Search Results (11,517)

Background: Nursing homes are congregate settings for elderly individuals where infectious diseases can easily spread. The elderly are at high risk of contracting and dying from influenza, and the most effective way to prevent this is to receive the influenza vaccine. Methods: This study conducted a cross-sectional survey of elderly people in nursing homes to investigate the occurrence of influenza symptoms during the 2024–2025 flu season, as well as vaccination status and reasons for receiving or not receiving the vaccine. Bivariate logistic regression was used to determine the factors influencing the vaccination rate. Results: Of the 1024 elderly people who participated in the survey, 25.39% reported experiencing flu-related symptoms in the previous flu season. While 16.21% of the elderly expressed willingness to receive vaccination, only 5.57% actually received it. Influenza vaccination was positively correlated with educational attainment (aOR 3.800, 95% CI 1.480–9.758 for middle school; aOR 5.138, 95% CI 1.738–15.191 for high school), monthly household income (aOR 0.216, 95% CI 0.072–0.644 for >8000), ability for self-care (aOR 0.269, 95% CI 0.123–0.591), and the scale of the nursing home (aOR 9.033, 95% CI 1.531–53.305 for 151–299; aOR 2.629, 95% CI 1.359–5.084 for ≥300). Willingness to receive the influenza vaccination was positively correlated with an unhealthy health status (aOR 0.398, 95% CI 0.204–0.779), symptoms of influenza (aOR 2.730, 95% CI 1.861–4.007), nursing home location (aOR 1.537, 95% CI 1.099–2.941 for outer suburbs), and the scale of the nursing home (aOR 1.991, 95% CI 1.154–3.435 for 151–299; aOR 2.158, 95% CI 1.374–3.390 for ≥300). Most elderly people who received the vaccine believed that vaccination could effectively prevent flu and that it could reduce the risk of complications, the rest were not vaccinated due to concerns about adverse reactions, mobility issues, or the distance to vaccination sites. Conclusions: Low awareness of flu vaccines and physical inability to travel to vaccination sites may be potential barriers to receiving the flu vaccine. It is worrying that the influenza vaccination rate is low among the elderly in nursing homes in Shanghai. As a result, it is crucial to prioritize targeted monitoring and intervention strategies for vulnerable populations living in collective institutions. Full article

Background/Objectives: Osteoporosis and osteoarthritis are age-related musculoskeletal disorders with a high socio-health burden, affecting both healthcare systems and individuals’ quality of life. Both conditions are generally accompanied by a concomitant decline in muscle mass and strength, referred to as sarcopenia. In this context, tensiomyography emerges as a novel, non-invasive potential diagnostic strategy for assessing muscle quality, as this parameter influences the progression of both conditions. Methods: Histomorphometric and immunohistochemical analyses were performed on vastus lateralis muscle tissue obtained from patients undergoing surgery for femoral fracture affected by osteoporosis or osteopenia, patients operated for hip osteoarthritis, and patients undergoing hip arthroplasty for osteoarthritis, concomitantly affected by osteoporosis or osteopenia. In addition, muscle function was assessed in these patients using tensiomyographic analysis. Results: In osteoarthritic, osteoporotic, and osteopenic patients, a reduction in muscle quality and function was observed compared with the other two experimental groups, indicating an unfavorable effect of the coexistence of the two conditions on the muscular component. Furthermore, contraction time (Tc) measured by tensiomyography was negatively correlated with lumbar spine bone mineral density values and positively correlated with the percentage of type II muscle fibers. Conclusions: This study highlights how tensiomyography may represent a valuable non-invasive diagnostic strategy for assessing muscle status in osteoporotic and osteoarthritic patients, as it is able to detect muscle alterations that parallel the worsening of bone status and that cannot be inferred from simple biopsy analysis. Thus, tensiomyography could be considered a practical adjunct tool in the clinical assessment of musculoskeletal frailty. Full article

