Search Results (183)

This study examines how large-scale school infrastructure reforms shape teaching practice, using Australia’s Building the Education Revolution (BER) initiative as a case example. Guided by Cultural-Historical Activity Theory (CHAT), the research explores how redesigned learning environments act as mediating tools that influence pedagogy, collaboration, and teacher wellbeing. An explanatory sequential mixed-methods design was employed, combining survey data from 34 teachers with focus group interviews involving 13 participants in a redeveloped Victorian Primary School, Australia. Quantitative results showed that 70.5% of teachers reported changes in their teaching practices directly linked to the new infrastructure, with 100% affirming that they had enhanced collaboration opportunities. Qualitative findings revealed that features such as breakout rooms, shared learning zones, and transparent sightlines enabled differentiated instruction, co-teaching, and improved supervision, while also fostering professional pride and collegial support. Contradictions emerged around automated lighting systems, limited display space, and partial teacher consultation during the design process. CHAT analysis demonstrated how physical spaces interact with rules, community, and division of labour within the school activity system, producing both enabling conditions and systemic tensions. The study underscores the need for infrastructure planning to be pedagogically informed, inclusive of teacher voice, and designed to support adaptive, collaborative, and inclusive teaching practices. Full article

Background: In September of 2024, the 2nd annual meeting of the Strategic Advances in Sarcoma Science (SASS) convened at the National Institutes of Health. This gathering of national sarcoma experts focused on preclinical studies, clinical trials, opportunities, challenges, and future directions in sarcoma biology and clinical care with a focus on immunotherapy. The Immunology in Sarcoma breakout group conducted a dedicated discussion focused on the current and future implementation of adoptive cellular therapies (ACTs) in sarcomas. The current manuscript summarizes these discussions and provides a comprehensive resource for researchers and clinicians. Results: Adoptive cell therapy (ACT) has shown encouraging results in sarcomas with afami-cel achieving durable responses in synovial sarcoma and early TCR-T trials against NY-ESO-1 and MAGE-A4 demonstrating meaningful response rates. Building on these outcomes will require discovering new targets, selecting optimal cell types, refining conditioning regimens, combining with alternative treatment strategies such as TKIs, and leveraging predictive biomarkers informed by a deeper understanding of the tumor microenvironment. Conclusions: Sarcomas are promising targets for adoptive cell therapy (ACT), as shown by afami-cel’s success in synovial sarcoma, but broader impact requires new target discovery, optimal cell selection, improved conditioning, combination treatments, deeper tumor microenvironment understanding, and predictive biomarkers to achieve more durable responses for more patients. Full article

Submarine pipelines are highly susceptible to lateral buckling failure under service conditions of high temperature and pressure. While existing bearing capacity evaluation methods mainly focus on flat seabeds, research on the ultimate bearing capacity of pipelines buried in sloping seabeds is limited. This study applies the FELA method to analyze the ultimate bearing capacity of pipelines buried in inclined sandy seabeds under various loading directions. The results reveal that in sloping seabeds, the minimum ultimate bearing capacity (P_u,b) does not occur in the vertical direction, but rather deviates toward the outward normal direction of the seabed surface, moving toward the foot of the slope. The P_u,b is only 57% of the uplift bearing capacity in the extreme case. A predictive model was proposed to accurately determine the direction of P_u,b. The results also indicated that increasing the seabed slope angle leads to a significant reduction of bearing capacity, while increases in the internal friction angle of the seabed and the pipeline–soil interface friction angle enhance the bearing capacity. Moreover, the design code of DNV (2017) was identified as unsafe due to its omission of seabed inclination effects, and the P_u,b is only 75% of the best estimate of DNV (2017) in the extreme case. A reduction factor model was developed to mitigate this gap, offering a more reliable framework for evaluating the bearing capacity of pipelines. Full article

