Search Results (3,599)

Silymarin—a standardized extract from the seeds of milk thistle (Silybum marianum L. Gaertn.)—is mainly used for the treatment of hepatitis and other liver diseases. In recent years, the attention of researchers has been directed to its use in dermatology and wound treatment. Despite the promising results, there are still many unresolved issues in this area. The aim of the present study is to develop and characterize hydrogel chitosan–pectin films containing silymarin as an active ingredient with potential medical application. Six variants of hydrogel films (control and silymarin-loaded) were obtained from chitosan and pectin solutions by the casting method and analyzed in terms of their physicochemical, structural, mechanical and optical properties, as well as the in vitro dissolution profile of silymarin. The highest tensile strength was measured for the chitosan-based films—23.35 ± 1.74 MPa (control) and 22.01 ± 2.67 MPa (silymarin-loaded), while the barrier properties to UV and visible light were the strongest for chitosan–pectin films with silymarin. The antioxidant potential of the films was determined by DPPH assay and it was found that the variants with silymarin have over 20 times higher antioxidant activity (from 2.020 ± 0.048 to 2.106 ± 0.190 mg TE/g) than the corresponding controls. The results showed that chitosan–pectin films with incorporated silymarin could find application as potential hydrogel dressings in the therapy of wounds and superficial burns. Full article

This paper presents the results of a comprehensive technological study of three bronze sculptures from the Jin Empire period (1115–1234 AD) from the collection of the Museum of Archaeology and Ethnography at the Institute of History, Archaeology and Ethnography of the Peoples of the Far East, Far Eastern Branch of the Russian Academy of Sciences (IHAE FEB RAS). Using photon-counting computed tomography (PCCT) and energy-dispersive X-ray spectroscopy (EDS), the production techniques were reconstructed, differences in alloy composition were identified, and specific features of the casting processes were determined. Tomographic analysis revealed two fundamentally different manufacturing approaches: a multi-stage technology involving the use of different alloys and the assembly of separately cast elements, and a single-cast technology with a homogeneous structure. Elemental analysis of the three sculptures using EDS demonstrated significant compositional variability—from 21% to 67% copper and from 9% to 69% tin in different parts of the objects—confirming the complexity of the technological processes. An expanded study of 20 bronze sculptures using portable X-ray fluorescence analysis (pXRF) allowed for the identification of four typological alloy groups: classic balanced lead–tin bronzes (Cu 30–58%, Sn 16–23%, Pb 16–28%), high-lead bronzes (Pb up to 52%), high-tin bronzes (Sn up to 30%), and low-tin alloys (Sn less than 11%). The morphological features of the sculptures suggest one of their possible interpretations as ancestor spirits used in ritual practices. The research findings contribute to the study of Jurchen metallurgical traditions and demonstrate the potential of interdisciplinary, non-destructive analytical methods for reconstructing the technological, social, and cultural aspects of medieval Far Eastern societies. Full article

Ultrasound-guided femoral vascular access (UFVA) is a crucial step in cardiovascular intervention, yet training models remain costly, anatomically limited, or insufficiently durable. This research aimed to develop and evaluate a reusable, self-healing vascularised leg phantom in collaboration with clinicians. This bifurcating vascular model was cast in Plastisol using a customisable silicone mould design. The material exhibited a Shore OO hardness of 18.0 ± 2.2, a speed of sound of 1454 ± 15 m/s, an acoustic attenuation of 1.66 ± 0.02 × 106 kg/m²s, and healed 18G needle lesions within 3 h. Training capabilities were evaluated in a workshop involving 18 medical students: FVA times improved by more than 60% after 5 min of free practice. Qualitative feedback was collected from 31 medical educators via a seven-question Likert survey, with most reporting they would adopt the phantom for teaching. Phantoms cost £7.87 for materials, yet educators valued the models at £100–£500, underscoring its perceived utility. Compared to commercial alternatives, this in-house production approach reduced costs by 10–60 times, achieving comparable durability and anatomical fidelity. This study establishes a scalable, ultra-low-cost method for producing anatomically realistic, self-healing vascular phantoms, validated for effective skill acquisition in both educational and research settings. Full article

