Search Results (16,012)

This article presents a model for orchestrating data extraction, processing, and storage, addressing the challenges posed by diverse data sources and increasing data volumes. The proposed model includes three primary components: data production, data transfer, and data consumption and storage. Key architectures for data production are explored, such as modular designs and distributed processes, each with advantages and limitations regarding scalability, fault tolerance, and resource efficiency. A buffering module is introduced to enable temporary data storage, ensuring resilience and asynchronous processing. The data consumption module focuses on transforming and storing data in data warehouses while providing options for parallel and unified processing architectures to enhance efficiency. Additionally, a notification module demonstrates real-time alerts based on specific data events, integrating seamlessly with messaging platforms like Telegram. The model is designed to ensure adaptability, scalability, and robustness for modern data-driven applications, making it a versatile solution for effective data flow management. Full article

Power batteries and their management technology are crucial for the safe and efficient operation of electric vehicles (EVs). The life and safety issues of power batteries have always plagued the EV industry. To achieve an intelligent battery management system (BMS), it is crucial to accurately estimate the internal state of the power battery. The purpose of this review is to analyze the current status of research on multi-state estimation of power batteries, which mainly focuses on the estimation of state of charge (SOC), state of energy (SOE), state of health (SOH), state of power (SOP), state of temperature (SOT), and state of safety (SOS). Moreover, it also analyzes and prospects the research hotspots, development trends, and future challenges of battery state estimation. It is a significant guide for designing BMSs for EVs, as well as for achieving intelligent safety management and efficient power battery use. Full article

Neuropathic pain is a significant global clinical issue that poses substantial challenges to both public health and the economy due to its complex underlying mechanisms. It has emerged as a serious health concern worldwide. Recent studies involving dorsal root ganglion (DRG) stimulation have provided strong evidence supporting its effectiveness in alleviating chronic pain and its potential for sustaining long-term pain relief. In addition to that, there has been ongoing research with clinical evidence relating to the role of small non-coding ribonucleic acids known as microRNAs in regulating gene expressions affecting pain signals. The signal pathway involves alterations in neuronal excitation, synaptic transmission, dysregulated signaling, and subsequent pro-inflammatory response activation and pain development. When microRNAs are dysregulated in the dorsal root ganglia neurons, they polarize macrophages from anti-inflammatory M2 to inflammatory M1 macrophages causing pain signal generation. By reversing this polarization, a therapeutic activity can be induced. However, the direct delivery of these nucleotides has been challenging due to limitations such as rapid clearance, degradation, and reduction in half-life. Therefore, safe and efficient carrier vehicles are fundamental for microRNA delivery. Here, we present a comprehensive analysis of miRNA-based nano-systems for chronic neuropathic pain, focusing on their impact in dorsal root ganglia. This review provides a critical evaluation of various delivery platforms, including viral, polymeric, lipid-based, and inorganic nanocarriers, emphasizing their therapeutic potential as well as their limitations in the treatment of chronic neuropathic pain. Innovative strategies such as hybrid nanocarriers and stimulus-responsive systems are also proposed to enhance the prospects for clinical translation. Serving as a roadmap for future research, this review aims to guide the development and optimization of miRNA-based therapies for effective and sustained neuropathic pain management. Full article

The low-carbon transition of the global energy system is an urgent necessity to address climate change and meet growing energy demand. As a major source of energy consumption and emissions, buildings play a key role in this transition. This study systematically analyzes the flexible resources of building energy systems and vehicle-to-grid (V2G) interaction technologies, and mainly focuses on the regulation characteristics and coordination mechanisms of distributed energy supply (renewable energy and multi-energy cogeneration), energy storage (electric/thermal/cooling), and flexible loads (air conditioning and electric vehicles) within regional energy systems. The study reveals that distributed renewable energy and multi-energy cogeneration technologies form an integrated architecture through a complementary “output fluctuation mitigation–cascade energy supply” mechanism, enabling the coordinated optimization of building energy efficiency and grid regulation. Electricity and thermal energy storage serve as dual pillars of flexibility along the “fast response–economic storage” dimension. Air conditioning loads and electric vehicles (EVs) complement each other via thermodynamic regulation and Vehicle-to-Everything (V2X) technologies, constructing a dual-dimensional regulation mode in terms of both power and time. Ultimately, a dynamic balance system integrating sources, loads, and storage is established, driven by the spatiotemporal complementarity of multi-energy flows. This paper proposes an innovative framework that optimizes energy consumption and enhances grid stability by coordinating distributed renewable energy, energy storage, and flexible loads across multiple time scales. This approach offers a new perspective for achieving sustainable and flexible building energy systems. In addition, this paper explores the application of demand response policies in building energy systems, analyzing the role of policy incentives and market mechanisms in promoting building energy flexibility. Full article

