Search Results (840)

To enhance the performance of online food delivery (OFD) services, it is essential to strengthen consumers’ intentions to use OFD apps, which are the core interface of this business. Accordingly, this study aims to identify the cognitive mechanisms that shape consumers’ intentions to use OFD apps and explore strategies to encourage their adoption. To achieve this, the study develops a research model that incorporates segmented dimensions of service convenience as key motivational factors, along with variables from the Technology Acceptance Model (TAM). A survey was conducted among OFD consumers in China, and the proposed research model was empirically tested using data from 478 valid responses. The analysis revealed that all six dimensions of service convenience serve as significant motivational drivers of OFD app usage. Furthermore, the study demonstrates that consumers’ coupon proneness and user-generated online reviews have significant moderating effects that reinforce the mechanism by which consumers adopt and use OFD apps. The findings and implications discussed in this study are expected to provide valuable insights and practical guidance for formulating effective strategies to promote more active consumer engagement with OFD apps in the future. Full article

This study comprehensively compares the performance of two non-destructive testing (NDT) techniques—active thermography (AT) and digital shearography (DS)—for identifying various damage types in composite structures. Three distinct composite specimens were inspected: a carbon-fiber-reinforced polymer (CFRP) plate with flat-bottom holes, an aluminum honeycomb core sandwich plate with a circular skin-core disbond, and a CFRP plate with two low-energy impacts damage. The research highlights the significant role of post-processing methods in enhancing damage detectability. For AT, algorithms such as fast Fourier transform (FFT) for temperature phase extraction and principal component thermography (PCT) for identifying significant temperature components were employed, generally making anomalies brighter and easier to locate and size. For DS, a novel band-pass filtering approach applied to phase maps, followed by summing the filtered maps, remarkably improved the visualization and precision of damage-induced anomalies by suppressing background noise. Qualitative image-based comparisons revealed that DS consistently demonstrated superior performance. The sum of DS filtered phase maps provided more detailed and precise information regarding damage location and size compared to both pulsed thermography (PT) and lock-in thermography (LT) temperature phase and amplitude. Notably, DS effectively identified shallow flat-bottom holes and subtle imperfections that AT struggled to clearly resolve, and it provided a more comprehensive representation of the impacts damage location and extent. This enhanced capability of DS is attributed to the novel phase map filtering approach, which significantly improves damage identification compared to the thermogram post-processing methods used for AT. Full article

The simulation analysis of a novel stay-in-place formwork (SIPF) beam reinforced with perforated steel pipe skeleton was conducted. The SIPF beam consists of a modified magnesium oxysulfide mortar (MMOM) formwork, a square steel pipe skeleton with holes dug on the sides and top, and cast-in-place concrete. The finite element (FE) analysis model of the SIPF beam was established by using the ABAQUS CAE 2021 software, and simulation analysis was conducted with the shear span ratio (SSR), the distance between the remaining steel strips, and the strength of concrete as the variation parameters. The results show that the stiffness and shear capacity of the SIPF beam decrease with the increase in SSR and increase with the decrease in strip spacing. Under the same conditions, when the concrete strength grade is increased from C30 to C50, the shear bearing capacity of the SIPF beam increases by 11.8% to 16.2%. When the spacing of the steel strips is reduced from 200 mm to 150 mm, the shear bearing capacity can be increased by 12.7% to 31.5%. When the SSR increases from 1.5 to 3.0, the shear bearing capacity decreases by 26.9% to 37.3%. Moreover, with the increase in the SSR, the influence of the steel strip spacing on the shear bearing capacity of the SIPF beam improves, while the influence of the concrete strength on the shear bearing capacity decreases. Taking parameters such as SSR, steel strip spacing, and concrete strength as variables, the influence of steel pipe constraining the core concrete on the shear bearing capacity was considered. The calculation formula for the shear bearing capacity of the SIPF beam with perforated steel pipe skeleton was established. The calculation results fit well with the laboratory test and simulation test results and can be used for the design and calculation of engineering structures. Full article

Historic cities across the globe have experienced profound changes in their spatial and functional characteristics over time, and the historic core of Patan, Nepal, is no exception. The area surrounding Patan Durbar Square was designated as a UNESCO World Heritage Site in 1979. Between 2003 and 2007, the Kathmandu Valley was placed on UNESCO’s List of World Heritage in Danger, largely due to various factors, including the rapid and unsympathetic transformation of its buffer zone. This study focuses on the Nagbahal neighborhood, a culturally significant locality within this buffer area, to explore a community-rooted and sustainable approach to conservation. Employing a mixed-methods research design, the study integrates qualitative and quantitative data gathered through interviews and surveys of native residents. It investigates the drivers and impacts of changes in the function, ownership, and physical form of traditional residential buildings, and assesses whether these changes align with principles of sustainable heritage conservation—social, cultural, economic, and environmental. While challenges persist, including the proliferation of reinforced concrete structures and limited enforcement of heritage policies, the findings reveal that Nagbahal remains resilient due to strong local traditions, active religious institutions, and cohesive social practices. The study offers transferable lessons for sustainable conservation in living heritage buffer zones globally. Full article

