Search Results (50,033)

Background/Objectives: Green tripe (GRET) is rich in essential fatty acids, vitamins, calcium, phosphorus, and other nutrients and contains various beneficial microorganisms, including lactobacillus, along with feed components consumed by ruminants. Methods: In this study, Latilactobacillus sakei and L. curvatus were isolated from GRET and evaluated for their potential as probiotics, focusing on their anti-inflammatory properties and ability to modulate inflammatory responses. Results: When heat-killed L. sakei or L. curvatus (10⁸ CFU/mL) and their metabolites (0.5 mg/mL) were applied to RAW 264.7 macrophages stimulated with LPS, nitric oxide (NO) production was reduced by approximately 10–35% and 2–11%, respectively. Furthermore, the expression levels of key anti-inflammatory cytokines, TNF-α and IL-6, were suppressed by more than 5%. These effects were not due to cytotoxicity but instead due to genuine anti-inflammatory activity. In addition, both strains exhibited antioxidant activity, as demonstrated by their performance in ABTS and FRAP assays. Conclusions: These findings suggest that L. sakei and L. curvatus have significant antioxidant and anti-inflammatory properties, highlighting their potential as probiotics and prebiotics. Moreover, these newly isolated strains from GRET are expected to serve as valuable functional ingredients for developing health-promoting foods and dietary supplements. Full article

This review comprehensively examines the application of deep learning technologies across the entire soybean production chain, encompassing areas such as disease and pest identification, weed detection, crop phenotype recognition, yield prediction, and intelligent operations. By systematically analyzing mainstream deep learning models, optimization strategies (e.g., model lightweighting, transfer learning), and sensor data fusion techniques, the review identifies their roles and performances in complex agricultural environments. It also highlights key challenges including data quality limitations, difficulties in real-world deployment, and the lack of standardized evaluation benchmarks. In response, promising directions such as reinforcement learning, self-supervised learning, interpretable AI, and multi-source data fusion are proposed. Specifically for soybean automation, future advancements are expected in areas such as high-precision disease and weed localization, real-time decision-making for variable-rate spraying and harvesting, and the integration of deep learning with robotics and edge computing to enable autonomous field operations. This review provides valuable insights and future prospects for promoting intelligent, efficient, and sustainable development in soybean production through deep learning. Full article

This paper investigates the problem of tracking targets with unknown but fixed 3D star-convex shapes using point cloud measurements. While existing methods typically model shape parameters as random variables evolving according to predefined prior models, this evolution process is often unknown in practice. We propose a particular approach within the Expectation Conditional Maximization (ECM) framework that circumvents this limitation by treating shape-defining quantities as parameters estimated directly via optimization. The objective is the joint estimation of target kinematics, extent, and orientation in 3D space. Specifically, the 3D shape is modeled using a radial function estimated via double Fourier series (DFS) expansion, and orientation is represented using the compact, singularity-free axis-angle method. The ECM algorithm facilitates this joint estimation: an Unscented Kalman Smoother infers kinematics in the E-step, while the M-step estimates DFS shape parameters and rotation angles by minimizing regularized cost functions, promoting robustness and smoothness. The effectiveness of the proposed algorithm is substantiated through two experimental evaluations. Full article

Reinforcement learning models often rely on uncertainty estimation to guide decision-making in dynamic environments. However, the role of memory limitations in representing statistical regularities in the environment is less understood. This study investigated how limited memory capacity influence uncertainty estimation, potentially leading to misestimations of outcomes and environmental statistics. We developed a computational model incorporating active working memory processes and lateral inhibition to demonstrate how relevant information is selected, stored, and used to estimate uncertainty. The model allows for the detection of contextual changes by estimating expected uncertainty and perceived volatility. Two experiments were conducted to investigate limitations in information availability and uncertainty estimation. The first experiment explored the effect of cognitive load on memory reliance for uncertainty estimation. The results show that cognitive load diminished reliance on memory, lowered expected uncertainty, and increased perceptions of environmental volatility. The second experiment assessed how outcome exposure conditions affect the ability to detect environmental changes, revealing differences in the mechanisms used for environmental change detection. The findings emphasize the importance of memory constraints in uncertainty estimation, highlighting how misestimation of uncertainties is influenced by individual experiences and the capacity of working memory (WM) to store relevant information. These insights contribute to understanding the role of WM in decision-making under uncertainty and provide a framework for exploring the dynamics of reinforcement learning in memory-limited systems. Full article

