Search Results (467)

Objectives: This study aimed to evaluate the 6-month real-world outcomes of switching to faricimab in patients with aflibercept-resistant neovascular age-related macular degeneration (nAMD). Methods: A retrospective review was conducted on the eyes of 60 patients with aflibercept-resistant nAMD that were switched to faricimab. Best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) parameters, including central subfield thickness (CST), subfoveal choroidal thickness (SFCT), and both the maximum height and width of pigment epithelial detachment (PED), at baseline and 1, 3, and 6 months after switching were evaluated. The type of PED and retinal fluid were also analyzed. Results: The results showed that BCVA remained stable at month 6 (p = 0.150), while CST significantly decreased (p = 0.020), and SFCT remained unchanged (p = 0.072). The maximum PED height significantly decreased (p = 0.030), while the maximum PED width did not change (p = 0.07). The mean injection interval significantly increased from 6.8 ± 2.4 weeks before switching to 11.2 ± 1.7 weeks after switching (p = 0.068). Furthermore, the dry macula rate was 43.3% at month 6. Conclusions: Switching to faricimab in aflibercept-resistant nAMD patients showed stable visual outcomes, significant anatomical improvements, and reduced treatment burden over 6 months in real-world clinical settings. Full article

The salt flotation of graphite in the presence of lithium nickel manganese cobalt oxide (NMC) was assessed by performing colloidal probe atomic force microscopy (CP-AFM) on sessile gas bubbles and conducting batch flotation tests with model lithium-ion-battery black mass. The modeling of film drainage and detachment during particle–bubble interactions provides insight into the fundamental microprocesses during salt flotation, a special variant of froth flotation. The interfacial properties of particles and gas bubbles were tailored with salt solutions containing sodium chloride and sodium acetate buffer. Graphite particles can attach to gas bubbles under all tested conditions in the range pH 3 to pH 10. The attractive forces for spherical graphite are strongest at high salt concentrations and pH 3. The conditions for the attachment of NMC to gas bubbles were evaluated with simulations using the Stokes–Reynolds–Young–Laplace model for film drainage, under consideration of DLVO forces and a hydrodynamic slip to account for irregularities of the particle surface. CP-AFM measurements in the capillary force regime provide additional parameters for the modeling of salt flotation, such as the force and work of detachment. The contact angles of graphite and NMC particles during retraction and detachment from gas bubbles were obtained from a quasi-equilibrium model using CP-AFM data as input. All CP-AFM experiments and theoretical results suggest that pristine NMC particles do not attach to gas bubbles during flotation, which is confirmed by the low rate of NMC recovery in batch flotation tests. Full article

This study aimed to evaluate the impact of preoperative anti-VEGF injections on pars plana vitrectomy (PPV) outcomes in patients with proliferative diabetic retinopathy (PDR). Material and methods: We analysed 232 eyes with proliferative diabetic vitreoretinopathy treated with posterior vitrectomy. There were 112 women and 120 men. The patients were divided into two groups of 116 eyes each. In 116 eyes (study group), an anti-VEGF injection was administered 3 to 5 days before vitrectomy. The control eyes were not injected with anti-VEGF due to systemic contraindications to anti-VEGF treatment or lack of patient consent. All participants underwent pars plana vitrectomy with silicone oil injection. The oil was removed within 2–3 months after PPV. Results: At 2 years of observation, after removal of silicone oil, visual acuity (VA) was 0.24 ± 0.27 logMAR in the study and 0.37 ± 0.45 logMAR in the control group (p = 0.003). Intraocular pressure was 16.84 ± 6.25 mmHg in the study group and 17.78 ± 6.22 mmHg in the control group (p = 0.04). The mean duration of surgery was 47.62 ± 9.87 and 50.05 ± 9.41 min in the study and control groups, respectively (p = 0.02). The size of intraoperative haemorrhage was 0.97 ± 0.86 dd in the study group and 1.51 ± 1.22 dd in the control group (p = 0.003). The frequency of surgery-induced retinal breaks was 0.34 ± 0.56 in the study group and 0.56 ± 0.76 in the control group (p = 0.003). The recurrence rate of retinal detachment was 0.05 ± 0.22 in the study group and 0.1 ± 0.31 in the control group (p = 0.15). Conclusions: Preoperative anti-VEGF therapy shortens the duration of surgery, reduces complications, and improves long-term outcomes in terms of visual acuity and maintenance of normal eye function. Full article

