Search Results (137)

This systematic review evaluated the effects of functional additives on fluoride release, fluoride recharge/re-release, and selected mechanical, physical, and biological properties of orthodontic glass ionomer cements (GICs) and glass ionomer-based adhesives. The review followed PRISMA guidelines. The protocol was retrospectively registered in the Open Science Framework. PubMed, Scopus, Web of Science, Embase, and WorldCat were searched for in vitro studies investigating modified orthodontic GICs and reporting fluoride-related or clinically relevant material properties. The final literature search was conducted on 30 April 2026. After screening 87 records, 23 studies were included in the qualitative synthesis. Owing to substantial methodological and outcome heterogeneity among the included studies, no meta-analysis was performed, and the findings were synthesized narratively. Risk of bias was assessed using the QUIN Tool; 20 studies were classified as having a medium risk of bias and three as having a low risk, while none were classified as having a high risk. The effects of additives on fluoride release varied according to additive type and concentration, material composition, storage conditions, pH, and evaluation period. Increases in fluoride release were reported in studies evaluating materials containing nCaF₂, TMPnano, nanofluorapatite or nanofluorohydroxyapatite, hydroxyapatite, nanochitosan, SNP/ZnONP, and ZnSO₄. Several additives maintained or improved mechanical performance, whereas higher concentrations of some agents adversely affected bond strength, microhardness, or material stability. Antibacterial and antibiofilm activity was most evident for CHX, DMAHDM, MDPB, propolis, silibinin, nanosilver, and zinc-containing systems. Limited evidence also suggested potential benefits regarding enamel protection and cytocompatibility. Functional additives may enhance the preventive potential of orthodontic GIC-based materials, particularly through improved fluoride release and antibacterial activity. However, further standardized long-term and clinical studies are required before clinical recommendations can be made. Full article

Background/Objectives: Glass ionomer cements (GICs), high-biocompatibility dental materials that release fluoride with a cariostatic and remineralising effect on hard dental tissues, are widely used in many fields of dentistry, including conservative dentistry, pediatric dentistry, prosthodontics, and orthodontics; however, their mechanical performance and wear resistance remain limited. This study investigated the effect of nanodiamond (ND) addition (0.5–4.0 wt.%) on the surface, mechanical, and tribological properties of a conventional self-curing GIC. Methods: Surface roughness, microhardness, wear resistance, coefficient of friction, and chemical composition were evaluated using confocal microscopy, Vickers microhardness testing, tribological measurements, and EDX analysis. Results: The incorporation of NDs reduced the coefficient of friction and modified the surface morphology of the cement. The lowest friction coefficient (0.444) was observed for the sample containing 2 wt.% ND. However, ND addition also resulted in an approximately 50 per cent decrease in microhardness and wear resistance compared with the unmodified cement. EDX analysis confirmed that the chemical composition of the GIC matrix remained largely unchanged. Conclusions: The results indicate that nanodiamonds can improve the tribological behavior of glass ionomer cements, although further optimization of nanoparticle concentration and dispersion is necessary to maintain adequate mechanical properties. Full article

Objectives: This scoping review summarized the evidence on the biocompatibility of pit and fissure sealants, focusing on cytotoxicity, genotoxicity, and overall biological safety of commercial and experimental materials evaluated in vitro and in vivo. Methods: Following the PRISMA-ScR guidelines, eligibility was defined using the Population, Concept, and Context (PCC) framework: the population comprised cell cultures, animal models, or human participants exposed to sealants; the concept was biocompatibility, including cytotoxicity, genotoxicity, and inflammatory or tissue response; and the context encompassed commercial and experimental pit and fissure sealants used in preventive dentistry, particularly in pediatric populations. PubMed and Scopus platforms were searched without restrictions on publication year or language. Studies assessing biocompatibility (cytotoxicity, genotoxicity, inflammatory or tissue response) in cell cultures, animal models, or humans were eligible; those evaluating only clinical efficacy were excluded. Two reviewers independently performed study selection and data extraction. Results: Of 406 records (291 after deduplication), 10 studies were included—nine in vitro and one in vivo. Resin-based sealants predominated, mainly assessing residual monomers (TEGDMA, Bis-GMA) and their effects on fibroblasts, keratinocytes, periodontal ligament cells, and buccal epithelial cells. TEGDMA was released most frequently, whereas Bis-GMA showed the highest cytotoxicity. Experimental sealants containing nano-calcium fluoride, calcium phosphate, bioactive glass, or antibacterial monomers generally showed favorable biocompatibility, although high additive concentrations reduced cell viability. The single in vivo study reported good biocompatibility without significant genotoxicity. Conclusions: Pit and fissure sealants generally show acceptable biocompatibility and remain safe for caries prevention, although the biological response depends on composition, degree of polymerization, and residual monomer release. Further standardized long-term in vivo research is needed, particularly in pediatric populations. Full article

