Search Results (418)

Infrared small-target detection remains a critical challenge in military reconnaissance, environmental monitoring, forest-fire prevention, and search-and-rescue operations, owing to the targets’ extremely small size, sparse texture, low signal-to-noise ratio, and complex background interference. Traditional convolutional neural networks (CNNs) struggle to detect such weak, low-contrast objects due to their limited receptive fields and insufficient feature extraction capabilities. To overcome these limitations, we propose a Multi-Scale Edge-Aware Convolution (MEAC) module that enhances feature representation for small infrared targets without increasing parameter count or computational cost. Specifically, MEAC fuses (1) original local features, (2) multi-scale context captured via dilated convolutions, and (3) high-contrast edge cues derived from differential Gaussian filters. After fusing these branches, channel and spatial attention mechanisms are applied to adaptively emphasize critical regions, further improving feature discrimination. The MEAC module is fully compatible with standard convolutional layers and can be seamlessly embedded into various network architectures. Extensive experiments on three public infrared small-target datasets (SIRSTD-UAVB, IRSTDv1, and IRSTD-1K) demonstrate that networks augmented with MEAC significantly outperform baseline models using standard convolutions. When compared to eleven mainstream convolution modules (ACmix, AKConv, DRConv, DSConv, LSKConv, MixConv, PConv, ODConv, GConv, and Involution), our method consistently achieves the highest detection accuracy and robustness. Experiments conducted across multiple versions, including YOLOv10, YOLOv11, and YOLOv12, as well as various network levels, demonstrate that the MEAC module achieves stable improvements in performance metrics while slightly increasing computational and parameter complexity. These results validate the MEAC module’s significant advantages in enhancing the detection of small and weak objects and suppressing interference from complex backgrounds. These results validate MEAC’s effectiveness in enhancing weak small-target detection and suppressing complex background noise, highlighting its strong generalization ability and practical application potential. Full article

Background: Hypoxia and immune components significantly shape the tumor microenvironment and influence prognosis and immunotherapy response in gastric cancer (GC). This study aimed to develop hypoxia- and immune-related gene signatures for prognostic evaluation in GC. Methods: Transcriptomic data from TCGA-STAD were integrated with hypoxia- and immune-related genes from InnateDB and MSigDB. A prognostic gene signature was constructed using Cox regression analyses and validated on an independent GSE84437 cohort and single-cell RNA dataset. We further analyzed immune cell infiltration, molecular characteristics of different risk groups, and their association with immunotherapy response. Single-cell RNA-seq data from the TISCH database were used to explore gene expression patterns across cell types. Results: Five genes (TGFB3, INHA, SERPINE1, GPC3, SRPX) were identified. The risk score effectively stratified patients by prognosis, with the high-risk group showing lower overall survival and lower T-cell expression. The gene signature had an association with immune suppression, ARID1A mutation, EMT features, and poorer response to immunotherapy. Gene signature, especially SRPX was enriched in fibroblasts. Conclusions: We developed a robust hypoxia- and immune-related gene signature that predicts prognosis and may help guide immunotherapy strategies for GC patients. Full article

Small object detection (SOD) in remote sensing images (RSIs) is a challenging task due to scale variation, severe occlusion, and complex backgrounds, often leading to high miss and false detection rates. To address these issues, this paper proposes a novel detection framework named HSF-YOLO, which is designed to jointly enhance feature encoding, attention interaction, and localization precision within the YOLOv8 backbone. Specifically, we introduce three tailored modules: Hybrid Atrous Enhanced Convolution (HAEC), a Spatial–Interactive–Shuffle attention module (C2f_SIS), and a Focal Gradient Refinement Loss (FGR-Loss). The HAEC module captures multi-scale semantic and fine-grained local information through parallel atrous and standard convolutions, thereby enhancing small object representation across scales. The C2f_SIS module fuses spatial and improved channel attention with a channel shuffle strategy to enhance feature interaction and suppress background noise. The FGR-Loss incorporates gradient-aware localization, focal weighting, and separation-aware constraints to improve regression accuracy and training robustness. Extensive experiments were conducted on three public remote sensing datasets. Compared with the baseline YOLOv8, HSF-YOLO improved mAP@0.5 and mAP@0.5:0.95 by 5.7% and 4.0% on the VisDrone2019 dataset, by 2.3% and 2.5% on the DIOR dataset, and by 2.3% and 2.1% on the NWPU VHR-10 dataset, respectively. These results confirm that HSF-YOLO is a unified and effective solution for small object detection in complex RSI scenarios, offering a good balance between accuracy and efficiency. Full article

