Search Results (127)

Although intracranial hypertension (ICH) has traditionally been framed as simply a numerical escalation of intracranial pressure (ICP) and usually dealt with in its clinical form and not in terms of its complex underlying pathophysiology, an emerging body of evidence indicates that ICH is not simply an elevated ICP process but a complex process of molecular dysregulation, glymphatic dysfunction, and neurovascular insufficiency. Our aim in this paper is to provide a complete synthesis of all the new thinking that is occurring in this space, primarily on the intersection of glymphatic dysfunction and cerebral vein physiology. The aspiration is to review how glymphatic dysfunction, largely secondary to aquaporin-4 (AQP4) dysfunction, can lead to delayed cerebrospinal fluid (CSF) clearance and thus the accumulation of extravascular fluid resulting in elevated ICP. A range of other factors such as oxidative stress, endothelin-1, and neuroinflammation seem to significantly impair cerebral autoregulation, making ICH challenging to manage. Combining recent studies, we intend to provide a revised conceptualization of ICH that recognizes the nuance and complexity of ICH that is understated by previous models. We wish to also address novel diagnostics aimed at better capturing the dynamic nature of ICH. Recent advances in non-invasive imaging (i.e., 4D flow MRI and dynamic contrast-enhanced MRI; DCE-MRI) allow for better visualization of dynamic changes to the glymphatic and cerebral blood flow (CBF) system. Finally, wearable ICP monitors and AI-assisted diagnostics will create opportunities for these continuous and real-time assessments, especially in limited resource settings. Our goal is to provide examples of opportunities that exist that might augment early recognition and improve personalized care while ensuring we realize practical challenges and limitations. We also consider what may be therapeutically possible now and in the future. Therapeutic opportunities discussed include CRISPR-based gene editing aimed at restoring AQP4 function, nano-robotics aimed at drug targeting, and bioelectronic devices purposed for ICP modulation. Certainly, these proposals are innovative in nature but will require ethically responsible confirmation of long-term safety and availability, particularly to low- and middle-income countries (LMICs), where the burdens of secondary ICH remain preeminent. Throughout the review, we will be restrained to a balanced pursuit of innovative ideas and ethical considerations to attain global health equity. It is not our intent to provide unequivocal answers, but instead to encourage informed discussions at the intersections of research, clinical practice, and the public health field. We hope this review may stimulate further discussion about ICH and highlight research opportunities to conduct translational research in modern neuroscience with real, approachable, and patient-centered care. Full article

The integration of artificial intelligence (AI) with wearable bioelectronics is revolutionizing digital healthcare by enabling proactive, personalized, and data-driven medical solutions. These advanced devices, equipped with multimodal sensors and AI-powered analytics, facilitate real-time monitoring of physiological and biochemical parameters—such as cardiac activity, glucose levels, and biomarkers—allowing for early disease detection, chronic condition management, and precision therapeutics. By shifting healthcare from reactive to preventive paradigms, AI-driven wearables address critical challenges, including rising chronic disease burdens, aging populations, and healthcare accessibility gaps. However, their widespread adoption faces technical, ethical, and regulatory hurdles, such as data interoperability, privacy concerns, algorithmic bias, and the need for robust clinical validation. This review comprehensively examines the current state of AI-enhanced wearable bioelectronics, covering (1) foundational technologies in sensor design, AI algorithms, and energy-efficient hardware; (2) applications in continuous health monitoring, diagnostics, and personalized interventions; (3) key challenges in scalability, security, and regulatory compliance; and (4) future directions involving 5G, the IoT, and global standardization efforts. We highlight how these technologies could democratize healthcare through remote patient monitoring and resource optimization while emphasizing the imperative of interdisciplinary collaboration to ensure equitable, secure, and clinically impactful deployment. By synthesizing advancements and critical gaps, this review aims to guide researchers, clinicians, and policymakers toward responsible innovation in the next generation of digital healthcare. Full article

