredner,
  • Sabine Kuznia,
  • Ben Schöttker,
  • Ute Mons and
  • Hermann Brenner

9 November 2021

Meta-analyses of randomized controlled trials (RCTs) have estimated a 13% reduction of cancer mortality by vitamin D supplementation among older adults. We evaluated if and to what extent similar effects might be expected from vitamin D fortification...

  • Review
  • Open Access
523 Citations
39,558 Views
15 Pages

15 March 2011

Periconceptional intake of folic acid is known to reduce a woman’s risk of having an infant affected by a neural tube birth defect (NTD). National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide...

  • Review
  • Open Access
26 Citations
8,291 Views
12 Pages

Food fortification programs have been conducted in several countries to overcome micronutrient deficiency and related problems with various degrees of effectiveness. Available information regarding the success of food fortification programs in some d...

  • Review
  • Open Access
15 Citations
6,801 Views
17 Pages

20 December 2020

Large-scale food fortification is an effective, sustainable, and scalable intervention to address vitamin and mineral deficiencies, however, pressing gaps exist globally around ensuring the quality of fortified foods. This paper summarizes the global...

  • Review
  • Open Access
41 Citations
14,692 Views
15 Pages

11 April 2023

Inadequate folate intake during pregnancy is the leading cause of the development of neural tube defects (NTDs) in newborns. For this reason, mandatory fortification of folic acid, a synthetic, easily bioavailable form, in processed cereals and cerea...

  • Review
  • Open Access
41 Citations
10,975 Views
19 Pages

12 April 2022

Iron fortification of foods has always been a challenge. This is because iron fortification compounds vary widely in relative absorption; because many foods undergo unacceptable changes in color or flavor from the addition of iron; and because many o...

  • Article
  • Open Access
4 Citations
3,807 Views
9 Pages

11 June 2021

Fortification of wheat flour with iron and folic acid became mandatory in Ivory Coast in 2007. The purpose of this study was to determine the time trend relation between mandatory double fortification of wheat flour with iron and folic acid and marke...

  • Opinion
  • Open Access
1,694 Views
4 Pages

Current Status of Folic Acid Fortification in Romania

  • Bianca-Margareta Salmen and
  • Roxana-Elena Bohîlțea

1 September 2023

Among other benefits, folic acid has proven its role in preventing neural tube defects in the fertile female population. The neural tube defect prevalence is 21.9 in 10.000 births in the Eastern Mediterranean, while in the United States of America, t...

  • Article
  • Open Access
418 Views
15 Pages

Impact of Cheese Micronutrient Fortification on Micronutrient Consumption in Children from Morocco: A Modelling Study

  • Alba M. Santaliestra-Pasías,
  • Isabel Rueda-De Torre,
  • Mª Isabel Benedicto-Toboso,
  • Luis Mariano Esteban,
  • Sergio Sabroso-Lasa,
  • Karima Sabounji,
  • Larbi Rjimati and
  • Luis A. Moreno

29 April 2026

Background/Objectives: Micronutrient malnutrition, particularly deficiencies in calcium, vitamin D, iron, zinc, and iodine, remains a significant public health issue among school-aged children in Morocco. Processed cheese, such as “The Laughing...

  • Article
  • Open Access
4 Citations
4,890 Views
14 Pages

Stakeholder’s Perceptions of Mexico’s Federal Corn Flour Fortification Program: A Qualitative Study

  • Anna W. Waller,
  • Astrid Dominguez-Uscanga,
  • Emely Lopez Barrera,
  • Juan E. Andrade and
  • Jeanette M. Andrade

8 February 2020

Background: In Mexico, the fortification of corn and wheat flours with iron, zinc, and folic acid and the restoration of B-vitamins is a mandatory program. However, the monitoring and evaluation (M&E) of this fortification process is not well und...

