Search Results (327)

In vitro testing of ventricular assist devices, constructing a mock circulation system that reproduces physiological cardiac function, is critical. However, current ventricular simulators often lack biomimetic fidelity and may introduce hemolysis and coagulation risks during prolonged operation, affecting hemocompatibility assessment. This study proposes a motor-driven torsional 3D-printed left ventricular simulator to reconstruct the hemodynamics of severe heart failure and related pathological conditions. The system integrates a 3D-printed elastic ventricular model with programmable torsional actuation, allowing the simulation of various cardiac conditions by adjusting the motor torsion angle and rotational speed, peripheral resistance and compliance. Fresh porcine blood was circulated for 4 h in a closed-loop system, with periodic measurements of plasma-free hemoglobin (PfHb), thrombin–antithrombin complex (TAT), and P-selectin. The results show that the system successfully reproduces typical hemodynamic features of severe heart failure, while hemolysis and coagulation markers remain low. After 4 h, PfHb was below 20 mg/dL, with no significant platelet activation or thrombosis. This study demonstrates that the proposed system enhances biomimicry while maintaining excellent hemocompatibility, offering a reliable platform for in vitro performance and safety evaluation of ventricular assist devices. Full article

Microfluidic technologies have ushered in a new era in cardiac tissue engineering, providing more predictive in vitro models compared to two-dimensional culture studies. This review examines Organ-on-a-Chip (OoC) and Lab-on-a-Chip (LoC) platforms, with a specific focus on cardiovascular applications. OoCs, and particularly Heart-on-a-Chip systems, have advanced biomimicry to a higher level by recreating complex 3D cardiac microenvironments in vitro and dynamic fluid flow. These platforms employ induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), engineered extracellular matrices, and dynamic mechanical and electrical stimulation to reproduce the structural and functional features of myocardial tissue. LoCs have introduced miniaturization and integration of analytical functions into compact devices, enabling high-throughput screening, advanced diagnostics, and efficient pharmacological testing. They enable the investigation of pathophysiological mechanisms, the assessment of cardiotoxicity, and the development of precision medicine approaches. Furthermore, progress in multi-organ systems expands the potential of microfluidic technologies to simulate heart–liver, heart–kidney, and heart–tumor interactions, providing more comprehensive predictive models. However, challenges remain, including the immaturity of iPSC-derived cells, the lack of standardization, and scalability issues. In general, microfluidic platforms represent strategic tools for advancing cardiovascular research in translation and accelerating therapeutic innovation within precision medicine. Full article

The stem–branch junction in trees demonstrates exceptional structural design. This study examined two key features of the branch junction in common ash (Fraxinus excelsior L.) wood: the interlocked area (ILA) formed above a knot and the spatial arrangement of fibers in the junction. Bio-inspired by the microstructural features revealed by micro-computed tomography imaging, we developed 3D-printed models and compared their mechanical performance to standard symmetrical T-joints. We evaluated the models using mechanical tests and finite element modeling (FEM). Asymmetrical 3D-printed joints mimicking vessel and fiber distribution in the stem–branch junction were 2% stiffer in the elastic region than symmetrical joints and showed, on average, 10% lower deflection at failure. While the ILA had minimal effect on elastic stiffness, measured surface strain analysis indicated that it positively influenced the redistribution of shear strain in the junctions. Thanks to the bio-inspired design, the joints were stiffer and can be utilized in multiple design configurations while maintaining the same underlying principle. Full article

The integration of biomimetics and artificial intelligence (AI) in architecture is reshaping the foundations of computational design. This paper provides a comprehensive review of the current research trends and applications that combine AI-driven modeling with biologically inspired principles to optimize architectural forms, material efficiency, and fabrication processes. By examining recent studies from Q1–Q2 journals (2019–2025), the paper identifies five primary “interfaces” through which AI expands the field of biomimetic design: biological pattern recognition, structural optimization, generative morphogenesis, resource management, and adaptive fabrication. The paper highlights the transition from conventional simulation-based design toward iterative, data-driven workflows integrating machine learning (ML), deep generative models, and reinforcement learning. The findings demonstrate that AI not only serves as a generative tool but also as a learning mechanism capable of translating biological intelligence into architectural logic. The paper concludes by proposing a methodological and educational framework for AI-driven biomimetic optimization, emphasizing the emergence of Artificial Intelligence in Architectural Design (AIAD) as a paradigm shift in architectural education and research. This convergence of biology, algorithms, and material systems is defining a new, adaptive approach to sustainable and intelligent architecture. Full article