Rural property rights reform is considered paramount for mobilizing land resources and promoting rural entrepreneurship. However, the outcomes of tenure clarification depend on the role of the land in household livelihoods. The study focuses on China’s homestead rights confirmation and examines its effects on farmer entrepreneurship. The analysis is based on data from 2337 households in Jiangsu Province from the 2020 China Land Economic Survey. The application of Probit and endogenous switching Probit models yielded the following finding: confirming homestead rights reduces the probability of farmer entrepreneurship by approximately 11.4 percentage points. This decline can be attributed to several factors, including a decrease in homestead utilization, a shift towards lower-investment-risk preferences, an increase in entrepreneurial risk perception, and a contraction in entrepreneurial social networks. Collectively, these factors contribute to a reshaping of households’ risk evaluation and asset allocation. The negative impact is primarily observed among households with higher dependency ratios, poorer housing conditions, older heads of household, and those residing in less developed areas. The findings indicate that the consequences of property rights confirmation are characterized by institutional and functional specificity, thereby underscoring the necessity for measures that promote land transfer, exit, and risk-sharing to harmonize tenure reform with entrepreneurship. Full article

To overcome active site blockage and poor interfacial contact in traditional syntheses, PtNi bimetallic nanoparticles were grown in situ on a microporous carbon paper via pulse electrodeposition. Firstly, the impact of deposition potential was investigated. The results indicate that the deposition potential significantly modulates the surface Pt⁰/Pt²⁺ ratio; concurrently, a shift toward more negative potentials intensified nanoparticle agglomeration. The effects of the duty cycle were investigated at an optimal deposition potential of −0.95 to −0.4 V. A duty cycle of 30% yielded the optimal Pt⁰/Pt²⁺ ratio. Furthermore, TEM revealed a coexisting strain profile of bulk PtNi lattice contraction and localized expansion at peripheral Pt (111) facets. This synergistic tuning of surface valence and strain optimizes the thermodynamic balance between oxygen adsorption and intermediate desorption on Pt sites. In summary, the optimal catalyst, prepared at a deposition potential of −0.95 V and a duty cycle of 30%, showed the best reaction behavior in the oxygen reduction reaction with an initial onset potential of 0.92 V (vs. RHE). After 5000 cycles of testing, the catalyst showed a constant durability, with the onset potential degrading only marginally to 0.87 V. This work successfully demonstrates that the surface morphology and valence states of the catalyst can be effectively tailored by regulating the pulse voltage and duty cycle. Full article

The Navel Orangeworm (Amyelois transitella Walker, 1863), a primary pest of nut crops native to North America, poses a significant potential threat to China’s agricultural biosecurity, yet its potential distribution dynamics under climate change remain unquantified. This study utilized the Biomod2 ensemble model platform to predict habitat suitability under current and future climate scenarios (SSP1-2.6 and SSP5-8.5). We evaluated the prediction accuracy of the ensemble model using calibration data, with TSS = 0.898 and AUC = 0.978, while spatially stratified cross-validation confirmed moderate spatial transferability to novel environments (median validation AUC = 0.60–0.75). The model identified thermal factors—Temperature Seasonality (Bio4) and the Mean Temperature of the Wettest Quarter (Bio8)—as the dominant drivers of distribution. While currently climatically suitable habitats are primarily confined to the tropical and subtropical regions of southern China, projections indicate a complex spatial shift driven by future warming: optimal southern habitats will undergo a net contraction due to heat stress, whereas low and moderately suitable areas will expand northward into key temperate agricultural areas. These results highlight that climate change will substantially alter the spatial topology of the pest’s climatic envelope, providing a critical scientific baseline of climatic suitability. These projections do not equate to realized invasion risk, which is further constrained by host availability, land use, irrigation, and human transport, offering a conservative framework for prioritizing early surveillance and optimizing quarantine measures. Full article