Underground gas storage (UGS) in heterogeneous carbonate reservoirs is crucial for energy security but frequently faces wellbore instability challenges, which traditional static methods struggle to address due to dynamic full life cycle changes. This study systematically analyzes the dynamic evolution of wellbore stress in the Bs8 well (Qianmiqiao carbonate UGS) during drilling, acidizing, and injection-production operations, establishing a quantitative risk assessment model based on the Mohr–Coulomb criterion. Results indicate a significantly higher wellbore instability risk during drilling and initial gas injection stages, primarily manifested as shear failure, with greater severity observed in deeper well sections (e.g., 4277 m) due to higher in situ stresses. During acidizing, while the wellbore acid column pressure can reduce principal stress differences, the process also significantly weakens rock strength (e.g., by approximately 30%), inherently increasing the risk of wellbore instability, though the primary collapse mode remains shallow shear breakout. In the injection-production phase, increasing formation pressure is identified as the dominant factor, shifting the collapse mode from initial shallow shear failure to predominant wide shear collapse, notably at 90°/270° from the maximum horizontal stress direction, thereby significantly expanding the unstable zone. This dynamic assessment method provides crucial theoretical support for full life cycle integrity management and optimizing safe operation strategies for carbonate gas storage wells. Full article

Next to solid wood, laminated particleboard is the most widely used wood-based material in the furniture industry. Ensuring the high quality of the laminate surface after machining is of critical importance for furniture manufacturers, particularly prior to the edge banding process, as this process significantly influences the final aesthetic and functional quality of panel elements. The objective of this review article is to gather and evaluate the current state of knowledge regarding the influence of machining process parameters and the physical and mechanical properties of laminated particleboard on machining quality. Particular emphasis is placed on the occurrence of laminate damage, commonly referred to as delamination, a prevalent defect in the furniture manufacturing sector. Both categories of influencing factors—process-related and material-related—are analyzed within the context of the three primary technological processes employed in the woodworking industry, namely drilling, cutting, and milling. The analysis revealed that a persistent research gap concerns the relationship between machining quality and material parameters, particularly in the case of milling—a process of critical importance in the furniture industry. Full article

Rheumatoid arthritis (RA) is one of the most representative autoimmune diseases. The peculiarity of this disease is synovial inflammation, which results in joint destruction and often disability. Although there are still several pathogenetic mechanisms to be clarified, lately, most studies have highlighted the involvement of mitochondria in the onset and progression of the disease. Mitochondrial functions are connected to many metabolic processes and the delivery of proinflammatory mediators. Mitochondria play a crucial role in the physiopathology of RA, contributing to chronic inflammation, cartilage and bone injury and chronic autoimmune response. Mitochondrial activity influences many aspects of the disease that will be discussed in terms of their correlation with the onset and persistence of RA, starting from mitochondrial dynamics up to bone homeostasis, passing through DAMPs and affecting immune cell functionality. Recent therapeutic approaches aim to improve mitochondrial function, reduce oxidative stress, modulate mitochondria-mediated inflammation and restore energy metabolism homeostasis. Full article

This paper investigates the shear performance of shear lugs commonly used in nuclear equipment foundations. A total of six groups of H-shaped steel shear lug specimens, six groups of angle steel shear lug specimens, and eight groups of steel plate shear lug specimens are designed and tested under horizontal shear loading. The failure modes, shear capacities, and deformation characteristics of the specimens are systematically examined. Furthermore, the influence of the embedment depth of the shear lug and the distance from the shear lug to the concrete edge on the shear performance of specimens is thoroughly analyzed. Based on the test results, equations for calculating the shear capacity of shear lugs are proposed. The result indicates that the failure modes of the three types of specimens under shear loading mainly show concrete shear breakout failure, and the changes in the embedment depth and concrete edge distance have a large effect on the shear capacity and ductility of the specimen. The proposed equations show good agreement with the test results, which can provide a theoretical foundation for the design of the shear lugs used in nuclear engineering. Full article

