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Keywords = flutter computation

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12 pages, 4291 KB  
Proceeding Paper
A Cross-Platform Novel Reading Application with Integrated AI-Driven Audiobook Narration Using the Flutter Framework
by Ika Safitri Windiarti, Agung Prabowo, Amar Ma’ruf, Della Agustiana and Haryadi
Eng. Proc. 2026, 137(1), 23; https://doi.org/10.3390/engproc2026137023 (registering DOI) - 7 Jul 2026
Abstract
Mobile reading applications often separate text reading from audiobook playback, limiting multimodal learning. This study proposes a cross-platform mobile application integrating synchronized text–audio interaction within a unified interface. Developed using the Flutter framework, the system incorporates Firebase Authentication, Cloud Firestore, and adjustable speed [...] Read more.
Mobile reading applications often separate text reading from audiobook playback, limiting multimodal learning. This study proposes a cross-platform mobile application integrating synchronized text–audio interaction within a unified interface. Developed using the Flutter framework, the system incorporates Firebase Authentication, Cloud Firestore, and adjustable speed playback with reading progress synchronization. A mixed engineering–UX evaluation was conducted through black-box testing and a user survey involving ten participants. The application achieved an 81.2% satisfaction score, indicating strong user acceptance. The results demonstrate that integrated text–audio systems enhance accessibility and flexibility, with future scalability supported by AI-driven neural text-to-speech narration. Full article
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28 pages, 4196 KB  
Article
IoT-Based Isolation Ward Monitoring System Prototype
by Mohamed A. Torad, Ahmed A. M. Torad, Mona Mohamed Taha and Eslam Samy El-Mokadem
Sensors 2026, 26(13), 4065; https://doi.org/10.3390/s26134065 - 26 Jun 2026
Viewed by 360
Abstract
The COVID-19 pandemic exposed critical vulnerabilities in healthcare systems worldwide, placing healthcare workers (HCWs) at severe infection risk through direct patient contact. Epidemiological data confirm that HCWs were approximately seven times more likely to develop severe COVID-19 than other occupations, with over 7000 [...] Read more.
The COVID-19 pandemic exposed critical vulnerabilities in healthcare systems worldwide, placing healthcare workers (HCWs) at severe infection risk through direct patient contact. Epidemiological data confirm that HCWs were approximately seven times more likely to develop severe COVID-19 than other occupations, with over 7000 HCW deaths recorded globally by mid-2020. This paper presents the design and laboratory proof-of-concept validation of an IoT-based remote patient-monitoring system prototype—the IoT-Based Isolation Ward Monitoring System Prototype—designed to eliminate unnecessary patient-to-HCW physical contact while maintaining continuous, real-time physiological surveillance. The system integrates multi-sensor hardware comprising an AD8232 ECG module, a MAX30100 pulse oximeter, an NTC thermistor, and an MQ-135 CO2 sensor. These sensors interface with an Arduino UNO for data acquisition, while localized edge computing is executed on a Raspberry Pi 3B. A convolutional neural network (CNN) trained on the MIT-BIH Arrhythmia Database classifies heartbeats into five distinct categories. By utilizing SMOTE resampling on 109,446 samples, the network achieves an on-device inference latency of under 200 ms. The sensor data are transmitted to a Firebase Realtime Database via an authenticated REST API, which synchronizes data across dual front-end interfaces: a LabVIEW desktop dashboard for clinical oversight and a cross-platform Flutter mobile application for mobile monitoring. End-to-end technical validation under controlled laboratory conditions confirmed round-trip cloud latencies between 300 and 800 ms, error-free threshold alert generation, and sub-second latency for the integrated chat utility. The proposed system uniquely combines hardware sensing, ML-based ECG classification, cloud storage, a LabVIEW physician dashboard, and bidirectional doctor–patient mobile communication into a single unified, low-cost platform. Full article
(This article belongs to the Special Issue AI-Enabled Biomedical Sensing and Digital Health Applications)
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97 pages, 60482 KB  
Review
Advances in the Dynamics of Pipes Conveying Fluids: A Review
by Tamer A. El-Sayed, Moustafa S. Taima, Fady E. Shoukry and Mohamed M. Z. Ahmed
Vibration 2026, 9(2), 40; https://doi.org/10.3390/vibration9020040 - 8 Jun 2026
Viewed by 448
Abstract
Pipes conveying fluids are important fluid–structure interaction systems encountered in aerospace, energy, marine, and industrial applications. Their dynamic behavior is strongly influenced by the interaction between structural motion and internal or external flow, leading to complex phenomena such as divergence, flutter, and flow-induced [...] Read more.
