Search Results (9,585)

Background: Varicella remains a prevalent vaccine-preventable disease, but breakthrough infections are increasingly reported. However, long-term, population-based studies investigating the temporal and demographic characteristics of breakthrough varicella remain limited. Methods: This retrospective study analyzed surveillance data from Jinhua City, China, from 2016 to 2024. Varicella case records were obtained from the China Information System for Disease Control and Prevention (CISDCP), while vaccination data were retrieved from the Zhejiang Provincial Immunization Program Information System (ISIS). Breakthrough cases were defined as infections occurring more than 42 days after administration of the varicella vaccine. Differences in breakthrough interval were analyzed across subgroups defined by dose, sex, age, population category, and vaccination type. A bivariate cubic regression model was used to assess the combined effect of initial vaccination age and dose interval on the breakthrough interval. Results: Among 28,778 reported varicella cases, 7373 (25.62%) were classified as breakthrough infections, with a significant upward trend over the 9-year period (p < 0.001). Most cases occurred in school-aged children, especially those aged 6–15 years. One-dose recipients consistently showed shorter breakthrough intervals than two-dose recipients (M = 62.10 vs. 120.10 months, p < 0.001). Breakthrough intervals also differed significantly by sex, age group, population category, and vaccination type (p < 0.05). Regression analysis revealed a negative correlation between the initial vaccination age, the dose interval, and the breakthrough interval (R² = 0.964, p < 0.001), with earlier and closely spaced vaccinations associated with longer protection. Conclusions: The present study demonstrates that a two-dose varicella vaccination schedule, when initiated at an earlier age and administered with a shorter interval between doses, provides more robust and longer-lasting protection. These results offer strong support for incorporating varicella vaccination into China’s National Immunization Program to enhance vaccine coverage and reduce the public health burden associated with breakthrough infections. Full article

New psychoactive substances (NPSs) have emerged as a significant global public health challenge due to their ability to mimic traditional drugs. Among these, mephedrone has gained attention because of its widespread use and associated toxicities. This review provides a comprehensive analysis of the structure, pharmacokinetic properties, and metabolic pathways of mephedrone, highlighting its phase I and phase II metabolites as potential biomarkers for detection and forensic applications. A comprehensive literature search was performed without date restrictions. The search employed key terms such as “mephedrone metabolites”, “pharmacokinetics of mephedrone”, “phase I metabolites of mephedrone”, and “phase II metabolites of mephedrone”. Additionally, the reference lists of selected studies were screened to ensure a thorough review of the literature. Mephedrone is a chiral compound existing in two enantiomeric forms, exhibiting different affinities for monoamine transporters and distinct pharmacological profiles. In vivo animal studies indicate rapid absorption, significant tissue distribution, and the formation of multiple phase I metabolites (e.g., normephedrone, dihydromephedrone, 4-carboxymephedrone) that influence its neurochemical effects. Phase II metabolism involves conjugation reactions leading to metabolites such as N-succinyl-normephedrone and N-glutaryl-normephedrone, further complicating its metabolic profile. These findings underscore the importance of elucidating mephedrone’s metabolic pathways to improve detection methods, enhance our understanding of its toxicological risks, and inform future therapeutic strategies. Full article

The use of remote sensing technologies for mapping forest fires has experienced significant growth in recent decades, driven by advancements in remote sensors, processing platforms, and artificial intelligence algorithms. This study presents a review of 192 scientific articles published between 1990 and 2024, selected using PRISMA criteria from the Scopus database. Trends in the use of active and passive sensors, spectral indices, software, and processing platforms as well as machine learning and deep learning approaches are analyzed. Bibliometric analysis reveals a concentration of publications in Northern Hemisphere countries such as the United States, Spain, and China as well as in Brazil in the Southern Hemisphere, with sustained growth since 2015. Additionally, the publishers, journals, and authors with the highest scientific output are identified. The normalized burn ratio (NBR) and the normalized difference vegetation index (NDVI) were the most frequently used indices in fire mapping, while random forest (RF) and convolutional neural networks (CNN) were prominent among the applied algorithms. Finally, the main technological and methodological limitations as well as emerging opportunities to enhance fire detection, monitoring, and prediction in various regions are discussed. This review provides a foundation for future research in remote sensing applied to fire management. Full article

