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  • Article
  • Open Access
24 Citations
3,564 Views
10 Pages

Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination

  • Alfonso Reginelli,
  • Roberta Grassi,
  • Beatrice Feragalli,
  • Maria Paola Belfiore,
  • Alessandro Montanelli,
  • Gianluigi Patelli,
  • Michelearcangelo La Porta,
  • Fabrizio Urraro,
  • Roberta Fusco and
  • Salvatore Cappabianca
  • + 6 authors

25 January 2021

To assess the performance of the second reading of chest compute tomography (CT) examinations by expert radiologists in patients with discordance between the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test for COV...

  • Article
  • Open Access
9 Citations
6,597 Views
17 Pages

An Area-Efficient up/down Double-Sampling Circuit for a LOFIC CMOS Image Sensor

  • Ai Otani,
  • Hiroaki Ogawa,
  • Ken Miyauchi,
  • Sangman Han,
  • Hideki Owada,
  • Isao Takayanagi and
  • Shunsuke Okura

4 May 2023

A lateral overflow integration capacitor (LOFIC) complementary metal oxide semiconductor (CMOS) image sensor can realize high-dynamic-range (HDR) imaging with combination of a low-conversion-gain (LCG) signal for large maximum signal electrons and a...

  • Article
  • Open Access
295 Views
14 Pages

A Low-Noise and High-Integration Readout IC with Pixel-Level Single-Ended CDS for Short-Wave Infrared Focal Plane Arrays

  • Hongyi Wang,
  • Songlei Huang,
  • Zhenghua Peng,
  • Song Jing,
  • Runze Xia,
  • Yu Chen,
  • Panjie Dai and
  • Jiaxiong Fang

28 January 2026

Improving sensitivity in short-wave infrared (SWIR) detection is crucial for low-signal applications, such as astronomy and hyperspectral imaging, which demand readout integrated circuits (ROICs) with minimal noise and high density. However, conventi...

  • Article
  • Open Access
4 Citations
3,131 Views
13 Pages

First Evidence of Function for Schistosoma japonicumriok-1 and RIOK-1

  • Mudassar N. Mughal,
  • Qing Ye,
  • Lu Zhao,
  • Christoph G. Grevelding,
  • Ying Li,
  • Wenda Di,
  • Xin He,
  • Xuesong Li,
  • Robin B. Gasser and
  • Min Hu

Protein kinases are known as key molecules that regulate many biological processes in animals. The right open reading frame protein kinase (riok) genes are known to be essential regulators in model organisms such as the free-living nematode Caenorhab...

  • Article
  • Open Access
7 Citations
2,769 Views
14 Pages

Potential of a Non-Contrast-Enhanced Abbreviated MRI Screening Protocol (NC-AMRI) in High-Risk Patients under Surveillance for HCC

  • François Willemssen,
  • Quido de Lussanet de la Sablonière,
  • Daniel Bos,
  • Jan IJzermans,
  • Robert De Man and
  • Roy Dwarkasing

17 August 2022

Purpose: To evaluate NC-AMRI for the detection of HCC in high-risk patients. Methods: Patients who underwent yearly contrast-enhanced MRI (i.e., full MRI protocol) of the liver were included retrospectively. For all patients, the sequences that const...

  • Article
  • Open Access
8 Citations
3,313 Views
9 Pages

Linked-Read Whole Genome Sequencing Solves a Double DMD Gene Rearrangement

  • Maria Elena Onore,
  • Annalaura Torella,
  • Francesco Musacchia,
  • Paola D’Ambrosio,
  • Mariateresa Zanobio,
  • Francesca Del Vecchio Blanco,
  • Giulio Piluso and
  • Vincenzo Nigro

21 January 2021

Next generation sequencing (NGS) has changed our approach to diagnosis of genetic disorders. Nowadays, the most comprehensive application of NGS is whole genome sequencing (WGS) that is able to detect virtually all DNA variations. However, even after...

