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Search Results (23,358)

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Keywords = development trend

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26 pages, 1886 KiB  
Article
Landscape Ecological Risk Assessment of Peri-Urban Villages in the Yangtze River Delta Based on Ecosystem Service Values
by Yao Xiong, Yueling Li and Yunfeng Yang
Sustainability 2025, 17(15), 7014; https://doi.org/10.3390/su17157014 (registering DOI) - 1 Aug 2025
Abstract
The rapid urbanization process has accelerated the degradation of ecosystem services (ESs) in peri-urban rural areas of the Yangtze River Delta (YRD), leading to increasing landscape ecological risks (LERs). Establishing a scientifically grounded landscape ecological risk assessment (LERA) system and corresponding control strategies [...] Read more.
The rapid urbanization process has accelerated the degradation of ecosystem services (ESs) in peri-urban rural areas of the Yangtze River Delta (YRD), leading to increasing landscape ecological risks (LERs). Establishing a scientifically grounded landscape ecological risk assessment (LERA) system and corresponding control strategies is therefore imperative. Using rural areas of Jiangning District, Nanjing as a case study, this research proposes an optimized dual-dimensional coupling assessment framework that integrates ecosystem service value (ESV) and ecological risk probability. The spatiotemporal evolution of LER in 2000, 2010, and 2020 and its key driving factors were further studied by using spatial autocorrelation analysis and geodetector methods. The results show the following: (1) From 2000 to 2020, cultivated land remained dominant, but its proportion decreased by 10.87%, while construction land increased by 26.52%, with minimal changes in other land use types. (2) The total ESV increased by CNY 1.67 × 109, with regulating services accounting for over 82%, among which water bodies contributed the most. (3) LER showed an overall increasing trend, with medium- to highest-risk areas expanding by 55.37%, lowest-risk areas increasing by 10.10%, and lower-risk areas decreasing by 65.48%. (4) Key driving factors include landscape vulnerability, vegetation coverage, and ecological land connectivity, with the influence of distance to road becoming increasingly significant. This study reveals the spatiotemporal evolution characteristics of LER in typical peri-urban villages. Based on the LERA results, combined with terrain features and ecological pressure intensity, the study area was divided into three ecological management zones: ecological conservation, ecological restoration, and ecological enhancement. Corresponding zoning strategies were proposed to guide rural ecological governance and support regional sustainable development. Full article
22 pages, 1929 KiB  
Article
Investigating Provincial Coupling Coordination Between Digital Infrastructure and Green Development in China
by Beibei Zhang, Zhenni Zhou, Juan Zheng, Zezhou Wu and Yan Liu
Buildings 2025, 15(15), 2724; https://doi.org/10.3390/buildings15152724 (registering DOI) - 1 Aug 2025
Abstract
Digital technologies could facilitate green development by enhancing energy efficiency. However, existing research on coupling coordination between digital infrastructure and green development remains scarce. To fill this research gap, this study analyzes the spatio-temporal variations and barriers of coupling coordination. An evaluation index [...] Read more.
Digital technologies could facilitate green development by enhancing energy efficiency. However, existing research on coupling coordination between digital infrastructure and green development remains scarce. To fill this research gap, this study analyzes the spatio-temporal variations and barriers of coupling coordination. An evaluation index system is established and then the coupling relationship and the barrier factors between digital infrastructure and green development are analyzed. A provincial analysis is conducted by using data from China. The results in the study indicate (1) coupling coordination between digital infrastructure and green development exhibits a relatively low state, characterized by an overall upward trend; (2) noteworthy disparities are observed in the spatio-temporal pattern of the coupling coordination degree, reflecting the overall evolutionary trend from low to high coupling coordination, along with the characteristics of positive spatial correlation and high spatial concentration; and (3) obstacle factors are analyzed from the aspects of digital infrastructure and green development, emphasizing the construction of mobile phone base stations and investment in pollution control, among other aspects. This study contributes valuable insights for improvement paths for digital infrastructure and green development, offering recommendations for optimizing strategies to promote their coupled development. Full article
(This article belongs to the Special Issue Promoting Green, Sustainable, and Resilient Urban Construction)
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20 pages, 9174 KiB  
Review
Marine-Derived Collagen and Chitosan: Perspectives on Applications Using the Lens of UN SDGs and Blue Bioeconomy Strategies
by Mariana Almeida and Helena Vieira
Mar. Drugs 2025, 23(8), 318; https://doi.org/10.3390/md23080318 (registering DOI) - 1 Aug 2025
Abstract
Marine biomass, particularly from waste streams, by-products, underutilized, invasive, or potential cultivable marine species, offers a sustainable source of high-value biopolymers such as collagen and chitin. These macromolecules have gained significant attention due to their biocompatibility, biodegradability, functional versatility, and broad applicability across [...] Read more.