In the current era, Indian agriculture faces a significant demand for increased food production, which has led to the integration of advanced technologies to enhance efficiency and productivity. Drones have emerged as transformative tools for enhancing precision agriculture, reducing costs, and improving sustainability. This study provides a comprehensive review of drone adoption in Indian agriculture by examining its effects on precision farming, crop monitoring, and pesticide application. This research evaluates technological advancements, regulatory frameworks, infrastructure, farmers’ perceptions, and the financial accessibility of drone technology in the Indian agricultural context. Key findings indicate that, while drone adoption enhances efficiency and sustainability, challenges such as high costs, lack of training, and regulatory barriers hinder widespread implementation. This paper also explores the growing market for agricultural drones in India, highlighting key industry players and projected market growth. Furthermore, it addresses regional differences in adoption rates and emphasizes the increasing social acceptance of drones among Indian farmers. To bridge the gap between potential and practice, the study proposes several policy and institutional recommendations, including government-led financial incentives, training programs, and public–private partnerships to facilitate drone integration. Moreover, this review article also highlights technological advancements, such as AI and IoT, in agriculture. Finally, open issues and future research directions for drones are discussed. Full article

Trajectory data contain numerous sensitive attributes. Unauthorized disclosure of precise user trajectory information generates persistent privacy and security concerns that significantly impact daily life. Most existing trajectory privacy protection schemes focus on geographic trajectories while neglecting the critical importance of semantic trajectories, resulting in ongoing privacy vulnerabilities. To address this limitation, we propose the Semantic Behavior Sequence-based Trajectory Privacy Protection method (SBS-TPP). Our approach integrates short-term and long-term behavioral patterns within a user behavior modeling layer to identify user preferences. A dual-model framework (geographic and semantic) generates noise-injected trajectories with maximized noise potential. This methodology applies symmetric noise addition to both geographic trajectory fragments and semantic trajectory segments, optimizing trajectory data utility while ensuring robust protection of sensitive information. The SBS-TPP framework operates in the following two phases: firstly, behavior modeling, which comprises interest extraction from behavioral trajectory sequences, and secondly, noise generation, which creates synthetic noise locations with maximal semantic expectation from original locations, yielding privacy-enhanced trajectories for publication. Experimental results demonstrate that our interest extraction model achieves 93.7% accuracy while maintaining 81.6% data utility under strict privacy guarantees. The proposed method significantly enhances data usability and enables effective recommendation services without compromising user privacy or security. Full article

Economic systems face critical challenges, including widening income inequality, unemployment driven by automation, mounting public debt, and environmental degradation. This study introduces Economocracy as a transformative framework aimed at addressing these systemic issues by integrating democratic principles into economic decision-making to achieve social equity, economic efficiency, and environmental sustainability. The research focuses on two core mechanisms: Economic Productive Resets (EPRs) and Economic Periodic Injections (EPIs). EPRs facilitate proportional redistribution of resources to reduce income disparities, while EPIs target investments to stimulate job creation, mitigate automion-related job displacement, and support sustainable development. The study employs a theoretical and analytical methodology, developing mathematical models to quantify the impact of EPRs and EPIs on key economic indicators, including the Gini coefficient for inequality, unemployment rates, average wages, and job displacement due to automation. Hypothetical scenarios simulate baseline conditions, EPR implementation, and the combined application of EPRs and EPIs. The methodology is threefold: (1) a mathematical–theoretical validation of the Cycle of Money framework, establishing internal consistency; (2) an econometric analysis using global historical data (2000–2023) to evaluate the correlation between GNI per capita, Gini coefficient, and average wages; and (3) scenario simulations and Difference-in-Differences (DiD) estimates to test the systemic impact of implementing EPR/EPI policies on inequality and labor outcomes. The models are further strengthened through tools such as OLS regression, and Impulse results to assess causality and dynamic interactions. Empirical results confirm that EPR/EPI can substantially reduce income inequality and unemployment, while increasing wage levels, findings supported by both the theoretical architecture and data-driven outcomes. Results demonstrate that Economocracy can significantly lower income inequality, reduce unemployment, increase wages, and mitigate automation’s effects on the labor market. These findings highlight Economocracy’s potential as a viable alternative to traditional economic systems, offering a sustainable pathway that harmonizes growth, social justice, and environmental stewardship in the global economy. Economocracy demonstrates potential to reduce debt per capita by increasing the efficiency of public resource allocation and enhancing average income levels. As EPIs stimulate employment and productivity while EPRs moderate inequality, the resulting economic growth expands the tax base and alleviates fiscal pressures. These dynamics lead to lower per capita debt burdens over time. The analysis is situated within the broader discourse of institutional economics to demonstrate that Economocracy is not merely a policy correction but a new economic system akin to democracy in political life. Full article