In patients, extraintestinal manifestations of inflammatory bowel disease (IBD) are attenuated ventricular contractile function and arrhythmia. To determine the mechanism of IBD-induced changes in ventricular function, we used a mouse model of dextran sodium sulfate (3.5% weight/volume; 7 days)-induced colitis. Changes in cardiac function were quantified in isolated ventricular myocytes (VM) by cell shortening, imaging of [Ca²⁺]_i, reactive oxygen species (ROS), and t-tubular density. During colitis, VMs exhibited attenuated cell-shortening and altered Ca²⁺-handling properties. A prolonged Ca²⁺ transient (CaT) rise time correlated with an increased coefficient of variation in the subcellular Ca²⁺ release and an attenuated t-tubular density. T-tubular loss was accompanied by increased ROS production, calpain-2 (CAPN2) expression, junctophilin-2 (JPH-2) cleavage, and autophagy. Inhibition of Angiotensin-converting enzyme during colitis (Perindopril: 3 mg/kg/day) prevented the increase in CAPN2, ROS production, autophagy, and t-tubular remodeling. It failed, however, to restore full length JPH-2. We conclude that, during IBD, the angiotensin II (AngII)-induced loss of t-tubular integrity and altered cellular Ca²⁺ handling can be prevented by suppression of the AngII-dependent increase in CAPN2 and autophagy and thus suppression of AngII signaling might benefit IBD patients with cardiac manifestations of the disease. Full article

The efficient recovery of rare earth elements from associated rare-earth-bearing phosphate ores is of paramount importance for expanding the supply of rare earth resources. In contrast to conventional studies that focus on extracting rare earths either from phosphate concentrates or from phosphogypsum generated during the sulfuric acid wet-process, this study takes as its subject the rare-earth-enriched residue—an intermediate product obtained after the selective leaching of phosphorus via the hydrochloric acid route—from a rare-earth-bearing phosphate ore in Zhijin, Guizhou Province. The occurrence states, leaching behavior, and kinetic mechanisms of rare earth elements within this residue were systematically elucidated. Analyses using scanning electron microscopy coupled with energy-dispersive spectroscopy (SEM–EDS) and aberration-corrected scanning transmission electron microscopy (STEM) reveal that rare earth elements are hosted in residual fluorapatite and newly formed CaF₂ through isomorphic substitution. The substitution of REE³⁺ for Ca²⁺ induces lattice contraction in CaF₂, with the interplanar spacing decreasing from 0.27 nm to 0.26 nm. Through single-factor experiments and response surface methodology (RSM) optimization, the optimal leaching conditions were determined to be a temperature of 80 °C, a leaching time of 120 min, a hydrochloric acid dosage of 160% of the theoretical requirement, a solid–liquid ratio of 1:6, and a agitation speed of 500 r·min⁻¹. Under these conditions, the leaching efficiency of rare earth elements reached as high as 92.69%. Kinetic analysis indicates that the leaching process follows the shrinking-core model, with the rate controlled by diffusion through the solid product layer. The apparent activation energy was calculated to be 37.2 kJ·mol⁻¹, characteristic of a diffusion-controlled process. Furthermore, response surface analysis of variance confirms that leaching temperature and time are the most significant factors influencing rare earth leaching. This study elucidates, from multiple perspectives, the leaching mechanism of rare earth elements from enriched residues within a hydrochloric acid system, thereby providing important theoretical support for the efficient recovery and process optimization of rare earth resources from associated phosphate ores. Full article

