Search Results (1,551)

In recent years, pervious oyster shell habitat (POSH) units have been developed and deployed as part of living shoreline projects in Northeast Florida. POSH units are modular artificial oyster reef structures made from cement and recycled oyster shells. POSH units aim to improve oyster recruitment, attenuate wave energy, trap sediment, and restore salt marsh habitat. Previous studies demonstrated the units’ ability to attract oyster larvae and reduce shoreline bed stress in some areas. This paper further explores the effect of POSH unit placement on bed stress under boat wake conditions using large-eddy simulations (LES). Results indicated that certain POSH unit arrangements may be preferable; a small overlap between segments may help block flow and reduce associated stresses, while a chevron pattern may benefit sites subject to oblique waves. However, even these more “optimized” configurations resulted in bed stresses with similar orders of magnitude when compared to more linear arrangements. Understanding how POSH units affect bed stress and potential erosion patterns can help restoration stakeholders design future living shorelines with POSH units or other similar structures. Full article

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes in younger women without typical atherosclerotic risk factors. Its distinct pathophysiology and vessel fragility create unique challenges for revascularization. Conservative management is preferred when hemodynamics and coronary flow permit, but selected cases necessitate intervention, primarily percutaneous coronary intervention (PCI). Despite growing insights into SCAD pathomechanics—the “outside-in” and “inside-out” hypotheses—and the central role of intracoronary imaging (OCT/IVUS), optimal device strategies remain under-researched. The present review covers contemporary SCAD-PCI pitfalls and limitations, expanding to the mechanistic underpinnings and procedural applications of drug-coated balloons (DCB) and bioresorbable scaffolds (BRS) as “leave-nothing-behind” alternatives. Both approaches have advantages and drawbacks but are attractive in selected scenarios: DCB delivers antiproliferative therapy without permanent caging, and BRS provides temporary scaffolding (amenable to overlap when required) with the potential to restore biomechanics/vasomotion after resorption. Acknowledging that definitive evidence is lacking and current data are largely observational, the review finally sets future research priorities including head-to-head trials of different DCB types and evaluation of next-generation, thinner-strut, predictably resorbing BRS. The overarching question is whether—and how—these modalities can be integrated into standardized, imaging-guided interventional algorithms for SCAD. Full article

In recent decades, rotating dynamic filtration (RDF) has attracted considerable attention due to its high efficiency and low energy consumption. While most studies have focused on separation behavior and membrane fouling, energy consumption in RDF has received limited attention. This study investigates the specific energy consumption (SEC) of the RDF process for ship exhaust gas cleaning (EGC) desulfurization wastewater treatment and proposes an optimization method based on both energy consumption and equipment cost. The total SEC increases with rotational velocity, circulation flow, feed concentration, and membrane size but decreases with temperature and remains unaffected by the number of membrane elements. In RDF, the total SEC is only 9.05–19.29% of that in tubular cross-flow filtration (CFF) at equivalent shear force ranging from 3.86 Pa to 121.14 Pa. Operating energy and investment costs are primarily determined by the number of membrane elements and the rotational velocity. According to the economic analysis, the lowest treatment cost for EGC wastewater is CNY 6.09 per cubic meter for a 5 m³·h⁻¹ capacity, using 84 membrane elements (374 mm, 0.2 µm) at a rotational velocity of 200 rpm, an operating pressure of 200 kPa, and a temperature of 40 °C. Full article

Since the 1970s, Tunisia has been a popular destination due to its diverse natural environment and a tourist offer based on recreation 3S (Sea–Sun–Sand). Tourist flow is therefore concentrated along its eastern Mediterranean coast, where there is a risk of overtourism. One of the proposed solutions to prevent this phenomenon is to assess the natural potential and tourism functions of Tunisia in the context of sustainable tourism. This goal was achieved through the use of the method of multidimensional comparative analysis, which allowed for a measurable comparison of the country’s tourist regions in terms of 23 characteristics illustrating the potential and functions of nature-based attractions and accommodation facilities (number of beds, number of tourists using accommodation). In light of the synthetic indicators obtained, the greatest threat to sustainable nature-based tourism was identified in the regions of Nabeul–Hammamet and Yasmine–Hammamet, as well as Monastir–Skanes. In the first region, this results from the large number of tourists visiting natural attractions, whereas in the second, it stems from the excessive number of people using accommodation facilities. Therefore, it is necessary to monitor tourist flow and take various measures to relieve pressure on these regions. Full article