This systematic review aimed to investigate the effect of titanium dioxide (TiO₂) incorporation on the mechanical, physicochemical, and biological properties of conventional glass ionomer cements (GICs). A systematic search was conducted in June 2026 in PubMed, Scopus, Embase, Web of Science and WorldCat databases. Search terms included combinations of glass ionomer AND titanium dioxide OR TiO₂ OR titanium oxide OR titanium nanotubes OR titanium nanoparticles. The study selection process followed the PRISMA guideline and was organized according to the PECO framework. The search yielded the identification of 475 articles, of which 34 met the eligibility criteria. The included studies investigated different TiO₂ forms, concentrations, and commercial GIC formulations. Many studies reported improvements in compressive strength, surface microhardness, fracture toughness, and antibacterial activity following TiO₂ incorporation. However, the findings were heterogeneous. Several studies reported no statistically significant differences or contradictory outcomes, particularly regarding flexural strength, fluoride release, cytocompatibility, and antibacterial performance. Beneficial effects were most frequently observed at TiO₂ concentrations between 3 and 5 wt%, whereas higher concentrations were occasionally associated with nanoparticle agglomeration and reduced material performance. Variability among studies was likely influenced by differences in TiO₂ characteristics, concentration, testing protocols, and GIC formulation. Overall, TiO₂ incorporation appears to be a promising approach for enhancing selected properties of conventional GICs. However, further standardized studies are required to confirm the consistency and clinical relevance of these effects. Full article

Background: Compomer materials combine the advantages of composite resins and glass ionomer cements, including fluoride release, durability, and aesthetics. This study evaluated the effects of silver nanoparticles (nAg⁰) and copper oxide (CuO) particles on fluoride ions release and the structural properties of a commercially available compomer. Methods: Compomer discs modified with 0.125 wt.%, 0.25 wt.%, and 0.5 wt.% nAg⁰ or CuO were prepared and analyzed in demineralized water and artificial saliva at various pH levels for 168 h. Fluoride release was measured using a fluoride-selective electrode, while structural and morphological properties were examined using X-ray diffraction (XRD) and scanning electron microscopy (SEM). Results: Under most of the tested conditions, the modified materials exhibited higher fluoride release than the unmodified compomer, with the greatest increase typically observed at higher additive concentrations. XRD analysis confirmed the presence of crystalline phases of Ag⁰ and CuO while maintaining the amorphous nature of the compomer matrix. SEM observations revealed better particle dispersion at lower additive concentrations and increased agglomeration at a 0.5% content. Conclusions: These results indicate that the incorporation of nAg⁰ and CuO particles may enhance the fluoride-releasing potential of compomer materials; however, further studies are necessary to evaluate their mechanical, antibacterial, cytotoxic, and aesthetic properties prior to clinical application. Full article

Bio-silica particles derived from rice husks were coated with MgAl layered double hydroxides (LDHs) and thermally converted into layered double oxides (LDOs) to evaluate fluoride capture and release capability. The deposition of an MgAl LDH layer on the silica particle makes the LDH more accessible for interaction. Fluoride loading was tested in aqueous and ethanol–water media, with mixed solvents consistently enhancing uptake. Release studies in demineralized water showed relatively rapid desorption (~1500 min), whereas embedding particles in an acrylic matrix reduced the release rate by nearly two orders of magnitude, enabling sustained release levels suitable for dental applications. Ethanol promoted both ion exchange and memory effect mechanisms, providing tunable control over fluoride incorporation and release. These functional composites demonstrate potential for controlled delivery in dental restorative materials, highlighting their potential as adaptive fillers that can enhance the mechanical properties while also serving a functional base for low fluoride release. Full article