To achieve efficient and sustainable marine aquaculture, STAR-CCM+ was used to simulate the internal and external field characteristics of a semi-submersible aquaculture platform based on a porous media model, focusing on the influence of incoming flow velocity and net solidity ratio. The results indicate that the flow field distribution around the platform exhibits no significant regularity and that low-velocity vortex regions are primarily concentrated near the pillars and nets. After velocity attenuation, the velocity reduction coefficients at the centers of the three cages are 90.26%, 63.65%, and 52.56%, respectively. Furthermore, the velocity attenuation inside the cages is minimally influenced by incoming flow velocity, with a maximum difference of 3.10%. In contrast, differences in net solidity ratio significantly affect velocity attenuation, particularly in downstream regions. The velocity reduction coefficient in the third cage varies by up to 43.25% depending on the net solidity ratio. These findings provide practical insights for the engineering design and application of aquaculture platforms. Full article

Inductive Wireless Power Transfer (WPT) technologies are advancing significantly in the electric vehicle (EV) charging applications. Misalignment between transmitting and receiving coils can considerably affect power transmission efficiency in WPT systems. Prior research involved power electronics as well as electromagnetic couplers. This work focuses on the coil design aspect of electromagnetic couplers. A relatively new concept of Symmetrical Cross Double-D (SCDD) type of the coil design is introduced specifically to maximize tolerance to misalignment while sustaining significant amount of power transferred. Mutual inductance was determined for the perfect alignment and misalignment positions of the SCDD coils. Mutual inductance obtained from the simulation was validated from the experimental measurements. The SCDD electromagnetic coupler demonstrated almost 2.5 times superior tolerance to misalignment of coils compared to the conventional circular coupler while maintaining at least 78% of maximum power transfer even at a lateral misalignment of 40 mm. Full article

The enzyme ABH2, one of nine human DNA dioxygenases of the AlkB family, belongs to the superfamily of Fe(II)/α-ketoglutarate-dependent dioxygenases and plays a crucial role in the direct reversal repair of nonbulky alkyl lesions in DNA nucleobases. ABH2 has broad substrate specificity, directly oxidizing DNA damages such as N¹-methyladenine, N³-methylcytosine, 1,N⁶-ethenoadenine, 3,N⁴-ethenocytosine, and a number of others. In our investigation, we sought to uncover the subtleties of the mechanisms governing substrate specificity in ABH2 by focusing on several critical amino acid residues situated in its active site. To gain insight into the function of this enzyme, we performed a functional mapping of its active site region, concentrating on pivotal residues, participating in forming a damaged binding pocket of the enzyme (Val99 and Ser125), as well as the residues directly involved in interactions with damaged bases, namely Arg110, Phe124, Arg172, and Glu175. To support our experimental data, we conducted a series of molecular dynamics simulations, exploring the interactions between the ABH2 mutant forms, bearing corresponding substitutions and DNA substrates, and harboring various types of methylated bases, specifically N¹-methyladenine or N³-methylcytosine. The comparative studies revealed compelling data indicating that alterations in most of the studied amino acid residues significantly influence both the binding affinity of the enzyme for DNA and its catalytic efficiency. Intriguingly, the findings suggest that the mutations impact the catalytic activity of ABH2 to a greater extent than its ability to associate with DNA strands. Collectively, these results show how changes to the active site affect molecular dynamics and reaction kinetics, improving our understanding of the substrate recognition process in this pivotal enzyme. Full article

The progressive collapse performance of reinforced concrete (RC) building structures has been extensively investigated using the alternate load path method. However, most studies have focused on newly designed structures, with limited attention given to existing buildings. Since progressive collapse can occur at any point during a structure’s service life and at various locations within the structural system, this study examines the progressive collapse behavior of deteriorated RC frames subjected to simulated reinforcement corrosion. This paper presents an investigation into the system-level progressive collapse responses of deteriorated RC frames, which extends the current state of the art in this field. The influence of different material deteriorations, different corrosion locations, different column removal scenarios, and dynamic effects on structural response is explored. According to the results obtained in this research, a significant reduction in progressive collapse resistance can be resulted in with increasing corrosion levels. Notably, only reinforcement corrosion in the beams located directly above the removed column (i.e., within the directly affected part) for the investigated RC frame had a substantial impact on structural performance. In contrast, corrosion in other regions and concrete deterioration exhibited minimal influence in this work. An increased number of corroded floors further reduced collapse resistance. Dynamic progressive collapse resistance was found to be considerably lower than its static counterpart and decreased at a slightly faster rate as corrosion progressed. Additionally, the energy-based method was shown to provide a reasonable approximation of the maximum dynamic responses at different corrosion levels, offering a computationally efficient alternative to full dynamic analysis. Full article