Marine biomass, particularly from waste streams, by-products, underutilized, invasive, or potential cultivable marine species, offers a sustainable source of high-value biopolymers such as collagen and chitin. These macromolecules have gained significant attention due to their biocompatibility, biodegradability, functional versatility, and broad applicability across health, food, wellness, and environmental fields. This review highlights recent advances in the uses of marine-derived collagen and chitin/chitosan. In alignment with the United Nations Sustainable Development Goals (SDGs), we analyze how these applications contribute to sustainability, particularly in SDGs related to responsible consumption and production, good health and well-being, and life below water. Furthermore, we contextualize the advancement of product development using marine collagen and chitin/chitosan within the European Union’s Blue bioeconomy strategies, highlighting trends in scientific research and technological innovation through bibliometric and patent data. Finally, the review addresses challenges facing the development of robust value chains for these marine biopolymers, including collaboration, regulatory hurdles, supply-chain constraints, policy and financial support, education and training, and the need for integrated marine resource management. The paper concludes with recommendations for fostering innovation and sustainability in the valorization of these marine resources. Full article
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34 pages, 1441 KiB  
Article
Empowering the Intelligent Transformation of the Manufacturing Sector Through New Quality Productive Forces: Value Implications, Theoretical Analysis, and Empirical Examination
by Yinyan Hu and Xinran Jia
Sustainability 2025, 17(15), 7006; https://doi.org/10.3390/su17157006 (registering DOI) - 1 Aug 2025
Abstract
Achieving sustainable development goals remains a core issue in global development. In response, China has proposed the development of new quality productive forces (NQPFs) through innovative thinking, emphasizing that fostering NQPFs is both an intrinsic requirement and a pivotal focus for advancing high-quality [...] Read more.
Achieving sustainable development goals remains a core issue in global development. In response, China has proposed the development of new quality productive forces (NQPFs) through innovative thinking, emphasizing that fostering NQPFs is both an intrinsic requirement and a pivotal focus for advancing high-quality development. Concurrently, the intelligent transformation of the manufacturing sector serves as a critical direction for China’s economic restructuring and upgrading. This paper places “new quality productive forces” and “intelligent transformation of manufacturing” within the same analytical framework. Starting from the logical chain of “new quality productive forces—three major mechanisms—intelligent transformation of manufacturing,” it concretizes the value implications of new quality productive forces into a systematic conceptual framework driven by the synergistic interaction of three major mechanisms: the mechanism of revolutionary technological breakthroughs, the mechanism of innovative allocation of production factors, and the mechanism of deep industrial transformation and upgrading. This study constructs a “3322” evaluation index system for NQPFs, based on three formative processes, three driving forces, two supporting systems, and two-dimensional characteristics. Simultaneously, it builds an evaluation index system for the intelligent transformation of manufacturing, encompassing intelligent technology, intelligent applications, and intelligent benefits. Using national time-series data from 2012 to 2023, this study assesses the development levels of both NQPFs and the intelligent transformation of manufacturing during this period. The study further analyzes the impact of NQPFs on the intelligent transformation of the manufacturing sector. The research results indicate the following: (1) NQPFs drive the intelligent transformation of the manufacturing industry through the three mechanisms of innovative allocation of production factors, revolutionary breakthroughs in technology, and deep transformation and upgrading of industries. (2) The development of NQPFs exhibits a slow upward trend; however, the outbreak of the pandemic and Sino-US trade frictions have caused significant disruptions to the development of new-type productive forces. (3) The level of intelligent manufacturing continues to improve; however, from 2020 to 2023, due to the impact of the COVID-19 pandemic and Sino-US trade conflicts, the level of intelligent benefits has slightly declined. (4) NQPFs exert a powerful driving force on the intelligent transformation of manufacturing, exerting a significant positive impact on intelligent technology, intelligent applications, and intelligent efficiency levels. Full article
39 pages, 959 KiB  
Review
Emerging Trends in Active Packaging for Food: A Six-Year Review
by Mariana A. Andrade, Cássia H. Barbosa, Regiane Ribeiro-Santos, Sidney Tomé, Ana Luísa Fernando, Ana Sanches Silva and Fernanda Vilarinho
Foods 2025, 14(15), 2713; https://doi.org/10.3390/foods14152713 (registering DOI) - 1 Aug 2025
Abstract
The development of active food packaging has evolved rapidly in recent years, offering innovative solutions to enhance food preservation and safety while addressing sustainability challenges. This review compiles and analyzes recent advancements (2019–2024) in release-type active packaging, focusing on essential oils, natural extracts, [...] Read more.
