Search Results (3,218)

Lower-limb strength is a health and performance indicator in adolescents, although its assessment often fails to account for the influence of sex and biological development. This study aimed to analyze the associations between anthropometric parameters, maturational status, and physical activity levels with jumping performance in adolescents. A cross-sectional study was conducted with male and female adolescents (mean age: 13.60 ± 1.50 years). Anthropometric variables, maturational status, and physical activity levels were assessed. Performance was measured using the Countermovement Jump (CMJ) and Standing Broad Jump (SBJ). In males, jumping performance was significantly associated with height (p = 0.002), lower-limb length (p < 0.001), and muscle mass (p < 0.001). However, fat mass emerged as a substantial factor, exhibiting a large effect size on performance (p < 0.001). Maturational status in males showed significant differences, with late maturers performing lower than on-time and early maturers (p < 0.023). In females, structural anthropometry and maturation showed limited-to-no significant associations with performance, except for a negative association with fat mass (p < 0.035) and a positive association between muscle mass and CMJ (p < 0.020). Active adolescents of both sexes performed significantly better than inactive ones in both CMJ and SBJ (p < 0.011). In conclusion, jumping performance in adolescents is characterized by marked sexual dimorphism. In males, greater height, lower-limb length, lower fat mass, and early maturation are positively associated with superior performance. Conversely, in females, these factors exhibit limited influence on jump outcomes. Full article

To achieve the large-scale, high-value utilization of vanadium–titanium slag (VTS) in the metallurgical industry, this study replaces blast furnace slag (BFS) with VTS to construct a quaternary all-solid-waste cementitious system composed of VTS, BFS, steel slag (SS), and desulfurization gypsum (DG). It systematically investigates the effects of VTS content (0–60%) on the mechanical properties, leaching toxicity, and hydration heat behavior of the system. XRD, TG–DSC, and SEM–EDS techniques are employed to explore the influence of VTS on hydration behavior and microstructural evolution. The results show that when VTS replaces 30% of the BFS (A3, VTS:BFS:SS:DG = 3:3:3:1), the 28-day compressive strength reaches 31.33 MPa. The leaching concentrations of heavy metals in all specimens are far below the standards for drinking water quality. Hydration heat analysis reveals that the incorporation of VTS advances the acceleration period of hydration. The A3 specimen maintains a relatively high heat release rate in the middle and later stages (after 72 h), and its cumulative heat release is significantly higher than that of the system without VTS, revealing the “slow hydration” mechanism of VTS at later stages. The [SiO₄]–[AlO₄] bonds in VTS undergo a depolymerization–repolymerization process. In addition, an appropriate amount of VTS promotes the deposition of hydration products such as ettringite (AFt), C–S–H, and C–A–S–H gels through micro-filling effects and heterogeneous nucleation, thereby improving the microstructure of the system. However, excessive VTS (≥45%) significantly inhibits the hydration reaction and reduces gel formation due to the decrease in highly reactive BFS components and the increased TiO₂ content. This study provides new insights into the resource utilization of VTS in multi-solid-waste cementitious materials. In addition, VTS-based cementitious materials are suitable for practical scenarios with low early strength requirements, such as goaf backfilling. Therefore, future studies should further investigate the long-term sulfate resistance and carbonation resistance of these materials under real application conditions. Full article

Opioid analgesics are essential in the management of severe and chronic pain; however, their prolonged use is limited by the onset of analgesic tolerance and opioid-induced hyperalgesia (OIH). Recent studies increasingly implicate both synaptic functional and structural plasticity within nociceptive pathways as crucial mechanisms in OIH and tolerance. This review integrates current mechanistic understanding of how opioids alter synaptic transmission throughout the dorsal root ganglia (DRG), spinal dorsal horn, and supraspinal nociceptive networks. Peripherally, μ-opioid receptor (MOR) activation on TRPV1-positive nociceptors initiates presynaptic long-term potentiation (LTP), forming an early substrate for central sensitization. In the spinal dorsal horn, chronic opioid exposure drives NMDAR-dependent LTP, TRPC-mediated calcium influx, and actin cytoskeleton remodeling, leading to persistent increases in synaptic strength and excitatory connectivity. In supraspinal regions—including the ventral hippocampus, prefrontal cortex, and amygdala—opioids promote experience-dependent plasticity and predictive coding, which link environmental cues to reduced analgesic effectiveness. In addition to synaptic functional plasticity, opioid-induced synaptic structural plasticity within nociceptive pathways has been shown to underlie the long-term nature of opioid analgesic tolerance. Collectively, these data define a distributed network of opioid-responsive synapses whose pathological potentiation underpins the development of tolerance and hyperalgesia. Elucidating these mechanisms underlying OIH and tolerance paves the way for targeted therapeutic strategies that maintain analgesic efficacy while minimizing adverse synaptic remodeling and negative outcomes. Full article