This study investigates a novel anchor-based method for controlled rock fragmentation, designed as an alternative to conventional excavation or explosive techniques. The proposed solution utilizes a specially modified undercut anchor that induces localized failure within the rock mass through radial expansion rather than traditional pull-out forces. Finite Element Method simulations, performed in ABAQUS with an extended fracture mechanics approach, were used to model the initiation and propagation of failure zones in sandstone. The results revealed a two-phase cracking process starting beneath the anchor’s driving element and progressing toward the rock’s free surface, forming a breakout cone. This behavior significantly deviates from conventional prediction models, such as the 45° cone or Concrete Capacity Design methods (cone 35°). The simulations were supported by field tests, confirming both the feasibility and practical advantages of the proposed anchor system, especially in confined or safety-critical environments. The findings offer valuable insights for the development of compact and efficient rock fragmentation technologies suitable for mining, rescue operations, and civil engineering applications. Full article

During the continuous casting process, the submerged entry nozzle (SEN) should be maintained at the geometric center of the mold. However, in actual production, factors such as deformation of the tundish bottom and inaccurate positioning of the traversing car occasionally cause SEN offset. SEN offset can make the molten steel flow field in the mold asymmetric, increasing the risks of slag entrainment on the surface of the casting blank and breakout accidents. To evaluate the influence of different SEN offsets on the mold flow field, this study uses a slab continuous casting mold with a cross-section of 920 mm × 200 mm from a specific factory as the research object. Mathematical simulations were used to investigate the influence of SEN offsets (including width-direction and thickness-direction offsets) on the flow behavior of molten steel in the mold. A physical water model at a 1:1 scale was established for verification. Two parameters, the symmetry index (S) and the bias flow index (N), were introduced to quantitatively evaluate the symmetry of the flow field, and the rationality of the liquid-level fluctuation under this flow field was verified using the F-number (proposed by Japanese experts for mold level fluctuation control) from the index model. The results show the following: when the SEN offset in the thickness direction increases from 0 to 50 mm, the longitudinal symmetry index (Sy) of the molten steel flow field in the mold decreases from 0.969 to 0.704—a reduction of 27.4%; the longitudinal bias flow index (Ny) of molten steel level fluctuation increases from 0.007 to 0.186, representing a 25.6-fold increase, and the F-number rises from 4.297 to 8.482; when the SEN offset in the width direction increases from 0 to 20 mm, the transverse-axis symmetry index (Sx) of the flow field decreases gradually from 0.969 to 0.753 at a 20 mm offset, which is a reduction of approximately 22.29%; the transverse-axis bias flow index (Nx) increases from 0.015 to 0.174 at a 20 mm offset—an increase of 10.6 times; and the F-number increases from 4.297 to 5.548. Considering the comprehensive evaluation of horizontal/vertical symmetry indices, bias flow indices, and F-numbers under the two working conditions, the width-direction SEN offset has the most significant impact on the symmetry of the molten steel flow field. Full article

Soft and flexible capacitive tactile sensors are vital in prosthetics, wearable health monitoring, and soft robotics applications. However, achieving accurate real-time force detection and spatial localization remains a significant challenge, especially in dynamic, non-rigid environments like prosthetic liners. This study presents a real-time force point detection and tracking system using a custom-fabricated soft elastomeric capacitive sensor array in conjunction with image processing and machine learning techniques. The system integrates Otsu’s thresholding, Connected Component Labeling, and a tailored cluster-tracking algorithm for anomaly detection, enabling real-time localization within 1 ms. A $6\times 6$ Dragon Skin-based sensor array was fabricated, embedded with copper yarn electrodes, and evaluated using a UR3e robotic arm and a Schunk force-torque sensor to generate controlled stimuli. The fabricated tactile sensor measures the applied force from 1 to 3 N. Sensor output was captured via a MUCA breakout board and Arduino Nano 33 IoT, transmitting the Ratio of Mutual Capacitance data for further analysis. A Python-based processing pipeline filters and visualizes the data with real-time clustering and adaptive thresholding. Machine learning models such as linear regression, Support Vector Machine, decision tree, and Gaussian Process Regression were evaluated to correlate force with capacitance values. Decision Tree Regression achieved the highest performance ($R^2=0.9996, RMSE=0.0446$), providing an effective correlation factor of $51.76$ for force estimation. The system offers robust performance in complex interactions and a scalable solution for soft robotics and prosthetic force mapping, supporting health monitoring, safe automation, and medical diagnostics. Full article