In both scientific and industrial fields, there has been a notable increase in attention toward High-Altitude Pseudo-Satellites (HAPSs) in recent years. This surge is driven by their distinct advantages over traditional satellites and Remotely Piloted Aircraft Systems (RPASs). These benefits are particularly evident in critical areas such as intelligent transportation systems, surveillance, remote sensing, traffic and environmental monitoring, emergency communications, disaster relief efforts, and the facilitation of large-scale temporary events. This review provides an overview of key aspects related to the propellers and propulsion systems of HAPSs. To date, propellers remain the most efficient means of propulsion for high-altitude applications. However, due to the unique operational conditions at stratospheric altitudes, propeller design necessitates specific approaches that differ from those applied in conventional applications. After a brief overview of the propulsion systems proposed in the literature or employed by HAPSs, focusing on both the technical challenges and advancements in this emerging field, this review integrates theoretical foundations, historical design approaches, and the latest multi-fidelity optimization techniques to provide a comprehensive comparison of propeller design methods for HAPSs. It identifies key trends, including the growing use of CFD-based simulations methodologies, which contribute to notable performance improvements. Additionally, the review includes a critical assessment of experimental methods for performance evaluation. These developments have enabled the design of propellers with efficiencies exceeding 85%, offering valuable insights for the next generation of high-endurance, high-altitude platforms. Full article

This study evaluated the effects of different doses of limonene essential oil (LEO) and a blend of cinnamaldehyde and carvacrol (BCC) on the fermentative quality and chemical–bromatological composition of total mixed ration (TMR) silages. Two independent trials were conducted, each focused on one additive, using a completely randomized design with four treatments (0, 200, 400, and 600 mg/kg of dry matter), replicated across two seasons (summer and autumn), with five replicates per treatment per season. The silages were assessed for their chemical composition, fermentation profile, aerobic stability (AS), and storage losses. In the LEO trial, the dry matter (DM) content increased significantly by 0.047% for each mg/kg added. Dry matter recovery (DMR) peaked at 97.9% at 473 mg/kg (p < 0.01), while lactic acid (LA) production reached 5.87% DM at 456 mg/kg. Ethanol concentrations decreased to 0.13% DM at 392 mg/kg (p = 0.04). The highest AS value (114 h) was observed at 203.7 mg/kg, but AS declined slightly at the highest LEO dose (600 mg/kg). No significant effects were observed for the pH, neutral detergent fiber (NDF), acid detergent fiber (ADF), crude protein (CP), or non-fiber carbohydrates (NFCs). In the BCC trial, DMR reached 98.2% at 548 mg/kg (p < 0.001), and effluent losses decreased by approximately 20 kg/ton DM. LA production peaked at 6.41% DM at 412 mg/kg (p < 0.001), and AS reached 131 h at 359 mg/kg. BCC increased NDF (from 23.27% to 27.73%) and ADF (from 35.13% to 41.20%) linearly, while NFCs and the total digestible nutrients (TDN) decreased by 0.0007% and 0.039% per mg of BCC, respectively. In conclusion, both additives improved the fermentation efficiency by increasing LA and reducing losses. LEO was more effective for DM retention and ethanol reduction, while BCC improved DMR and AS, with distinct effects on fiber and energy fractions. Full article

Soluble solids content (SSC) in fruits, as one of the key indicators of fruit quality, plays a critical role in postharvest quality assessment and grading. While traditional destructive methods can provide precise measurements of sugar content, they have limitations such as damaging the fruit’s integrity and the inability to perform rapid detection. In contrast, non-destructive detection technologies offer the advantage of preserving the fruit’s integrity while enabling fast and efficient sugar content measurements, making them highly promising for applications in fruit quality detection. This review summarizes recent advances in non-destructive detection technologies for fruit sugar content measurement. It focuses on elucidating the principles, advantages, and limitations of mainstream technologies, including near-infrared spectroscopy (NIR), X-ray technology, computer vision (CV), electronic nose (EN) technology and so on. Critically, our analysis identifies key challenges hindering the broader implementation of these technologies, namely: the integration and optimization of multi-technology approaches, the development of robust intelligent and automated detection systems, and issues related to high equipment costs and barriers to widespread adoption. Based on this assessment, we conclude by proposing targeted future research directions. These focus on overcoming the identified challenges to advance the development and practical application of non-destructive SSC detection technologies, ultimately contributing to the modernization and intelligentization of the fruit industry. Full article