Background/Objectives: Motor creativity is a vital component of preschoolers’ growth and development. However, its underlying determinants remain largely underexplored. This study investigates the interrelationship among playful behavior, social profile, and motor creativity in preschool children, emphasizing its implications for holistic health and development. Methods: A total of 200 children and their kindergarten teachers from Greece participated in the study. The Children’s Playfulness Scale (CPS) was employed to assess the children’s playfulness, while a sociometric test was used to evaluate their social standing within peer groups. Motor creativity was measured through TCAM, a performance-based test focusing on fluency, imagination, and originality. Results: The findings revealed that the dimensions of playful behavior, particularly motor and social playfulness, significantly and positively influenced motor creativity, a core component of physical and mental health in early childhood. Conversely, certain aspects of social behavior had a negative association with imaginative capacities. Conclusions: The study underscores the critical role of movement-based playful activities in fostering children’s physical, emotional, cognitive, and social health. It highlights the need for educators to design developmentally appropriate motor play activities that cultivate creativity and social integration, promoting a balanced and health-oriented early education framework. The results contribute to educational policy and practice by reinforcing the importance of structured motor play in supporting preschoolers’ well-being and comprehensive development. Full article

Intimal hyperplasia (IH) compromises the patency of arteriovenous fistula (AVF) vascular access in patients with end-stage kidney disease. Uncontrolled cell proliferation and migration, driven by inflammation, shear stress and surgery, are well-known triggers in IH. Recently, microRNAs (miRNAs) have emerged as regulators of core mechanisms in cardiovascular diseases and as potential markers of IH. This study was aimed at identifying a specific miRNA panel in failed AVFs and clarifying the miRNA involvement in IH. miRNA profiling performed in tissues from patients with IH (AVFs) and normal veins (NVs) highlighted a subset of four miRNAs significantly deregulated (hsa-miR-155-5p, hsa-miR-449a-5p, hsa-miR-29c-3p, hsa-miR-194-5p) between the two groups. These miRNAs were analyzed in tissue-derived cells (NVCs and AVFCs), human aortic smooth muscle cells (HAOSMCs) and human umbilical vein endothelial cells (HUVECs). The panel of hsa-miR-449a-5p, hsa-miR-155-5p, hsa-miR-29c-3p and hsa-miR-194-5p was up-regulated in AVFCs, HAOSMCs and HUVEC under inflammatory stimuli. Notably, overexpression of hsa-miR-449a-5p exacerbated the proliferative, migratory and inflammatory features of AVFCs. In vitro pharmacological modulation of these miRNAs with pioglitazone, particularly the down-regulation of hsa-miR-155-5p and hsa-miR-29c-3p, suggested their involvement in IH pathogenesis and a potential translational application. Overall, these findings provide new insights into the pathogenesis of AVF failure, reinforcing the miRNA contribution to IH detection and prevention. Full article

This study examined the dynamic interconnectedness and portfolio implications within the cryptocurrency ecosystem, focusing on five representative digital assets across the core functional categories: Layer 1 cryptocurrencies (Bitcoin (BTC) and Ethereum (ETH)), decentralized finance (Uniswap (UNI)), stablecoins (Dai), and crypto infrastructure tokens (Maker (MKR)). Using the Extended Joint Connectedness Approach within a Time-Varying Parameter VAR framework, the analysis captured time-varying spillovers of return shocks and revealed a heterogeneous structure of systemic roles. Stablecoins consistently acted as net absorbers of shocks, reinforcing their defensive profile, while governance tokens, such as MKR, emerged as persistent net transmitters of systemic risk. Foundational assets like BTC and ETH predominantly absorbed shocks, contrary to their perceived dominance. These systemic roles were further translated into portfolio design, where connectedness-aware strategies, particularly the Minimum Connectedness Portfolio, demonstrated superior performance relative to traditional variance-based allocations, delivering enhanced risk-adjusted returns and resilience during stress periods. By linking return-based systemic interdependencies with practical asset allocation, the study offers a unified framework for understanding and managing crypto network risk. The findings carry practical relevance for portfolio managers, algorithmic strategy developers, and policymakers concerned with financial stability in digital asset markets. Full article