This study introduces a synergistic drop-casting, sonication, and thermal treatment (DSTT) method for fabricating multi-walled carbon nanotube (MWCNT)-coated conductive cotton fabrics. The process produced uniform MWCNT networks with a minimum sheet resistance of 0.072 ± 0.004 kΩ/sq. at ~30 wt.% loading. Scanning electron microscopy confirmed an improved MWCNT network. Reproducibility was demonstrated for different fabric sizes, with resistance values remaining consistent within experimental errors. Stability tests showed only minor changes in sheet resistance after 16 weeks of ambient storage and periodic manual bending. Compared to conventional methods such as room-temperature drying, vacuum drying, and sonication alone, DSTT consistently performed better, yielding fabrics with lower resistance and more reliable conductivity. These results highlight DSTT as a reproducible and scalable method for producing conductive cotton fabrics suitable for smart textiles and wearable electronics. Full article

Underwater optical images are the primary carriers of underwater scene information, playing a crucial role in marine resource exploration, underwater environmental monitoring, and engineering inspection. However, wavelength-dependent absorption and scattering severely deteriorate underwater images, leading to reduced contrast, chromatic distortions, and loss of structural details. To address these issues, we propose a U-shaped underwater image enhancement framework that integrates Swin-Transformer blocks with lightweight attention and residual modules. A Dual-Window Multi-Head Self-Attention (DWMSA) in the bottleneck models long-range context while preserving fine local structure. A Global-Aware Attention Map (GAMP) adaptively re-weights channels and spatial locations to focus on severely degraded regions. A Feature-Augmentation Residual Network (FARN) stabilizes deep training and emphasizes texture and color fidelity. Trained with a combination of Charbonnier, perceptual, and edge losses, our method achieves state-of-the-art results in PSNR and SSIM, the lowest LPIPS, and improvements in UIQM and UCIQE on the UFO-120 and EUVP datasets, with average metrics of PSNR 29.5 dB, SSIM 0.94, LPIPS 0.17, UIQM 3.62, and UCIQE 0.59. Qualitative results show reduced color cast, restored contrast, and sharper details. Code, weights, and evaluation scripts will be released to support reproducibility. Full article

Magnetotactic bacteria (MTB) have attracted interest in recent years, mainly due to their natural ability to form intracellular magnetic nanocrystals with potential for biomedical and environmental applications. In this study, we focused on the morphological analysis of the Paramagnetospirillum magnetotacticum MS-1 strain, trying to keep the bacteria as close to their natural state as possible. An important element of this work is the use of untreated bacterial cells, without conductive coating or chemical fixation, using a simple and low-cost support. This choice was made intentionally to avoid changes induced by metallization and to allow direct observation of characteristics that may be relevant in applications where the interaction of the bacteria with the environment plays an important role, such as biosensors. In addition, the analysis was performed on a bacterial suspension stored for approximately 10 months at 4 °C to assess whether the morphology specific to the MS-1 strain is maintained over time. The obtained results show that the general cell morphology and magnetosome organization can be clearly and reproducibly observed even after long-term storage. Without attempting to replace studies based on conventional sample preparation methods, this work provides a complementary perspective and suggests that magnetotactic bacteria may represent a natural and effective alternative to synthetic magnetic nanoparticles, with potential applications in the biomedical and environmental fields. Full article