Due to its significant environmental impact, the built environment faces growing pressure to transition toward more sustainable practices. Biomimicry, a novel field of practice that entails design and innovation inspired by nature’s time-tested strategies, offers a promising pathway to enhance sustainability in the construction industry. Hence, this study examines the perceived benefits of applying biomimicry principles in the construction sector, aiming to identify the key dimensions that underpin its transformative potential. An exploratory factor analysis (EFA) was conducted using data collected through a structured questionnaire survey, which contained 18 indicators derived from a targeted literature synthesis. The questionnaire was administered to 120 purposively sampled, duly registered, practising construction and biomimicry professionals in South Africa. The instrument captured perceptions of the environmental, economic, and socio-functional benefits of adopting and implementing biomimicry. The EFA revealed four principal factors: socio-economic and health, ecological resilience, performance enhancement and green market efficiency. These four factors cumulatively accounted for approximately 70% of the total variance, indicating a strong internal structure of perceived benefits. The findings demonstrate that stakeholders perceive biomimicry as a tool for reducing environmental footprints and as a catalyst for innovation, circularity, and regenerative design practices in the built environment. This research contributes to the emerging discourse on biomimicry in the built environment by providing empirical evidence on its multifaceted value. It highlights the importance of integrating natural design intelligence into construction to foster more adaptive, efficient, resilient and sustainable systems. The paper recommends policy support, interdisciplinary collaboration, and further research to operationalise biomimicry within mainstream construction processes. Full article

The increasing demand for sustainable climate control has spurred research into our hydronic conditioning system with a patented radiant ceiling panel (AU 2024227462) inspired by biomimetic methodologies. This study develops a framework that utilizes natural systems for heating and cooling, enhancing system performance and environmental sustainability. Biometric analysis was the primary method for testing these systems, focusing on heat transfer mechanisms modeled after human biology. Findings indicate that the proposed hydronic system excels in cooling mode, achieving an average capacity of 95 W/m² while maintaining thermal comfort levels (PMV) with solar heat gains under 1.5 kW in an 18 m² space. However, in heating mode, the system shows a capacity of 85 W/m² but struggles with vertical air-temperature stratification, especially in the radiant ceiling component. This highlights the potential of biomimetic designs to enhance energy efficiency and comfort in sustainable development. The hydronic panel system parallels the human body in energy transfer; both can emit 75–90 W/m² through radiation. Convection over the panel can increase energy transfer by 50–80%, akin to the human body’s heat loss through convection. Notably, natural perspiration facilitates latent energy transfer of 20–25%. When the conditioned panel operates below the dew point, it generates water vapor, boosting cooling capacity by 5–15% and enhancing latent energy transfer. Overall, the heat transfer processes of the hydronic panel mimic certain aspects of human physiology, distinguishing it from conventional HVAC systems. Full article

The global energy transition faces a chasm between current policy commitments (IEA’s STEPS) and the deep, rapid transformation required to realize all national net zero pledges (IEA’s APC). This perspective addresses the critical innovation and policy gap blocking the APC pathway, where many high-impact, clean technologies remain at low-to-medium Technology Readiness Levels (TRLs 3–6) and lack formal policy support. The insufficient nature of current climate policy nomenclature is highlighted, which often limits Nature-based Solutions (NbS) to incremental projects rather than driving systemic technological change (Bio-inspiration). Then, we propose that a deliberate shift from simple biomimetics (mimicking form) to biomimicry (emulating life cycle sustainability) is the essential proxy for acceleration. Biomimicry inherently targets the grand challenges of resilience, resource efficiency, and multi-functionality that carbon-centric metrics fail to capture. To institutionalize this change, we advocate for the mandatory integration of bio-inspired design into National Determined Contributions (NDCs) by reframing NbS as Nature-based Innovation (NbI) and introducing novel quantitative metrics. Finally, a three-step roadmap to guide this systemic shift is presented, from deployment of prototypes (2025–2028), to scaling evidence and standardization (2029–2035), to consolidation and regenerative integration (2036–2050). Formalizing these principles through policy will de-risk investment, mandate greater R&D rigor, and ensure that the next generation of energy infrastructure is not just carbon-neutral, but truly regenerative, aligning technology deployment with the necessary speed and depth of the APC scenario. Full article