Detection of surface defects can significantly elongate mechanical service time and mitigate potential risks during safety management. Traditional defect detection methods predominantly rely on manual inspection, which suffers from low efficiency and high costs. Some machine learning algorithms and artificial intelligence models for defect detection, such as Convolutional Neural Networks (CNNs), present outstanding performance, but they are often data-dependent and cannot provide guarantees for new test samples. To this end, we construct a detection model by combining Mask R-CNN, selected for its strong baseline performance in pixel-level segmentation, with Conformal Risk Control. The former evaluates the distribution that discriminates defects from all samples based on probability. The detection model is improved by retraining with calibration data that is assumed to be independent and identically distributed (i.i.d) with the test data. The latter constructs a prediction set on which a given guarantee for detection will be obtained. First, we define a loss function for each calibration sample to quantify detection error rates. Subsequently, we derive a statistically rigorous threshold by optimization of error rates and a given guarantee significance as the risk level. With the threshold, defective pixels with high probability in test images are extracted to construct prediction sets. This methodology ensures that the expected error rate on the test set remains strictly bounded by the predefined risk level. Furthermore, our model shows robust and efficient control over the expected test set error rate when calibration-to-test partitioning ratios vary. Full article

The empowerment of women in rural areas implies that they have power and control over their lives and participate in individual and collective decision-making. Empowerment depends on autonomy or the ability to act independently. The lack or weakness of autonomy is due to traditional gender roles in rural communities, which reinforce norms and expectations that restrict women, limiting their empowerment and ability to make informed and effective decisions. This context fosters the creation of unequal power structures and women’s dependence on male figures. This article explores the relationship between autonomy and decision-making capacity in rural women. Through a review using the PRISMA approach, we analysed whether the absence of autonomy limits empowerment and decision-making. A total of 141 records were identified, and after excluding duplicate documents, those with no relation to the population and the purpose of this article, 35 articles with research results were included in this review. The categories addressed were empowerment, autonomy, decision-making and sustainable development, the latter emerging in the reviewed literature. Full article

Existing research has predominantly framed defensive silence as an avoidance response to interpersonal mistreatments. Moving beyond this view, this study theorizes defensive silence as a proactive strategy for managing interpersonal relationships through the lens of sociometer theory. We posit that workplace ostracism will reduce employees’ organization-based self-esteem (OBSE), which in turn increases their subsequent defensive silence to avert further damage to relationships. In addition, we also expect a moderating role of the sense of power in mitigating the negative impact of workplace ostracism on OBSE. Based on the multi-wave, multi-source data of 345 employees and their 82 immediate supervisors, we tested all the hypotheses. Results from multilevel modeling indicated that OBSE mediated the indirect effect of workplace ostracism on defensive silence, and also supported the moderation role of sense of power. Our theoretical model provides a novel perspective that deepens the understanding of defensive silence and suggests implications for managerial practices. Full article