The transition toward sustainable and decentralized energy solutions necessitates the development of innovative bioelectronic systems capable of harvesting and converting renewable energy. Here, we present a novel photo-bioelectrochemical fuel cell architecture based on a biohybrid anode integrating laser-induced graphene (LIG), poly(3,4-ethylenedioxythiophene) (PEDOT), and isolated thylakoid membranes. LIG provided a porous, conductive scaffold, while PEDOT enhanced electrode compatibility, electrical conductivity, and operational stability. Compared to MXene-based systems that involve complex, multi-step synthesis, PEDOT offers a cost-effective and scalable alternative for bioelectrode fabrication. Thylakoid membranes were immobilized onto the PEDOT-modified LIG surface to enable light-driven electron generation. Electrochemical characterization revealed enhanced redox activity following PEDOT modification and stable photocurrent generation under light illumination, achieving a photocurrent density of approximately 18 µA cm⁻². The assembled photo-bioelectrochemical fuel cell employing a gas diffusion platinum cathode demonstrated an open-circuit voltage of 0.57 V and a peak power density of 36 µW cm⁻² in 0.1 M citrate buffer (pH 5.5) under light conditions. Furthermore, the integration of a charge pump circuit successfully boosted the harvested voltage to drive a low-power light-emitting diode, showcasing the practical viability of the system. This work highlights the potential of combining biological photosystems with conductive nanomaterials for the development of self-powered, light-driven bioelectronic devices. Full article

Bioelectronics for wearable and implantable biomedical devices has attracted significant attention due to its potential for continuous health monitoring, early disease diagnosis, and real-time therapeutic interventions. Among the various materials explored for bioelectronic applications, hydrogels derived from natural biopolymers have emerged as highly promising candidates, owing to their inherent biocompatibility, mechanical compliance akin to biological tissues, and tunable structural properties. This review provides a comprehensive overview of recent advancements in the design and application of protein-based hydrogels, including gelatin, collagen, silk fibroin, and gluten, as well as carbohydrate-based hydrogels such as chitosan, cellulose, alginate, and starch. Particular emphasis is placed on elucidating their intrinsic material characteristics, modification strategies to improve electrical and mechanical performance, and their applicability for bioelectronic interfaces. The review further explores their diverse applications in physiological and biochemical signal sensing, bioelectric signal recording, and electrical stimulation. Finally, current challenges and future perspectives are discussed to guide the ongoing innovation of hydrogel-based systems for next-generation bioelectronic technologies. Full article

High-performance flexible sensors capable of direct integration with biological tissues are essential for personalized health monitoring, assistive rehabilitation, and human–machine interaction. However, conventional devices face significant challenges in achieving conformal integration with biological surfaces, along with sufficient biomechanical compatibility and biocompatibility. This research presents an in situ 3D biomanufacturing strategy utilizing Direct Ink Writing (DIW) technology to fabricate functional bioelectronic interfaces directly onto human skin, based on a novel annealing PEDOT:PSS/PVA composite bio-ink. Central to this strategy is the utilization of a novel annealing PEDOT:PSS/PVA composite material, subjected to specialized processing involving freeze-drying and subsequent thermal annealing, which is then formulated into a DIW ink exhibiting excellent printability. Owing to the enhanced network structure resulting from this unique fabrication process, films derived from this composite material exhibit favorable electrical conductivity (ca. 6 S/m in the dry state and 2 S/m when swollen) and excellent mechanical stretchability (maximum strain reaching 170%). The material also demonstrates good adhesion to biological interfaces and high-fidelity printability. Devices fabricated using this material achieved good conformal integration onto a finger joint and demonstrated strain-sensitive, repeatable responses during joint flexion and extension, capable of effectively transducing local strain into real-time electrical resistance signals. This study validates the feasibility of using the DIW biomanufacturing technique with this novel material for the direct on-body fabrication of functional sensors. It offers new material and manufacturing paradigms for developing highly customized and seamlessly integrated bioelectronic devices. Full article