Gallium nitride (GaN) enhancement-mode high-electron-mobility transistors ( E-HEMTs) deliver superior performance compared to traditional silicon (Si) and silicon carbide (SiC) counterparts. Their faster switching speeds, lower on-state resistances, and higher operating frequencies enable more efficient and compact power converters. However, their integration into high-power applications is limited by critical reliability concerns, particularly regarding their short-circuit (SC) withstand capability and overvoltage (OV) resilience. GaN devices typically exhibit SC withstand times of only a few hundred nanoseconds, needing ultrafast protection circuits, which conventional desaturation (DESAT) methods cannot adequately provide. Furthermore, their high switching transients increase the risk of false activation events. The lack of avalanche capability and the dynamic nature of GaN breakdown voltage exacerbate issues related to OV stress during fault conditions. Although SC-related behaviour in GaN devices has been previously studied, a focused and comprehensive review of protection strategies tailored to GaN technology remains lacking. This paper fills that gap by providing an in-depth analysis of SC and OV failure phenomena, coupled with a critical evaluation of current and next-generation protection schemes suitable for GaN-based high-power converters. Full article

This study explores the impact of graphene integration on lithium niobate (LiNbO₃, LN) ridge waveguides and directional couplers, focusing on coupling efficiency, polarization-dependent light absorption, and temperature sensitivity. Experimental and simulation results reveal that graphene loading significantly alters the effective mode refractive index and enhances waveguide coupling, enabling precise control over light transmission and power distribution. The temperature-dependent behavior of graphene–LN structures demonstrates strong thermal sensitivity, with notable changes in output power ratios between cross and through ports under varying temperatures. These findings highlight the potential of graphene–LN hybrid devices for compact, high-performance photonic circuits and temperature sensing applications. This study provides valuable insights into the design of advanced integrated photonic systems, paving the way for innovations in optical communication, sensing, and quantum technologies. Full article

This study analyzes the evolution of Pakistan’s energy policies from 1990 to 2024, documenting their transition from a singular focus on generation capacity to an integrated approach prioritizing renewable energy and efficiency. Through a systematic literature review of 110 initially screened studies, with 50 meeting the inclusion criteria and 22 selected for in-depth analysis, we evaluated policy effectiveness and identified implementation barriers. Our methodology employed predefined criteria focusing on energy efficiency, environmental sustainability, and climate impact, utilizing the Web of Science and Scopus databases. Early policies like the National Energy Conservation Policy (1992) and the Energy Policy (1994) emphasized energy security through generation capacity expansion while largely neglecting renewable sources and efficiency improvements. The policy landscape evolved in the 2000s with the introduction of renewable energy incentives and efficiency initiatives. However, persistent challenges include short-term planning, inconsistent implementation, and fossil fuels dependence. Recent framework like the Alternative and Renewable Energy Policy (2019) and the National Energy Efficiency and Conservation Plan (2020–2025) demonstrate progress toward sustainable energy practices. However, institutional, financial, and regulatory barriers continue to constrain effectiveness. We recommend that Pakistan’s energy strategy prioritize the following: (1) long-term planning horizon; (2) enhanced fiscal incentives; and (3) strengthened institutional support to meet global energy security and climate resilience standards. These measures would advance Pakistan’s sustainable energy transition while supporting both energy security and environmental objectives. Full article

The demand for biomass has been growing in recent years for several reasons, related to environmental, economic, and social trends. In the context of global climate changes and the depletion of natural resources, the recycling of plant biomass waste is a promising strategy for sustainable development that contributes to minimizing waste, improving resource efficiency, and achieving the goal of creating a circular economy. One of the highly demanded products of agricultural waste recycling is glucose. Glucose is an important organic substrate that allows a number of value-added products to be obtained. In this review, we focused on the commercially significant products of glucose oxidation: gluconic and glucaric acids. This review summarized the latest available data on the scope of the application of each product as well as the methods of their production. The capabilities and limitations of currently used methods of synthesis were highlighted. Full article