  • Article
  • Open Access
20 Citations
11,169 Views
20 Pages

An Assessment of the Impact of Fortification of Staples and Condiments on Micronutrient Intake in Young Vietnamese Children

  • Arnaud Laillou,
  • Le Bach Mai,
  • Le Thi Hop,
  • Nguyen Cong Khan,
  • Dora Panagides,
  • Frank Wieringa,
  • Jacques Berger and
  • Regina Moench-Pfanner

24 August 2012

Targeted fortification programs for infants and young children are an effective strategy to prevent micronutrient deficiencies in developing countries, but the role of large-scale fortification of staple foods and condiments is less clear. Dietary mo...

  • Article
  • Open Access
5 Citations
4,600 Views
14 Pages

Risk–Benefit Assessment of an Increase in the Iodine Fortification Level of Foods in Denmark—A Pilot Study

  • Lea Sletting Jakobsen,
  • Josefine Ostenfeld Nielsen,
  • Sophie Egesø Paulsen,
  • Malene Outzen,
  • Allan Linneberg,
  • Line Tang Møllehave,
  • Tue Christensen and
  • Gitte Ravn-Haren

28 April 2022

Iodine deficiency is one of the most common nutritional disorders worldwide. In Denmark, the mandatory iodine fortification of salt of 13 ppm was introduced in 2000 to eradicate mild to moderate iodine deficiency and the fortification level was incre...

  • Systematic Review
  • Open Access
20 Citations
5,217 Views
29 Pages

Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews

  • Patrick Nyamemba Nyakundi,
  • Zsuzsanna Némethné Kontár,
  • Attila Kovács,
  • Luca Járomi,
  • Afshin Zand and
  • Szimonetta Lohner

26 August 2023

Vitamin D deficiency is a global public health concern with significant implications for bone health and chronic disease prevention. Our aim was to summarize the evidence from Cochrane and other systematic reviews evaluating the benefits or harms of...

  • Article
  • Open Access
261 Views
21 Pages

Iodine Fortification of a Fermented Dairy Product: Development and Quality Assessment

  • Aigul Tayeva,
  • Talgat Kulazhanov,
  • Fatima Dikhanbayeva,
  • Zhadyra Imangaliyeva,
  • Rimma Elemanova,
  • Mamura Absalimova,
  • Aliya Kengesova,
  • Dariya Tapalova and
  • Ulzhan Anarbekova

10 June 2026

Iodine deficiency remains a major nutritional concern worldwide, and fermented dairy products are considered promising vehicles for iodine fortification. However, the chemical form of iodine may influence the physicochemical and microbiological stabi...

  • Article
  • Open Access
3 Citations
1,721 Views
19 Pages

11 September 2025

Iron (Fe) and zinc (Zn) deficiencies, globally prevalent nutritional disorders, underscore the need for effective fortification strategies in staple foods like rice. This study evaluates a bioprocess-based technique for single (SF) and double fortifi...

  • Review
  • Open Access
14 Citations
5,903 Views
15 Pages

Small and Medium Enterprises’ Perspectives on Food Fortification Amid the Growing Burden of Malnutrition

  • Jimena Monroy-Gomez,
  • Chiara Ferraboschi,
  • Kesso Gabrielle van Zutphen,
  • Breda Gavin-Smith,
  • Daniel Amanquah and
  • Klaus Kraemer

16 September 2022

The need for a profound food system transformation has never been greater. The growing burden of malnutrition has become the new normal, with two billion people who are overweight, over 140 million children under five who are stunted and over two bil...

  • Article
  • Open Access
56 Citations
14,091 Views
11 Pages

Poor Knowledge and Practices Related to Iodine Nutrition during Pregnancy and Lactation in Australian Women: Pre- and Post-Iodine Fortification

  • Karen Charlton,
  • Heather Yeatman,
  • Catherine Lucas,
  • Samantha Axford,
  • Luke Gemming,
  • Fiona Houweling,
  • Alison Goodfellow and
  • Gary Ma

20 September 2012

A before-after review was undertaken to assess whether knowledge and practices related to iodine nutrition, supplementation and fortification has improved in Australian women since the introduction of mandatory iodine fortification in 2009. Surveys o...