Postsecondary institutions are seeing an increased prevalence of student mental health concerns and disabilities, highlighting the need for campus-based approaches that support student well-being. While college campuses provide many services to support students, occupational therapists are largely absent from these support systems, despite growing interest in this emerging field of practice. This program description and implementation case study examines preliminary indicators of feasibility for the WILL Thrive program, which delivered occupational therapy (OT) services on a college campus through a Level II fieldwork placement. Feasibility was examined across domains of acceptability, demand and implementation using an integrated approach combining a needs assessment, service development and process evaluation. Data sources included environmental observations, surveys, stakeholder interviews and process evaluation measures, including service delivery tracking, referral patterns, and resource utilization. Referrals and service utilization in this case were most frequently observed among students reporting neurodevelopmental and mental health-related functional challenges, providing preliminary indicators of potential service users, though a small, heterogeneous sample size limits generalizability. Referral patterns and engagement from the wellness center and accessibility staff highlight preliminary strengths of the program, including early indicators of acceptability and demand. In contrast, implementation barriers were also identified, including limited campus-wide understanding of the OT scope and role and constraints in on-campus OT supervision. Findings offer early, exploratory signals of feasibility for integrating OT services through an OT fieldwork II model and suggest that OT may complement existing campus supports by addressing participation-focused, functionally orientated needs. Results should be viewed as preliminary and inform future implementation studies that include systematic outcome measures, comparative analysis with existing services, and broader assessment across diverse higher education contexts. Full article

Background: A novel titanium scleral buckle implant (TSBI) was developed for the treatment of posterior pole retinal detachments, analytically modeled and structurally tested as part of preclinical approval studies. The strength and stiffness requirements to apply pressure for retinal reattachment also suggested potential benefits for correcting high myopia greater than 8 diopters. Methods: Laboratory load testing and analytical calculations were complemented by nonlinear finite element modeling (FEM), applied for the first time to capture the interaction between the highly deformed myopic eye and the TSBI. Simulations were used to visualize posterior pole indentation and force distribution across anatomical regions. Seven TSBI units were tested in the transverse direction and six in the longitudinal direction. Results: The simulations confirmed that stable indentation is maintained even in areas distant from the sutures. The TSBI’s minimum midspan bending capacity was 40 N at yield and 60 N at ultimate. These values, together with FEM predictions, demonstrated a very large safety margin and showed that the implant deforms insignificantly under high intraocular pressure changes. Conclusions: The TSBI withstands ocular forces, cushions the sclera safely, and retains its geometry, a behavior that may differ from softer buckle materials, which can exhibit time-dependent deformation under sustained loading. Early controlled clinical applications outside the USA, followed for over three years, further validate its safety and potential effectiveness. Full article

Background: Androgen deprivation therapy (ADT) is widely used in the management of prostate cancer (PCa) and remains a cornerstone of treatment across multiple disease settings. Although ADT contributes substantially to disease control, it also induces significant adverse metabolic and body composition changes. These alterations include loss of lean mass, increased fat mass, and deterioration in muscle quality, together contributing to a clinical phenotype consistent with sarcopenic obesity (SO). Importantly, ADT-induced SO is characterized not only by reductions in skeletal muscle mass but also by impaired muscle quality, particularly the fatty infiltration of skeletal muscle, or myosteatosis, an underrecognized but defining feature of this syndrome. Methods: This narrative review examines current evidence regarding interventions aimed at mitigating sarcopenic obesity in men treated with ADT for prostate cancer, identifies key gaps in the literature, and proposes a mechanism-driven path forward for intervention development. Results: Several exercise- and nutrition-based interventions have been evaluated in men receiving ADT and demonstrate improvements in selected outcomes such as muscle strength, body composition, and metabolic parameters. However, most studies have been limited by small sample sizes, short intervention durations, and a focus on isolated intervention components. Importantly, muscle quality and intramuscular fat infiltration (myosteatosis), a central component of sarcopenic obesity, have rarely been incorporated as biomarkers or endpoints in intervention trials targeting men receiving ADT. Conclusions: Future interventions designed to mitigate SO and its associated metabolic abnormalities should evaluate comprehensive, bundled strategies initiated early during ADT and sustained long enough to capture clinically meaningful changes. Outcomes should include biomarkers of muscle mass, strength, and quality, including imaging-based measures of myosteatosis, along with metabolic syndrome markers, inflammatory mediators, functional outcomes, adherence, and quality of life. These changes should evaluate the correlation with underlying biological mechanisms such as NF-κB signaling and pro-inflammatory cytokines. Such data may inform future phase III trials and ultimately support clinical strategies to mitigate ADT-related sarcopenic obesity and its downstream cardiometabolic and oncologic consequences. Full article