  • Article
  • Open Access
592 Views
17 Pages

AI-Assisted Double-Headed Capsule Endoscopy: Multicentre Prospective Diagnostic Accuracy Study Across Small Bowel Indications

  • Kamran Mushtaq,
  • Yun Jeong Lim,
  • Cristiano Spada,
  • Alessandro Mussetto,
  • Anastasios Koulaouzidis,
  • Thake Kaung,
  • Dean-Martin Borrow,
  • Cesare Casadei,
  • Praful Patel and
  • Imdadur Rahman

Background/Aims: Double-headed capsule endoscopy enhances visualization and diagnostic yield in small bowel evaluation but increases reading time. This study aimed to assess the diagnostic performance of AI-assisted double-headed capsule endoscopy (M...

  • Article
  • Open Access
10 Citations
4,879 Views
12 Pages

Blinded Independent Central Review (BICR) in New Therapeutic Lung Cancer Trials

  • Hubert Beaumont,
  • Antoine Iannessi,
  • Yi Wang,
  • Charles M. Voyton,
  • Jennifer Cillario and
  • Yan Liu

9 September 2021

Background: Double reads in blinded independent central reviews (BICRs) are recommended to control the quality of trials but they are prone to discordances. We analyzed inter-reader discordances in a pool of lung cancer trials using RECIST 1.1. Metho...

  • Article
  • Open Access
354 Views
20 Pages

4 March 2026

Background/Objectives: This study assesses the cost-effectiveness of integrating artificial intelligence (AI) into breast cancer screening programs in Singapore. It evaluates AI as a standalone reader and as a companion reader alongside a consultant...

  • Proceeding Paper
  • Open Access
2,876 Views
13 Pages

The research explores some peculiar aspects of the study of the Abruzzo cartography from the middle of the sixteenth century up to the nineteenth century. In particular, it is analyzed the geographical language on one hand, and the illustrative appar...

  • Article
  • Open Access
80 Citations
13,072 Views
18 Pages

The Apis mellifera Filamentous Virus Genome

  • Laurent Gauthier,
  • Scott Cornman,
  • Ulrike Hartmann,
  • François Cousserans,
  • Jay D. Evans,
  • Joachim R. De Miranda and
  • Peter Neumann

9 July 2015

A complete reference genome of the Apis mellifera Filamentous virus (AmFV) was determined using Illumina Hiseq sequencing. The AmFV genome is a double stranded DNA molecule of approximately 498,500 nucleotides with a GC content of 50.8%. It encompass...

  • Comment
  • Open Access
1 Citations
2,595 Views
2 Pages

22 February 2023

I read with interest the paper by Sung et al. entitled “Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial” where a reduction in body fat mass after Bifidobacterium breve...

  • Review
  • Open Access
3 Citations
3,166 Views
20 Pages

Single CT Appointment for Double Lung and Colorectal Cancer Screening: Is the Time Ripe?

  • Mario Mascalchi,
  • Giulia Picozzi,
  • Donella Puliti,
  • Giuseppe Gorini,
  • Paola Mantellini and
  • Lapo Sali

27 September 2022

Annual screening of lung cancer (LC) with chest low-dose computed tomography (CT) and screening of colorectal cancer (CRC) with CT colonography every 5 years are recommended by the United States Prevention Service Task Force. We review epidemiologica...

  • Article
  • Open Access
21 Citations
4,661 Views
15 Pages

Calibration, Compensation and Accuracy Analysis of Circular Grating Used in Single Gimbal Control Moment Gyroscope

  • Yue Yu,
  • Lu Dai,
  • Mao-Sheng Chen,
  • Ling-Bo Kong,
  • Chao-Qun Wang and
  • Zhi-Peng Xue

6 March 2020

The accuracy of the circular grating is the key point for control precision of the single gimbal control moment gyroscope servo system used in civilian micro-agile satellites. Instead of using the multi reading heads to eliminate eccentricity errors,...