Images captured underwater frequently suffer from color casts, blurring, and distortion, which are mainly attributable to the unique optical characteristics of water. Although conventional UIE methods rooted in physics are available, their effectiveness is often constrained, particularly in challenging aquatic and illumination conditions. More recently, deep learning has become a leading paradigm for UIE, recognized for its superior performance and operational efficiency. This paper proposes UCA-Net, a lightweight CNN-Transformer hybrid network. It incorporates multiple attention mechanisms and utilizes composite attention to effectively enhance textures, reduce blur, and correct color. A novel adaptive sparse self-attention module is introduced to jointly restore global color consistency and fine local details. The model employs a U-shaped encoder–decoder architecture with three-stage up- and down-sampling, facilitating multi-scale feature extraction and global context fusion for high-quality enhancement. Experimental results on multiple public datasets demonstrate UCA-Net’s superior performance, achieving a PSNR of 24.75 dB and an SSIM of 0.89 on the UIEB dataset, while maintaining an extremely low computational cost with only 1.44M parameters. Its effectiveness is further validated by improvements in various downstream image tasks. UCA-Net achieves an optimal balance between performance and efficiency, offering a robust and practical solution for underwater vision applications. Full article

Cementitious materials prepared by the ice-templating method appear to have difficulty simultaneously possessing good mechanical properties and an oriented microstructure with microchannels. Surface micro-ceramicization of TiB₂ and the decomposed products of cement hydrates at high temperatures can be regarded as in situ solid–solid reactions involving oxygen, thereby enhancing mechanical properties. This study investigates the mechanical property changes in cement paste with different water-to-cement ratios containing 25% TiB₂ micron powder before and after high-temperature treatment. Cementitious samples are prepared using both freeze-casting (F-CAST) and regular casting (R-CAST) methods with and without the heating post-treatment. The average compressive strength of samples with a W/C of 0.65 prepared by the freeze-casting method at −60 °C with a heating post-treatment is much larger than that of samples prepared by the regular casting method with and without the same heating process. The freeze-casting process for preparing cementitious composites with TiB₂ not only reorders the distribution of water molecules but also redistributes the concentrations of the TiB₂ particles and the main hydrates in the frozen samples. Due to the concentration increase near ice crystal channels within the samples, led by the freeze concentration effect, the new products are formed and cover the channel surfaces after high-temperature treatment. This enhances both the overall and internal properties of the cement-based TiB₂ composite material. The variation in TiB₂ content within the specimens is of paramount importance. Full article

In this study, we consider multi-pair user frequency division duplexing massive MIMO relay systems and design a two-stage combining and beamforming (TSCB) scheme based on statistical channel state information (S-CSI). By leveraging S-CSI to co-design the pre-combining matrix and the pre-beamforming matrix, the scheme reduces the equivalent channel matrix dimensions, thereby cutting the pilot overhead. In the first stage, the two matrices are constructed through a selection of beams from a discrete Fourier transform codebook and mathematically cast as a multivariate optimization problem. An alternative optimization algorithm is proposed by splitting it into three sub-problems. The first two are 0–1 integer programming problems solved by iterative beam selection, while the third is a convex problem that is solved using a convex optimization algorithm. In the second stage, the reduced-dimension equivalent matrices are then estimated with low overhead, and a digital precoding matrix is then designed using zero-forcing algorithms. Simulations confirm the TSCB scheme’s superior ESE performance over that of existing methods. Full article

Some expressway emergency lanes adopt simplified pavement structures that fail to meet load-bearing requirements after reconstruction. To address the issue of subgrade reinforcement without excavation, a finite element method was employed to analyze the effects of enlarged-borehole grouting (EBG), considering variations in grouting depth and inter-pile subgrade modulus, on pavement load-bearing capacity. Furthermore, field experiments were conducted to evaluate grouting techniques, including enlarged-borehole micro-expansive cement casting (EB-MECC) and enlarged-borehole steel flower pipe split grouting (EB-SFPSG), and three composite grouting schemes. Results indicated that EBG effectively improved the fatigue cracking life of the semi-rigid base layer. Reinforcement effectiveness was positively correlated with grouting depth and subgrade modulus, with the latter exhibiting a more significant influence. Therefore, a 1.5 m grouting depth combined with splitting or compaction is recommended to enhance subgrade stiffness. Field experiments showed that EB-SFPSG effectively enhanced pile–subgrade interaction and mitigated stress concentration around the pile–pavement interface. Comparison of the three composite grouting schemes revealed that both the scheme employing only EB-SFPSG and the hybrid scheme using EB-SFPSG in the middle row with EB-MECC in the side rows exhibited favorable mechanical performance. The latter, however, was achieved at a lower construction cost. Another hybrid scheme that further replaced the middle row with enlarged-borehole conventional pressure grouting (EB-CPG) provided limited reinforcement and poorer uniformity. Full article