The accumulation of highly alkaline red mud poses serious environmental risks due to land occupation and potential soil/groundwater contamination. Recycling red mud as a secondary resource offers an eco-friendly solution, yet its influence on the performance of high-performance mortar (HPM) remains incompletely understood, particularly in aggressive environments. This study aims to systematically evaluate the effects of red mud on the fresh and hardened properties of HPM, including rheological parameters, setting time, mechanical strength, drying shrinkage, and sulfate dry–wet erosion resistance. The novelty lies in (1) quantifying the nonlinear relationships between red mud content and rheological/setting behaviors, (2) revealing the dual effect of red mud with curing age, and (3) using XRD/SEM-EDS to elucidate the micro-mechanisms related to hydration products and elemental changes (Al and Fe). The results show that increasing red mud content reduces slump flow (max 76.03%), plastic viscosity (46.7%), and yield stress (42.3%) while also shortening initial/final setting times (67.91% and 76.18% max reductions). At curing ages below 7 days, flexural and compressive strength increase (up to 64.53% and 33.35%, respectively), following cubic functions; however, at 7 and 28 days, both strength values decrease (max reductions of 13.43% and 12.98%). Red mud increases drying shrinkage and delays sulfate-induced degradation. Microstructural analysis reveals improved compactness of hydration products at early ages but reduced compactness at later ages, accompanied by increased Al/Fe content and enhanced SiO₂/calcium silicate hydrate crystals. These findings provide valuable insights for applying red mud HPM in marine environments. Full article

Natural pumice can reduce the self-weight of concrete, but its high porosity, high water absorption, and weak interfacial bonding tend to limit the strength and durability of lightweight aggregate concrete. To address this issue, this study proposes a method for preparing and applying reinforced pumice lightweight aggregates, namely, using nano-SiO₂-modified fly ash to construct a nanocomposite material at the micro-interface for the reinforcement treatment of natural pumice aggregates, and reveals the mechanism by which this treatment enhances the performance of lightweight aggregate concrete. Through aggregate performance tests, compressive strength tests, XRD, SEM, and freeze–thaw cycle tests, the effects of the reinforced pumice aggregate on the performance of lightweight concrete were systematically investigated. The results show that after the reinforcement treatment, the water absorption of the pumice aggregate decreases by 17.6%, and the cylinder compressive strength increases by 34.3%. As the replacement ratio of reinforced pumice increases, both the early-age and later-age compressive strengths of the concrete continuously improve. When all the pumice aggregate is reinforced, the 3 d and 28 d compressive strengths increase by 35.1% and 33.44%, respectively. Meanwhile, the reinforced pumice effectively improves the interfacial bonding between the aggregate and the cement paste, reducing the width of the interfacial transition zone by 32%, enhancing the matrix compactness, and delaying crack propagation. The study demonstrates that the reinforced pumice aggregate possesses favorable characteristics, not only effectively improving the mechanical properties and freeze–thaw resistance of lightweight concrete but also providing a new technical pathway for the high-performance utilization of porous lightweight aggregates, offering a reference for the resource utilization of industrial solid waste and engineering applications in cold regions. Full article

The literature identifies concrete and steel as the primary contributors to embodied carbon in building structures and highlights a strong relationship between sustainability and structural system geometry. However, existing studies predominantly focus on one-way systems and flat slabs, while research on two-way joist slabs remains limited and often centred on strength optimisation. In particular, there is a lack of systematic life cycle comparisons of alternative beam configurations within this system. This gap is critical, as early-stage design decisions largely determine the environmental impact of structural systems. This study presents a comprehensive, span-dependent evaluation of four beam configurations, namely Without Beam, Internal Beam, Perimeter Beam, and Full Beam, for reinforced concrete two-way joist slabs used in office buildings. A parametric framework was developed using Eurocode-compliant structural design and nonlinear finite element modelling to assess 36 span combinations ranging from 4 × 4 m to 14 × 14 m. Material quantities were extracted from the final designs and converted into embodied carbon values using cradle-to-gate (A1–A3) emission factors derived from the ICE database. The results demonstrate that beam configuration has a significant influence on embodied carbon and construction cost. For spans below approximately 8 m, beamless systems provide the most material-efficient solution. For spans exceeding approximately 10 m, full-beam configurations offer improved structural efficiency and reduced embodied carbon due to enhanced stiffness and load distribution. Full article