The development of active food packaging has evolved rapidly in recent years, offering innovative solutions to enhance food preservation and safety while addressing sustainability challenges. This review compiles and analyzes recent advancements (2019–2024) in release-type active packaging, focusing on essential oils, natural extracts, and phenolic compounds as active agents. Primarily plant-derived, these compounds exhibit significant antioxidant and antimicrobial activities, extending shelf life and enhancing food quality. Technological strategies such as encapsulation and polymer blending have been increasingly adopted to overcome challenges related to volatility, solubility, and sensory impact. Integrating bio-based polymers, including chitosan, starch, and polylactic acid, further supports the development of environmentally friendly packaging systems. This review also highlights trends in compound-specific research, release mechanisms, and commercial applications, including a detailed analysis of patents and case studies across various food matrices. These developments have already been translated into practical applications, such as antimicrobial sachets for meat and essential oil-based pads for fresh produce. Moreover, by promoting the valorization of agro-industrial by-products and the use of biodegradable materials, emission-type active packaging contributes to the principles of the circular economy. This comprehensive overview underscores the potential of natural bioactive compounds in advancing sustainable and functional food packaging technologies. Full article
20 pages, 1489 KiB  
Article
Preparation Optimization and Antioxidant Properties of the β-Glucan and Ferulic Acid/Quercetin Complex from Highland Barley (Hordeum vulgare var. nudum)
by Yuanhang Ren, Yanting Yang, Mi Jiang, Wentao Gu, Yanan Cao, Liang Zou and Lianxin Peng
Foods 2025, 14(15), 2712; https://doi.org/10.3390/foods14152712 (registering DOI) - 1 Aug 2025
Abstract
Polysaccharides and phenols are commonly co-localized in various plant-derived foods, including highland barley (Hordeum vulgare L. var. nudum Hook. f.). The interactions between these compounds can influence multiple characteristics of food products, including their physicochemical properties and functional performance, such as bioavailability, [...] Read more.