Obesity is a growing global health concern with widespread impacts on physical, psychological, and social well-being. Clinically, it is a major driver of type 2 diabetes (T2D), cardiovascular disease (CVD), non-alcoholic fatty liver disease (NAFLD), and cancer, reducing life expectancy by 5–20 years and imposing a staggering economic burden of USD 2 trillion annually (2.8% of global GDP). Despite its significant health and socioeconomic impact, earlier obesity medications, such as fenfluramine, sibutramine, and orlistat, fell short of expectations due to limited effectiveness, serious side effects including valvular heart disease and gastrointestinal issues, and high rates of treatment discontinuation. The advent of glucagon-like peptide-1 (GLP-1) receptor agonists (e.g., semaglutide, tirzepatide) has revolutionized obesity management. These agents demonstrate unprecedented efficacy, achieving 15–25% mean weight loss in clinical trials, alongside reducing major adverse cardiovascular events by 20% and T2D incidence by 72%. Emerging therapies, including oral GLP-1 agonists and triple-receptor agonists (e.g., retatrutide), promise enhanced tolerability and muscle preservation, potentially bridging the efficacy gap with bariatric surgery. However, challenges persist. High costs, supply shortages, and unequal access pose significant barriers to the widespread implementation of obesity treatment, particularly in low-resource settings. Gastrointestinal side effects and long-term safety concerns require close monitoring, while weight regain after medication discontinuation emphasizes the need for ongoing adherence and lifestyle support. This review highlights the transformative potential of incretin-based therapies while advocating for policy reforms to address cost barriers, equitable access, and preventive strategies. Future research must prioritize long-term cardiovascular outcome trials and mitigate emerging risks, such as sarcopenia and joint degeneration. A multidisciplinary approach combining pharmacotherapy, behavioral interventions, and systemic policy changes is critical to curbing the obesity epidemic and its downstream consequences. Full article

Individual willingness to pay (WTP) for green energy plays a vital role in mitigating climate change. Based on social cognitive theory (SCT), which emphasizes the dynamic interaction among individual cognition, behavior and the environment, this study develops a theoretical model to identify factors influencing green energy WTP. The study is based on 585 valid questionnaire responses from urban areas in China and uses Structural Equation Modeling (SEM) to reveal the linear causal path. Meanwhile, fuzzy-set Qualitative Comparative Analysis (fsQCA) is utilized to identify the combined paths of multiple conditions leading to a high WTP, making up for the limitations of SEM in explaining complex mechanisms. The SEM analysis shows that social trust, social networks, and social norms have a significant positive impact on individual green energy WTP. And this influence is further transmitted through the mediating role of environmental self-efficacy and expectations of environmental outcomes. The FsQCA results identified three combined paths of social capital and environmental cognitive conditions, including the Netong–Norm path, the Netong–efficacy path and the Netong–Outcome path, all of which can achieve a high level of green energy WTP. Among them, the social networks are a core condition in every path and a key element for enhancing the high green energy WTP. This study promotes the expansion of SCT, from emphasizing the linear role of individual cognition to focusing on the configuration interaction between social structure and psychological cognition, provides empirical evidence for formulating differentiated social intervention strategies and environmental education policies, and contributes to sustainable development and the green energy transition. Full article

Background and objectives: Life expectancies have increased globally, including in Romania, leading to an aging population and thus increasing the burden of chronic diseases. Over 80% of individuals over 65 have more than three chronic conditions, with many exceeding ten and often requiring multiple medications and supplements. This widespread polypharmacy raises concerns about drug interactions, side effects, and inappropriate prescribing. This review examines the impact of polypharmacy in older adult patients, focusing on the physiological changes affecting drug metabolism and the potential risks associated with excessive medication use. Special attention is given to proton pump inhibitors (PPIs), a commonly prescribed drug class with significant benefits but also risks when misused. The aging process alters drug absorption and metabolism, necessitating careful prescription evaluation. Methods: We conducted literature research on polypharmacy and PPIs usage in the older adult population and the risk associated with this practice, synthesizing 217 articles within this narrative review. Results: The overuse of medications, including PPIs, may lead to adverse effects and increased health risks. Clinical tools such as the Beers criteria, the STOPP/START Criteria, and the FORTA list offer structured guidance for optimizing pharmacological treatments while minimizing harm. Despite PPIs’ well-documented safety and efficacy, inappropriate long-term use has raised concerns in the medical community. Efforts are being made internationally to regulate their consumption and reduce the associated risks. Conclusions: Physicians across all specialties must assess the risk–benefit balance when prescribing medications to older adult patients. A personalized treatment approach, supported by evidence-based prescribing tools, is essential to ensure safe and effective pharmacotherapy. Addressing inappropriate PPI use is a priority to prevent potential health complications. Full article