In order to verify the rationality and feasibility of a demountable and replaceable fabricated RC beam with bolted connection under mid-span compression, one cast-in-place RC beam and four fabricated RC beams were designed and fabricated. Through the mid-span static loading test and analysis of five full-scale RC beams, the effects of high-strength bolt specifications and stiffeners were compared, and the behavior of the fabricated RC beams with bolted connections was analyzed. The test process was observed and the test results were analyzed. The failure mode, cracking load, yield load, ultimate load, stiffness change, deflection measured value, ductility, and other indicators of the specimens were compared and analyzed. It was shown that the failure mode of the fabricated RC beam was reinforcement failure, which met the three stress stages of the normal section bending of the reinforcement beam. The failure position occurred at 10~15 cm of the concrete outside the bolt connection, and the beam support and the core area of the bolt connection were not damaged. The fabricated RC beam has good mechanical performance and high bearing capacity. In addition, comparing the test value with the simulation value, it is found that they are in good agreement, indicating that ABAQUS software of 2024 can be well used for the simulation analysis of the behavior of fabricated RC beam structure. Full article

Background/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. Methods: To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted. A total of 53,670 documents were retrieved related to opioid scientific production, among which 1423 articles (3%) focused specifically on fentanyl. The 21,546 MeSH terms identified in these documents were analysed by publication year and specific fields: Psychiatry and Psychology, Chemicals and Drugs, Healthcare, Diseases, and Phenomena and Processes. R-statistical/FactoMineR libraries were used for the correspondence analysis. Results: In the first overdose death wave, research focused on improving therapies and reducing side effects. The second wave emphasised detoxification methods with naltrexone, methadone, and behavioural therapies. The third wave addressed psychological treatments and HIV-syringe-sharing prevention. The fourth wave prioritised less addictive analogues and understanding consumer profiles to combat the epidemic. Conclusions: Fentanyl research has evolved alongside real-world challenges, reinforcing the connection between patients’ needs, healthcare professionals’ roles, illicit users, policymakers, and the research community’s contributions to addressing both therapeutic use and its broader societal impact. These findings highlight the necessity for an interdisciplinary approach to scientific research integrating prevention, treatment, education, legal reform, and social support, emphasising the need for public health policies and collaborative research to mitigate its impact. Full article

The human PrimPol counteracts DNA replication stress by repriming DNA synthesis when fork progression is hindered by UV light or hydroxyurea treatment, or by encountering complex DNA structures, such as G-quadruplexes, R-loops, or interstrand crosslinks. The Mus musculus PrimPol (MmPrimPol) shares a high degree of amino acid similarity with its human ortholog; however, as shown here, MmPrimPol exhibits a more powerful primase activity compared to the human enzyme. Such a robust primase activity relies on an enhanced ability to bind the 5′ site nucleotide, and consequently to form initial dimers and further mature primers. Additionally, a shorter linker between the AEP core and the Zn finger domain (ZnFD) in the murine homolog likely promotes a constitutive closing of these domains into a primase-ready configuration. Consequently, a reinforced close configuration of the ZnFD would explain why MmPrimPol has a more robust primase, but a very limited DNA polymerization on an existing primer. Full article

A synthesis of substituted 1,4-benzodiazepines has been developed via palladium-catalyzed cyclization of N-tosyl-disubstituted 2-aminobenzylamines with propargylic carbonates. The reaction proceeds through the formation of π-allylpalladium intermediates, which undergo intramolecular nucleophilic attack by the amide nitrogen to afford seven-membered benzodiazepine cores. In reactions involving unsymmetrical diaryl-substituted carbonates, regioselectivity was observed to favor nucleophilic attack at the alkyne terminus substituted with the more electron-rich aryl group, suggesting that electronic effects play a key role in determining product distribution. The versatility of this reaction was further demonstrated by constructing a benzodiazepine framework found in bioactive molecules, indicating its potential utility in medicinal chemistry. Mechanistic insights supported by stereochemical outcomes and X-ray crystallographic analysis of key intermediates reinforce the proposed reaction pathway. This palladium-catalyzed protocol thus offers an efficient and practical approach to access structurally diverse benzodiazepine derivatives. Full article