Polysaccharides and phenols are commonly co-localized in various plant-derived foods, including highland barley (Hordeum vulgare L. var. nudum Hook. f.). The interactions between these compounds can influence multiple characteristics of food products, including their physicochemical properties and functional performance, such as bioavailability, stability, and digestibility, which may support promising application of the phenol and polysaccharide complex in health food industry. In this study, two complexes with potential existence in highland barley, such as β-glucan-ferulic acid (GF) and β-glucan-quercetin (GQ), were prepared using the equilibrium dialysis method in vitro. FTIR and SEM results showed that ferulic acid and quercetin formed complexes with β-glucan separately, with covalent and non-covalent bonds and a dense morphological structure. The pH value, reaction temperature, and concentration of phosphate buffer solution (PBS) were confirmed to have an impact on the formation and yield of the complex. Through the test of the response surface, it was found that the optimum conditions for GF and (GQ) preparations were a pH of 6.5 (6), a PBS buffer concentration of 0.08 mol/L (0.3 mol/L), and a temperature of 8 °C (20 °C). Through in vitro assays, GF and GQ were found to possess good antioxidant activity, with a greater scavenging effect of DPPH, ABTS, and hydroxyl radical than the individual phenolic acids and glucans, as well as their physical mixtures. Taking GF as an example, the DPPH radical scavenging capacity ranked as GF (71.74%) > ferulic acid (49.50%) > PGF (44.43%) > β-glucan (43.84%). Similar trends were observed for ABTS radical scavenging (GF: 54.56%; ferulic acid: 44.37%; PGF: 44.95%; β-glucan: 36.42%) and hydroxyl radical elimination (GF: 39.16%; ferulic acid: 33.06%; PGF: 35.51%; β-glucan: 35.47%). In conclusion, the convenient preparation method and excellent antioxidant effect of the phenol–polysaccharide complexes from highland barley provide new opportunities for industrial-scale production, development, and design of healthy food based on these complexes. Full article
18 pages, 2864 KiB  
Article
Physiological and Chemical Response of Urochloa brizantha to Edaphic and Microclimatic Variations Along an Altitudinal Gradient in the Amazon
by Hipolito Murga-Orrillo, Luis Alberto Arévalo López, Marco Antonio Mathios-Flores, Jorge Cáceres Coral, Melissa Rojas García, Jorge Saavedra-Ramírez, Adriana Carolina Alvarez-Cardenas, Christopher Iván Paredes Sánchez, Aldi Alida Guerra-Teixeira and Nilton Luis Murga Valderrama
Agronomy 2025, 15(8), 1870; https://doi.org/10.3390/agronomy15081870 (registering DOI) - 1 Aug 2025
Abstract
Urochloa brizantha (Brizantha) is cultivated under varying altitudinal and management conditions. Twelve full-sun (monoculture) plots and twelve shaded (silvopastoral) plots were established, proportionally distributed at 170, 503, 661, and 1110 masl. Evaluations were conducted 15, 30, 45, 60, and 75 days [...] Read more.
Urochloa brizantha (Brizantha) is cultivated under varying altitudinal and management conditions. Twelve full-sun (monoculture) plots and twelve shaded (silvopastoral) plots were established, proportionally distributed at 170, 503, 661, and 1110 masl. Evaluations were conducted 15, 30, 45, 60, and 75 days after establishment. The conservation and integration of trees in silvopastoral systems reflected a clear anthropogenic influence, evidenced by the preference for species of the Fabaceae family, likely due to their multipurpose nature. Although the altitudinal gradient did not show direct effects on soil properties, intermediate altitudes revealed a significant role of CaCO3 in enhancing soil fertility. These edaphic conditions at mid-altitudes favored the leaf area development of Brizantha, particularly during the early growth stages, as indicated by significantly larger values (p < 0.05). However, at the harvest stage, no significant differences were observed in physiological or productive traits, nor in foliar chemical components, underscoring the species’ high hardiness and broad adaptation to both soil and altitude conditions. In Brizantha, a significant reduction (p < 0.05) in stomatal size and density was observed under shade in silvopastoral areas, where solar radiation and air temperature decreased, while relative humidity increased. Nonetheless, these microclimatic variations did not lead to significant changes in foliar chemistry, growth variables, or biomass production, suggesting a high degree of adaptive plasticity to microclimatic fluctuations. Foliar ash content exhibited an increasing trend with altitude, indicating greater efficiency of Brizantha in absorbing calcium, phosphorus, and potassium at higher altitudes, possibly linked to more favorable edaphoclimatic conditions for nutrient uptake. Finally, forage quality declined with plant age, as evidenced by reductions in protein, ash, and In Vitro Dry Matter Digestibility (IVDMD), alongside increases in fiber, Neutral Detergent Fiber (NDF), and Acid Detergent Fiber (ADF). These findings support the recommendation of cutting intervals between 30 and 45 days, during which Brizantha displays a more favorable nutritional profile, higher digestibility, and consequently, greater value for animal feeding. Full article
(This article belongs to the Section Agricultural Biosystem and Biological Engineering)
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14 pages, 2350 KiB  
Article
Temporal Deformation Characteristics of Hydraulic Asphalt Concrete Slope Flow Under Different Test Temperatures
by Xuexu An, Jingjing Li and Zhiyuan Ning
Materials 2025, 18(15), 3625; https://doi.org/10.3390/ma18153625 (registering DOI) - 1 Aug 2025
Abstract
To investigate temporal deformation mechanisms of hydraulic asphalt concrete slope flow under evolving temperatures, this study developed a novel temperature-controlled slope flow intelligent test apparatus. Using this apparatus, slope flow tests were conducted at four temperature levels: 20 °C, 35 °C, 50 °C, [...] Read more.