Biomimicry is an engineering field where inspiration from nature is leveraged to engineer sustainable solutions. Biomimicry is not a subject typically taught in undergraduate curriculum. This study explores the effects of intercultural context on the learning of biomimicry. Visiting students from the United States of America and home students from Singapore gathered for a one-day workshop on biomimicry in Singapore. The workshop consisted of a lecture with in-class activities and laboratory experiments in groups, followed by students’ presentations. The students’ responses to pre- and post-workshop surveys are analyzed, along with their answers from the in-class activities and their presentations. The results show that the international context of the biomimicry workshop made an overall positive contribution to the motivation, appreciation, and enjoyment of all students. Some differences were observed between the visiting and home students, which likely stemmed from the visiting students being better prepared for the event. However, despite high levels of enjoyment and communication, the learning outcomes lacked technical depth and sustainability focus. This suggests the need for a consistent and higher level of preparation and guidance for all participating students on these topics. This study serves as a preliminary example of a workshop that explores the global theme of biomimicry in an international and intercultural setting. Similar workshops could be conducted with larger and more diverse student populations for more robust results. This work could inspire other educators in engineering to explore ways to prepare students for more holistic education. Full article

The field of experimental radiooncology and the quality assessment (QA) aimed at patient safety both profit from the utilisation of biomimetic principles. The work with phantoms based on biological structures of animals or humans, utilising the principles of anatomic mimicry, has a long tradition in radiotherapy research. When phantoms are produced from tissue-equivalent materials, they mimic the radiological properties of tissues and organs, allowing researchers and clinicians to study dose distribution and optimise treatment plans without exposing real patients to radiation. Biomechanical mimicry would take this a step further by creating phantoms that replicate the movement and deformation of organs during physiological movement, such as heartbeat or breathing, enabling a more accurate simulation of dynamic treatment scenarios. Bioinspired sensor technologies, such as artificial skin or integrated detectors, can be used to monitor radiation exposure, organ motion or temperature changes during therapy with high precision. The utility of such a phantom could be further enhanced by creating a realistic tumour microenvironment as an irradiation target, following the principles of microenvironmental biomimicry. Thus, biomimetic strategies can be exploited in the validation of radiotherapy technologies and open new perspectives for adaptive radiotherapy and real-time monitoring. Full article

RNA interference (RNAi) offers programmable, sequence-specific silencing via small interfering RNA (siRNA) and microRNA (miRNA), but clinical translation hinges on overcoming instability, immunogenicity, and inefficient endosomal escape. This review synthesizes advances in non-viral nanocarriers—liposomes, polymeric nanoparticles, and extracellular vesicles (EVs)—that stabilize nucleic acids, tune biodistribution, and enable organ- and cell-selective delivery. We highlight design levers that now define the field: ligand-guided targeting, stimuli-responsive release, biomimicry and endogenous carriers, and rational co-delivery with small molecules. Across major disease areas—cancer and cardiovascular, respiratory, and urological disorders—these platforms achieve tissue-selective uptake (e.g., macrophages, endothelium, and myocardium), traverse physiological barriers (including the blood–brain barrier and fibrotic stroma), and remodel hostile microenvironments or immune programs to enhance efficacy while maintaining favorable safety profiles. Early clinical studies reflect this diversity, spanning targeted nanoparticles, local drug depots, exosome and cellular carriers, and inhaled formulations, e.g., and converge on core phase-I endpoints (safety, maximum tolerated dose, pharmacokinetics/pharmacodynamics, and early activity). Looking ahead, priorities include good manufacturing practice scale, consistent manufacture—especially for EVs; more efficient loading and cargo control; improved endosomal escape and biodistribution; and rigorous, long-term safety evaluation with standardized, head-to-head benchmarking. Emerging directions such as in vivo EVs biogenesis, theragnostic integration, and data-driven formulation discovery are poised to accelerate translation. Collectively, nanoparticle-enabled RNAi has matured into a versatile, clinically relevant toolkit for precise gene silencing, positioning the field to deliver next-generation therapies across diverse indications. Full article

Gyroids are fascinating natural structures characterized by their local minimum surface area with equal periodicity in all three spatial directions, making them continuous and isotropic. Such intricate patterns have led to various lightweight innovative constructions. This article proposes a novel approach to enhance their compressive performance via edge modification, taking inspiration from biomimicry, specifically following a plant-growth algorithm. Later, a patch surface was generated using these edges, while maintaining the same aspect ratio. The 3D-printed prototypes were tested under compressive load and further validated using FE analysis. The results provide good evidence for modified gyroids being superior, as compared to conventional gyroids. Full article