Vehicle detection in remote sensing images faces significant challenges due to small object sizes, scale variation, and cluttered backgrounds. To address these issues, we propose RSW-YOLO, an enhanced detection model built upon the YOLOv8n framework, designed to improve feature extraction and robustness against environmental noise. A Restormer module is incorporated into the backbone to model long-range dependencies via self-attention, enabling better handling of multi-scale features and complex scenes. A dedicated detection head is introduced for small objects, focusing on critical channels while suppressing irrelevant information. Additionally, the original CIoU loss is replaced with WIoU, which dynamically reweights predicted boxes based on their quality, enhancing localization accuracy and stability. Experimental results on the DJCAR dataset show mAP@0.5 and mAP@0.5:0.95 improvements of 5.4% and 6.2%, respectively, and corresponding gains of 4.3% and 2.6% on the VisDrone dataset. These results demonstrate that RSW-YOLO offers a robust and accurate solution for UAV-based vehicle detection, particularly in urban scenes with dense or small targets. Full article

Time-frequency analysis (TFA) technology is an important tool for analyzing non-Gaussian mechanical fault vibration signals. In the complex background of infinite variance process noise and Gaussian colored noise, it is difficult for traditional methods to obtain the highly concentrated time-frequency representation (TFR) of fault vibration signals. Based on the insensitive property of fractional low-order statistics for infinite variance and Gaussian processes, robust fractional lower order adaptive linear chirplet transform (FLOACT) and fractional lower order adaptive scaling chirplet transform (FLOASCT) methods are proposed to suppress the mixed complex noise in this paper. The calculation steps and processes of the algorithms are summarized and deduced in detail. The experimental simulation results show that the improved FLOACT and FLOASCT methods have good effects on multi-component signals with short frequency intervals in the time-frequency domain and even cross-frequency trajectories in the strong impulse background noise environment. Finally, the proposed methods are applied to the feature analysis and extraction of the mechanical outer race fault vibration signals in complex background environments, and the results show that they have good estimation accuracy and effectiveness in lower MSNR, which indicate their robustness and adaptability. Full article

Hydraulic concrete is a critical infrastructure material, with its surface condition playing a vital role in quality assessments for water conservancy and hydropower projects. However, images taken in complex hydraulic environments often suffer from degraded quality due to low lighting, shadows, and noise, making it difficult to distinguish defects from the background and thereby hindering accurate defect detection and damage evaluation. In this study, following systematic analyses of hydraulic concrete color space characteristics, we propose a Dual-Branch Luminance–Chrominance Attention Network (DBLCANet-HCIE) specifically designed for low-light hydraulic concrete image enhancement. Inspired by human visual perception, the network simultaneously improves global contrast and preserves fine-grained defect textures, which are essential for structural analysis. The proposed architecture consists of a Luminance Adjustment Branch (LAB) and a Chroma Restoration Branch (CRB). The LAB incorporates a Luminance-Aware Hybrid Attention Block (LAHAB) to capture both the global luminance distribution and local texture details, enabling adaptive illumination correction through comprehensive scene understanding. The CRB integrates a Channel Denoiser Block (CDB) for channel-specific noise suppression and a Frequency-Domain Detail Enhancement Block (FDDEB) to refine chrominance information and enhance subtle defect textures. A feature fusion block is designed to fuse and learn the features of the outputs from the two branches, resulting in images with enhanced luminance, reduced noise, and preserved surface anomalies. To validate the proposed approach, we construct a dedicated low-light hydraulic concrete image dataset (LLHCID). Extensive experiments conducted on both LOLv1 and LLHCID benchmarks demonstrate that the proposed method significantly enhances the visual interpretability of hydraulic concrete surfaces while effectively addressing low-light degradation challenges. Full article