Lagrangian Coherent Structures (LCSs) in the mesoscale circulation of the Western Equatorial Atlantic (WEA), a region governed by the North Brazil Current (NBC) and its retroflection, are analyzed. Observations from 63 surface drifters deployed between 2018 and 2019 were combined with ocean analysis/forecast fields. The Finite-Time Lyapunov Exponent (FTLE) was computed using 15- and 90-day integrations to identify transport barriers and persistent structures. FTLE ridges showed strong seasonal correspondence with drifter trajectories, with 34–74% of drifter positions lying within 0.25° of attracting or repelling LCSs. Characteristic FTLE magnitudes reached ~0.3 d⁻¹, implying particle separation e-folding times of approximately 3.3 days. Spatial agreement between drifter-derived and model-based FTLE fields exhibited similar variability across seasons, with the highest correspondence during periods of intensified frontal activity. These results indicate that a substantial portion of the observed drifter motion follows or remains close to FTLE-defined pathways, supporting the robustness of the Lagrangian structures identified in the WEA. Overall, the study provides the first quantitative LCS-based characterization of mesoscale transport in this region, revealing recurrent eddies, instability zones, and flow boundaries associated with the NBC system and its interaction with the North Equatorial Countercurrent. Full article

In order to minimize problems associated with the operation of surface water intakes, passive wedge-wire screens are increasingly being used. Deflectors of special design are placed inside the intake heads to reduce local maximum inlet velocities and to ensure a uniform velocity distribution over their surface. The use of computer software based on Computational Fluid Dynamics (CFD) methods enabled simulations and optimization of the intake head design. Subsequently, a series of laboratory tests was conducted. Several scenarios were considered, varying the flow rates in the hydraulic flume and taking into account both the presence and absence of the deflector. Velocities around the intake head were measured, and the amount of particles in the water attracted to the head surface under the analyzed conditions was assessed. The results confirm the clear effect of the deflector on the velocity distribution. Its use originates reduced velocities near the head surface, as well as a smaller amount of debris deposited on the screen, while maintaining efficiency. At the same time, lower inlet velocities close to the head surface reduce the risk of entrainment and potential injury or mortality of young fish, fry, and eggs. Full article

While extensive research has explored the determinants of foreign direct investment (FDI) and foreign portfolio investment (FPI) in BRICS nations, there remains a notable gap in understanding the influence of intangible factors, particularly soft power and nation branding. Historically, academic discourse has underemphasized the role of nation branding as a crucial emotional and perceptual component in investment decision-making processes. Consequently, governments in BRICS countries must enhance their national branding efforts to attract both capital and portfolio investment flows. The principal aim of this study was to jointly analyse the tangible and intangible determinants influencing FDI and FPI in BRICS from 1994 to 2024. Employing advanced econometric techniques, specifically the Autoregressive Distributed Lag (ARDL) bounds testing approach for cointegration and Vector Error Correction Models (VECM) for estimation. This study makes a unique contribution to existing literature by examining the nexus between nation branding, FDI and FPI, thereby introducing a novel perspective on the factors driving investment in the BRICS context with an emphasis on non-tangible determinants. The findings indicate that nation branding, along with exchange rate stability, property rights, and financial market development, are significant positive determinants of FPI in these countries. Conversely, capital openness demonstrated a negative relationship with FPI. Moreover, the positive impact of nation branding on FDI within BRICS nations was reaffirmed. This study substantiates the critical role of nation branding as a pivotal driver for both FDI and FPI, emphasising its strategic importance in the economic landscape of BRICS countries. Full article

When blood flow to a part of the myocardial muscle is reduced or blocked, it leads to tissue ischemia in that region. Myocardial infarction (MI) occurs when the ischemic insult is of sufficient duration in time to induce cardiomyocyte death and subsequent activation of the innate immune response. MI initiates a complex cascade of cellular and molecular events within the left ventricle. Inflammatory cells rapidly infiltrate the infarcted area to remove necrotic tissue, setting the stage for reparative wound healing processes. Over the ensuing days, various cell populations—including leukocytes, fibroblasts, and endothelial cells—are attracted to the infarcted site by inflammatory cytokines and chemokines. The activated cells at the site of injury contribute to tissue remodeling and scar formation through the deposition of extracellular matrix components, particularly collagen. While scar formation is essential for structural stabilization of the infarct region to replace the loss of cardiomyocytes, scar tissue also increases myocardial stiffness and impairs cardiac contractile function. This review summarizes our knowledge regarding cellular dynamics, inflammatory signaling, and cardiac remodeling that govern MI healing. We identify the current gaps in the field and provide a foundational resource for those seeking to understand the biological underpinnings of cardiac repair following MI. Full article