In the continuous casting of special steel blooms, low casting speeds result in slow renewal of the molten steel surface in the mold, adversely affecting mold flux melting and liquid slag layer supply, which may lead to surface cracks, slag entrapment, and breakout incidents. To optimize the flow and heat transfer behavior in the mold, a three-dimensional numerical model was developed based on the VOF multiphase flow model, $k-ϵ$ RNG turbulence model, and DPM discrete phase model, employing the finite volume method with SIMPLEC algorithm for solution. The effects of casting speed, argon injection rate, and mold flux properties were systematically investigated. Simulation results demonstrate that when casting speed increases from 0.35 m·min⁻¹ to 0.75 m·min⁻¹, the jet penetration depth increases by 200 mm and meniscus velocity rises by 0.014 m·s⁻¹. Increasing argon flow rate from 0.50 L·min⁻¹ to 1.00 L·min⁻¹ leads to 350 mm deeper bubble penetration, 10 mm reduction in jet penetration depth, 0.002 m·s⁻¹ increase in meniscus velocity, and decreased meniscus temperature due to bubble cooling. When mold flux viscosity increases from 0.2 Pa·s to 0.6 Pa·s, the average liquid slag velocity decreases by 0.006 m·s⁻¹ with a maximum temperature drop of 10 K. Increasing density from 2484 kg·m⁻³ to 2884 kg·m⁻³ results in 0.005 m·s⁻¹ higher slag velocity and average 8 K temperature reduction. Comprehensive analysis indicates that optimal operational parameters are casting speed 0.35–0.45 m·min⁻¹, argon flow ≤ 0.50 L·min⁻¹, mold flux viscosity 0.2–0.4 Pa·s, and density 2484–2684 kg·m⁻³. These conditions ensure more stable flow and heat transfer characteristics, effectively reducing slab defects and improving casting process stability. Full article

On 3 March 2024, a new effusive eruption began from a sub-circular fissure on the southeast upper flank of the Fernandina volcano (Galápagos archipelago, Ecuador). Although the eruption posed no threat to people, as the island is uninhabited, it provided an opportunity to test a rapid response system for effusive eruptions, based on satellite infrared (IR) data. In this work, we illustrate how the analysis of data from multiple IR sensors allowed us to monitor the eruption in near real-time (NRT), providing recurrent updates on key parameters, such as (i) lava discharge rate and trend, (ii) erupted lava volume, (iii) lava field area, (iv) active flow front position (v) flow velocity, (vi) location of active vents and breakouts, and (vii) emplacement style. Overall, the eruption lasted 68 days, during which 58.5 ± 29.2 Mm³ of lava was erupted and an area of 14.9 ± 0.5 km² was invaded. The eruption was characterized by a peak effusion rate of 206 ± 103 m³/s, an initial velocity of ~2.3 km/h, and by an almost exponential decline in the effusion rate, accompanied by a transition from channel- to tube-fed emplacement style. The advance of the lava flow was characterized by three lengthening phases that allowed the front to reach the coast (~12.5 km from the vent) after 36 days (at an average velocity of ~0.015 km/h). The results demonstrate the efficiency of satellite thermal data in responding to effusive eruptions and maintaining situational awareness at remote volcanoes where ground-based data are limited or completely unavailable. The requirements, limitations, and future perspectives for applying this rapid response protocol on a global scale are finally discussed. Full article