  • Perspective
  • Open Access
10 Citations
3,642 Views
9 Pages

Aligning the Epidemiology of Malnutrition with Food Fortification: Grasp Versus Reach

  • Megan W. Bourassa,
  • Reed Atkin,
  • Jonathan Gorstein and
  • Saskia Osendarp

22 April 2023

Large-scale food fortification (LSFF) has been recognized as one of the most cost-effective interventions to improve the intake of vitamins and minerals and decrease the burden of micronutrient deficiency. Indeed, the simple addition of micronutrient...

  • Article
  • Open Access
11 Citations
8,481 Views
19 Pages

External Mill Monitoring of Wheat Flour Fortification Programs: An Approach for Program Managers Using Experiences from Jordan

  • James P. Wirth,
  • Erin Nichols,
  • Hanan Mas'd,
  • Rawhieh Barham,
  • Quentin W. Johnson and
  • Mary Serdula

21 November 2013

The fortification of wheat flour with micronutrients is a common strategy to increase vitamin and mineral intake. While wheat flour mills are often inspected by agencies affiliated with national ministries to ensure compliance with national fortifica...

  • Article
  • Open Access
3 Citations
3,885 Views
21 Pages

Expanding Fortification with Folic Acid: Thinking Outside the Cereal-Grain Box

  • Becky L. Tsang,
  • Carlen Stadnik,
  • Michelle Duong,
  • Helena Pachón and
  • Homero Martinez

27 April 2024

(1) Background: Fortifying maize and wheat flours with folic acid has effectively reduced neural tube defect-affected births. However, maize and wheat flours may not be widely consumed in all countries; further reduction in neural tube defect-affecte...

  • Article
  • Open Access
5 Citations
4,162 Views
15 Pages

Adjusted versus Targeted Fortification in Extremely Low Birth Weight Preterm Infants: Fortin Study—A Randomized Clinical Trial

  • Maria Sanchez-Holgado,
  • Miguel Saenz de Pipaon,
  • Maria Concepcion Jimenez,
  • Gema Crespo Sanchez,
  • Marta Molero-Luis,
  • Maria Teresa Montes,
  • Cristina Segovia,
  • Itsaso Losantos-García,
  • María Jimenez-Gonzalez and
  • Marta Cabrera-Lafuente
  • + 1 author

30 August 2024

Fortified human milk is the first choice for preterm infants. Although individualized fortification is recommended, the optimal method for this population remains uncertain. We conducted a comparative study assessing the growth effects of adjusted (A...

  • Review
  • Open Access
5 Citations
5,864 Views
12 Pages

Using Nature to Nurture: Breast Milk Analysis and Fortification to Improve Growth and Neurodevelopmental Outcomes in Preterm Infants

  • Katherine Marie Ottolini,
  • Elizabeth Vinson Schulz,
  • Catherine Limperopoulos and
  • Nickie Andescavage

29 November 2021

Premature infants are born prior to a critical window of rapid placental nutrient transfer and fetal growth—particularly brain development—that occurs during the third trimester of pregnancy. Subsequently, a large proportion of preterm ne...

  • Article
  • Open Access
14 Citations
7,794 Views
15 Pages

Vitamin A Status of Women and Children in Yaoundé and Douala, Cameroon, is Unchanged One Year after Initiation of a National Vitamin A Oil Fortification Program

  • Reina Engle-Stone,
  • Martin Nankap,
  • Alex Ndjebayi,
  • Marie-Madeleine Gimou,
  • Avital Friedman,
  • Marjorie J. Haskell,
  • Ann Tarini and
  • Kenneth H. Brown

20 May 2017

Vitamin A (VA) fortification of cooking oil is considered a cost-effective strategy for increasing VA status, but few large-scale programs have been evaluated. We conducted representative surveys in Yaoundé and Douala, Cameroon, 2 years before and 1...

  • Article
  • Open Access
7 Citations
7,557 Views
13 Pages

25 January 2023

Micronutrient deficiencies are still highly prevalent in Asia. Fortification of cooking aids, such as condiments (fish and soy sauces), seasonings, and bouillon cubes, may be an additional strategy to improve micronutrient intake. The current study e...