Background: Corrosion of orthodontic archwires raises biocompatibility concerns; yet, comparative multi-element data across manufacturers remain scarce. Methods: Ni, Cr, Fe, and Ti release was quantified by ICP-OES from SS and NiTi rectangular archwires (0.43 × 0.64 mm) from four manufacturers (Ormco, 3M Unitek, Dentaurum, and American Orthodontics) and immersed in artificial saliva (pH~7.0) and fluoride-containing saliva (+0.05% NaF) at six time points (days 1–35). Release was normalised to wire mass (mg g⁻¹). Non-parametric tests were applied. Results: NiTi wires released significantly more Ni than SS wires in +NaF at all time points (p = 0.029). An exploratory manufacturer effect on Ni release from NiTi was detected (Kruskal–Wallis H = 12.99, p = 0.005); American Orthodontics exceeded Dentaurum and Ormco. Ormco SS released ~3-fold more Fe than other SS wires (H = 13.68, p = 0.003). Ti was detectable exclusively in NiTi wires in +NaF; all specimens were below LOQ in pH~7.0. Cr release was uniformly low (0.017–0.023 mg g⁻¹). Conclusions: Manufacturer identity influences Ni and Fe release independently of alloy type. Fluoride selectively disrupts the NiTi passive film. These exploratory findings, derived from a single-specimen pilot design, may inform clinical material selection in nickel-sensitive patients pending replication. Full article

Secondary caries and biofilm accumulation remain major causes of failure in provisional crowns and restorations, highlighting the need for multifunctional resin coatings with antibacterial and remineralizing capabilities. This study aimed to develop a novel bioactive and antibacterial resin-based surface coating incorporating 10% dimethylaminododecyl methacrylate (DMADDM), 20% nanoparticles of amorphous calcium phosphate (NACP), and/or 20% calcium fluoride nanoparticles (nCaF₂) within a urethane dimethacrylate/triethylene glycol divinylbenzyl ether (UDMA/TEG-DVBE) matrix. Coatings were evaluated for degree of conversion (DC), flow, shear bond strength, brushing wear resistance (10,000 cycles), and calcium (Ca), phosphate (PO₄), and fluoride (F) ion release up to 70 days. All groups achieved clinically acceptable polymerization, with the lowest DC at 50%. NACP-containing coatings significantly increased shear bond strength to 18.3 ± 2.8 MPa, representing a ~170% increase compared with the experimental control (6.8 ± 2.1 MPa) and exceeding the ISO 10477 minimum threshold of 5 MPa. After brushing simulation, experimental coatings demonstrated low wear depth (0.93–1.19 µm), which was ~40% lower than the commercial control (1.85 ± 0.40 µm). Sustained ion release was achieved for 70 days, with 20% NACP-formula releasing 1.22 mmol/L Ca and 0.90 mmol/L PO₄, while the dual NACP–nCaF₂ formulation provided simultaneous Ca (0.62 mmol/L) and F (0.33 mmol/L) release. The developed coatings demonstrated promising physicochemical properties, bonding performance, wear resistance, and sustained remineralizing ion release, supporting their potential application as therapeutic surface coatings for provisional restorations. Full article

Advances in dental material science over recent decades have significantly improved the mechanical, physical, esthetic, and adhesive properties of restorative systems. As clinical performance and durability have reached high standards, research has progressively shifted from purely mechanical replacement toward the development of bioactive materials capable of interacting beneficially with biological tissues. Rather than functioning solely as passive restoratives, contemporary materials are increasingly designed to contribute to disease prevention and tissue repair. Bioactive functionality encompasses both bioprotective and biopromotive effects, including antimicrobial activity, reinforcement of the dental substrate, promotion of remineralization, modulation of inflammatory responses, and stimulation of regenerative pathways. In this context, the surface pre-reacted glass ionomer (S-PRG) particle has emerged as a multifunctional bioactive technology. Its unique three-layer structure enables sustained release of multiple ions, fluoride, strontium, boron, sodium, silicate, and aluminum, associated with mineralization, biofilm inhibition, inflammatory regulation, and activation of cellular signaling pathways. An integrative review was conducted through a literature search in PubMed, SciELO and Scopus using the descriptors “Surface-reaction-type prereacted glass ionomer” and “S-PRG.” Experimental studies evaluating antimicrobial, anti-inflammatory, remineralizing, cellular, or regenerative effects of S-PRG-containing materials were considered eligible. A total of 49 studies met the inclusion criteria and were analyzed through descriptive synthesis. The available evidence indicates that the biological activity of S-PRG-containing materials extends beyond caries prevention, including modulation of inflammatory responses, enhancement of mineralization processes, and stimulation of cellular pathways related to tissue repair. These findings highlight the potential of S-PRG technology as a promising strategy for the development of restorative materials with regenerative and preventive properties. Full article