Triply Periodic Minimal Surfaces (TPMSs) are mathematically defined surfaces that exhibit periodicity in three dimensions while maintaining a minimal surface property. TPMS-based lattices have gained significant attention in recent years, fueled by advancements in Additive Manufacturing (AM). These structures exhibit exceptional mechanical, thermal, and mass transfer properties, positioning them as a promising class of next-generation materials. However, fully leveraging their potential requires a comprehensive understanding of their design, properties, optimization, and applications. Given the hierarchical nature of TPMSs, achieving optimal performance requires multiscale optimization at the macro- and micro-levels. Addressing these complexities requires advanced computational methods to balance structural integrity and functional performance. In this narrative review, design strategies like functional grading and hybridization to create optimized TPMS-based lattices are summarized. Herein, the performance of such lattices in the mechanical, thermal, and mass transfer domains is focused upon. The role of topology optimization (TO) in the creation of architectured materials for specific application is discussed along with the emerging integration of machine learning. Furthermore, multidisciplinary applications of TPMS structures are examined, particularly in heat sinks, interpenetrating phase composites (IPCs), and biomimetic scaffolds, with their potential to enhance heat dissipation, structural resistance, and biomimicry of biological scaffolds. In addition, various additive manufacturing technologies for fabricating TPMS structures are reviewed, emphasizing how additive manufacturing allows high reproducibility construction of their complex geometry in a precise manner. Further unexplored areas of research are also discussed. Full article

Cactaceae are plants equipped with spines and adapted to extremely arid environments. In particular, Echinocactus grusonii spines are almost cylindrical structures, which may occasionally present an enlargement of their proximal cross sectional area. In this work, the spines of Echinocactus grusonii were explored as a possible source of biomimetic inspiration for the design and the implantation strategies of self-inserting intraneural interfaces. More specifically, the elastic stability of spines was theoretically studied for structures able to puncture the surface of an external object, as well as for structures unable to pierce it. The biomimicry of Echinocactus grusonii spines suggested an improved insertion strategy for self-inserting intraneural interfaces together with structural changes able to increase their elastic stability. The theoretical approach provided in this work was able to predict an increase of the first buckling threshold up to 39% for not puncturing self-inserting neural interfaces, and up to 59% for puncturing ones. Full article

Animal welfare education requires pedagogical models that bridge conceptual knowledge with practice. This study presents GamifyWELL, a biomimetic, gamified learning environment for students, farmers, and veterinary technicians. Grounded in ecological principles of adaptation, diversification, and niche specialization, the design emulates how living systems evolve through feedback and cooperation. These principles were translated into an instructional model that integrates a core pathway (Pre-Test, Levels 1–4, Post-Test) with optional enrichment tasks and a role-specific Reward Marketplace. Question formats are constant across levels (MCQ, image-based, video-based) while cognitive difficulty increases, culminating in Positive Welfare scenarios. We describe the learning design structure and report preliminary implementation observations using a mixed-methods evaluation plan (pre/post knowledge assessments and engagement indicators). Results from early deployment indicate strong usability and engagement, with high voluntary uptake of enrichment tasks and positive learner feedback on role-tailored rewards; full empirical testing is in progress. Findings support the feasibility and pedagogical promise of biomimetic gamification to enhance knowledge, motivation, and intended practice in animal welfare education. GamifyWELL offers a replicable framework for nature-inspired instructional design that can be extended to allied sustainability domains. Full article

This study explores the aerodynamic behavior of bioinspired airfoils under extremely low Reynolds number conditions, simulating those found in the Martian atmosphere. Modified NACA 0018 profiles with sinusoidal leading-edge tubercles were tested to assess their influence on flow separation and overall aerodynamic performance. Experiments were carried out in a hydrodynamic towing tank using ink-based flow visualization, enabling detailed observation of the evolution of the separation point with varying angles of attack. The study focuses on comparing different tubercle configurations, analyzing how wavelength and orientation affect the aerodynamics of the airfoil. The results showed variations in flow stability and delayed separation compared to the baseline profile, indicating potential aerodynamic benefits. These findings offer valuable insights for the application of bioinspired geometries in the design of aerial platforms intended for Mars exploration and low-speed flight regimes, with special attention paid to Micro Aerial Vehicles (MAVs). Full article