Electroactive polymers (EAPs) have emerged as versatile materials for self-powered actuators and biosensors, revolutionizing biomedical diagnostics and healthcare technologies. These materials harness various energy harvesting mechanisms, including piezoelectricity, triboelectricity, and ionic conductivity, to enable real-time, energy-efficient, and autonomous sensing and actuation without external power sources. This review explores recent advancements in EAP-based self-powered systems, focusing on their applications in biosensing, soft robotics, and biomedical actuation. The integration of nanomaterials, flexible electronics, and wireless communication technologies has significantly enhanced their sensitivity, durability, and multifunctionality, making them ideal for next-generation wearable and implantable medical devices. Additionally, this review discusses key challenges, including material stability, biocompatibility, and optimization strategies for enhanced performance. Future perspectives on the clinical translation of EAP-based actuators and biosensors are also highlighted, emphasizing their potential to transform smart healthcare and bioelectronic applications. Full article

Recent advancements in wearable electronics have significantly enhanced human–device interaction, enabling applications such as continuous health monitoring, advanced diagnostics, and augmented reality. While progress in material science has improved the flexibility, softness, and elasticity of these devices for better skin conformity, their optical properties, particularly transparency, remain relatively unexplored. Transparent wearable electronics offer distinct advantages: they allow for non-invasive health monitoring by enabling a clear view of biological systems and improve aesthetics by minimizing the visual presence of electronics on the skin, thereby increasing user acceptance. Hydrogels have emerged as a key material for transparent wearable electronics due to their high water content, excellent biocompatibility, and tunable mechanical and optical properties. Their inherent softness and stretchability allow intimate, stable contact with dynamic biological surfaces. Furthermore, their ability to support ion-based conductivity is advantageous for bioelectronic interfaces and physiological sensors. Current research is focused on advancing hydrogel design to improve transparency, mechanical resilience, conductivity, and adhesion. The core components of transparent wearable systems include physiological sensors, energy storage devices, actuators, and real-time displays. These must collectively balance efficiency, functionality, and long-term durability. Practical applications span continuous health tracking and medical imaging to next-generation interactive displays. Despite progress, challenges such as material durability, scalable manufacturing, and prolonged usability remain. Addressing these limitations will be crucial for the future development of transparent, functional, and user-friendly wearable electronics. Full article

Wearable and implantable BioMEMSs (biomedical microelectromechanical systems) have transformed modern healthcare by enabling continuous, personalized, and minimally invasive monitoring, diagnostics, and therapy. Wearable BioMEMSs have advanced rapidly, encompassing a diverse range of biosensors, bioelectronic systems, drug delivery platforms, and motion tracking technologies. These devices enable non-invasive, real-time monitoring of biochemical, electrophysiological, and biomechanical signals, offering personalized and proactive healthcare solutions. In parallel, implantable BioMEMS have significantly enhanced long-term diagnostics, targeted drug delivery, and neurostimulation. From continuous glucose and intraocular pressure monitoring to programmable drug delivery and bioelectric implants for neuromodulation, these devices are improving precision treatment by continuous monitoring and localized therapy. This review explores the materials and technologies driving advancements in wearable and implantable BioMEMSs, focusing on their impact on chronic disease management, cardiology, respiratory care, and glaucoma treatment. We also highlight their integration with artificial intelligence (AI) and the Internet of Things (IoT), paving the way for smarter, data-driven healthcare solutions. Despite their potential, BioMEMSs face challenges such as regulatory complexities, global standardization, and societal determinants. Looking ahead, we explore emerging directions like multifunctional systems, biodegradable power sources, and next-generation point-of-care diagnostics. Collectively, these advancements position BioMEMS as pivotal enablers of future patient-centric healthcare systems. Full article