  • Article
  • Open Access
9 Citations
6,153 Views
10 Pages

With technology scaling, achieving a target read yield of resistive nonvolatile memories becomes more difficult due to increased process variation and decreased supply voltage. Recently, an offset-canceling dual-stage sensing circuit (OCDS-SC) has be...

  • Article
  • Open Access
1 Citations
2,889 Views
24 Pages

21 June 2024

Affect theory, non-representational theory, and assemblage theory have been among the most impactful developments in the theoretical humanities in the wake of, and in reaction to, poststructuralism. These interlocking bodies of theory and critical pr...

  • Article
  • Open Access
1,469 Views
16 Pages

In advanced integrated circuit manufacturing, the quality of chemical mechanical polishing (CMP) is a key factor affecting chip performance and yield. Designers need to use CMP simulation tools to locate and analyze the defects in the layout after th...

  • Article
  • Open Access
8 Citations
3,488 Views
12 Pages

Comparing Prognostic Factors of Cancers Identified by Artificial Intelligence (AI) and Human Readers in Breast Cancer Screening

  • Cary J. G. Oberije,
  • Nisha Sharma,
  • Jonathan J. James,
  • Annie Y. Ng,
  • Jonathan Nash and
  • Peter D. Kecskemethy

6 June 2023

Invasiveness status, histological grade, lymph node stage, and tumour size are important prognostic factors for breast cancer survival. This evaluation aims to compare these features for cancers detected by AI and human readers using digital mammogra...

  • Article
  • Open Access
45 Citations
7,299 Views
14 Pages

8 July 2019

In this study, a novel strain gauge arrangement and error reduction techniques were proposed to minimize crosstalk reading and simultaneously increase sensitivity on a decoupled six-axis force–moment (F/M) sensor. The calibration process that c...

  • Article
  • Open Access
8 Citations
5,817 Views
22 Pages

25 January 2024

Children with developmental dyslexia (DD) often struggle with executive function difficulties which can continue into adulthood if not addressed. This double-blinded randomized clinical trial study evaluated the short-term effects of the Verbal Worki...

  • Article
  • Open Access
5 Citations
2,662 Views
12 Pages

Mammographic Breast Density Model Using Semi-Supervised Learning Reduces Inter-/Intra-Reader Variability

  • Alyssa T. Watanabe,
  • Tara Retson,
  • Junhao Wang,
  • Richard Mantey,
  • Chiyung Chim and
  • Homa Karimabadi

16 August 2023

Breast density is an important risk factor for breast cancer development; however, imager inconsistency in density reporting can lead to patient and clinician confusion. A deep learning (DL) model for mammographic density grading was examined in a re...

  • Article
  • Open Access
2 Citations
1,928 Views
14 Pages

Functional MRI Assessment of Brain Activity Patterns Associated with Reading in Medulloblastoma Survivors

  • Josue L. Dalboni da Rocha,
  • Ping Zou Stinnett,
  • Matthew A. Scoggins,
  • Samuel S. McAfee,
  • Heather M. Conklin,
  • Amar Gajjar and
  • Ranganatha Sitaram

6 September 2024

Medulloblastoma, a malignant brain tumor primarily affecting children, poses significant challenges to patients and clinicians due to its complex treatment and potential long-term cognitive consequences. While recent advancements in treatment have si...

  • Article
  • Open Access
6 Citations
9,065 Views
13 Pages

10 February 2024

Teacher-centered instruction is prevalent in preparation courses for large-scale standardized language tests. Student-centered instruction, while known to be effective in enhancing communicative competence, has been considered ineffective and time-co...