Pipes conveying fluids are important fluid–structure interaction systems encountered in aerospace, energy, marine, and industrial applications. Their dynamic behavior is strongly influenced by the interaction between structural motion and internal or external flow, leading to complex phenomena such as divergence, flutter, and flow-induced vibration. This review presents a comprehensive assessment of the dynamics and stability of pipes conveying fluids by integrating classical theories with recent developments in modeling, computation, materials, and control. The review covers mathematical formulations based on Euler–Bernoulli, Rayleigh, Timoshenko, and shell theories, together with analytical and numerical solution methods used for stability and vibration analysis. The effects of geometry, boundary conditions, flow configuration, damping, and material properties on dynamic response and instability thresholds are discussed. Special attention is given to composite, viscoelastic, functionally graded, and smart materials, as well as micro- and nanoscale pipe systems. Recent advances in vibration suppression, reduced-order modeling, machine learning, and physics-informed computational approaches are also reviewed. Finally, the paper identifies current challenges and future research directions, including multiphysics coupling, experimental validation, digital twins, and AI-assisted predictive modeling for fluid-conveying pipe systems. Full article
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28 pages, 5696 KB  
Article
Discrete Bar-Chain Model for Aeroelastic Stability Analyses of Flexible Slender Thin Wings in Subsonic Flow at Low Speed
by Marco Berci
Appl. Sci. 2026, 16(11), 5687; https://doi.org/10.3390/app16115687 - 5 Jun 2026
Viewed by 339
Abstract
A novel semi-analytical computational approach is formulated and assessed for the dynamic aeroelastic stability analysis of flexible slender thin wings in incompressible flow, which can boost the preliminary airframe design and optimisation of lightweight aircraft, offering both theoretical and practical insights. Hencky’s bar-chain [...] Read more.
A novel semi-analytical computational approach is formulated and assessed for the dynamic aeroelastic stability analysis of flexible slender thin wings in incompressible flow, which can boost the preliminary airframe design and optimisation of lightweight aircraft, offering both theoretical and practical insights. Hencky’s bar-chain model is explicitly adopted as a discrete numerical implementation of the Euler–Bernoulli continuous beam idealisation for the flexible wing structure and its deformation, resulting in a linear system of coupled ordinary differential equations for its bending and torsion dynamics. Modified strip theory is employed for the unsteady sectional airload, where approximate yet effective analytical expressions are efficiently adopted for its build-up and distribution, combining two- and three-dimensional effects in subsonic potential flow. Once the natural vibration modes of the wing are obtained from its physical model, a reduced set is selected, and a modal approach is then employed to perform its aeroelastic stability analysis with either “p-k” or “p” method, depending on the aerodynamic model. Numerical results from such a reduced-order model are critically assessed for the flutter analysis of Goland’s, Loring’s, and Pazy wings and demonstrate excellent agreement with literature results for two- and three-dimensional airflow, also for the case of the swept wing. Full article
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31 pages, 2885 KB  
Article
Assistive Mobile Application for Fire Emergency Evacuation of Visually Impaired People
by Adrian Mocanu, Camelia Avram, Dan Radu, Ioan Valentin Sita and Adina Astilean
Sensors 2026, 26(5), 1572; https://doi.org/10.3390/s26051572 - 2 Mar 2026
Cited by 1 | Viewed by 821
Abstract
The emergency evacuation of visually impaired individuals during fire incidents presents critical challenges that require innovative technological solutions. While existing evacuation systems provide static route guidance, they fail to adapt dynamically to evolving fire conditions, blocked passages, or dangerous zones in buildings with [...] Read more.