The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes. Organic bioelectronics has emerged as a powerful tool in this pursuit, offering a unique ability to interact with biology due to the mixed ionic–electronic conduction and tissue-mimetic mechanical properties of conducting polymers (CPs). These materials enable seamless integration with biological systems across different levels of complexity, from monolayers to complex 3D models, microfluidic chips, and even clinical applications. CPs can be processed into diverse formats, including thin films, hydrogels, 3D scaffolds, and electrospun fibers, allowing the fabrication of advanced bioelectronic devices such as multi-electrode arrays, transistors (EGOFETs, OECTs), ion pumps, and photoactuators. This review examines the integration of CP-based bioelectronics in vivo and in in vitro microphysiological systems, focusing on their ability to monitor key biological events, including electrical activity, metabolic changes, and biomarker concentrations, as well as their potential for electrical, mechanical, and chemical stimulation. We highlight the versatility and biocompatibility of CPs and their role in advancing personalized medicine and regenerative therapies and discuss future directions for organic bioelectronics to bridge the gap between biological systems and electronic technologies. Full article

Nowadays, due to improvements in living standards, more attention is reserved to all-around disease prevention and health care. In particular, research efforts have been made for developing novel methods and treatments for anti-cancer therapy. Self-powered nanogenerators have emerged in recent years as an attractive cost-effective technology to harvest energy or for biosensing applications. Bioelectronic nanogenerators can be used for inducing tissue recovery and for treating human illness through electrical stimulation. However, there is still a lack of comprehensive cognitive assessment of these devices and platforms, especially regarding which requirements must be satisfied and which working principles for energy transduction can be adopted effectively in the body. This review covers the most recent advances in bioelectronic nanogenerators for anti-cancer therapy, based on different transducing strategies (photodynamic therapy, drug delivery, electrical stimulation, atomic nanogenerators, etc.), and the potential mechanisms for tissue repair promotion are discussed. The prospective challenges are finally summarized with an indication of a future outlook. Full article

A chronic wound is a wound that fails to progress through the normal stages of healing within a typical time frame, often remaining open and unhealed for more than 4 to 6 weeks. The delayed healing is often associated with comorbidities, and its clinical consequences have posed great concern to patients, caregivers, and researchers. The use of electrostimulation to enhance healing in chronic wounds has received attention in the last 20 years. Innovative wearable electroceutical devices are engineered to enhance the healing of chronic wounds while prioritizing patient convenience. These devices employ controlled micro-electrostimulation to reactivate endogenous bioelectric activities needed for cellular signaling. However, these devices and their mechanisms of electrostimulation have not been fully explored. In this systematic review, three databases with articles published between 2000 and 2023 were searched and screened using strict inclusion criteria while adhering to the PRISMA checklist. We identified direct, pulsed, and alternating electric currents as the primary modalities by electroceutical devices to deliver electrical stimulation in chronic wounds. Typical chronic wounds identified include diabetic foot ulcers, pressure ulcers, and diabetic venous ulcers. Additionally, a few materials crucial for chronic wound healing were reviewed, and recent devices in research were considered in this study. Various devices, including triboelectric and piezo-nanogenerators, were identified for their potential functionalities in generating electrical stimulation relevant to chronic wound applications. The literature lacked closed-loop electroceutical platforms for treatment and concurrent monitoring of wound healing. The analysis taken from this systematic review provides opportunities at the intersection of epidermal soft bioelectronics, wound care, and remote sensing. Full article