Background: Thallium is a metal that is ubiquitous in our natural environment. Despite its potential for high toxicity, thallium is understudied and not regulated in food. The California Department of Public Health was alerted to a household cluster of elevated urine thallium levels noted among a mother (peak 5.6 µg/g creatinine; adult reference: ≤0.4 µg/g creatinine) and her three young children (peak 10.5 µg/g creatinine; child reference: ≤0.8 µg/g creatinine). Objectives: This case report identifies questions raised after a public health investigation linked a household’s thallium exposure to a commercially available food product. We provide an overview of the public health investigation. We then explore concerns, such as gaps in toxicological data and limited surveillance of thallium in the food supply, which make management of individual and population exposure risks challenging. Methods: We highlight findings from a cross-agency investigation, including a household exposure survey, sampling of possible environmental and dietary exposures (ICP-MS analysis measured thallium in kale chips at 1.98 mg/kg and 2.15 mg/kg), and monitoring of symptoms and urine thallium levels after the source was removed. We use regulatory and research findings to describe the challenges and opportunities in characterizing the scale of thallium in our food supply and effects of dietary exposures on health. Discussion: Thallium can bioaccumulate in our food system, particularly in brassica vegetables like kale. Thallium concentration in foods can also be affected by manufacturing processes, such as dehydration. We have limited surveillance data nationally regarding this metal in our food supply. Dietary reviews internationally show increased thallium intake in toddlers. Limited information is available about low-dose or chronic exposures, particularly among children, although emerging evidence shows that there might be risks associated at lower levels than previously thought. Improved toxicological studies are needed to guide reference doses and food safety standards. Promising action towards enhanced monitoring of thallium is being pursued by food safety agencies internationally, and research is underway to deepen our understanding of thallium toxicity. Full article

Urban street canyons in high-density areas exacerbate PM_2.5 accumulation, posing significant public health risks. Through integrated empirical and computational methods—including empirical PM_2.5 and microclimate measurements, multivariate regression analysis, and high-resolution ENVI-met5.1 simulations—this study quantifies the threshold effects of pedestrian-oriented morphological indicators on PM_2.5 exposure in east–west-oriented residential streets. Key findings include the following: (1) the height-to-width ratio (H/W) negatively correlates with exposure, where H/W = 2.0 reduces the peak concentrations by 37–41% relative to H/W = 0.5 through enhanced vertical advection; (2) the Build-To-Line ratio (BTR) exhibits a positive correlation with exposure, with BTR = 63.2% mitigating exposure by 12–15% compared to BTR = 76.8% by reducing aerodynamic stagnation; (3) pollution exposure can be mitigated by enhancing airflow ventilation within street canyons through architectural facade design. These evidence-based morphological thresholds (H/W ≥ 1.5, BTR ≤ 70%) provide actionable strategies for reducing health risks in polluted urban corridors, supporting China to meet its national air quality improvement targets. Full article