Background/Objectives: Liquid biopsy is a minimally invasive alternative to tissue biopsy and is used to obtain information about a disease from a blood sample or other body fluids. In the context of cancer, circulating tumor cells (CTC) can be used as biomarkers to determine the nature of the tumor, its stage of progression, and the efficiency of the administered therapy through monitoring. However, the low concentration of CTCs in blood (1–10 cells/mL) is a challenge for their isolation. Therefore, a minimally invasive medical device (BMProbe™) was developed that isolates CTCs via antigen–antibody binding directly from the bloodstream. Current investigations focus on the process of detaching bound cells from the BMProbe™ surface for cell cultivation and subsequent drug testing to enable personalized therapy planning. Methods: This article presents two approaches for detaching LNCaP cells from anti-EpCAM coated BMProbes™: enzymatic detachment using TrypLE™ and detachment through enzymatic pretreatment with supplementary flow-induced shear stress. The additional shear stress is intended to increase the detachment efficiency. To determine the flow rate required to gently detach the cells, a computational fluid dynamics (CFD) simulation was carried out. Results: The experimental test results demonstrate that 91% of the bound cells can be detached enzymatically within 10 min. Based on the simulation, a maximum flow rate of 47.76 mL/min was defined in the flow detachment system, causing an average shear stress of 8.4 Pa at the probe edges. The additional flow treatment did not increase the CTC detachment efficiency. Conclusions: It is feasible that the detachment efficiency can be further increased by a longer enzymatic incubation time or higher shear stress. The influence on the integrity and viability of cells must, however, be considered. Full article

Apple harvesting faces increasing challenges owing to rising labor costs and the limited seasonal workforce availability, highlighting the need for robotic harvesting solutions in precision agriculture. This study presents a 6-DOF robotic arm system designed for harvesting in dwarf hedge-planted orchards, featuring a lightweight perception module, a task-adaptive motion planner, and an adaptive soft gripper. A lightweight approach was introduced by integrating the Faster module within the C2f module of the You Only Look Once (YOLO) v8n architecture to optimize the real-time apple detection efficiency. For motion planning, a Dynamic Temperature Simplified Transition Adaptive Cost Bidirectional Transition-Based Rapidly Exploring Random Tree (DSA-BiTRRT) algorithm was developed, demonstrating significant improvements in the path planning performance. The adaptive soft gripper was evaluated for its detachment and load-bearing capacities. Field experiments revealed that the direct-pull method at 150 mN·m torque outperformed the rotation-pull method at both 100 mN·m and 150 mN·m. A custom control system integrating all components was validated in partially controlled orchards, where obstacle clearance and thinning were conducted to ensure operation safety. Tests conducted on 80 apples showed a 52.5% detachment success rate and a 47.5% overall harvesting success rate, with average detachment and full-cycle times of 7.7 s and 15.3 s per apple, respectively. These results highlight the system’s potential for advancing robotic fruit harvesting and contribute to the ongoing development of autonomous agricultural technologies. Full article

Autosomal recessive types of both syndromic and non-syndromic inherited myopia are common in Saudi Arabia (SA) because many people marry their relatives. The prevalence of syndromic myopathies in SA, like Stickler syndrome (SS), Knobloch syndrome (KS), and Marfan syndrome (MFS), further complicates the disease spectrum. The causative genes linked to the Knobloch, Marfan, and Pierson syndromes are COL18A1, FBN1, and LAMB2, respectively. Additionally, we found recessive types of non-syndromic high myopia that have a high chance of causing retinal detachment, like those linked to LRPAP1 and LEPREL1. In these cases, regular evaluation and early intervention, including prophylactic laser photocoagulation and pars plana vitrectomy, may improve the outcome. Advancements in genetic testing for diagnosis and prevention accelerate detection, facilitate early interventions, and provide genetic counseling. The utilization of artificial intelligence (AI), machine learning (ML), and the advancement of gene therapy offer promising avenues for personalized care. We place a high value on using genetic knowledge to create a national screening program and patient registry aimed at understanding the national burden of myopia, knowing that we have a high rate of consanguinity, which reflects pathogenic homozygous alleles and founder mutations. This initiative will incorporate genetic counseling and leverage innovative technologies, which are crucial for disease management, early identification, and prevention in Saudi Arabia’s healthcare system. Full article