Lunar crater detection plays a crucial role in geological analysis and the advancement of lunar exploration. Accurate identification of craters is also essential for constructing high-resolution topographic maps and supporting mission planning in future lunar exploration efforts. However, lunar craters often suffer from insufficient feature representation due to their small size and blurred boundaries. In addition, the visual similarity between craters and surrounding terrain further exacerbates background confusion. These challenges significantly hinder detection performance in remote sensing imagery and underscore the necessity of enhancing both local feature representation and global semantic reasoning. In this paper, we propose a novel Spatial Channel Fusion and Context-Aware YOLO (SCCA-YOLO) model built upon the YOLO11 framework. Specifically, the Context-Aware Module (CAM) employs a multi-branch dilated convolutional structure to enhance feature richness and expand the local receptive field, thereby strengthening the feature extraction capability. The Joint Spatial and Channel Fusion Module (SCFM) is utilized to fuse spatial and channel information to model the global relationships between craters and the background, effectively suppressing background noise and reinforcing feature discrimination. In addition, the improved Channel Attention Concatenation (CAC) strategy adaptively learns channel-wise importance weights during feature concatenation, further optimizing multi-scale semantic feature fusion and enhancing the model’s sensitivity to critical crater features. The proposed method is validated on a self-constructed Chang’e 6 dataset, covering the landing site and its surrounding areas. Experimental results demonstrate that our model achieves an $mA{P}_{0.5}$ of 96.5% and an $mA{P}_{0.5:0.95}$ of 81.5%, outperforming other mainstream detection models including the YOLO family of algorithms. These findings highlight the potential of SCCA-YOLO for high-precision lunar crater detection and provide valuable insights into future lunar surface analysis. Full article

Background: The glucocorticoid receptor (GR) regulates the transcription of thousands of genes. In cancer, both oncogenic and tumor suppressive roles of GR have been proposed. Methods: A tissue microarray containing 18,527 samples from 147 tumor (sub-)types and 608 samples from 76 normal tissue types was analyzed for GR expression by immunohistochemistry. Results: GR positivity was found in 76.4% of 14,349 interpretable cancers, including 18.5% with weak, 19.6% with moderate, and 38.3% with strong positivity. GR positivity appeared in all 147 tumor types, with at least one strongly positive tumor in 136 types. Of out tumor entities, 77 of the 147 showed GR positivity in 100% of the cases analyzed. Only six tumor types had less than 50% GR-positive cases, including adenomas with low-/high-grade dysplasia (32.5%/21.7%), adenocarcinomas (17%) and neuroendocrine carcinomas (45.5%) of the colorectum, endometrial carcinomas (25.6%), and rhabdoid tumors (25%). Reduced GR staining was associated with grade progression in pTa (p < 0.0001) and with nodal metastasis in pT2-4 (p = 0.0051) urothelial bladder carcinoma, advanced pT stage (p = 0.0006) in breast carcinomas of no special type (NST), and high grade (p = 0.0066), advanced pT stage (p < 0.0001), and distant metastasis (p = 0.0081) in clear cell renal cell carcinoma. GR expression was unrelated to clinico-pathological parameters in gastric, pancreatic, and colorectal adenocarcinoma, and in serous high-grade carcinoma of the ovary. Conclusions: GR expression is frequent across all cancer types. Associations between reduced GR expression and unfavorable tumor features in certain cancers suggest that the functional importance of GR-regulated genes in cancer progression depends on the cell of tumor origin. Full article

To address challenges of background interference and limited multi-scale feature extraction in infrared small target detection, this paper proposes a YOLO-HVS detection algorithm inspired by the human visual system. Based on YOLOv8, we design a multi-scale spatially enhanced attention module (MultiSEAM) using multi-branch depth-separable convolution to suppress background noise and enhance occluded targets, integrating local details and global context. Meanwhile, the C2f_DWR (dilation-wise residual) module with regional-semantic dual residual structure is designed to significantly improve the efficiency of capturing multi-scale contextual information by expanding convolution and two-step feature extraction mechanism. We construct the DroneRoadVehicles dataset containing 1028 infrared images captured at 70–300 m, covering complex occlusion and multi-scale targets. Experiments show that YOLO-HVS achieves mAP50 of 83.4% and 97.8% on the public dataset DroneVehicle and the self-built dataset, respectively, which is an improvement of 1.1% and 0.7% over the baseline YOLOv8, and the number of model parameters only increases by 2.3 M, and the increase of GFLOPs is controlled at 0.1 G. The experimental results demonstrate that the proposed approach exhibits enhanced robustness in detecting targets under severe occlusion and low SNR conditions, while enabling efficient real-time infrared small target detection. Full article