To investigate temporal deformation mechanisms of hydraulic asphalt concrete slope flow under evolving temperatures, this study developed a novel temperature-controlled slope flow intelligent test apparatus. Using this apparatus, slope flow tests were conducted at four temperature levels: 20 °C, 35 °C, 50 °C, and 70 °C. By applying nonlinear dynamics theory, the temporal evolution of slope flow deformation and its nonlinear mechanical characteristics under varying temperatures were thoroughly analyzed. Results indicate that the thermal stability of hydraulic asphalt concrete is synergistically governed by the phase-transition behavior between asphalt binder and aggregates. Temporal evolution of slope flow exhibits a distinct three-stage pattern as follows: rapid growth (0~12 h), where sharp temperature rise disrupts the primary skeleton of coarse aggregates; decelerated growth (12~24 h), where an embryonic secondary skeleton forms and progressively resists deformation; stabilization (>24 h), where reorganization of coarse aggregates is completed, establishing structural equilibrium. The thermal stability temperature influence factor (δ) shows a nonlinear concave growth trend with increasing test temperature. Dynamically, this process transitions sequentially through critical stability, nonlinear stability, period-doubling oscillatory stability, and unsteady states. Full article
(This article belongs to the Special Issue Advances in Material Characterization and Pavement Modeling)
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20 pages, 17646 KiB  
Article
An Observational Study of a Severe Squall Line Crossing Hong Kong on 15 March 2025 Based on Radar-Retrieved Three-Dimensional Winds and Flight Data
by Pak-wai Chan, Ying-wa Chan, Ping Cheung and Man-lok Chong
Appl. Sci. 2025, 15(15), 8562; https://doi.org/10.3390/app15158562 (registering DOI) - 1 Aug 2025
Abstract
The present paper reports for the first time the comparison of radar-derived eddy dissipation rate (EDR) and vertical velocity with measurements from six aircraft for an intense squall line crossing Hong Kong. The study objectives are three-fold: (i) to characterise the structural dynamics [...] Read more.
The present paper reports for the first time the comparison of radar-derived eddy dissipation rate (EDR) and vertical velocity with measurements from six aircraft for an intense squall line crossing Hong Kong. The study objectives are three-fold: (i) to characterise the structural dynamics of the intense squall line; (ii) to identify the dynamical change in EDR and vertical velocity during its eastward propagation across Hong Kong with a view to gaining insight into the intensity change of the squall line and the severity of its impact on aircraft flying near it; (iii) to carry out quantitative comparison of EDR and vertical velocity derived from remote sensing instruments, i.e., weather radars and in situ measurements from aircraft, so that the quality of the former dataset can be evaluated by the latter. During the passage of the squall line and taking reference of the radar reflectivity, vertical circulation and the subsiding flow at the rear, it appeared to be weakening in crossing over Hong Kong, possibly due to land friction by terrain and urban morphology. This is also consistent with the maximum gusts recorded by the dense network of ground-based anemometers in Hong Kong. However, from the EDR and the vertical velocity of the aircraft, the weakening trend was not very apparent, and rather severe turbulence was still recorded by the aircraft flying through the squall line into the region with stratiform precipitation when the latter reached the eastern coast of Hong Kong. In general, the radar-based and the aircraft-based EDRs are consistent with each other. The radar-retrieved maximum vertical velocity may be smaller in magnitude at times, possibly arising from the limited spatial and temporal resolutions of the aircraft data. The results of this paper could be a useful reference for the development of radar-based turbulence products for aviation applications. Full article
(This article belongs to the Section Environmental Sciences)
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18 pages, 6642 KiB  
Article
Flood Impact and Evacuation Behavior in Toyohashi City, Japan: A Case Study of the 2 June 2023 Heavy Rain Event
by Masaya Toyoda, Reo Minami, Ryoto Asakura and Shigeru Kato
Sustainability 2025, 17(15), 6999; https://doi.org/10.3390/su17156999 (registering DOI) - 1 Aug 2025
Abstract
Recent years have seen frequent heavy rainfall events in Japan, often linked to Baiu fronts and typhoons. These events are exacerbated by global warming, leading to an increased frequency and intensity. As floods represent a serious threat to sustainable urban development and community [...] Read more.