Tactile pavings (Tenji Blocks) are prone to wear, obstruction, and improper installation, posing significant safety risks for visually impaired pedestrians. This system incorporates a lightweight YOLOv8 (You Only Look Once version 8) model for real-time detection using a fisheye camera to maximize field-of-view coverage, which is highly advantageous for low-altitude UAV navigation in complex urban settings. To enable lightweight deployment, a novel Lightweight Shared Detail Enhanced Oriented Bounding Box (LSDE-OBB) head module is proposed. The design rationale of LSDE-OBB leverages the consistent structural patterns of tactile pavements, enabling parameter sharing within the detection head as an effective optimization strategy without significant accuracy compromise. The feature extraction module is further optimized using StarBlock to reduce computational complexity and model size. Integrated Contextual Anchor Attention (CAA) captures long-range spatial dependencies and refines critical feature representations, achieving an optimal speed–precision balance. The framework demonstrates a 25.13% parameter reduction (2.308 M vs. 3.083 M), 46.29% lower GFLOPs, and achieves 11.97% ${\mathrm{mAP}}_{50:95}$ on tactile paving datasets, enabling real-time edge deployment. Validated through public/custom datasets and actual UAV flights, the system realizes robust tactile paving detection and stable navigation in complex urban environments via hierarchical control algorithms for dynamic trajectory planning and obstacle avoidance, providing an efficient and scalable platform for automated infrastructure inspection. Full article

Continuous progress in the sector of additive manufacturing has drastically aided the design and fabrication of urban furniture, offering high levels of customization and adaptability. This work looks into the potential of 3D printing to transform urban public spaces by allowing for the creation of functional, aesthetically pleasing, and user-centered furniture solutions. Through additive manufacturing processes, urban furniture can be tailored to meet the unique needs of diverse communities, allowing for the extended usage of sustainable materials, modular designs, and smart technologies. The flexibility of 3D printing also promotes the fabrication of complex, intricate designs that would be difficult or cost-prohibitive using traditional methods. Additionally, 3D-printed furniture can be optimized for specific environmental conditions, providing solutions that enhance accessibility, improve comfort, and promote inclusivity. The various advantages of 3D-printed urban furniture are examined, including reduced material waste and the ability to rapidly prototype and iterate designs alongside the potential for on-demand, local production. By embedding sensors and IoT devices, 3D-printed furniture can also contribute to the development of smart cities, providing real-time data for urban management and improving the overall user experience. As cities continue to encourage and adopt sustainable and innovative solutions, 3D printing is believed to play a crucial role in future urban infrastructure planning. Full article

Social media has become a vital communication tool for higher education institutions (HEIs) to reach larger targets, attract followers, and engage with diverse audiences. This study conducted a quantitative and qualitative analysis of 4148 Facebook posts from 16 public and private HEIs in the United Arab Emirates (UAE). The aim of the study is to evaluate users’ engagement through their reactions to various post characteristics, including format, language, and content type. The posts generated 177,022 emotes, 17,269 shares, and 8374 comments. The results showed that images are an efficient format for boosting interaction, whereas plain text posts did not generate high engagement. The English language was more conducive for generating shares, while Arabic-language posts generated more emotes and likes. The comparative analysis results showed that private HEIs are more active on their Facebook pages than public HEIs. The content analysis suggested that student-related posts generate the highest level of engagement, while announcements and faculty- and research-related posts drive the lowest levels of engagement. These results offer valuable insights into how HEIs can optimize their social media strategies to enhance user engagement. Full article

Cybersecurity threats are becoming increasingly sophisticated, frequent, and diverse, posing a major risk to critical infrastructure, public trust, and digital economies. Traditional intrusion detection systems often struggle with detecting novel or rare attack types, particularly when data availability is limited or heterogeneous. The current study tries to address these challenges by proposing a unified, multimodal threat detection framework that leverages the combination of synthetic data generation through Generative Adversarial Networks (GANs), advanced ensemble learning, and transfer learning techniques. The research objective is to enhance detection accuracy and resilience against zero-day, botnet, and image-based malware attacks by integrating multiple data modalities, including structured network logs and malware binaries, within a scalable and flexible pipeline. The proposed system features a dual-branch architecture: one branch uses a CNN with transfer learning for image-based malware classification, and the other employs a soft-voting ensemble classifier for tabular intrusion detection, both trained on augmented datasets generated by GANs. Experimental results demonstrate significant improvements in detection performance and false positive reduction, especially when multimodal outputs are fused using the proposed confidence-weighted strategy. The findings highlight the framework’s adaptability and practical applicability in real-world intrusion detection and response systems. Full article