Effective forest trail planning requires objective and transparent tools to balance user accessibility, recreation quality, and environmental protection. This research explores how geospatial analysis and multi-criteria decision-making can be integrated to optimize the allocation of rest and recreation facilities within forest trail networks, where limited resources and ecological constraints often restrict development. The Mount Paiko trail system in northern Greece was analyzed using a hybrid GIS–AHP–PROMETHEE II framework. Five evaluation criteria—trail difficulty, trail class, scenic attractiveness, distance from the trailhead, and traversal time from the nearest facility—were assessed to represent both physical effort and spatial accessibility. Stakeholder-based AHP weighting identified traversal time (C5) and trail difficulty (C1) as the most influential criteria, emphasizing the importance of user fatigue and service gaps. PROMETHEE II produced a clear hierarchy of forty candidate sites, prioritizing medium-difficulty and visually appealing routes located over 10 km from the starting point. Net flow values ranged from −0.228 to +0.309, with the highest-ranked location (PTF 12) highlighting a medium-difficulty, scenic segment with one of the longest traversal times from the nearest facility. By merging quantitative network analysis with structured expert judgment, the proposed framework offers a reproducible and evidence-based decision-support tool for forest planners and policymakers, promoting sustainable trail development that maximizes accessibility while minimizing environmental disturbance. Full article

This paper presents a novel system dynamics-based framework for forecasting market share evolution in the telecommunications sector. The framework conceptualizes market share as flows of subscribers—driven by churn, attraction, and market growth—between interconnected compartments representing providers. It is designed to operate with limited available market data and incorporates stochastic processes to capture market uncertainty, enabling risk-informed forecasts. The framework is applied to the Greek mobile telecommunications market using historical data (2006–2022), with a 5-year hold-back period for validation. Results highlight the dominant role of churn management in market share variability, particularly for the incumbent provider Cosmote, while subscriber attraction parameters show moderate influence for alternative providers Vodafone and Wind Hellas. Sensitivity analysis confirms the model’s robustness and identifies key drivers of forecast variability. The proposed framework provides actionable insights for strategic decision-making, making it a valuable tool for providers and policymakers to address churn, optimize attraction strategies, and ensure long-term competitiveness in dynamic markets. Full article

Within the “One Health, One Medicine” and comparative oncology paradigms, algal extracts have attracted attention, containing natural compounds (NCs) with biological activities, including anti-cancer properties. To characterize the biological effects of a Sphaerococcus coronopifolius extract (SCE), two canine mastocytoma and two normal cell lines were used. After a preliminary screening of three algal extracts, SCE cytotoxicity was measured using Alamar Blue, Sulforhodamine B, and Neutral Red Uptake assays. After assessing the selectivity versus tumor cells and its chemical characterization, SCE mechanisms of action were investigated using RNA-seq, quantitative PCR, flow cytometry and immunoblotting approaches. SCE showed an IC₅₀ comprised between 25 and 35 μg/mL in tumor cell lines, but it also affected normal ones (selectivity index < 2.0). RNA-seq and flow cytometry revealed that SCE negatively affected cell cycle and mevalonate pathway in tumor cells. Additional flow cytometry and immunoblotting investigations suggested a concentration- and time-dependent pro-apoptotic effect of SCE and DNA damage events. In conclusion, SCE demonstrated promising anti-cancer activity in mastocytoma cell lines by targeting the mevalonate pathway, arresting the cell cycle, and inducing apoptosis and DNA damage. Furthermore, the results presented here reinforce the idea that NCs may be promising candidates in comparative anti-cancer chemotherapy. Full article