  • Article
  • Open Access
5 Citations
6,721 Views
27 Pages

Reconstructing Prehistoric Viral Genomes from Neanderthal Sequencing Data

  • Renata C. Ferreira,
  • Gustavo V. Alves,
  • Marcello Ramon,
  • Fernando Antoneli and
  • Marcelo R. S. Briones

27 May 2024

DNA viruses that produce persistent infections have been proposed as potential causes for the extinction of Neanderthals, and, therefore, the identification of viral genome remnants in Neanderthal sequence reads is an initial step to address this hyp...

  • Article
  • Open Access
9 Citations
4,523 Views
13 Pages

De Novo SNP Discovery and Genotyping of Iranian Pimpinella Species Using ddRAD Sequencing

  • Shaghayegh Mehravi,
  • Gholam Ali Ranjbar,
  • Ghader Mirzaghaderi,
  • Anita Alice Severn-Ellis,
  • Armin Scheben,
  • David Edwards and
  • Jacqueline Batley

30 June 2021

The species of Pimpinella, one of the largest genera of the family Apiaceae, are traditionally cultivated for medicinal purposes. In this study, high-throughput double digest restriction-site associated DNA sequencing technology (ddRAD-seq) was used...

  • Article
  • Open Access
6 Citations
3,775 Views
15 Pages

This article analyses the search strategies of first families in Bolivia contesting the separation of their children through transnational adoption. These first parents’ claims to visibility and acknowledgement have remained largely ignored by...

  • Article
  • Open Access
10 Citations
3,010 Views
19 Pages

Strategy to Decrease the Angle Measurement Error Introduced by the Use of Circular Grating in Dynamic Torque Calibration

  • Yongbin Du,
  • Feng Yuan,
  • Zongze Jiang,
  • Kai Li,
  • Shuiwang Yang,
  • Qingbai Zhang,
  • Yinghui Zhang,
  • Hongliang Zhao,
  • Zhaorui Li and
  • Shunli Wang

16 November 2021

A circular grating angle encoder is a key component in the dynamic torque calibration system. To improve the accuracy of an angle measurement, in this paper, the source of the angle measurement error of the circular grating is analyzed; an eccentrici...

  • Article
  • Open Access
10 Citations
6,931 Views
13 Pages

Correlation between Eye Movements and Asthenopia: A Prospective Observational Study

  • Ziyuan Liu,
  • Kaiyun Zhang,
  • Shuang Gao,
  • Jiarui Yang and
  • Weiqiang Qiu

28 November 2022

Purpose: To analyze the correlation between eye movements and asthenopia so as to explore the possibility of using eye-tracking techniques for objective assessment of asthenopia. Methods: This prospective observational study used the computer visual...

  • Article
  • Open Access
14 Citations
4,211 Views
9 Pages

28 April 2022

Purpose: To study the association of parents’ reports about their children’s near work and outdoor habits with myopia in their children. Methods: Data from a questionnaire study conducted in 1983 among Finnish schoolchildren were reanalyz...

  • Feature Paper
  • Article
  • Open Access
1 Citations
12,291 Views
11 Pages

9 November 2017

Sophocles’ Oedipus the King has often inspired concurrent interpretations examining the tragic irony of the play and the traumatic neurosis of its protagonist. The Theban king epitomizes a man who knows everything but himself, and Sophocles’ use of i...

  • Brief Report
  • Open Access
4 Citations
3,238 Views
12 Pages

Investigation of Different Library Preparation and Tissue of Origin Deconvolution Methods for Urine and Plasma cfDNA Methylome Analysis

  • Nicholas Kueng,
  • Daniel Sidler,
  • Vanessa Banz,
  • Carlo R. Largiadèr,
  • Charlotte K. Y. Ng and
  • Ursula Amstutz

Methylation sequencing is a promising approach to infer the tissue of origin of cell-free DNA (cfDNA). In this study, a single- and a double-stranded library preparation approach were evaluated with respect to their technical biases when applied on c...