Multispectral object detection faces challenges in effectively integrating complementary information from different modalities in complex environmental conditions. This paper proposes SDRFPT-Net (Spectral Dual-stream Recursive Fusion Perception Target Network), a novel architecture that integrates three key innovative modules: (1) the Spectral Hierarchical Perception Architecture (SHPA), which adopts a dual-stream separated structure with independently parameterized feature extraction paths for visible and infrared modalities; (2) the Spectral Recursive Fusion Module (SRFM), which combines hybrid attention mechanisms with recursive progressive fusion strategies to achieve deep feature interaction through parameter-sharing multi-round recursive processing; and (3) the Spectral Target Perception Enhancement Module (STPEM), which adaptively enhances target region representation and suppresses background interference. Extensive experiments on the VEDAI, FLIR-aligned, and LLVIP datasets demonstrate that SDRFPT-Net significantly outperforms state-of-the-art methods, with improvements of 2.5% in mAP50 and 5.4% in mAP50:95 on VEDAI, 11.5% in mAP50 on FLIR-aligned, and 9.5% in mAP50:95 on LLVIP. Ablation studies further validate the effectiveness of each proposed module. The proposed method provides an efficient and robust solution for multispectral object detection in remote sensing image interpretation, making it particularly suitable for all-weather monitoring applications from aerial and satellite platforms, as well as in intelligent surveillance and autonomous driving domains. Full article

Infrared small target detection (IRSTD) aims to locate and separate targets from complex backgrounds. The challenges in IRSTD primarily come from extremely sparse target features and strong background clutter interference. However, existing methods typically perform discrimination directly on the features extracted by deep networks, neglecting the distinct characteristics of weak and small targets in the frequency domain, thereby limiting the improvement of detection capability. In this paper, we propose a frequency-aware masked-attention network (FM-Net) that leverages multi-scale frequency clues to assist in representing global context and suppressing noise interference. Specifically, we design the wavelet residual block (WRB) to extract multi-scale spatial and frequency features, which introduces a wavelet pyramid as the intermediate layer of the residual block. Then, to perceive global information on the long-range skip connections, a frequency-modulation masked-attention module (FMM) is used to interact with multi-layer features from the encoder. FMM contains two crucial elements: (a) a mask attention (MA) mechanism for injecting broad contextual feature efficiently to promote full-level semantic correlation and focus on salient regions, and (b) a channel-wise frequency modulation module (CFM) for enhancing the most informative frequency components and suppressing useless ones. Extensive experiments on three benchmark datasets (e.g., SIRST, NUDT-SIRST, IRSTD-1k) demonstrate that FM-Net achieves superior detection performance. Full article

The occurrence of construction site fires is consistently accompanied by casualties and property damage. To address the issues of large target-scale variations and frequent false detections in construction site fire monitoring, we propose a fire detection algorithm based on an improved YOLOv8 model, achieving real-time and efficient detection of fires on construction sites. First, considering the wide range of scale variations in detected objects, an additional detection layer with a 64-times down-sampling rate is introduced to enhance the algorithm’s detection capability for multi-scale targets. Then, the MBConv module and the ESE attention block are integrated into the C2f structure to enhance feature extraction capabilities while reducing computational complexity. An iCBAM attention module is designed to suppress background noise interference and enhance the representation capability of the network. Finally, the WIoUv3 metric is adopted in the loss function for bounding box regression to mitigate harmful gradient issues. Comparative experiments demonstrate that, on a self-constructed construction site fire dataset, the improved algorithm achieves an accuracy and recall increase of 4.6% and 3.0%, respectively, compared to the original YOLOv8 model. Additionally, mAP50 and mAP50-95 are improved by 1.6% and 1.5%, respectively. This algorithm provides a more effective solution for fire monitoring in construction environments. Full article