Although the Tesla valve is a well-known technology spanning almost 100 years, its wide range of potential applications in modern engineering problems has made it particularly attractive to researchers in the last few years. The major factor that characterizes the Tesla’s valve effectiveness is the diodicity (D), which is practically defined as the ratio of the pressure difference in reverse to forward flow $D={\displaystyle \frac{\Delta P_{rev}}{\Delta P_{for}}}$. Under this framework, a geometry of multi-staged Tesla valves was selected to investigate the correlation between the Reynolds (Re) number and diodicity. Initial simulations were performed for $N=2$, $N=6$ and $N=10$ multi-staged micro Tesla valves using the OpenFoam platform, with Reynolds numbers of $Re$ 50–450. Here, the maximum diodicity values obtained were $D=1.43$, $D=2.76$ and $D=3.58$ for double-, six- and ten-staged micro Tesla valves under $Re=450$, respectively. Further simulations were performed for $N=3$ and $N=5$ under the same initial conditions in order to investigate the proportionality between N and D. Full article

Recent technological advances in communication networks, intelligent devices, power electronics, and phasor measurement units have significantly transformed the operation of modern power systems. This evolution gave rise to smart grids, which enable the flow of real-time information on the operational state of the grid and of control commands across multiple communication infrastructures, using a variety of protocols and standards, between control centers and devices deployed throughout the grid’s physical structure. At the same time, it has exposed power systems to new challenges and threats, due to the vulnerabilities inherited from the different components they integrate. Attackers have a variety of attacks at their disposal, by which they can disturb the availability of electricity as well as cause damage to the smart grid’s physical structure. Therefore, cybersecurity has become an important aspect of the smart grid concept. This field of research has attracted the attention of many researchers, and in the last decade or so, the number of studies on the cyber-physical security of smart grids has surged significantly. Proportionally, an important number of survey papers were published as well. It has therefore become more difficult to navigate literature on the topic of smart grid cyber-physical security due to the large number of papers, the complexity of the grid’s structure, and the variety of attacks, resolution methods, and techniques. To address this issue, in this work, we present a comprehensive review of existing literature reviews on the topic of smart grid cyber-physical security. We reviewed 100 survey papers, which were categorized into general surveys, attack-specific surveys, method-specific surveys, and component-specific surveys. We discussed and highlighted research tendencies in terms of attacks and methods used to protect smart grids. Additionally, we presented an overview of the different research challenges and possible future directions. Full article

Protein droplets exhibit complex self-assembly and deposition behaviors driven by evaporation, which has attracted increasing attention in recent years. Under evaporation, limited volume and locally concentrated protein solutions can undergo liquid–liquid phase separation (LLPS) and liquid–liquid crystalline phase separation (LLCPS), inducing the formation of concentrated droplets and anisotropic structures. The combined effects of interfacial tension and internal flow field induce a variety of deposition patterns on the substrate, providing great significance for the development of functional biomaterials. This paper reviews the physical processes experienced by protein/fibril droplets during evaporation, focusing on the formation mechanism of evaporation and their phase separation behaviors. At the same time, the review systematically summarized the key factors affecting the deposition patterns, and a variety of methods were introduced to pattern deposition, such as external electric field and micro-structured substrates. Furthermore, the potential applications of proteins/fibrils droplet deposition were discussed in multiple fields. This review aims to provide systematic theoretical support and experimental reference for understanding and controlling the deposition behavior of proteins/fibrils droplets, and to promote their further application in functional materials and biomedical engineering. Full article

Glioblastoma is one of the most aggressive and therapeutically challenging brain tumors. It is characterized by a highly immunosuppressive tumor microenvironment and poor prognosis, requiring novel treatment strategies. Along this line, ferroptosis has been proposed. To study the impact of ferroptosis on glioblastoma cells and immune cell infiltration, we established a spheroid model using LN229 glioblastoma cells and verified ferroptosis by measuring lipid peroxidation and RNA expression of ferroptosis-related genes. We then co-cultured spheroids with human peripheral blood mononuclear cells to follow the infiltration of distinct immune cell subsets by flow cytometry and immunohistochemistry. T lymphocyte infiltration into ferroptotic spheroids compared to control spheroids became apparent with the notion that ferroptotic cells attracted T cells more efficiently compared to apoptotic or necrotic cells. Mechanistically, ferroptotic glioblastoma spheroids released high amounts of ATP, which caused T cell attraction, while ATP deprivation reduced this effect. Ferroptosis appears to be an interesting therapy approach but might need co-treatments to ensure proper T cell activation. Full article