In tight sandstone gas reservoirs, proppant flowback severely limits stable gas production. This study uses laboratory flowback experiments and field analyses of the ShaXimiao tight sandstone in the Wenxing gas area to investigate the mechanisms controlling sand production. The experiments show that displacing fluid viscosity significantly affects the critical sand-flow velocity: with high-viscous slickwater (5 mPa·s), the critical velocity is 66% lower than with low-viscous formation water (1.15 mPa·s). The critical velocity for coated proppant is three times that of the mixed quartz sand and coated proppant. If the confining pressure is maintained, but the flow rate is further increased after the proppant flowback, a second instance of sand production can be observed. X-ray diffraction (XRD) tests were conducted for sand produced from practical wells to help find the sand production reasons. Based on experimental and field data analysis, sand production in Well X-1 primarily results from proppant detachment during rapid shut-in/open cycling operations, while in Well X-2, it originates from proppant crushing. The risk of formation sand production is low for both wells (the volumetric fraction of calcite tested from the produced sands is smaller than 0.5%). These findings highlight the importance of fluid viscosity, proppant consolidation, and pressure management in controlling sand production. Full article

Enhanced oil recovery (EOR) via CO₂ flooding is a promising strategy for improving hydrocarbon recovery and carbon sequestration, yet the influence of pH on solid–liquid interfacial interactions in quartz-dominated reservoirs remains poorly understood. This study employs molecular dynamics (MD) simulations to investigate the pH-dependent adsorption behavior of crude oil components on quartz surfaces and its impact on CO₂ displacement mechanisms. Three quartz surface models with varying ionization degrees (0%, 9%, 18%, corresponding to pH 2–4, 5–7, and 7–9) were constructed to simulate different pH environments. The MD results reveal that aromatic hydrocarbons exhibit significantly stronger adsorption on quartz surfaces at high pH, with their maximum adsorption peak increasing from 398 kg/m³ (pH 2–4) to 778 kg/m³ (pH 7–9), while their alkane adsorption peaks decrease from 764 kg/m³ to 460 kg/m³. This pH-dependent behavior is attributed to enhanced cation–π interactions that are facilitated by Na⁺ ion aggregation on negatively charged quartz surfaces at high pH, which form stable tetrahedral configurations with aromatic molecules and surface oxygen ions. During CO₂ displacement, an adsorption–stripping–displacement mechanism was observed: CO₂ first forms an adsorption layer on the quartz surface, then penetrates the oil phase to induce the detachment of crude oil components, which are subsequently displaced by pressure. Although high pH enhances the Na⁺-mediated weakening of oil-surface interactions, which leads to a 37% higher diffusion coefficient (8.5 × 10⁻⁵ cm²/s vs. 6.2 × 10⁻⁵ cm²/s at low pH), the tighter packing of aromatic molecules at high pH slows down the displacement rate. This study provides molecular-level insights into pH-regulated adsorption and CO₂ displacement processes, highlighting the critical role of the surface charge and cation–π interactions in optimizing CO₂-EOR strategies for quartz-rich reservoirs. Full article

As major bleaching continues to ravage reefs worldwide, there is an urgent need for active coral restoration. However, the high cost of such a project is inhibitive for many countries. Here, we introduce a cost-effective design for Acropora robusta and Acroporavalenciennesi coral gardening through fragmentation and direct transplantation. Implemented off Boundary Island, Hainan Province, China, the project demonstrated high coral survival rates (>94%) at a reduced cost of USD 2.50 per coral after 246 days, besides exhibiting an efficient outplanting rate at 30 coral h⁻¹ person⁻¹. Growth monitoring suggested that the transplanted Acropora spp. follow an exponential growth model over time. Initial fragment size did not seem to affect the growth rate of outplanted Acropora spp., although a weak negative correlation was found at day 246 for A. robusta. Finally, the design used in this study employs detachable steel grid nurseries and is plastics-free, ensuring sustainability and adaptability to different reef conditions, and thus providing a promising strategy for affordable coral reef restoration. Full article