  • Article
  • Open Access
47 Citations
8,175 Views
12 Pages

An IoT-Based Glucose Monitoring Algorithm to Prevent Diabetes Complications

  • Francisco Valenzuela,
  • Armando García,
  • Erica Ruiz.,
  • Mabel Vázquez,
  • Joaquín Cortez and
  • Adolfo Espinoza

31 January 2020

Diabetes mellitus (DM) is a metabolic disorder characterized by blood glucose levels above normal limits. The impact of this disease on the population has increased in recent years. It is already a public health problem worldwide and one of the leadi...

  • Article
  • Open Access
4 Citations
3,034 Views
19 Pages

Evidence of a Set of Core-Function Genes in 16 Bacillus Podoviral Genomes with Considerable Genomic Diversity

  • Ahmed Ismail,
  • Tanuj Saini,
  • Ahmed Al Qaffas,
  • Ivan Erill,
  • Steven M. Caruso,
  • Louise Temple and
  • Allison A. Johnson

18 January 2023

Bacteriophage genomes represent an enormous level of genetic diversity and provide considerable potential to acquire new insights about viral genome evolution. In this study, the genome sequences of sixteen Bacillus-infecting bacteriophages were expl...

  • Article
  • Open Access
6 Citations
4,125 Views
17 Pages

A Standardized Pipeline for Assembly and Annotation of African Swine Fever Virus Genome

  • Edward Spinard,
  • Mark Dinhobl,
  • Cassidy N. G. Erdelyan,
  • James O’Dwyer,
  • Jacob Fenster,
  • Hillary Birtley,
  • Nicolas Tesler,
  • Sten Calvelage,
  • Mikael Leijon and
  • Douglas P. Gladue
  • + 16 authors

13 August 2024

Obtaining a complete good-quality sequence and annotation for the long double-stranded DNA genome of the African swine fever virus (ASFV) from next-generation sequencing (NGS) technology has proven difficult, despite the increasing availability of re...

  • Proceeding Paper
  • Open Access
1 Citations
2,121 Views
5 Pages

Respiratory Inductive Plethysmography System for Knitted Helical Coils

  • Kevin Kiener,
  • Aishwarya Anand,
  • William Fobelets and
  • Kristel Fobelets

Three-dimensional knitted helical coils are very sensitive inductive sensors that can be used to monitor breathing. Their inductance is high and the quality factor relatively low. A read-out circuit is designed and tested to track the inductance vari...

  • Article
  • Open Access
567 Views
21 Pages

A 5000 Fps, 4 Megapixel, Radiation-Tolerant, Wafer-Scale CMOS Image Sensor for the Direct Detection of Electrons and Photons

  • Andrew Scott,
  • Claus Bauzà,
  • Adrià Bofill-Petit,
  • Albert Font,
  • Mireia Gargallo,
  • Robert Gifreu,
  • Kamran Latif,
  • Armand Mollà Garcia,
  • Michele Sannino and
  • Renato Turchetta

6 January 2026

We present the design and characterisation of a 4.2-megapixel, wafer-scale CMOS image sensor, achieving over 5000 frames per second at full resolution. The sensor has a pixel pitch of 58 µm square pixels, thus being as large as a full 200 mm wa...

  • Article
  • Open Access
2 Citations
2,949 Views
15 Pages

Hardware Design and Implementation of a Lightweight Saber Algorithm Based on DRC Method

  • Weifang Zheng,
  • Huihong Zhang,
  • Yuejun Zhang,
  • Yongzhong Wen,
  • Jie Lv,
  • Lei Ni and
  • Zhiyi Li

With the development of quantum computers, the security of classical cryptosystems is seriously threatened, and the Saber algorithm has become one of the potential candidates for post-quantum cryptosystems (PQCs). To address the problems of long dela...