Glass ionomer cements (GICs) are considered functionally biomimetic as they participate in ion-exchange processes that partially resemble the behavior of natural enamel and dentin, chemically bond to dental hard tissues, and release fluoride. While GICs are designed to interact with aqueous oral environments, their exposure to dietary beverages may affect their esthetic stability and water-related behavior within the oral environment. For biomimetic restorative materials to perform successfully in the oral environment, they must maintain not only bioactive properties but also esthetic stability and resistance to water-related degradation during exposure to dietary beverages. This study evaluated beverage-induced color changes, water sorption, and water solubility of six GICs following their immersion in coffee, tea, berry juice, cola, and distilled water (n = 5 per material per solution). Color measurements were recorded at baseline and after 2, 4, 6, and 8 weeks using a spectrophotometer, and color change (ΔE) values were calculated using the CIE L*a*b* system. Specimen mass was measured at baseline, after 8 weeks of immersion and then after 4 weeks of desiccation. Data were analyzed using repeated-measures Analysis of Variance (ANOVA) and Fisher’s least significant difference post hoc tests (α = 0.05). The results showed time, material, and solution significantly affected ΔE (p < 0.001). Tea produced the greatest discoloration overall, followed by coffee. ChemFil exhibited the greatest staining susceptibility, while Fuji II showed the lowest staining susceptibility. Water sorption and solubility were material- and solution-dependent. Clinically relevant discoloration of GICs was found when immersed in common beverages over time, with tea showing the strongest staining effect. These findings indicate that although GICs exhibit biomimetic characteristics through their interaction with tooth structures and aqueous environments, their long-term esthetic stability and resistance to environmental challenges should also be considered when selecting restorative materials for clinically visible areas. Full article

The present study demonstrates that the corrosion behavior of dental cobalt–chromium (Co–Cr) alloys is strongly influenced by the interaction between microstructure, manufacturing technique, and oral chemical environment. A comparative investigation was conducted on Co–Cr specimens fabricated using four technological routes: conventional casting, CAD/CAM machining, Selective Laser Melting (SLM), and Direct Metal Laser Sintering (DMLS). The study included microstructural characterization, evaluation of generalized corrosion behavior using the rotating electrode technique, assessment of localized crevice corrosion, and quantitative analysis of the release of twenty metallic cations. Extraction tests were performed for 168 h in two media simulating aggressive oral environments: 0.07 N HCl (acidic medium) and a fluoride-containing electrolyte (0.1% NaF + 0.1% KF). Electrochemical measurements were recorded in the current density range of 10⁻¹⁰ to 10⁻⁷ A/cm², while released cation concentrations were quantified at the µg/L level. All alloys exhibited very low corrosion current densities (icorr in the 10⁻⁸ to 10⁻⁹ A·cm⁻² range), confirming overall good corrosion resistance. Among all manufacturing routes, CAD/CAM specimens demonstrated the highest electrochemical performance, with a wide passivity domain extending up to approximately 740 mV/SCE. A statistical interaction analysis between extraction media and manufacturing techniques was performed using the non-parametric Mann–Whitney (MW) U test. Among the analyzed elements, only chromium showed a statistically significant difference between media (p < 0.05), with an approximately 25-fold-higher release in acidic conditions compared with the fluoride medium, confirming the predominant role of proton-induced destabilization of the protective Cr₂O₃ passive film. In contrast, fluoride-containing media induced selective release of elements such as Cu (3× higher), W (2.5× higher), and Mo (1.4× higher), associated with complexation phenomena. The manufacturing route significantly influences corrosion behavior. Although additive manufacturing technologies (SLM/DMLS) enable highly accurate and customized prosthetic designs, rapid solidification and microstructural heterogeneities may increase susceptibility to localized corrosion compared with more homogeneous CAD/CAM materials. Clinically, these findings suggest that future restorative strategies should incorporate corrosion-aware material selection within digital workflows. As digital dentistry evolves, predictive models integrating patient-specific oral conditions may assist clinicians in selecting the most appropriate material system for long-term performance. In conclusion, the long-term success of dental Co–Cr prosthetic devices depends not only on mechanical strength and precision of fit, but also on sustained electrochemical stability in the complex oral environment. Full article