Salmonella is a major foodborne pathogen, yet real-time data on duck-derived strains in China remain scarce. This study investigated the epidemiology, antimicrobial resistance (AMR), gene profiles, and PFGE patterns of 114 Salmonella isolates recovered from 397 deceased ducks (2021–2024) across nine provinces (isolation rate: 28.72%). Fourteen serotypes were identified, with S. Typhimurium (23.68%), S. Indiana (21.93%), S. Kentucky (18.42%), and S. Enteritidis (12.28%) being predominant. Most isolates showed high resistance to β-lactams, tetracyclines, quinolones, and sulfonamides, with extensive multidrug resistance (MDR) observed—especially in S. Indiana, S. Typhimurium, and S. Kentucky. Among the 23 detected resistance genes, tet(B) had the highest prevalence (75.44%), particularly in S. Indiana. Biofilm formation was observed in 99.12% of isolates, with 84.21% demonstrating moderate to strong capacity. Eighteen virulence genes were detected; S. Enteritidis carried more spvB/C, sipB, and sodC1, while S. Indiana had higher cdtB carriage. PFGE revealed substantial genetic diversity among strains. This comprehensive analysis highlights the high AMR and biofilm potential of duck-derived Salmonella in China, emphasizing the urgent need for enhanced surveillance and control measures to mitigate public health risks. Full article

The increasing frequency and intensity of wildfires pose serious threats to ecosystems, property, and human safety worldwide. Accurate semantic segmentation of wildfire images is essential for real-time fire monitoring, spread prediction, and disaster response. However, existing deep learning methods heavily rely on large volumes of pixel-level annotated data, which are difficult and costly to obtain in real-world wildfire scenarios due to complex environments and urgent time constraints. To address this challenge, we propose a semi-supervised wildfire image segmentation framework that enhances segmentation performance under limited annotation conditions by integrating multi-scale structural information fusion and pixel-level contrastive consistency learning. Specifically, a Lagrange Interpolation Module (LIM) is designed to construct structured interpolation representations between multi-scale feature maps during the decoding stage, enabling effective fusion of spatial details and semantic information, and improving the model’s ability to capture flame boundaries and complex textures. Meanwhile, a Pixel Contrast Consistency (PCC) mechanism is introduced to establish pixel-level semantic constraints between CutMix and Flip augmented views, guiding the model to learn consistent intra-class and discriminative inter-class feature representations, thereby reducing the reliance on large labeled datasets. Extensive experiments on two public wildfire image datasets, Flame and D-Fire, demonstrate that our method consistently outperforms other approaches under various annotation ratios. For example, with only half of the labeled data, our model achieves 5.0% and 6.4% mIoU improvements on the Flame and D-Fire datasets, respectively, compared to the baseline. This work provides technical support for efficient wildfire perception and response in practical applications. Full article

Rapid data growth in large systems has introduced significant challenges in real-time monitoring and analysis. One of these challenges is detecting anomalies in time series data with high-dimensional inputs that contain complex inter-correlations between them. In addition, the lack of labeled data leads to the use of unsupervised learning that relies on daily system data to train models, which can contain noise that affects feature extraction. To address these challenges, we propose PCA-AAE, a novel anomaly detection model for time series data using an Adversarial Autoencoder integrated with Principal Component Analysis (PCA). PCA contributes to analyzing the latent space by transforming it into uncorrelated components to extract important features and reduce noise within the latent space. We tested the integration of PCA into the model’s phases and studied its efficiency in each phase. The tests show that the best practice is to apply PCA to the latent code during the adversarial training phase of the AAE model. We used two public datasets, the SWaT and SMAP datasets, to compare our model with state-of-the-art models. The results indicate that our model achieves an average F1 score of 0.90, which is competitive with state-of-the-art models, and an average of 58.5% faster detection speed compared to similar state-of-the-art models. This makes PCA-AAE a candidate solution to enhance real-time anomaly detection in high-dimensional datasets. Full article