The Republican era of China witnessed three primary positions regarding Buddhist monastic robe reform. Taixu advocated preserving canonical forms (法服) for ritual garments while adapting regular robes (常服) to contemporary needs; Dongchu proposed diminishing ritual distinctions by establishing a tripartite hierarchical system—virtue-monk robes (德僧服), duty-monk robes (職僧服), and scholar-monk robes (學僧服); and Lengjing endorsed the full secularization of monastic robes. As a reformist leader, Taixu pursued reforms grounded in both doctrinal authenticity and contextual responsiveness. His initial advocacy for robe modifications, however, rendered him a target for traditionalists like Cihang, who conflated his measured approach with the radicalism of Dongchu’s faction. Ultimately, the broader Buddhist reform collapsed, with robe controversies serving as a critical lens into its failure. The reasons for its failure include not only wartime disruption and inadequate governmental support, but also the structural disadvantages of the reformists compared to the traditionalists, which proved decisive. This was due to the fact that the traditionalists mostly controlled monastic economies, wielded institutional authority, and commanded discursive hegemony, reinforced by lay Buddhist alignment. These debates crystallize the core tension in Buddhist modernization—the dialectic between “disenchantment” and “preservation of monastic discipline”. This dynamic of negotiated adjustment offers a vital historical framework for navigating contemporary Buddhism’s engagement with modernity. Full article

This review provides a comprehensive analysis of the transformative impact of artificial intelligence (AI) and machine learning (ML) on modern drug design, specifically focusing on how these advanced computational techniques address the inherent limitations of traditional small-molecule drug design methodologies. It begins by outlining the historical challenges of the drug discovery pipeline, including protracted timelines, exorbitant costs, and high clinical failure rates. Subsequently, it examines the core principles of structure-based virtual screening (SBVS) and ligand-based virtual screening (LBVS), establishing the critical bottlenecks that have historically impeded efficient drug development. The central sections elucidate how cutting-edge ML and deep learning (DL) paradigms, such as generative models and reinforcement learning, are revolutionizing chemical space exploration, enhancing binding affinity prediction, improving protein flexibility modeling, and automating critical design tasks. Illustrative real-world case studies demonstrating quantifiable accelerations in discovery timelines and improved success probabilities are presented. Finally, the review critically examines prevailing challenges, including data quality, model interpretability, ethical considerations, and evolving regulatory landscapes, while offering forward-looking critical perspectives on the future trajectory of AI-driven pharmaceutical innovation. Full article

Knowing the configuration of psychopathological dimensions in patients according to suicidal ideation in an applied context is fundamental in clinical approaches. A cross-sectional and retrospective single-measurement study was carried out in 625 patients of the University Psychology Clinic of the Complutense University of Madrid (CUP-UCM) divided into two groups: with and without suicidal ideation. Network analysis was used as the main methodology. Anxiety and interpersonal variables appeared as core symptoms of the group with suicidal ideation, reinforcing theoretical models where the social component is a key part of present suicidal ideation. Even though the configuration of networks was not significantly different between the two groups, the severity of symptoms in the group with suicidal ideation was higher. In the predictive analyses, depressive symptoms, hostility, somatization, paranoid ideation, and psychoticism were independently associated with suicidal ideation. This result highlights the complex and multidimensional nature of suicide risk, which cannot be fully explained by depressive symptoms alone. Anxiety and interpersonal variables stand out as core symptoms with influence on others, which may guide clinicians in prioritization in therapeutic goals. Full article

Technology roadmapping is conducted by systematic mapping of technological evolution through patent analytics to inform innovation strategies. This study proposes an integrated framework combining hierarchical Latent Dirichlet Allocation (LDA) modeling with multiphase technology lifecycle theory, analyzing 113,449 Derwent patent abstracts (2008–2022) across three dimensions: technological novelty, functional applications, and competitive advantages. By segmenting innovation stages via logistic growth curve modeling and optimizing topic extraction through perplexity validation, we constructed dynamic technology roadmaps to decode latent evolutionary patterns in AI-powered programmable manipulators (B25J classification) within an innovation trajectory. Key findings revealed: (1) a progressive transition from electromechanical actuation to sensor-integrated architectures, evidenced by 58% compound annual growth in embedded sensing patents; (2) application expansion from industrial automation (72% early stage patents) to precision medical operations, with surgical robotics growing 34% annually since 2018; and (3) continuous advancements in adaptive control algorithms, showing 2.7× growth in reinforcement learning implementations. The methodology integrates quantitative topic modeling (via pyLDAvis visualization and cosine similarity analysis) with qualitative lifecycle theory, addressing the limitations of conventional technology analysis methods by reconciling semantic granularity with temporal dynamics. The results identify core innovation trajectories—precision control, intelligent detection, and medical robotics—while highlighting emerging opportunities in autonomous navigation and human–robot collaboration. This framework provides empirically grounded strategic intelligence for R&D prioritization, cross-industry investment, and policy formulation in Industry 4.0. Full article