Background: Immediate loading of dental implants shortens treatment time and improves early function, but it also exposes the healing peri-implant tissue to a critical mechanical environment. This study compared the biomechanical and mechanobiological response of a conventional threaded implant and a porous scaffold-based implant under immediate and delayed loading conditions. Methods: A three-dimensional finite element model of a bone block with a 0.2 mm peri-implant callus was developed in ABAQUS/Standard. Model A was a threaded Ti-6Al-4V implant, while Model B was a porous implant with 64.26% porosity. Bone tissues were modeled as poroelastic materials. Immediate and delayed loading were simulated through frictional and tied bone-implant interfaces, respectively. Mechanobiological predictions were performed using the Prendergast-Huiskes stimulus. Results: Under immediate loading, the porous implant reduced cortical bone stress (32.5 MPa vs. 88 MPa) and markedly increased callus stimulation (20.5–31.6 MPa vs. about 2.5 MPa) compared with the threaded implant. Mechanobiological analysis showed that Model B promoted higher fractions of immature and mature bone and lower fractions of cartilage and fibrous tissue. In all cases, implant stresses remained below the yield strength of the corresponding materials. Conclusions: The porous implant provided a more favorable mechanical environment for early peri-implant healing, particularly under immediate loading, and may be a promising strategy to enhance callus maturation and reduce stress shielding. Full article

Snow density plays a crucial role in water resource estimation, runoff forecasting, and early warning of natural disasters such as avalanches and blizzards. This study uses optical satellite multispectral reflectance data to retrieve snow density, providing a novel perspective for snow density retrieval research. Supported by auxiliary data including CanSWE in situ measurements, Sentinel-2 satellite data, and ERA5-Land reanalysis data, this study constructs a hybrid model (Snow_ACMix) that integrates the strengths of the multi-head attention mechanism and convolutional neural networks, realizing direct snow density retrieval from multispectral satellite reflectance data for the first time. This research was primarily conducted in Canada and Alaska. For the Canadian region, the model achieves a mean absolute error (MAE) of 0.034 g/cm³, a root mean square error (RMSE) of 0.051 g/cm³, and a coefficient of determination (R²) of 0.547. For the Alaska region, the model yields an MAE of 0.020 g/cm³, an RMSE of 0.029 g/cm³, and an R² of 0.803. Feature and module ablation experiments are carried out, and one-shot transfer learning is adopted to perform snow density retrieval in the Alaska region. The spatial transfer prediction results show an MAE of 0.027 g/cm³, an RMSE of 0.038 g/cm³, and an R² of 0.747, which verify the model’s excellent spatial generalization ability and superior performance in data-scarce regions. The advantages and limitations of the Snow_ACMix model are investigated through comparative validation across different land cover types, regions, time periods, and against ERA5 data. The Snow_ACMix model achieves favorable retrieval performance in mountainous areas, and its practical application capability is verified by snow density retrieval in the Silver Star Mountain region. However, the model still has limitations: it is vulnerable to the effects of wet snow, resulting in large fluctuations in retrieval results in wet snow regions. Full article

Background/Objectives: Acute pancreatitis (AP) lacks disease-modifying pharmacotherapy. Neuroimmune, serotonergic, and redox-regulated pathways may modulate inflammatory amplification and acinar injury, although pharmacovigilance data link some psychotropic drug classes to AP risk. This review synthesized controlled rodent studies evaluating neuromodulatory interventions with serotonergic, stress-axis, or ferroptosis-linked targets in experimental AP. Methods: PubMed, Scopus, eLIBRARY.ru, and Elicit were searched in January 2026, supplemented by Google Scholar audit and citation chasing. Eligible studies were controlled in vivo rodent experiments using validated AP models with quantitative outcomes. Intervention timing was classified a priori as a primary analytic variable. Risk of bias was assessed with SYRCLE. A prespecified audit showed that no subset met the criteria for quantitative pooling because of heterogeneity in model class, compounds, timing, outcome definitions, units, and sampling timepoints. Mechanism-stratified qualitative synthesis was therefore performed. The protocol was registered on OSF (doi: 10.17605/OSF.IO/CZXDJ). Results: Nine studies (1992–2023) yielded 410 outcome rows across three mechanistic strands. Serotonergic modulation (5-HT₂/5-HT₂A-focused; six studies) reduced serum amylase/lipase (−37% to −65% vs. disease controls) and histological injury, with receptor-selectivity data supporting 5-HT₂A-mediated mechanisms. Stress-axis modulation with thiadiazine L-17 reduced 7-day mortality in two severe models (from 50–70% to 30%). Olanzapine attenuated ferroptosis-linked injury via off-target antioxidant activity independent of serotonergic receptors. All interventions were prophylactic, peri-induction, or very early post-induction; no delayed therapeutic-window studies were identified. Most SYRCLE domains were unclear, particularly allocation concealment and blinding-related procedures. Conclusions: Neuromodulatory pathways modulate experimental AP in rodents, but evidentiary strength differs across mechanistic strands. Inference is constrained by absent therapeutic-window testing, heterogeneous endpoints, and reporting deficits. The findings support mechanism-level target prioritization rather than clinical repurposing. Full article