The emergency evacuation of visually impaired individuals during fire incidents presents critical challenges that require innovative technological solutions. While existing evacuation systems provide static route guidance, they fail to adapt dynamically to evolving fire conditions, blocked passages, or dangerous zones in buildings with multiple routes and exits. This paper presents a comprehensive implementation of a mobile application built with Flutter/Dart that addresses these limitations by enabling real-time, dynamic route computation based on live sensor data. The presented system operates in a decentralized manner, performing all critical computations on-device to ensure its functionality even when some parts of the building infrastructure fail. A dynamic route calculation modified Dijkstra’s algorithm was implemented on each user’s phone for guidance. If initial path adjustments are needed, they are computed from sensor data to evaluate fire evolution and other relevant factors, including the user’s current position and crowd congestion. An audio–visual interface was designed to provide navigation instructions and to help users follow safety routes efficiently. Field testing with visually impaired participants demonstrated significant improvements in evacuation efficiency, with shorter evacuation times than traditional static guidance approaches. The system architecture complies with international fire safety standards while maintaining user privacy through a no-tracking design philosophy. This work contributes to both theoretical advances in adaptive evacuation algorithms and practical insights for deploying assistive technologies in emergency scenarios. Full article
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18 pages, 1303 KB  
Article
Timoshenko Theories in the Analysis of Cantilever Beams Subjected to End Mass and Dynamic End Moment
by Maria Anna De Rosa and Maria Lippiello
Appl. Mech. 2025, 6(4), 87; https://doi.org/10.3390/applmech6040087 - 4 Dec 2025
Cited by 1 | Viewed by 1540
Abstract
This paper investigates the effects of shear deformation on the flutter and divergence instabilities of a cantilever beam subjected to a concentrated mass and applied dynamic couple. The beam is modeled using classical and truncated Timoshenko beam theory, accounting for both shear deformation [...] Read more.
This paper investigates the effects of shear deformation on the flutter and divergence instabilities of a cantilever beam subjected to a concentrated mass and applied dynamic couple. The beam is modeled using classical and truncated Timoshenko beam theory, accounting for both shear deformation and rotary inertia. The inclusion of rotary inertia is shown to significantly influence the dynamic response, particularly for beams with greater thickness. According to Hamilton’s principle, the equations of motion for the cantilevered beam are derived, applying both classical and truncated Timoshenko beam theories. Auxiliary functions are utilized to solve the resulting system analytically. Various numerical examples are presented, illustrating typical results to demonstrate the effectiveness of the proposed approach. The numerical findings show significant convergence and computational effectiveness. The effect of the location of a concentrated mass and the dynamic couple applied at the free end is analyzed for various beam slenderness ratios and curvature positions, emphasizing their impact on modifying the critical instability limits. To highlight the significance of shear effects, a comparison is made between the outcomes of the Timoshenko model and those of the Euler-Bernoulli beam model, showing notable variations in the anticipated divergence and flutter stability characteristics. All the examples were executed using both classical theory and the truncated Timoshenko theory, and the findings indicated a remarkable level of convergence. Finally, a numerical comparisons with literature papers was performed. The results achieved showed strong alignment. Full article
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20 pages, 4147 KB  
Article
An Augmented Reality Mobile App for Recognizing and Visualizing Museum Exhibits
by Madina Ipalakova, Zhiger Bolatov, Yevgeniya Daineko, Dana Tsoy, Damir Khojayev and Ekaterina Reznikova
Computers 2025, 14(11), 492; https://doi.org/10.3390/computers14110492 - 13 Nov 2025
Cited by 2 | Viewed by 3266
Abstract
Augmented reality (AR) offers a novel way to enrich museum visits by deepening engagement and enhancing learning. This study presents the development of a mobile application for the Abylkhan Kasteyev State Museum of Arts (Almaty, Kazakhstan), designed to recognize and visualize exhibits through [...] Read more.