This study presents a comparative analysis of the water droplet erosion resistance of three compressor wheels coated with Ni-P and Si-P layers. The tests were conducted using a custom-developed experimental apparatus in accordance with the ASTM G73-10 standard. The degree of erosion was monitored through continuous precision mass measurements, and structural changes on the surfaces of both the base materials and the coatings were examined using a Zeiss Crossbeam 350 scanning electron microscope (SEM). Hardness values were determined using a Vickers KB 30 hardness tester, while the chemical composition was analysed using a WAS Foundry Master optical emission spectrometer. Significant differences in erosion resistance were observed among the various compressor wheels, which can be attributed to differences in coating hardness values, as well as to the detachment of the Ni-P layer from the base material under continuous erosion. In all cases, water droplet erosion led to a reduction in the isentropic efficiency of the compressor—measured using a hot gas turbocharger testbench—with the extent of efficiency loss depending upon the type of coating applied. Although blade protection technologies for turbocharger compressor impellers used in the automotive industry have been the subject of only a limited number of studies, modern technologies, such as the application of certain alternative fuels and exhaust gas recirculation, have increased water droplet formation, thereby accelerating the erosion rate of the impeller. The aim of this study is to evaluate the resistance of three different coating layers to water droplet erosion through standardized tests conducted using a custom-designed experimental apparatus. Full article

Efficient and low-loss harvesting methods are crucial for preserving the postharvest quality of the first crop of goji berries grown in saline–alkali soils. However, as a brittle horticultural fruit rich in diverse bioactive compounds, goji berries are highly vulnerable to mechanical damage during harvesting, which adversely affects their storability and subsequent processing. To address this challenge, a multi-degree-of-freedom vibration model was developed based on the growth characteristics of first-crop organic goji berry fruit-bearing branches in the Qinghai region. The dynamic response of the branches under various excitation conditions was simulated, and the effects of excitation position, frequency, force amplitude, and phase angle on the fruit detachment rate, impurity rate, and breakage rate were systematically analyzed. Based on both the simulation and experimental results, a response surface methodology (RSM) was employed to optimize the picking parameters. The results of the field experiment showed that under the optimal conditions of vibration excitation in the ripe fruit area, a frequency of 5.7 Hz, an amplitude of excitation force of 0.27 N, a phase angle of 135°, a fruit picking rate of 97.58%, a miscellaneous content rate of 5.12%, and a breakage rate of 7.66% could be realized. The results of this study help to maintain the postharvest quality of first-crop goji berry fruits in saline–alkali land, and also provide a theoretical basis and practical reference for the optimization of first-crop goji berry harvesting equipment. Full article

Aeration used in wastewater treatment is energy-intensive, subsequently increasing the cost of treatment. Aeration is used to supply oxygen that is required for bacterial metabolism that degrades organic compounds in wastewater. In this review, we will focus on the effect of aeration rates on the performance of biofilm-based technologies for wastewater treatment and the evaluation of the oxygen transfer rate (OTR) of these technologies. The performance of biofilm reactors in terms of removal efficiency increases with air flow rate, as increased flow helps to increase the contact area between wastewater and the biofilm on the carrier. The same is true for the OTR due to the greater availability of oxygen at higher airflow rates. Excessive aeration can negatively affect wastewater treatment through biofilm shearing and detachment from the carrier. Through a critical review of these technologies, the optimal air flow rate and aeration methods can be determined in biofilm reactors to improve the quality of the treated water, increase the efficiency of the aeration system, and attain energy savings. Full article

Background/Objectives: Different surgical techniques are available in cases of missing or insufficient capsular bag support. Next to the anterior chamber or iris-fixated intraocular lenses (IOL), the implantation of the Carlevale IOL provides a sutureless and scleral fixated treatment method. Methods: In a retrospective single-center study, the perioperative data of 100 patients who consecutively received a scleral fixated Carlevale IOL combined with a 25 gauge (G) pars plana vitrectomy between September 2021 and June 2024 were investigated. The intraoperative and postoperative results were analyzed in terms of complication rates and refractive outcomes. Results: IOL dislocation was the most common surgical indication (50%) for sutureless Carlevale IOL implantation, followed by postoperative aphakia in 35 patients (35%). Nearly every fourth patient (24%) had a preoperative traumatic event, and 21% had pseudoexfoliation (PEX) syndrome. The average surgery time was 60.2 (±20.1) min. Intraoperative intraocular hemorrhage occurred in seven cases, and IOL haptic breakage in two patients. Temporary intraocular pressure fluctuations represented the most common postoperative complications (28%). Severe complications such as endophthalmitis or retinal detachment were not observed in our cohort. The mean refractive prediction error was determined in 67 patients and amounted to an average of −0.7 ± 2.0 diopters. The best corrected visual acuity (BCVA) at the last postoperative follow-up showed an improvement of 0.2 ± 0.5 logMAR (n = 76) compared to the preoperative BCVA (p = 0.0002). The postoperative examination was performed in 72% of the patients, and the mean follow-up period amounted to 7.2 ± 6.4 months. Conclusions: Overall, sutureless and scleral fixated implantation of the Carlevale IOL represents a valuable therapeutic option in the treatment of aphakia and lens as well as IOL dislocation in the absence of capsular bag support with minor postoperative complications and positive refractive outcomes. Full article