Recent years have seen frequent heavy rainfall events in Japan, often linked to Baiu fronts and typhoons. These events are exacerbated by global warming, leading to an increased frequency and intensity. As floods represent a serious threat to sustainable urban development and community resilience, this study contributes to sustainability-focused risk reduction through integrated analysis. This study focuses on the 2 June 2023 heavy rain disaster in Toyohashi City, Japan, which caused extensive damage due to flooding from the Yagyu and Umeda Rivers. Using numerical models, this study accurately reproduces flooding patterns, revealing that high tides amplified the inundation area by 1.5 times at the Yagyu River. A resident questionnaire conducted in collaboration with Toyohashi City identifies key trends in evacuation behavior and disaster information usage. Traditional media such as TV remain dominant, but younger generations leverage electronic devices for disaster updates. These insights emphasize the need for targeted information dissemination and enhanced disaster preparedness strategies, including online materials and flexible training programs. The methods and findings presented in this study can inform local and regional governments in building adaptive disaster management policies, which contribute to a more sustainable society. Full article
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30 pages, 2537 KiB  
Review
The State of Health Estimation of Lithium-Ion Batteries: A Review of Health Indicators, Estimation Methods, Development Trends and Challenges
by Kang Tang, Bingbing Luo, Dian Chen, Chengshuo Wang, Long Chen, Feiliang Li, Yuan Cao and Chunsheng Wang
World Electr. Veh. J. 2025, 16(8), 429; https://doi.org/10.3390/wevj16080429 (registering DOI) - 1 Aug 2025
Abstract
The estimation of the state of health (SOH) of lithium-ion batteries is a critical technology for enhancing battery lifespan and safety. When estimating SOH, it is essential to select representative features, commonly referred to as health indicators (HIs). Most existing studies primarily focus [...] Read more.
The estimation of the state of health (SOH) of lithium-ion batteries is a critical technology for enhancing battery lifespan and safety. When estimating SOH, it is essential to select representative features, commonly referred to as health indicators (HIs). Most existing studies primarily focus on HIs related to capacity degradation and internal resistance increase. However, due to the complexity of lithium-ion battery degradation mechanisms, the relationships between these mechanisms and health indicators remain insufficiently explored. This paper provides a comprehensive review of core methodologies for SOH estimation, with a particular emphasis on the classification and extraction of health indicators, direct measurement techniques, model-based and data-driven SOH estimation approaches, and emerging trends in battery management system applications. The findings indicate that capacity, internal resistance, and temperature-related indicators significantly impact SOH estimation accuracy, while machine learning models demonstrate advantages in multi-source data fusion. Future research should further explore composite health indicators and aging mechanisms of novel battery materials, and improve the interpretability of predictive models. This study offers theoretical support for the intelligent management and lifespan optimization of lithium-ion batteries. Full article
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15 pages, 1071 KiB  
Article
A Synthetic Difference-in-Differences Approach to Assess the Impact of Shanghai’s 2022 Lockdown on Ozone Levels
by Yumin Li, Jun Wang, Yuntong Fan, Chuchu Chen, Jaime Campos Gutiérrez, Ling Huang, Zhenxing Lin, Siyuan Li and Yu Lei
Sustainability 2025, 17(15), 6997; https://doi.org/10.3390/su17156997 (registering DOI) - 1 Aug 2025
Abstract
Promoting sustainable development requires a clear understanding of how short-term fluctuations in anthropogenic emissions affect urban environmental quality. This is especially relevant for cities experiencing rapid industrial changes or emergency policy interventions. Among key environmental concerns, variations in ambient pollutants like ozone (O [...] Read more.