This study introduces a digital fabrication process for producing recyclable, closed-loop wax formwork for architectural concrete applications with visually rich surface articulation while drastically reducing formwork milling time. As such, this paper presents (a) a circular large-scale production method for wax blocks via a single casting process; (b) four machine-time-optimized surface articulation strategies through CNC toolpath-driven design; (c) the investigation of different coating systems to improve architectural concrete surface quality and to ease demolding; and (d) the integration of robotic concrete shotcreting using a low-CO₂ fine-grain concrete. For the first time, wax formwork technology, characterized by its waste-free approach, has been combined with robotic shotcreting in a digital and automated workflow to fabricate fiber-reinforced, geometrically complex thin-shell concrete elements with distinct surface articulations. To evaluate the process, a series of four thin-shell concrete elements was produced, employing four distinct parametric toolpath-driven designs: linear surface articulation, crossed surface articulation, topology-adapted curve flow surface articulation, and robotic drill topology-adapted surface articulation. Results revealed a possible reduction in milling time of between 77% and 94% compared to traditional milling methods. The optimized toolpaths and design-driven milling strategies achieved a high degree of visual richness, showcasing the potential of this integrated approach for the production of high-quality architectural concrete elements. Full article

Non-destructive evaluation techniques are increasingly recognised as effective alternatives to destructive testing for estimating the compressive strength of lightweight aggregate concrete (LWAC). Among these, ultrasonic pulse velocity (UPV) is a well-established and widely employed method, characterised by its speed, non-invasiveness, and relative simplicity of implementation. In this study, an experimental dataset comprising 640 core segments from 160 cylindrical specimens, provided for analysis, was investigated. Each segment was described by physical and processing variables or features, including lightweight aggregate (LWA) and concrete densities, casting and vibration times, experimental dry density, and P-wave velocity obtained through UPV testing. A segregation index, derived from UPV measurements and defined as the ratio of local to mean P-wave velocity within each specimen, was also considered, following approaches previously suggested in the literature. A range of machine learning techniques was applied to assess the predictive capacity of local P-wave velocity and segregation index. Most ensemble-based methods and support vector regression (SVR) achieved the highest predictive performance when the segregation index was excluded, suggesting that its inclusion did not improve the predictive ability of the models. By contrast, Gaussian process regression (GPR) showed slight improvements when the segregation index was included. The results confirmed that the P-wave velocity measured by UPV testing is a reliable non-destructive predictor of compressive strength in LWAC. At the same time, the added value of the segregation index remained negligible under conditions of low segregation, as reflected by segregation index values above 0.8. These findings highlight the practical potential of integrating UPV-based measurements with data-driven modelling to enhance the reliability of concrete characterisation and quality control. Full article