At the dawn of the 20th century, seminal studies revealed that muscle fibers produce less heat and generate greater force during elongation than during shortening actions, laying the foundation for contemporary research on eccentric exercise. Today, eccentric exercise is widely used by athletes to enhance strength and by older adults to maintain functional capacity, yet it may cause muscle damage, particularly in unaccustomed muscles. Despite more than a century of investigation, the precise mechanisms of eccentric exercise-induced muscle damage remain incompletely resolved. Nevertheless, eccentric exercise serves as a valuable model for studying muscle injury and repair and adaptation. This review organizes current evidence into nine key themes: (1) eccentric exercise-induced muscle damage and flawed biomarkers, (2) satellite cell-mediated and alternative repair pathways, (3) high-force, low-cost contractions and metabolic impact, (4) repeated bout effect and protective adaptations, (5) architectural remodeling of fascicles, sarcomeres and tendon, (6) distinct neural control, proprioception, and cross-education adaptations, (7) mitochondrial, sarcoplasmic reticulum, and cytoskeletal stress remodeling, (8) connective tissue perturbation, remodeling, and joint stability, and (9) targeted, cautious use of antioxidant supplementation. Rather than offering a comprehensive overview, this review highlights pivotal experiments, concepts, and controversies within these themes to guide readers to the most impactful discoveries in eccentric exercise and muscle damage. Full article

This work aims to introduce the concept of graphic rational contractions in the framework of extended $\mathcal{F}$-metric spaces and to establish fixed point theorems related to these mappings. In addition, we define and examine the class of interpolative Ćirić–Reich–Rus-type cyclic contractions in the same setting, deriving several new fixed point results that broaden existing theories. To illustrate the validity and originality of the obtained results, appropriate examples are presented. Furthermore, the developed theoretical results are applied to study the existence of solutions for fractional differential equations and nonlinear mixed Volterra–Fredholm integral equations, highlighting their effectiveness and practical importance. Full article

In the context of the coordinated development of high-proportion renewable energy integration and alternating current/direct current (AC/DC) hybrid transmission, the sending-end power grid faces challenges such as decreased system strength, contracted stability boundaries, and difficulties in covering high-risk operating conditions. This paper proposes a new renewable energy scale impact analysis method that integrates “typical scenario construction-scale ladder comparison–prediction-driven time series injection” in response to the operational constraints of AC/DC transmission. In terms of method implementation, firstly, a two-layer typical scenario system is constructed under unified transmission constraints and fixed grid boundaries: A regular benchmark scenario covers the main operating range, and a set of high-risk scenarios near the boundaries is obtained through multi-objective intelligent search, which is then refined through clustering to form a computable stress-test scenario library. Here, the boundary scenarios are generated by a multi-objective search that simultaneously drives multiple key section load rates towards their limits, subject to AC power-flow feasibility and operational constraints, and the resulting Pareto candidates are reduced into a compact stress-test library by clustering. Secondly, a ladder scenario with increasing renewable energy scale is constructed, and cross-scale comparisons are carried out within the same scenario system to extract the scale effect and critical laws of key safety indicators. Finally, data resampling and Gated Recurrent Unit multi-step prediction are introduced to generate wind power output time series, enabling the temporal mapping of prediction results to scenario injection quantities, and constructing a closed-loop input interface of “prediction–scenario–grid indicators”. The results demonstrate that the proposed hierarchical framework, under unified AC/DC export constraints, can effectively construct a compact stress-test scenario library with enhanced boundary-risk coverage and can reveal how transient voltage security evolves across renewable expansion scales. By coupling boundary-oriented scenario construction, cross-scale comparable assessment, and forecasting-driven time series injection, the framework improves engineering interpretability and practical applicability compared with conventional scenario sampling/reduction workflows. For the forecasting module, the Gated Recurrent Unit (GRU) model achieves MAPE = 8.58% and RMSE = 104.32 kW on the test set, outperforming Linear Regression (LR)/Random Forest (RF)/Support Vector Regression (SVR) in multi-step ahead prediction. Full article