Augmented reality (AR) offers a novel way to enrich museum visits by deepening engagement and enhancing learning. This study presents the development of a mobile application for the Abylkhan Kasteyev State Museum of Arts (Almaty, Kazakhstan), designed to recognize and visualize exhibits through AR. Using computer vision and machine learning, the application identifies artifacts via a smartphone camera and overlays interactive 3D models in an augmented environment. The system architecture integrates Flutter plugins for AR rendering, YOLOv8 for exhibit recognition, and a cloud database for dynamic content updates. This combination enables an immersive educational experience, allowing visitors to interact with digital reconstructions and multimedia resources linked to the exhibits. Pilot testing in the museum demonstrated recognition accuracy above 97% and received positive feedback on usability and engagement. These results highlight the potential of AR-based mobile applications to increase accessibility to cultural heritage and enhance visitor interaction. Future work will focus on enlarging the exhibit database, refining performance, and incorporating additional interactive features such as multi-user collaboration, remote access, and gamified experiences. Full article
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18 pages, 1562 KB  
Article
NS-Assist: Nephrotic Syndrome Assistance System for Pediatric Decision-Making in Pandemic Situations
by Nada Zendaoui, Nardjes Bouchemal, Naila Bouchemal, Imane Boussebough and Galina Ivanova
Appl. Sci. 2025, 15(21), 11433; https://doi.org/10.3390/app152111433 - 26 Oct 2025
Cited by 1 | Viewed by 1257
Abstract
The COVID-19 pandemic has underscored the need for telemedicine to ensure continuity of pediatric care during health emergencies. This paper presents NS-Assist, a hybrid web–mobile decision support system for managing Idiopathic Nephrotic Syndrome (INS) in children. The system combines rule-based reasoning and fuzzy [...] Read more.
The COVID-19 pandemic has underscored the need for telemedicine to ensure continuity of pediatric care during health emergencies. This paper presents NS-Assist, a hybrid web–mobile decision support system for managing Idiopathic Nephrotic Syndrome (INS) in children. The system combines rule-based reasoning and fuzzy inference to assist clinicians in diagnosis, treatment adjustment, and relapse monitoring, while enabling caregivers to record and track daily health data. Implemented using Spring Boot, ReactJS, and Flutter with a secure MySQL database, NS-Assist integrates medical expertise with computational intelligence to support remote decision-making. A pilot evaluation involving 40 participants, including clinicians and caregivers, showed improved communication, reduced consultation time, and enhanced follow-up continuity. These results highlight the system’s potential as a reliable and adaptable framework for pediatric telemedicine in resource-constrained and emergency settings. Full article
(This article belongs to the Special Issue Applications in Neural and Symbolic Artificial Intelligence)
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26 pages, 10389 KB  
Article
Study on the Aeroelastic Characteristics of a Large-Span Joined-Wing Solar-Powered UAV
by Xinyu Tong, Xiaoping Zhu, Zhou Zhou, Junlei Sun, Jian Zhang and Qiang Wang
Aerospace 2025, 12(10), 892; https://doi.org/10.3390/aerospace12100892 - 2 Oct 2025
Cited by 1 | Viewed by 1679
Abstract
When a joined-wing configuration is applied to the design of solar-powered UAVs, the increasing span amplifies aeroelastic effects, while structure complexity poses greater challenges to computational effectiveness during the conceptual design phase. This paper focuses on a large-span joined-wing solar-powered UAV (LJS-UAV) engineering [...] Read more.
When a joined-wing configuration is applied to the design of solar-powered UAVs, the increasing span amplifies aeroelastic effects, while structure complexity poses greater challenges to computational effectiveness during the conceptual design phase. This paper focuses on a large-span joined-wing solar-powered UAV (LJS-UAV) engineering prototype. The structural finite element model of the whole system is constructed by developing the ‘Simplified beam-shell model’ (SBSM) and verified by a structural mode test. A numerical simulation approach is employed to comprehensively analyse and summarise the aeroelastic characteristics of the LJS-UAV from the perspectives of static aeroelasticity, flutter, and gust response. The mode test identified 30 global modes with natural frequencies below 10 Hz, indicating that the LJS-UAV possesses an exceptionally flexible structure and exhibits highly complex aeroelastic characteristics. The simulation results reveal that the structural elasticity induces significant variations in aerodynamic forces, moments, and derivatives during flight, which cannot be neglected. The longitudinal trim strategies can considerably influence the aeroelastic boundary of the LJS-UAV. Utilising the front-wing control surfaces for trim is beneficial in improving structural performance and expanding the flight envelope. Full article
(This article belongs to the Section Aeronautics)
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25 pages, 4854 KB  
Article
Computational Fluid Dynamics Approach to Aeroelastic Stability in Cable-Stayed Bridges
by Zouhir S. M. Louhibi, Nadji Chioukh, Sidi Mohammed Daoud, Zouaoui R. Harrat, Ehsan Harirchian and Walid Mansour
Buildings 2025, 15(19), 3509; https://doi.org/10.3390/buildings15193509 - 28 Sep 2025
Viewed by 1763
Abstract
Long-span cable-supported bridges, such as cable-stayed and suspension bridges, are highly sensitive to wind-induced effects due to their flexibility, low damping, and relatively light weight. Aerodynamic analysis is therefore essential in their design and safety assessment. This study examines the aeroelastic stability of [...] Read more.