Active packages have become a significant center of attention, and especially those based on biodegradable materials, due to their ability to enhance food preservation and extend shelf life. A suitable base for obtaining such types of packages has turned out to be polymers with natural origin, such as hydroxylpropyl methylcellulose (HPMC) and zein. Therefore, the present study is focused on developing films using the casting method based on pure HPMC and blends between HPMC and zein. Three types of polymer matrices were developed: pure HPMC film, HPMC 3:1 zein, and HPMC 1:1 zein. Further, all of them were loaded with curcumin to improve their biological activity, and mainly their antioxidant activity. In order to investigate the potential of these films, some of their most vital properties in terms of potential application as packaging material are established, such as mechanical properties (strain at break, Young’s modulus), barrier properties (water vapor transmission rate), and morphology. A significant change in the Young’s modulus was present after the addition of zein; it went from 276.98 ± 28.48 MPa for pure HPMC to 52.17 ± 10.19 MPa in a 1:1 ratio between the polymers. Meanwhile, strain at break showed a slight drop from 86.74 ± 8.64% to 72.44 ± 9.62%. Barrier properties were also influenced by the formation of composite film and the addition of polyphenol, lowering the water vapor transmission rate from 913.07 ± 74.01 g/m².24 h for pure HPMC to 873.05 ± 9.07 g/m².24 h for 1:1 ratio film and further to 826.35 ± 33.67 g/m².24 h after the addition of rutin to the latter. Additional characterization of radical scavenging ability towards DPPH free radicals showed a similar A-shaped trend to the values of Young’s modulus, due to the presence of hydrogen bonds, which affect both properties of the film structures. Thermal behavior and phase state investigation of the films obtained by differential scanning calorimetry prior to and after polyphenol addition was carried out, indicating full phase transition of rutin from crystalline to amorphous state. Full article

Background: Renal impairment is a frequent and severe complication of multiple myeloma, most commonly caused by light-chain cast nephropathy. Therapeutic plasma exchange (TPE) has been proposed as an adjunctive approach to rapidly reduce circulating free light chains; however, its clinical benefit remains controversial. Methods: We retrospectively analyzed 71 patients treated between 2013 and 2023, of whom 30 received TPE in addition to anti-myeloma therapy and 41 received anti-myeloma therapy alone. Renal outcomes were assessed within a predefined early treatment window encompassing the first 4–6 cycles of therapy. Renal response was defined as a ≥50% reduction in serum creatinine and/or dialysis independence. Multivariable logistic regression and sensitivity analyses were performed to adjust for baseline imbalances, including renal function and anti-myeloma backbone therapy. Results: Although renal function improved significantly over time in both groups, renal response rates were comparable between patients treated with and without TPE (40% vs. 36.6%). In multivariable analysis, TPE was not independently associated with renal response. Importantly, in a sensitivity analyses restricted to patients receiving bortezomib-based regimens, the addition of TPE remained unassociated with improved renal outcomes. Conclusions: In this real-world cohort, adjunctive TPE did not confer a significant advantage in renal recovery or dialysis independence beyond contemporary anti-myeloma therapy. These findings indicate that renal recovery is predominantly driven by effective anti-myeloma treatment rather than extracorporeal light-chain removal. Full article

Nickel–Aluminum–Bronze (NAB) has gained significant attention in marine applications due to its excellent corrosion resistance and has shown growing potential for laser powder bed fusion (L-PBF) additive manufacturing. However, research on the fabrication of NAB alloys using L-PBF remains relatively limited. In this study, fully dense NAB samples were successfully fabricated through L-PBF process parameter optimization. The microstructural evolution and mechanical properties of both as-built and annealed L-PBF samples were systematically investigated and compared with those of traditionally cast NAB. The results reveal that the as-built L-PBF specimens primarily consist of columnar β′ grains, with the α phase distributed along the grain boundaries and a small amount of κ phase precipitated within the β′ matrix, distinctly different from the cast microstructure characterized by a columnar α-phase matrix with precipitated β′ and κ phases. After annealing at 675 °C for 6 h, the β′ phase in both methods decomposed into α + κ phases, and the original columnar structure in the L-PBF specimens transformed into a dendritic morphology. Compared to the cast samples, the L-PBF-produced NAB alloy exhibited significantly enhanced yield strength, tensile strength, and microhardness, attributable to rapid solidification during the L-PBF process. Following annealing, the yield strength and elongation increased by 12.8% and 184.4%, respectively, compared to the as-built condition, resulting from the decomposition of the martensitic phase into α + κ phases and further grain refinement. Full article