  • Brief Report
  • Open Access
8 Citations
4,861 Views
8 Pages

Vitamin D Fortification of Milk Would Increase Vitamin D Intakes in the Australian Population, but a More Comprehensive Strategy Is Required

  • Eleanor Dunlop,
  • Anthony P. James,
  • Judy Cunningham,
  • Anna Rangan,
  • Alison Daly,
  • Mairead Kiely,
  • Caryl A. Nowson,
  • Paul Adorno,
  • Paul Atyeo and
  • Lucinda J. Black

9 May 2022

Low vitamin D status (serum 25-hydroxyvitamin D (25(OH)D) concentration < 50 nmol/L) is prevalent in Australia, ranging between 15% and 32% in the adolescent and adult populations. Vitamin D intakes are also low across the population and were rece...

  • Article
  • Open Access
8 Citations
5,521 Views
15 Pages

25 January 2023

Human milk is recommended for very low birth weight infants. Their nutritional needs are high, and the fortification of human milk is a standard procedure to optimize growth. Targeted fortification accounts for the variability in human milk compositi...

  • Article
  • Open Access
11 Citations
8,646 Views
11 Pages

8 September 2016

Over two billion people suffer from micronutrient deficiencies. Food fortification is a prominent nutrition intervention to combat such deficiencies; however, its effectiveness, risks, and ethical implications vary depending on the contexts associate...

  • Article
  • Open Access
16 Citations
3,184 Views
21 Pages

Augmenting Functional and Sensorial Quality Attributes of Kefir through Fortification with Encapsulated Blackberry Juice

  • Vanja Travičić,
  • Olja Šovljanski,
  • Ana Tomić,
  • Milica Perović,
  • Maja Milošević,
  • Nenad Ćetković and
  • Mirjana Antov

17 November 2023

Kefir is a fermented dairy product claimed to confer many health-promoting effects, but its acidic taste is not appealing to some consumers. Therefore, the aim of this study was to enhance the functional and sensorial quality attributes of kefir thro...

  • Review
  • Open Access
1 Citations
7,018 Views
20 Pages

Zinc Fortification and Supplementation to Reduce Diarrhea in Children: A Literature Review

  • Sehar Iqbal,
  • Zoha Imtiaz Malik,
  • Maher Al Dabbas,
  • Ishmal Akhtar and
  • Aya Hussein

20 November 2025

Background: Zinc deficiency is a major global health issue and appears to be responsible for risk of diarrhea and death, particularly in children under 5 years. This review therefore aimed to summarize the existing literature related to zinc suppleme...

  • Article
  • Open Access
1 Citations
2,344 Views
14 Pages

Freeze-Dried Donor Milk for Fortification of Mother’s Own Milk in Preterm Infants: A Preliminary Observational Study

  • Niels Rochow,
  • Gisela Adrienne Weiss,
  • Katja Knab,
  • Isabell Prothmann,
  • Stefan Schäfer,
  • Jasper L. Zimmermann,
  • Anastasia Meis,
  • Stefanie Lohmüller-Weiß,
  • Kerstin Simon and
  • Christoph Fusch
  • + 2 authors

25 September 2025

Background/Objectives: Freeze-dried high-temperature short-time pasteurized human milk fortifiers offer potential for exclusive human milk feeding in preterm infants while providing necessary nutritional supplementation. However, clinical data on saf...

  • Review
  • Open Access
3 Citations
3,397 Views
26 Pages

8 April 2021

Efforts to address Micronutrient deficiencies (MNDs) in lower-and middle-income countries (LMICs) have been gaining pace in recent years. Commodities such as staple foods (e.g., cereals, roots, and tubers) and condiments (e.g., salt) have been target...

  • Article
  • Open Access
6 Citations
3,462 Views
15 Pages

Background: Initiatives to tackle micronutrient deficiencies (MNDs) in low-and middle-income countries (LMICs) have increased steadily in recent years. Commodities such as staple foods (e.g., cereals) and condiments (e.g., salt) have been targeted as...

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