Long-span cable-supported bridges, such as cable-stayed and suspension bridges, are highly sensitive to wind-induced effects due to their flexibility, low damping, and relatively light weight. Aerodynamic analysis is therefore essential in their design and safety assessment. This study examines the aeroelastic stability of the Oued Dib cable-stayed bridge in Mila, Algeria, with emphasis on vortex shedding, galloping, torsional divergence, and classical flutter. A finite element modal analysis was carried out on a three-dimensional model to identify natural frequencies and mode shapes. A two-dimensional deck section was then analyzed using Computational Fluid Dynamics (CFD) under a steady wind flow of U = 20 m/s and varying angles of attack (AoA) from −10° to +10°. The simulations employed a RANS k-ω SST turbulence model with a wall function of Y+ = 30. The results provided detailed airflow patterns around the deck and enabled the evaluation of static aerodynamic coefficients—drag (CD), lift (CL), and moment (CM)—as functions of AoA. Finally, the bridge’s aeroelastic performance was assessed against the four instabilities. The findings indicate that the Oued Dib Bridge remains stable under the design wind conditions, although fatigue due to vortex shedding requires further consideration. Full article
(This article belongs to the Section Building Structures)
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27 pages, 6795 KB  
Article
Dynamic Analysis of Variable-Stiffness Laminated Composite Plates with an Arbitrary Damaged Area in Supersonic Airflow
by Pingan Zou, Dong Shao, Ningze Sun and Weige Liang
Aerospace 2025, 12(9), 802; https://doi.org/10.3390/aerospace12090802 - 5 Sep 2025
Cited by 2 | Viewed by 1218
Abstract
In response to the urgent need for performance predictions of damaged aerospace structures, this study undertakes a comprehensive investigation into the flutter characteristics of damaged variable-stiffness composite laminate (VSCL) plates. The governing boundary value problem for the dynamics of damaged VSCL plates is [...] Read more.
In response to the urgent need for performance predictions of damaged aerospace structures, this study undertakes a comprehensive investigation into the flutter characteristics of damaged variable-stiffness composite laminate (VSCL) plates. The governing boundary value problem for the dynamics of damaged VSCL plates is formulated using first-order shear deformation theory (FSDT). Additionally, the first-order piston theory is utilized to model the aerodynamic pressure in supersonic airflow. A novel coupling methodology is developed through the integration of penalty function methods and irregular mapping techniques, which effectively establishes the interaction between damaged and undamaged plate elements. The vibration characteristics and aeroelastic responses are systematically analyzed using the Chebyshev differential quadrature method (CDQM). The validity of the proposed model is thoroughly demonstrated through comparative analyses with the existing literature and finite element simulations, confirming its computational accuracy and broad applicability. A notable characteristic of this research is its ability to accommodate arbitrary geometric configurations within damaged regions. The numerical results unequivocally demonstrate that accurately predicting the flutter characteristics of damaged VSCL plates constitutes an effective strategy for mitigating structural stability degradation. This approach provides valuable insights for aerospace structural design and maintenance. Full article
(This article belongs to the Section Aeronautics)
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27 pages, 6700 KB  
Article
Experimental and Computational Analysis of Large-Amplitude Flutter in the Tacoma Narrows Bridge: Wind Tunnel Testing and Finite Element Time-Domain Simulation
by Bishang Zhang and Ledong Zhu
Buildings 2025, 15(15), 2800; https://doi.org/10.3390/buildings15152800 - 7 Aug 2025
Cited by 3 | Viewed by 1942
Abstract
Nonlinear wind-induced vibrations and coupled static–dynamic instabilities pose significant challenges for long-span suspension bridges, especially under large-amplitude and high-angle-of-attack conditions. However, existing studies have yet to fully capture the mechanisms behind large-amplitude torsional flutter. To address this, wind tunnel experiments were performed on [...] Read more.