Promoting sustainable development requires a clear understanding of how short-term fluctuations in anthropogenic emissions affect urban environmental quality. This is especially relevant for cities experiencing rapid industrial changes or emergency policy interventions. Among key environmental concerns, variations in ambient pollutants like ozone (O3) are closely tied to both public health and long-term sustainability goals. However, traditional chemical transport models often face challenges in accurately estimating emission changes and providing timely assessments. In contrast, statistical approaches such as the difference-in-differences (DID) model utilize observational data to improve evaluation accuracy and efficiency. This study leverages the synthetic difference-in-differences (SDID) approach, which integrates the strengths of both DID and the synthetic control method (SCM), to provide a more reliable and accurate analysis of the impacts of interventions on city-level air quality. Using Shanghai’s 2022 lockdown as a case study, we compare the deweathered ozone (O3) concentration in Shanghai to a counterfactual constructed from a weighted average of cities in the Yangtze River Delta (YRD) that did not undergo lockdown. The quasi-natural experiment reveals an average increase of 4.4 μg/m3 (95% CI: 0.24–8.56) in Shanghai’s maximum daily 8 h O3 concentration attributable to the lockdown. The SDID method reduces reliance on the parallel trends assumption and improves the estimate stability through unit- and time-specific weights. Multiple robustness checks confirm the reliability of these findings, underscoring the efficacy of the SDID approach in quantitatively evaluating the causal impact of emission perturbations on air quality. This study provides credible causal evidence of the environmental impact of short-term policy interventions, highlighting the utility of SDID in informing adaptive air quality management. The findings support the development of timely, evidence-based strategies for sustainable urban governance and environmental policy design. Full article
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19 pages, 1310 KiB  
Review
A Survey of Machine and Deep Learning Techniques in Analog Integrated Circuit Layout Synthesis
by Ricardo M. F. Martins
Microelectronics 2025, 1(1), 2; https://doi.org/10.3390/microelectronics1010002 (registering DOI) - 1 Aug 2025
Abstract
Automatic techniques for analog integrated circuit layout design have been proposed in the literature for over four decades. However, as analog design moves into deep nanometer integration nodes, the increasing number of design rules, the influence of layout-dependent effects, congestion, and the impact [...] Read more.
Automatic techniques for analog integrated circuit layout design have been proposed in the literature for over four decades. However, as analog design moves into deep nanometer integration nodes, the increasing number of design rules, the influence of layout-dependent effects, congestion, and the impact of parasitic structures constantly challenges existing automatic layout generation techniques and keeps the pressure on for further improvement. At the time of writing, no automatic tool or flow has been established in the industrial environment, resulting in a time-consuming and difficult-to-reuse design process. However, very recently, machine and deep learning techniques started to offer solutions for problems not dealt with in the previous generation of automatic layout tools and are reshaping analog design automation. Therefore, this paper conducts a review of the most recent analog integrated circuit automatic layout techniques powered by machine and deep learning methods, covering placement, routing, and trends on post-layout performance estimation, as well as providing an actual, complete, and comprehensive guide for circuit designers and design automation developers. Full article
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31 pages, 2032 KiB  
Review
Leflunomide Applicability in Rheumatoid Arthritis: Drug Delivery Challenges and Emerging Formulation Strategies
by Ashish Dhiman and Kalpna Garkhal
Drugs Drug Candidates 2025, 4(3), 36; https://doi.org/10.3390/ddc4030036 (registering DOI) - 1 Aug 2025
Abstract
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder primarily targeting joints, leading to pain, swelling, and stiffness. RA results from the body’s own immune system attacking its own tissues. Currently, there are various treatments available for RA including disease-modifying antirheumatic drugs (DMARDs) [...] Read more.