Molecular Mechanisms and Therapy of Gliomas
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 594
Special Issue Editor
Interests: cancer biology; colorectal cancer; neuropathology; surgical pathology; prognostic markers; cancer biomarkers; can-cer diagnostics; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, knowledge of the molecular landscape of gliomas has greatly expanded. It has been shown that histologically similar tumors display distinct epigenetic, genetic, transcriptomic, and proteomic features and that the clinical outcome of gliomas can be better predicted by integrating histological and molecular data rather than by histology. This has led to the development of novel glioma classification schemes. Indeed, the latest World Health Organization Classification of gliomas, published in 2021, subdivided gliomas not only on their growth pattern, that is, diffuse or circumscribed, on their histopathological features and on their anatomical location, but also on genetic alterations. In addition, the essential diagnostic criterion for some tumor types is a unique DNA methylation profile.
An increasing understanding of the molecular features of gliomas has also led to the identification of novel potential therapeutic targets.
This Special Issue aims to collect papers on recent advances in the molecular mechanisms of glioma pathogenesis and progression and on novel therapeutic strategies for these tumors.
Dr. Valeria Barresi
Guest Editor
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Keywords
- glioma
- epigenetic
- methylome
- therapy
- genetic alteration
- transcriptomic
- proteomic
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