Nonlinear wind-induced vibrations and coupled static–dynamic instabilities pose significant challenges for long-span suspension bridges, especially under large-amplitude and high-angle-of-attack conditions. However, existing studies have yet to fully capture the mechanisms behind large-amplitude torsional flutter. To address this, wind tunnel experiments were performed on H-shaped bluff sections and closed box girders using a high-precision five-component piezoelectric balance combined with a custom support system. Complementing these experiments, a finite element time-domain simulation framework was developed, incorporating experimentally derived nonlinear flutter derivatives. Validation was achieved through aeroelastic testing of a 1:110-scale model of the original Tacoma Narrows Bridge and corresponding numerical simulations. The results revealed Hopf bifurcation phenomena in H-shaped bluff sections, indicated by amplitude-dependent flutter derivatives and equivalent damping coefficients. The simulation results showed less than a 10% deviation from experimental and historical wind speed–amplitude data, confirming the model’s accuracy. Failure analysis identified suspenders as the critical failure components in the Tacoma collapse. This work develops a comprehensive performance-based design framework that improves the safety, robustness, and resilience of long-span suspension bridges against complex nonlinear aerodynamic effects while enabling cost-effective, targeted reinforcement strategies to advance modern bridge engineering. Full article
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31 pages, 26260 KB  
Article
Aeroelastic Analysis of a Tailless Flying Wing with a Rotating Wingtip
by Weiji Wang, Xinyu Ai, Xin Hu, Chongxu Han, Xiaole Xu, Zhihai Liang and Wei Qian
Aerospace 2025, 12(8), 688; https://doi.org/10.3390/aerospace12080688 - 31 Jul 2025
Viewed by 1718
Abstract
This paper presents a preliminary investigation into the aeroelastic behavior of a tailless flying wing equipped with a rotating wingtip. Based on the configuration of Innovative Control Effectors (ICE) aircraft, an aeroelastic model of the tailless flying wing with a rotating wingtip has [...] Read more.
This paper presents a preliminary investigation into the aeroelastic behavior of a tailless flying wing equipped with a rotating wingtip. Based on the configuration of Innovative Control Effectors (ICE) aircraft, an aeroelastic model of the tailless flying wing with a rotating wingtip has been developed. Both numerical simulation and wind tunnel tests (WTTs) are employed to study the aeroelastic characteristics of this unique design. The numerical simulation involves the coupling of computational fluid dynamics (CFD) and implicit dynamic approaches (IDAs). Using the CFD/IDA coupling method, aeroelastic response results are obtained under different flow dynamic pressures. The critical flutter dynamic pressure is identified by analyzing the trend of the damping coefficient, with a focus on its transition from negative to positive values. Additionally, the critical flutter velocity and flutter frequency are obtained from the WTT results. The critical flutter parameters, including dynamic pressure, velocity, and flutter frequency, are examined under different wingtip rotation frequencies and angles. These parameters are derived using both the CFD/IDA coupling method and WTT. The results indicate that the rotating wingtip plays a significant role in influencing the flutter behavior of aircraft with such a configuration. Research has shown that the rotation characteristics of the rotating wingtip are the primary factor affecting its aeroelastic behavior, and increasing both the rotation frequency and rotation angle can raise the flutter boundary and effectively suppress flutter onset. Full article
(This article belongs to the Special Issue Aeroelasticity, Volume V)
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13 pages, 4782 KB  
Case Report
Anti-Ri Paraneoplastic Neurological Syndrome Presenting with Ocular Flutter in a Patient with Breast Cancer
by Francesca Cascone, Federica Stella, Christian Barbato, Antonio Minni and Giuseppe Attanasio
Brain Sci. 2025, 15(6), 628; https://doi.org/10.3390/brainsci15060628 - 11 Jun 2025
Cited by 3 | Viewed by 2429
Abstract
Ocular flutter is an uncommon ophthalmic finding that may indicate paraneoplastic phenomena, and it is clinically characterized by intermittent bursts of conjugate, horizontal saccades without an intersaccadic interval. Ocular flutter must be differentiated from opsoclonus, which, although also characteristic of certain paraneoplastic syndromes, [...] Read more.