To address the challenges in ship plate detection under complex maritime scenarios—such as small target size, extreme aspect ratios, dense arrangements, and multi-angle rotations—this paper proposes a multi-module collaborative detection algorithm, RT-DETR-HPA, based on an enhanced RT-DETR framework. The proposed model integrates three core components: an improved High-Frequency Enhanced Residual Block (HFERB) embedded in the backbone to strengthen multi-scale high-frequency feature fusion, with deformable convolution added to handle occlusion and deformation; a Pinwheel-shaped Convolution (PConv) module employing multi-directional convolution kernels to achieve rotation-adaptive local detail extraction and accurately capture plate edges and character features; and an Adaptive Sparse Self-Attention (ASSA) mechanism incorporated into the encoder to automatically focus on key regions while suppressing complex background interference, thereby enhancing feature discriminability. Comparative experiments conducted on a self-constructed dataset of 20,000 ship plate images show that, compared to the original RT-DETR, RT-DETR-HPA achieves a 3.36% improvement in mAP@50 (up to 97.12%), a 3.23% increase in recall (reaching 94.88%), and maintains real-time detection speed at 40.1 FPS. Compared with mainstream object detection models such as the YOLO series and Faster R-CNN, RT-DETR-HPA demonstrates significant advantages in high-precision localization, adaptability to complex scenarios, and real-time performance. It effectively reduces missed and false detections caused by low resolution, poor lighting, and dense occlusion, providing a robust and high-accuracy solution for intelligent ship supervision. Future work will focus on lightweight model design and dynamic resolution adaptation to enhance its applicability on mobile maritime surveillance platforms. Full article

Background/Objectives: Isocitrate dehydrogenase (IDH) mutations are hallmark features in subsets of gliomas, producing the oncometabolite D-2-hydroxyglutarate (2HG). Although IDH mutations are associated with better clinical outcomes, their relationship with tumor progression is complex. This study aimed to investigate, in vitro and in vivo, the phenotypic consequences of IDH mutation and 2HG exposure in glioblastoma (GBM) under normoxic and hypoxic conditions and under temozolomide (TMZ) and radiation exposure. Methods: Experiments were conducted using IDH-wildtype (IDH-wt) and IDH-mutant (IDH-mut) glioma cell lines under controlled oxygen conditions. Functional assays included cell viability, cell cycle analysis, apoptosis profiling, migration, and surface marker expression via flow cytometry. Orthotopic xenografts were established in immunocompromised mice to assess in vivo tumor growth and morphology, followed by MRI and histological analysis. Treatments included TMZ, radiation, and 2HG at varying concentrations. Statistical analyses were performed using SPSS and RStudio. Results:IDH-wt cells exhibited faster proliferation and greater adaptability under hypoxia, while IDH-mut cells showed cell cycle arrest and limited growth. 2HG recapitulated IDH-mut features in IDH-wt cells, including increased apoptosis under TMZ, reduced proliferation, and altered CD24/CD44 expression. In vivo, IDH-wt tumors were larger and more infiltrative, while 2HG administration reduced tumor volume and promoted compact morphology. Notably, migration was initially similar across genotypes but increased in IDH-mut and 2HG-treated IDH-wt cells over time, though suppressed under therapeutic stress. Conclusions: IDH mutation and 2HG modulate glioma cell biology, including cell cycle dynamics, proliferation rates, migration, and apoptosis. While the IDH mutation and its metabolic product confer initial growth advantages, they enhance treatment sensitivity and reduce invasiveness, highlighting potential vulnerabilities for targeted therapy. Full article

Deep learning methods have achieved remarkable success in remote sensing object detection. Existing object detection methods focus on integrating convolutional neural networks (CNNs) and Transformer networks to explore local and global representations to improve performance. However, existing methods relying on fixed convolutional kernels and dense global attention mechanisms suffer from computational redundancy and insufficient discriminative feature extraction, particularly for small and rotation-sensitive targets. To address these limitations, we propose a Dynamic Multi-Kernel Position-Aware Feature Pyramid Network (PAMFPN), which integrates adaptive sparse position modeling and multi-kernel dynamic fusion to achieve robust feature representation. Firstly, we design a position-interactive context module (PICM) that incorporates distance-aware sparse attention and dynamic positional encoding. It selectively focuses computation on sparse targets through a decay function that suppresses background noise while enhancing spatial correlations of critical regions. Secondly, we design a dual-kernel adaptive fusion (DKAF) architecture by combining region-sensitive attention (RSA) and reconfigurable context aggregation (RCA). RSA employs orthogonal large-kernel convolutions to capture anisotropic spatial features for arbitrarily oriented targets, while RCA dynamically adjusts the kernel scales based on content complexity, effectively addressing scale variations and intraclass diversity. Extensive experiments on three benchmark datasets (DOTA-v1.0, SSDD, HWPUVHR-10) demonstrate the effectiveness and versatility of the proposed PAMFPN. This work bridges the gap between efficient computation and robust feature fusion in remote sensing detection, offering a universal solution for real-world applications. Full article