Climate warming and drought often co-occur to form warm–dry climate patterns. However, systematic comparative studies of the responses of invasive plants from different families to their combined effects remain limited. We conducted a greenhouse experiment to investigate the interactive effects of warm (normal vs. warming) and drought (well-watered vs. drought) conditions on the growth, root traits, and competitive performance of 11 invasive plant species from three families (Amaranthaceae, Poaceae, and Asteraceae) growing in competition with native communities. Our results showed that warming did not significantly increase the total biomass of all invasive species combined but significantly promoted biomass accumulation in Poaceae and Asteraceae. Drought consistently reduced the biomass across all invasive species. Notably, a marginally significant interaction effect of warm and drought conditions on the biomass proportion of Amaranthaceae was detected. Specifically, under normal conditions, drought increased the biomass proportion of Amaranthaceae species, whereas under the warming treatment, drought decreased it. Furthermore, root traits of invasive species exhibited clear family level differentiation. Poaceae adopted an expansion strategy by increasing root length and root surface area under warming treatment, Amaranthaceae exhibited a contraction strategy by reducing root investment under drought treatment, and Asteraceae displayed an efficient strategy with increased specific root length under drought treatment. Except for the biomass proportion of Amaranthaceae, no significant interactive effects were found for most other parameters, indicating that the combined effects of warming and drought were primarily additive. Our results revealed that warm, dry climates influence invasive plants in a taxon-specific manner, with different families employing distinct root trait adjustment strategies in response to environmental stress. These findings highlight the importance of family level comparative studies for predicting invasion dynamics and developing targeted management strategies for future climate scenarios. Full article

Design coordination is a critical process for avoiding spatial conflicts and ensuring design alignment in large-scale construction projects. While Building Information Modelling (BIM) tools have improved coordination through 3D model integration and clash detection, inefficiencies persist due to fragmented workflows, frequent tool switching, and challenges with issue documentation. Cloud-based BIM collaboration tools offer a promising alternative by enabling real-time model sharing, centralized issue tracking, and enhanced stakeholder communication. However, empirical evidence on their practical implementation and effects on coordination processes remains limited. Unlike prior cloud-BIM reviews that focus on technical capabilities or adoption barriers in isolation, this study provides an empirically grounded framework that links specific tool features to observable workflow changes and their downstream impacts on coordination outcomes. This study investigates the impact of cloud-based BIM collaboration tools on the design coordination process, with a focus on issue identification, resolution, and documentation. A framework was developed using a mixed-methods approach comprising action research, an ethnographic case study, and comparative analysis of three large infrastructure projects to categorize workflow changes resulting from tool adoption. The findings indicate that cloud-based BIM tools streamline coordination by reducing manual transitions, automating documentation, and improving information accessibility during meetings. Nevertheless, their effectiveness is constrained by organizational structures and contract limitations. This study provides a validated process-change framework and practical insights for engineering managers seeking to align digital collaboration tools with project delivery strategies, contributing to both theory and practice in BIM-based coordination and digital transformation in the AEC industry. Full article

Pomacea canaliculata, as a significant invasive alien species, poses severe threats to agricultural development. Currently, chemical applications demonstrate notable efficacy in controlling this pest. However, metaldehyde exhibits overly singular toxicity towards P. canaliculata; niclosamide sulfate is not a molluscicide; and fentin acetate is a fungicide. Currently, these findings fail to elucidate the physiological and biochemical effects of the compounds after they enter the P. canaliculata’s body. In this study, we evaluated the toxicity of metaldehyde (ME), niclosamide sulfate (NS), and fentin acetate (FA) against P. canaliculata and analyzed the morphological and physiological changes in response to chemical stress. The results indicated that three chemicals exhibited potent molluscicidal activity, especially in the NS treatment group. After 12 h exposure to LC₅₀ concentrations (48 h LC₅₀), the surface area of livers was reduced significantly by 12.1%, 13.9%, and 2.8% compared to the control group, while the kidneys expanded significantly by 6.4%, 3.2%, and 16.7%, respectively. The heart showed marked enlargement by 152.1% and 44.2% under niclosamide sulfate and metaldehyde treatments. The pulmonary sac significantly contracted by 23.6% under niclosamide sulfate stress but expanded by 6.1% under fentin acetate exposure. The stomach enlarged significantly after niclosamide sulfate treatment, whereas it shrank by 2.1% and 5.7% under metaldehyde and fentin acetate treatments, respectively. Metabolomic analysis of liver tissues revealed 553, 99, and 585 differential metabolites compared to the control group, respectively. KEGG pathway enrichment analysis showed that the metabolism pathway, lysine degradation, and bile secretion are likely related to the response to chemical stress in P. canaliculata. Further examination showed a significant decrease in total protein content and the activities of malondialdehyde (MDA), acetylcholinesterase (AChE), superoxide dismutase (SOD), and catalase (CAT) under chemical stress. These findings enhance our understanding of the targeted mechanisms of molluscicides against P. canaliculata. Metaldehyde may exert neurotoxic effects on the P. canaliculata, while niclosamide sulfate may interfere with its respiratory system. Additionally, both chemicals affect metabolic pathways in the snail’s liver, including lipid metabolism and metabolic pathways associated with energy metabolism. These findings provide valuable insights for designing a novel snail control agent and formulating scientific management strategy. Full article