The primary objective of any conservation breeding program is to preserve the genetic diversity of populations. This objective is a persistent challenge, especially in small populations which are prone to loss of heterozygosity. In this study, we proposed a novel parent-selection strategy aimed at the long-term maintenance of high levels of genetic diversity. Our approach is based on estimating the Probability of Offspring Heterozygosity (POH)—the likelihood that a mating will produce heterozygous offspring—using SNP genotype data. This strategy was evaluated through computer simulations, where parental pairs with the highest POH values were preferentially selected to produce the next generation. Simulations explored the effects of varying the number of breeding pairs, and the number of unlinked SNP markers. Selection based on POH resulted in observed heterozygosity (H_OBS) consistently exceeding expected heterozygosity (H_EXP), a trend that was sustained for up to 1000 generations. While further evaluation is needed within more complex population genetic frameworks—accounting for linkage disequilibrium, recombination, optimal contribution, and phenotypic selection—our findings highlight the potential of POH as a valuable tool for enhancing genetic diversity in conservation breeding programs. Full article

Public service innovation research often focuses on the private or general public sectors, leaving the distinct challenges government entities face unexplored. An empirical study was carried out to bridge this gap using survey results from the United Arab Emirates (UAE) government entities. This study built on that research by further analyzing the relationships among these challenges through a social network approach, visualizing and analyzing the connections between them by utilizing betweenness centrality and eigenvector centrality as key metrics. Based on this analysis, the challenges were classified into different categories; 8 out of 22 challenges were identified as critical due to their high values in both metrics. Addressing these critical challenges is expected to create a cascading impact, helping to resolve many others. Targeted strategies are proposed, and leveraging open innovation is highlighted as an effective and versatile solution to address and mitigate these challenges. This study is one of the few to adopt a social network analysis perspective to visualize and analyze the relationships among challenges, enabling the identification of critical ones. This research offers novel and valuable insights that could assist decision-makers in UAE government entities and countries with similar contexts with actionable strategies to advance public service innovation. Full article

This study presents a computational analysis of industry-specific advertising message strategies through the theoretical lens of the FCB (Foote, Cone & Belding) grid framework. Leveraging the AiSAC (AI Analysis System for Ad Creation) system developed by the Korea Broadcast Advertising Corporation (KOBACO), we analyzed 27,000 Korean advertisements across five major industries using advanced machine learning techniques. Through Latent Dirichlet Allocation topic modeling with a coherence score of 0.78, we identified five distinct message strategies: emotional appeal, product features, visual techniques, setting and objects, and entertainment and promotion. Our computational analysis revealed that each industry exhibits a unique “message strategy fingerprint” that significantly discriminates between categories, with discriminant analysis achieving 62.7% classification accuracy. Time-series analysis using recurrent neural networks demonstrated a significant evolution in strategy preferences, with emotional appeal increasing by 44.3% over the study period (2015–2024). By mapping these empirical findings onto the FCB grid, the present study validated that industry positioning within the grid’s quadrants aligns with theoretical expectations: high-involvement/think (IT and Telecom), high-involvement/feel (Public Institutions), low-involvement/think (Food and Household Goods), and low-involvement/feel (Services). This study contributes to media science by demonstrating how computational methods can empirically validate the established theoretical frameworks in advertising, providing a data-driven approach to understanding message strategy patterns across industries. Full article

Space-based gravitational wave detectors, such as the Laser Interferometer Space Antenna (LISA) and Taiji, will observe GWs from $O\left({10}^8\right)$ galactic binary systems, allowing a completely unobscured view of the Milky Way structure. While previous studies have established theoretical expectations based on idealized data-analysis methods that use the true catalog of sources, we present an end-to-end analysis pipeline for inferring galactic structure parameters based on the detector output alone. We employ the GBSIEVER algorithm to extract GB signals from LISA Data Challenge data and develop a maximum likelihood approach to estimate a bulge-disk galactic model using the resolved GBs. We introduce a two-tiered selection methodology, combining frequency derivative thresholding and proximity criteria, to address the systematic overestimation of frequency derivatives that compromises distance measurements. We quantify the performance of our pipeline in recovering key Galactic structure parameters and the potential biases introduced by neglecting the errors in estimating the parameters of individual GBs. Our methodology represents a step forward in developing practical techniques that bridge the gap between theoretical possibilities and observational implementation. Full article