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder primarily targeting joints, leading to pain, swelling, and stiffness. RA results from the body’s own immune system attacking its own tissues. Currently, there are various treatments available for RA including disease-modifying antirheumatic drugs (DMARDs) and NSAIDs. Leflunomide (LEF) is a USFDA-approved synthetic DMARD which is being widely prescribed for the management of RA; however, it faces several challenges such as prolonged drug elimination, hepatotoxicity, and others. LEF exerts its therapeutic effects by inhibiting dihydroorotate dehydrogenase (DHODH), thereby suppressing pyrimidine synthesis and modulating immune responses. Emerging nanotechnology-based therapies help in encountering the current challenges faced in LEF delivery to RA patients. This review enlists the LEF’s pharmacokinetics, mechanism of action, and clinical efficacy in RA management. A comparative analysis with methotrexate, biologics, and other targeted therapies, highlighting its role in monotherapy and combination regimens and the safety concerns, including hepatotoxicity, gastrointestinal effects, and teratogenicity, is discussed alongside recommended monitoring strategies. Additionally, emerging trends in novel formulations and drug delivery approaches are explored to enhance efficacy and minimize adverse effects. Overall, LEF remains a perfect remedy for RA patients, specifically individuals contraindicated with drugs like methotrexate. The therapeutic applicability of LEF could be enhanced by developing more customized treatments and advanced drug delivery approaches. Full article
(This article belongs to the Section Marketed Drugs)
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27 pages, 6094 KiB  
Article
National Multi-Scenario Simulation of Low-Carbon Land Use to Achieve the Carbon-Neutrality Target in China
by Junjun Zhi, Chenxu Han, Qiuchen Yan, Wangbing Liu, Likang Zhang, Zuyuan Wang, Xinwu Fu and Haoshan Zhao
Earth 2025, 6(3), 85; https://doi.org/10.3390/earth6030085 (registering DOI) - 1 Aug 2025
Abstract
Refining the land use structure can boost land utilization efficiency and curtail regional carbon emissions. Nevertheless, prior research has predominantly concentrated on static linear planning analysis. It has failed to account for how future dynamic alterations in driving factors (such as GDP and [...] Read more.
Refining the land use structure can boost land utilization efficiency and curtail regional carbon emissions. Nevertheless, prior research has predominantly concentrated on static linear planning analysis. It has failed to account for how future dynamic alterations in driving factors (such as GDP and population) affect simulation outcomes and how the land use spatial configuration impacts the attainment of the carbon-neutrality goal. In this research, 1 km spatial resolution LULC products were employed to meticulously simulate multiple land use scenarios across China at the national level from 2030 to 2060. This was performed by taking into account the dynamic changes in driving factors. Subsequently, an analysis was carried out on the low-carbon land use spatial structure required to reach the carbon-neutrality target. The findings are as follows: (1) When employing the PLUS (Patch—based Land Use Simulation) model to conduct simulations of various land use scenarios in China by taking into account the dynamic alterations in driving factors, a high degree of precision was attained across diverse scenarios. The sustainable development scenario demonstrated the best performance, with kappa, OA, and FoM values of 0.9101, 93.15%, and 0.3895, respectively. This implies that the simulation approach based on dynamic factors is highly suitable for national-scale applications. (2) The simulation accuracy of the PLUS and GeoSOS-FLUS (Systems for Geographical Modeling and Optimization, Simulation of Future Land Utilization) models was validated for six scenarios by extrapolating the trends of influencing factors. Moreover, a set of scenarios was added to each model as a control group without extrapolation. The present research demonstrated that projecting the trends of factors having an impact notably improved the simulation precision of both the PLUS and GeoSOS-FLUS models. When contrasted with the GeoSOS-FLUS model, the PLUS model attained superior simulation accuracy across all six scenarios. The highest precision indicators were observed in the sustainable development scenario, with kappa, OA, and FoM values reaching 0.9101, 93.15%, and 0.3895, respectively. The precise simulation method of the PLUS model, which considers the dynamic changes in influencing factors, is highly applicable at the national scale. (3) Under the sustainable development scenario, it is anticipated that China’s land use carbon emissions will reach their peak in 2030 and achieve the carbon-neutrality target by 2060. Net carbon emissions are expected to decline by 14.36% compared to the 2020 levels. From the perspective of dynamic changes in influencing factors, the PLUS model was used to accurately simulate China’s future land use. Based on these simulations, multi-scenario predictions of future carbon emissions were made, and the results uncover the spatiotemporal evolution characteristics of China’s carbon emissions. This study aims to offer a solid scientific basis for policy-making related to China’s low-carbon economy and high-quality development. It also intends to present Chinese solutions and key paths for achieving carbon peak and carbon neutrality. Full article
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