  • Article
  • Open Access
6 Citations
3,221 Views
9 Pages

Performance of Computed Tomography Angiography (CTA) for the Diagnosis of Hypo-Attenuated Leaflet Thickening (HALT)

  • Manuel Hein,
  • Philipp Breitbart,
  • Jan Minners,
  • Philipp Blanke,
  • Simon Schoechlin,
  • Christopher Schlett,
  • Tobias Krauss,
  • Martin Soschynski,
  • Franz-Josef Neumann and
  • Philipp Ruile

25 March 2022

(1) Background: Early hypo-attenuated leaflet thickening (HALT) is diagnosed by computed tomography angiography (CTA) in approximately 15% of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to investigate the diagnostic p...

  • Article
  • Open Access
30 Citations
8,675 Views
15 Pages

A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae

  • Angela M. Crabtree,
  • Emily A. Kizer,
  • Samuel S. Hunter,
  • James T. Van Leuven,
  • Daniel D. New,
  • Matthew W. Fagnan and
  • Paul A. Rowley

16 January 2019

Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically cha...

  • Article
  • Open Access
24 Citations
6,497 Views
14 Pages

Embedded Memories for Cryogenic Applications

  • Esteban Garzón,
  • Adam Teman and
  • Marco Lanuzza

The ever-growing interest in cryogenic applications has prompted the investigation for energy-efficient and high-density memory technologies that are able to operate efficiently at extremely low temperatures. This work analyzes three appealing embedd...

  • Article
  • Open Access
11 Citations
5,400 Views
17 Pages

Secondary School Students’ Construction and Interpretation of Statistical Tables

  • Jocelyn D. Pallauta,
  • Pedro Arteaga and
  • José A. Garzón-Guerrero

11 December 2021

Understanding statistical tables is a main component of statistical literacy, although related research dealing with secondary school students is scarce. The purpose of this study was to investigate secondary school students’ performance when t...

  • Article
  • Open Access
974 Views
20 Pages

In 3D virtual environments, effective information presentation relies on clear label layouts to annotate complex objects. As label density increases, structured and adaptive layouts become critical to prevent visual clutter and maintain clarity. Howe...

  • Article
  • Open Access
2 Citations
2,236 Views
14 Pages

30 March 2025

Emerging applications like deep neural networks require high off-chip memory bandwidth and low dynamic loaded Double Data Rate SDRAM (DDR) latency. However, under the stringent physical constraints of chip packages and system boards, it is extremely...

  • Article
  • Open Access
12 Citations
3,972 Views
23 Pages

17 February 2022

Double flowers are one of the important objectives of ornamental plant breeding. Sagittaria sagittifolia is an aquatic herb in the Alismataceae family that is widely used as an ornamental plant in gardens. However, the reference genome has not been p...

  • Article
  • Open Access
3 Citations
2,872 Views
15 Pages

6 October 2024

With the advancement of CMOS technology, the susceptibility of SRAM to single node upset (SNU), double node upset (DNU), and multiple node upset (MNU) induced by radiation has increased. To address this issue, various cutting-edge solutions, such as...

  • Article
  • Open Access
1 Citations
14,089 Views
17 Pages

27 January 2017

Pequot Native and Methodist Minister William Apess has received growing recognition among historians as a unique voice for Native Americans—and minorities in general—during the early Republic. This essay began by inquiring into Apess’s relationship w...

  • Article
  • Open Access
13 Citations
2,937 Views
24 Pages

Terahertz Radiation from High Electron Mobility Avalanche Transit Time Sources Prospective for Biomedical Spectroscopy

  • Sahanowaj Khan,
  • Aritra Acharyya,
  • Hiroshi Inokawa,
  • Hiroaki Satoh,
  • Arindam Biswas,
  • Rudra Sankar Dhar,
  • Amit Banerjee and
  • Alexey Y. Seteikin

A Schottky barrier high-electron-mobility avalanche transit time (HEM-ATT) structure is proposed for terahertz (THz) wave generation. The structure is laterally oriented and based on AlGaN/GaN two-dimensional electron gas (2-DEG). Trenches are introd...

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