The central role of YB-1 in messenger ribonucleoprotein particle (mRNP) metabolism and stress-granule biology highlights the importance of defining the determinants of its self-assembly. YB-1 fibrillogenesis has been attributed primarily to the cold shock domain (CSD). Here, we show that the YB-1 fragment spanning residues 1–129 (AP–CSD) form amyloid fibrils under near-physiological ionic strength (0.12–0.15 M KCl). Fibrillization proceeds without a pronounced exponential growth phase and increases approximately linearly over 45–50 h. Far-UV circular dichroism (CD) and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) indicate no substantial change in overall secondary-structure content during aggregation. In parallel, ¹H nuclear magnetic resonance (NMR) spectroscopy reveals the depletion of soluble species, and oriented fiber X-ray diffraction displays the hallmark cross-β reflections at approximately 4.7 Å and 10 Å. The prolonged formation time implies an activation barrier that is unlikely to require global refolding. Instead, it may reflect early association events such as dimerization or other local rearrangements required for primary nucleation, followed by consolidation into stable intermolecular contacts. Aggregation that preserves a largely native-like fold while establishing cross-β order may reduce recognition by cellular quality-control systems that preferentially target globally unfolded or strongly destabilized states. This provides a plausible framework for how YB-1 derived assemblies could persist under stress and during age-associated proteostasis decline. Full article

Comparing cold-recycled asphalt mixtures (CRAMs) to conventional hot-mix asphalt (HMA) shows that CRAMs offer several logistical, financial, and environmental advantages. However, such CRAMs, when using asphalt emulsion, still suffer from excessive water damage and poor early-age performance. The main aim of this study is to improve CRAMs by incorporating two biomass ashes and reclaimed asphalt pavement (RAP): palm leaf ash (PLA) and reed ash (RA) with different percentages of RAP. RAP was used in five percentage levels, 0%, 25%, 50%, 75%, and 100% by weight of mix, to develop the CRAMs. In addition, the improvement in CMA mechanical properties was assessed by incorporating PLA as filler replacement in five percentages, namely: 0%, 1.75%, 3.5%, 5.25%, and 7% by weight of aggregate. RA was used as an activator at 0.25%, 0.5, 1%, and 2% by weight of aggregate. The moisture susceptibility test, Indirect Tensile Strength Test (ITS), and Marshall test were used to assess the mechanical properties. The results obtained showed that the durability and mechanical properties of CMA are effectively enhanced with the addition of 1.5% PLA, 0.45% RA, and 5.5% Ordinary Portland Cement (OPC) as fillers. In addition, CRAMs with a higher percentage of RAP 75%, showed higher strength in terms of Marshall stability. These findings demonstrate that the studied CRAMs offer a reliable alternative for pavement applications, namely when sustainable and cost-effective materials are required. Full article

Employing eco-friendly and low-carbon methods to restore petroleum-polluted soil is a growing trend. However, the low-carbon remediation theories and methods for petroleum-polluted soil are still in their early stages. Herein, the carbon footprint and environmental impacts of different petroleum-polluted soil remediation methods were studied based on life cycle assessment (LCA). It was found that the carbon footprint and environmental impacts of the solidification/stabilization (S/S) method were much lower than those of pyrolysis and chemical oxidation methods. Moreover, compared with other S/S materials, the carbon footprint of lime–fly ash solidification for petroleum-polluted soil was the lowest, at only 12.72 kg CO₂ eq. Moreover, its unconfined compressive strength (UCS) increased by 700% compared to the untreated petroleum-polluted soil. On this basis, the response surface method was further employed to optimize remediation parameters using carbon footprint and UCS growth rate as response variables. The results showed that the optimal parameters for solidifying petroleum-polluted soil were lime content of 10.41%, fly ash content of 21.89%, and a curing time of 27 days. This study provides the important theoretical basis and practical guidance for the low-carbon and efficient remediation of petroleum-polluted soil. Full article