Ocular flutter is an uncommon ophthalmic finding that may indicate paraneoplastic phenomena, and it is clinically characterized by intermittent bursts of conjugate, horizontal saccades without an intersaccadic interval. Ocular flutter must be differentiated from opsoclonus, which, although also characteristic of certain paraneoplastic syndromes, is instead defined by multidirectional saccades on both the horizontal and vertical planes. This report describes a very rare presentation of anti-Ri syndrome in a patient with an undiagnosed breast cancer, presenting with ocular flutter, dizziness, blurred vision, photophobia, and vomiting. Comprehensive evaluations, including contrast-enhanced brain Magnetic Resonance Imaging (MRI), brain Computed Tomography (CT) scan, ophthalmological assessment, viral serology, complete blood count and thyroid, renal coagulation, hepatic function assessments, vitamin D and B12 levels, were all normal. Upon excluding other potential etiologies for the neurological symptoms, a paraneoplastic origin was considered. Serological tests confirmed the presence of anti-Ri onconeural antibodies, and a whole-body CT scan identified nodules in the right breast. Despite surgical excision of the primary tumor and subsequent medical therapy, there was no improvement in the neurological symptoms. Follow-up evaluations at 2 months, 6 months, 1 year and 2 years revealed persistent vestibular and neurological symptoms, with serum tests remaining positive for anti-Ri antibodies and no clinical or radiological evidence of neoplastic recurrence. Full article
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34 pages, 1568 KB  
Review
Biophysical Modeling of Cardiac Cells: From Ion Channels to Tissue
by Sergio Alonso, Enrique Alvarez-Lacalle, Jean Bragard and Blas Echebarria
Biophysica 2025, 5(1), 5; https://doi.org/10.3390/biophysica5010005 - 14 Feb 2025
Cited by 7 | Viewed by 6506
Abstract
Cardiovascular diseases have become the leading cause of death in developed countries. Among these, some are related to disruptions in the electrical synchronization of cardiac tissue leading to arrhythmias such as atrial flutter, ventricular tachycardia, or ventricular fibrillation. Their origin is diverse and [...] Read more.
Cardiovascular diseases have become the leading cause of death in developed countries. Among these, some are related to disruptions in the electrical synchronization of cardiac tissue leading to arrhythmias such as atrial flutter, ventricular tachycardia, or ventricular fibrillation. Their origin is diverse and involves several spatial and temporal scales, ranging from nanoscale ion channel dysfunctions to tissue-level fibrosis and ischemia. Mathematical models play a crucial role in elucidating the mechanisms underlying cardiac arrhythmias by simulating the electrical and physiological properties of cardiac tissue across different spatial scales. These models investigate the effects of genetic mutations, pathological conditions, and anti-arrhythmic interventions on heart dynamics. Despite their varying levels of complexity, they have proven to be important in understanding the triggers of arrhythmia, optimizing defibrillation protocols, and exploring the nonlinear dynamics of cardiac electrophysiology. In this work, we present diverse modeling approaches to the electrophysiology of cardiac cells and share examples from our own research where these approaches have significantly contributed to understanding cardiac arrhythmias. Although computational modeling of the electrical properties of cardiac tissue faces challenges in integrating data across multiple spatial and temporal scales, it remains an indispensable tool for advancing knowledge in cardiac biophysics and improving therapeutic strategies. Full article
(This article belongs to the Special Issue State-of-the-Art Biophysics in Spain 2.0)
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