This study investigates the fracture toughness of adhesive joints between carbon fiber-reinforced polymer composites (CFRP) and boron-alloyed high-strength steel under Mode I and II loading, based on linear elastic fracture mechanics (LEFM). Two adhesive types were examined: the excess resin from the prepreg composite, forming a thin layer, and a toughened structural epoxy (Sika Power-533), designed for the automotive industry, forming a thick layer. Modified double cantilever beam (DCB) and end-notched flexure (ENF) specimens were used for testing. The results show that using Sika Power-533 increases the critical energy release rate by up to 30 times compared to the prepreg resin, highlighting the impact of adhesive layer thickness. Joints with the thick Sika adhesive performed similarly regardless of whether uncoated or Al–Si-coated steel was used, indicating the composite/Sika interface as the failure point. In contrast, the thin resin adhesive layer exhibited poor bonding with uncoated steel, which detached during sample preparation. This suggests that, for thin layers, the resin/steel interface is the weakest link. These findings underline the importance of adhesive selection and layer thickness for optimizing joint performance in composite–metal hybrid structures. Full article

Background: Intra-arterial chemotherapy (IAC) is increasingly useful for treating intraocular retinoblastoma (Rb). It offers targeted delivery of chemotherapy with reduced systemic exposure. In this study, we evaluate management outcomes and identify predictive factors for globe salvage following IAC in children with Rb. Methods: This retrospective study included 20 eyes of 20 melphalan-based IAC-treated patients (67 sessions) between 2015 and 2023 in a tertiary cancer center (King Hussein Cancer Center) in Jordan. Data collection included patients’ demographics, tumor staging, eye salvage, complications, and survival, followed by statistical comparisons between eye salvage rates and clinical factors. Results: The median age of IAC initiation was 38 months (range: 6–78 months). IAC was used as a primary treatment in 35% (7/20) of eyes and as a secondary treatment following systemic chemotherapy in 65% (13/20) of eyes. Nineteen (95%) eyes showed initial tumor regression, 15 (75%) eyes showed short term tumor control, and long-term eye salvage was achieved in 11 (55%) eyes. Poor prognostic factors for eye salvage included advanced tumor stage (Group D/E: 43% salvage rate vs. Group C: 83%; p = 0.047), vitreous seeding at the time of IAC (38% with seeding vs. 75% without; p = 0.046), use of IAC as a secondary rather than a primary treatment (46% vs. 71%; p = 0.047), and the need for >3 IAC cycles (20% success with >3 cycles vs. 67% with ≤3 cycles; p = 0.034). Complications were notable: systemic adverse effects were seen in five (25%) patients, including neutropenia (20%) and bronchospasm (6%). Procedure-related complications were seen with 22% of injections, including failure of the procedure (7%), ophthalmic artery spasm (6%), and intra-procedural stroke (3%). Five (25%) eyes developed ocular complications, including vitreous hemorrhage (15%), retinal detachment (10%), optic atrophy (10%), and retinal or choroidal ischemia (10%). Notably, all infants under 12 months of age (4/4) developed complications, including the two events of stroke. At a median follow-up of 60 months, eye salvage was achieved in 11 (55%) eyes, and none of the 9 (45%) enucleated eyes showed high-risk pathological features. There was no orbital recurrence, and one (5%) child developed CNS metastasis and passed away. Conclusion: IAC achieves long-term globe salvage in 55% of Rb cases; however, outcomes are poorer with Group D/E tumors, vitreous seeds, prior IVC failure, or requiring >3 IAC cycles. While reducing systemic chemotherapy toxicity, IAC carries significant risks of vision- and life-threatening complications. Infants and single-eyed patients require particularly cautious consideration. Though IAC remains crucial for globe preservation, optimal implementation demands improved patient selection criteria, multicenter collaboration, and long-term outcome studies to maximize safety and efficacy. Full article