Orthodontic treatment with fixed appliances increases the risk of enamel demineralization and biofilm accumulation around brackets and other devices. Conventional orthodontic bonding materials provide adequate mechanical retention but limited bioactive protection. This narrative review summarizes current in vitro, in vivo, and clinical evidence on nanoparticles (NPs) incorporated into orthodontic adhesives and cements, focusing on antimicrobial and remineralizing effects, mechanical performance, potential clinical relevance, and safety. Electronic searches of PubMed, Science Direct and Google Scholar identified laboratory, animal, and human studies evaluating NP-modified orthodontic bonding systems. Most available data derive from in vitro experiments, which consistently show that silver, zinc oxide, titanium dioxide, calcium phosphate-based particles, and related nanoparticles can inhibit cariogenic biofilms, reduce enamel demineralization surrogates, and, in many formulations, maintain clinically acceptable shear bond strength while enabling fluoride or calcium/phosphate ion release. A smaller number of in vivo and short-term clinical studies suggest reduced plaque accumulation and fewer or less severe white-spot lesions when nanoparticle-containing materials are used, although study designs and outcome measures are heterogeneous. Overall, NP-enhanced orthodontic bonding materials appear promising for combining mechanical durability with biological protection. However, the current level of evidence is limited by the predominance of in vitro data, small sample sizes, and short follow-up in clinical studies. Well-designed, long-term clinical trials with standardized outcomes are required before routine clinical adoption can be recommended. Full article

Ion-releasing restorative biomaterials have gained increasing attention in minimally invasive dentistry due to their potential to combine mechanical reliability with therapeutic functionality. Cention^® N is an alkasite-based restorative material designed to release fluoride, calcium, and hydroxyl ions while exhibiting mechanical properties comparable to resin-based composites. The present study aimed to systematically evaluate the clinical performance of this ion-releasing restorative material in comparison with conventional resin composites and glass ionomer cements. A comprehensive systematic search was conducted in PubMed (MEDLINE), Cochrane Library, Web of Science, Scopus, EMBASE, and SciELO databases up to 31 October 2024, following the PRISMA guidelines. Clinical studies assessing restorative performance outcomes were included. Meta-analyses were performed using Review Manager software (version 5.1). Fourteen studies met the inclusion criteria for qualitative synthesis, of which ten were eligible for quantitative analysis. The pooled results demonstrated comparable clinical performance between alkasite restoratives and resin-based composites regarding retention and secondary caries incidence, while superior outcomes were observed when compared with glass ionomer cements. Within the limitations of the available evidence, ion-releasing alkasite restorative materials represent a clinically acceptable alternative to conventional restorative options, combining functional biomaterial properties with reliable clinical performance. The conclusions should be interpreted within the context of the included studies, which exhibited clinical heterogeneity and, in several cases, a moderate risk of bias. Full article

Conventional glass ionomer cement (GIC) is a reaction product formulated from glass powders and polycarboxylic acid aqueous solution. This material has garnered significant attention in restorative dentistry due to its favorable properties, including chemical adhesion to tooth structure, biocompatibility, and sustained fluoride release, coupled with its minimal pulp irritation. However, its low mechanical strength, high brittleness, and susceptibility to cracking limit its use in stress-bearing areas of teeth. To expand the clinical application scope of GIC and develop an “ideal” dental restorative material, enhancing traditional GIC is necessary. This narrative review summarizes the main strategies for enhancing GIC, covering modifications to both the powder and liquid components. The key findings indicate that incorporating reinforcing fillers into the powder or modifying the polyacid chemistry can significantly improve mechanical properties such as compressive, tensile, and flexural strength. Additionally, some modifications help maintain or enhance fluoride release. However, the translation of many laboratory-based improvements to clinical practice requires further validation. In conclusion, while numerous promising enhancement routes exist, future development should focus on synergistic approaches and rigorous clinical evaluation to advance towards high-performance, durable restorative materials. Full article

Ultrapure water (UPW) distribution loops must deliver stable hydraulics while limiting contamination from polymer piping. This study integrates computational fluid dynamics (CFD) with systematic pipe autopsy to examine contaminant behavior in a pilot-scale UPW loop constructed using chlorinated polyvinyl chloride (CPVC) and polyvinylidene fluoride (PVDF) and operated under identical conditions. CFD predicted nearly identical loop-scale velocity, pressure, and temperature fields for both materials, and identified low-shear recirculation at elbows and downstream tees as zones of elevated particle residence. Lagrangian particle tracking (0.05 μm, no-sticking) showed rapid breakthrough and complete flushing within 13 min, providing a hydraulic susceptibility map for transient retention. After eight months of operation, 17 sections were inspected endoscopically and leached at 60 °C. CPVC exhibited yellow–brown discoloration and highly heterogeneous total organic carbon (TOC) release with hot spots of 16–18 mg·L⁻¹, whereas PVDF showed low, spatially uniform TOC (0.4–2.3 mg·L⁻¹) and minimal fouling; inorganic ions remained at sub-mg·L⁻¹ levels for both materials. Overall, geometry governs where contamination can accumulate, while material properties control its magnitude and persistence, with PVDF providing greater resistance to long-term organic contamination than CPVC. Full article