Silk fibroin, a biocompatible and flexible biopolymer derived from Bombyx mori silkworms, has shown promise in bioelectronics, due to its adjustable dielectric properties. This study investigates the influence of spin coating parameters on the optical, electrical, and dielectric properties of thin silk fibroin films. Silk fibroin solutions were spin coated onto indium tin oxide (ITO)/glass substrates at speeds ranging from 1000 to 7000 revolutions per minute (RPM), resulting in films with thicknesses that varied from 264.8 nm to 81.9 nm. Atomic force microscopy analysis revealed that the surface roughness remained consistent at approximately 1.5 nm across all the spin coating speeds, while the film thickness decreased with the increasing spin speed. Ultraviolet (UV)–visible spectroscopy showed that the transmittance at 550 nm increased from 81.2% at 1000 RPM to 93.8% at 7000 RPM, and the optical bandgap widened from 3.82 eV at 1000 RPM to 3.92 eV at 7000 RPM, which was attributed to reduced molecular packing and quantum confinement effects. Electrical characterization showed that thinner films (a spin speed of 5000–7000 RPM) exhibited a 15-fold increase in the leakage current, rising from 2.99 pA at 1000 RPM to 44.9 pA at 7000 RPM, and a decrease in resistance from 334 GΩ at 1000 RPM to 22.2 GΩ at 7000 RPM. The capacitance–voltage measurements indicated a 4-fold increase in voltage-dependent capacitance for thinner films, with capacitance values increasing from 36 pF at 1000 RPM to 176 pF at 7000 RPM. Dielectric loss analysis revealed that thinner films experienced higher energy dissipation at low frequencies (tan δ of 0.041 at 0.01 MHz for 7000 RPM), but lower losses at high frequencies (tan δ of 0.123 at 1 MHz for 7000 RPM). These findings emphasize the importance of film thickness control in optimizing the performance of silk fibroin-based bioelectronic devices. Full article

Gel electrolyte-gated organic electrochemical transistors (OECTs) are promising bioelectronic devices known for their high transconductance, low operating voltage, and integration with biological systems. Despite extensive research on the performance of OECTs, a precise model defining the dependence of OECT performance on gel electrolytes is still lacking. In this work, we refine the device model to comprehensively account for the electrical double layer (EDL)’s capacitance of the gel electrolyte. Both experimental data and theoretical calculations indicate that the maximum transconductance of the OECT is contingent upon ion concentration, drain voltage, and scan rate, highlighting a strong correlation between the transconductance and the hydrogel electrolyte. Overall, this model serves as a theoretical tool for improving the performance of OECTs, enabling the further development of bioelectronic devices. Full article

Flexible devices are soft, lightweight, and portable, making them suitable for large-area applications. These features significantly expand the scope of electronic devices and demonstrate their unique value in various fields, including smart wearable devices, medical and health monitoring, human–computer interaction, and brain–computer interfaces. Protein materials, due to their unique molecular structure, biological properties, sustainability, self-assembly ability, and good biocompatibility, can be applied in electronic devices to significantly enhance the sensitivity, stability, mechanical strength, energy density, and conductivity of the devices. Protein-based flexible devices have become an important research direction in the fields of bioelectronics and smart wearables, providing new material support for the development of more environmentally friendly and reliable flexible electronics. Currently, many proteins, such as silk fibroin, collagen, ferritin, and so on, have been used in biosensors, memristors, energy storage devices, and power generation devices. Therefore, in this paper, we provide an overview of related research in the field of protein-based flexible devices, including the concept and characteristics of protein-based flexible devices, fabrication materials, fabrication processes, characterization, and evaluation, and we point out the future development direction of protein-based flexible devices. Full article

Flexible sensors are revolutionizing wearable and implantable devices, with conductive hydrogels emerging as key materials due to their biomimetic structure, biocompatibility, tunable transparency, and stimuli-responsive electrical properties. However, their fragility and limited durability pose significant challenges for broader applications. Drawing inspiration from the self-healing capabilities of natural organisms like mussels, researchers are embedding self-repair mechanisms into hydrogels to improve their reliability and lifespan. This review highlights recent advances in self-healing (SH) conductive hydrogels, focusing on synthesis methods, healing mechanisms, and strategies to enhance multifunctionality. It also explores their wide-ranging applications, including in vivo signal monitoring, wearable biochemical sensors, supercapacitors, flexible displays, triboelectric nanogenerators, and implantable bioelectronics. While progress has been made, challenges remain in balancing self-healing efficiency, mechanical strength, and sensing performance. This review offers insights into overcoming these obstacles and discusses future research directions for advancing SH hydrogel-based bioelectronics, aiming to pave the way for durable, high-performance devices in next-generation wearable and implantable technologies. Full article