This study examined the influence of the effective embedment depth h_ef of undercut anchors and the diameter of their heads on the formation of the so-called cone failure angle α. Cone failure formation during simulated anchor pull-out tests was analyzed numerically using the Finite Element Method (FEM) with the ABAQUS software and the XFEM algorithm. The analysis was conducted for three sizes of undercut anchor heads and four embedment depths. The numerical analysis results were compared with field test results obtained during pull-out tests of anchors installed in a rock medium (sandstone). Good agreement was observed between the numerical and field test results. The results of the numerical study are highly consistent with those obtained during the field survey. Moreover, they align closely with findings from previous numerical studies conducted by members of the research team, as presented in earlier publications. For the assumed simulation and field test conditions (sedimentary rocks, gray sandstone), no clear correlation was found between the embedment depth or the anchor head diameter and the value of the cone failure angle in the initial phase of the failure zone development. This result contrasts with certain findings reported in the literature. Many existing studies on anchor bolts focus on material properties or load-bearing capacity, but lack an in-depth analysis of how anchor depth influences the geometry of the failure cone. This research addresses that gap, providing valuable insights with practical implications for design codes and safety evaluations. Full article

Background: Family caregivers provide most (75–90%) of the essential unpaid care and support for individuals living with chronic conditions, disabilities, and age-related needs in the community, with about half performing medical tasks traditionally performed by professionals. Caregivers also assist with 15 to 35% of the care in congregate care settings. Yet despite their critical contributions to patient care, caregivers face stress, declining well-being, and insufficient recognition in healthcare systems. Addressing these challenges requires innovative, person-centered approaches to training healthcare providers. Co-design or co-production are participatory research methods that involve individuals with lived experience to ensure relevance and impact. Objective: This study sought to understand how participatory co-design principles influenced learning, collaboration, and engagement among diverse participants in developing a caregiver-centered education program for healthcare providers. Actionable recommendations for optimizing co-design processes are provided. Methods: Eighty-five participants from a team of 155 collaborators, including caregivers, healthcare providers, educators, policymakers, and leaders, participated in ten focus group sessions conducted in Zoom breakout rooms. Interviews were transcribed verbatim and analyzed using Thorne’s interpretive description and Braun and Clarke’s reflexive thematic analysis. Results: Participants described the co-design process as fostering collaboration, inclusivity, and skill enhancement. Exposure to diverse perspectives expanded transformative understanding and prompted reflection on caregiver support within professional practices. Skilled facilitation ensured equitable engagement. Challenges included information overload and personal time constraints. Participants liked using breakout rooms to mitigate the dynamics of large group management. Still, they recommended pre-meeting materials, flexible scheduling, and expanding stakeholder diversity (e.g., rural, Indigenous, and immigrant caregivers). Conclusions: Co-design fosters meaningful, caregiver-centered education through collaboration and inclusivity. Addressing logistical challenges and representation gaps can further enhance the impact of co-design and empower multi-level, interdisciplinary partners to inform equitable healthcare education. Full article

The relevance of the study is related to the need to join dissimilar copper and nickel alloys by laser direct energy and material deposition (LDED). The purpose of research is studying the distribution of elements, structure, and properties of contact zone of nickel-based super alloy and CuCr1 bronze obtained by direct energy and material deposition with preliminary formation of relief of contact surface. For the purposes of research, samples were made from UNS C18200 copper alloy CuCr1 without relief, with a relief of 0.5 mm depth, and with a relief of 1 mm depth. The Ni₅₀Cr₃₃W_4.5Mo_2.8TiAlNb (EP648) alloy powder was deposited onto the bronze samples with a micro-relief. The deposition was produced by direct injection of energy and material. The influence of interphase interaction of CuCr-chromium carbide system on the possibility of initiation of a crack in the area of carbide secretions is not significant and does not exceed 3.1% according to CIC criterion from the background level for CuCr1 (CIC = 1.54% for CuCr1-Al₄C₃ interface and CIC = 3.1% for CuCr1-Cr₂₃C₆ interface). An X-ray analysis revealed the presence of tensile residual macro-stresses, arising from differences in thermal expansion coefficients in the CuCr1-EP648 interface area, which may be the main cause of crack formation. Cracks are generated and run along the grain boundaries, on which traces of excretion are visible. The contact surface in the CuCr1-EP648 interface area has no visible defects, which indicates the good adhesion of materials when applying an initial layer of EP648 by LDED. The presence of a 0.5-mm micro-relief on CuCr1 has a positive effect on the strength of the connection, as it increases the surface area of the contact CuCr1-EP648 and therefore reduces the contact stress of the breakout. Full article