Takotsubo cardiomyopathy (TCM) is characterized by contractile impairment of the left ventricular apex and excessive contraction of the base of the heart, resulting in transient cardiac dysfunction. Here, we report a case of an implantable cardioverter defibrillator (ICD) that was activated for ventricular fibrillation (VF) caused by TCM one day after removal of maxillomandibular exostoses. The patient was a 53-year-old female who underwent removal of maxillomandibular exostoses in the mid-palate area, bilateral molars of the maxilla, and bilateral mandibular premolars under general anesthesia. Because the patient had a history of VF, an ICD was implanted. Removal was performed without any problems, but VF occurred on the following day, and the ICD was frequently required. Ultrasound examination suggested contractile impairment of the ventricular apex and excessive contraction of the base. Examinations led to a diagnosis of TCM using the Mayo Clinic diagnostic criteria. VF was resolved by administration of amiodarone hydrochloride. The wound in the oral cavity healed favorably, and the patient was discharged from hospital on day 33 without further occurrence of VF. This case highlights important perioperative risk assessment and anesthesia considerations for oral and maxillofacial surgeons managing medically compromised patients undergoing oral surgery. Full article

Declining birth rates are reshaping higher education across East Asia, accelerating the large-scale underutilization and, in some contexts, partial abandonment of university campus assets. Although adaptive reuse has been widely discussed, campus transformation is often framed primarily as a programmatic or policy problem, with limited attention to the inherited spatial logic embedded in campus morphology. This study revisits Le Corbusier’s concept of unlimited growth as a generative framework for campus transformation. Rather than treating it as a museum-specific historical typology, the research reinterprets unlimited growth as a scalable spatial logic defined by modular continuity, circulation hierarchy, and open-ended sequencing. To enhance reproducibility and operational clarity, the study formalizes a typo-morphological decoding protocol—modules, circulation, and growth sequence—and applies it through plan-, section-, and diagram-based analysis. Through comparative examination of three museum precedents—Sanskar Kendra Museum, the National Museum of Western Art (Tokyo), and the Chandigarh Museum and Art Gallery—the study extracts a set of transferable spatial mechanisms: modular increment, circulation-centered ordering, directional displacement, and fifth-façade ecological continuity. These mechanisms are then translated into an operational right-sizing model and tested through a design-operational demonstrator on a single anonymized Taiwanese campus experiencing demographic contraction. The findings indicate that unlimited growth functions not merely as a formal principle but as a spatial governance logic that supports phased consolidation, adaptive recomposition, and system-level coherence under long-term uncertainty. Importantly, this framework contributes to sustainability by reducing land consumption through spatial consolidation, minimizing unnecessary new construction, enabling adaptive reuse of existing campus assets, and improving long-term resource-use efficiency through phased right-sizing and ecological continuity. This study further advances a reproducible, mechanism-based methodological framework for institutional spatial transformation, providing a transferable approach for large-scale campus restructuring under conditions of long-term demographic and environmental uncertainty. Full article